Great presentations, including the student contributors. Credit to the convenor and Prof Hagg for making the point about working with metabolomics, proteomics etc for newer clocks, where specific molecules and pathways can be identified, thereby allowing subsequent mechanistic investigations. That's the major roadblock for the epigenetic clocks. Inferring backwards is always challenging, even in systems with less variability than biological systems.
kind of disapointing. Just parroting Horvaths marketing gigs. No reflection on those clocks, despite there are so many "challenges". They do not have functional relevance, so why building on them? Phenoage (Levine, Horvath) being the worrst of all, using chrno age on both sides of the regression equation. DNA Methylation smears out with age and gets unspecific, some sites getting more, some much less methylated. DNA meth clocks are measuring just a stochastic process. No semantic relevance at all. Grimage works for mortalitty, but only by enforcing smoking and diabetes as covariates... surprise surprise... And such, last but not least, such studies are a huge amount of wasted money.
Great presentations, including the student contributors. Credit to the convenor and Prof Hagg for making the point about working with metabolomics, proteomics etc for newer clocks, where specific molecules and pathways can be identified, thereby allowing subsequent mechanistic investigations. That's the major roadblock for the epigenetic clocks. Inferring backwards is always challenging, even in systems with less variability than biological systems.
That intro with the music was horrible
Do u need a professionals UA-cam thumbnail designer and video seo experts?
kind of disapointing. Just parroting Horvaths marketing gigs. No reflection on those clocks, despite there are so many "challenges". They do not have functional relevance, so why building on them? Phenoage (Levine, Horvath) being the worrst of all, using chrno age on both sides of the regression equation. DNA Methylation smears out with age and gets unspecific, some sites getting more, some much less methylated. DNA meth clocks are measuring just a stochastic process. No semantic relevance at all. Grimage works for mortalitty, but only by enforcing smoking and diabetes as covariates... surprise surprise...
And such, last but not least, such studies are a huge amount of wasted money.