Can anyone please explain why writhe is less than zero in case of RH helix??? Because if writhe is less than 0 that means we are applying negative supercoiling to right handed helix which will in turn decrease the number of twist and Linking number. Again, applying writhe greater than 0 will cause the right handed helix to twist more in right handed side causing increase in number of twist and Linking number. I may be wrong. Please explain 🙏🏻
I think here the negative and positive sign when calculating only shows the direction of turning with respect to the original clock/aniti clock twisting of DNA. By definition negative supercoiling usually refers to when DNA is un winded whereas positive supercoiling is when DNA is condensed further. But here cause the linking number can't be changed and is kept constant we use -(negative) or +(positive) signs to maintain the ratio between twists(Tw) and writhe(Wr). ( As Lk = Tw+ Wr) So even if a strand of DNA which in RH in nature is being twisted clockwise it's supercoiling would still be positive as the number of twists (in equation) decreases and to maintain constant Lk we're required to add writhe (Wr) hence making it positive. This is what I understand,do provide info if I made a mistake.
Just like how DNA in humans is stored via coiling around histone proteins,it's by definition an ex of positive supercoiling and we can say that here the number of twists might be decreasing as it's writhe is increasing (coiling around histone proteins). So as per equation Wr would be + as twist might be decreasing in number but still decreasing of twists doesn't equal DNA not condensing as it is being coiled into smaller size. I.e, just cause number of twists are decreased doesn't mean condensing isn't happening.
Wrong info Write show amount of coiling. 5 + three writhes is 8. Now 8 time s we need to open both strands. Your example change lk to again 5 that is again definition of lk
She has covered Watson completely in her videos. Very well explained
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@@RethinkBiology You're welcome! I've always wanted to make a DNA Topology video on my channel haha, yours was great!
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Mam great explanation 👍👍👍👍 support from Odisha
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@@RethinkBiology Absolutely, you guys are an excellent resource for students, keep it up!
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Can anyone please explain why writhe is less than zero in case of RH helix??? Because if writhe is less than 0 that means we are applying negative supercoiling to right handed helix which will in turn decrease the number of twist and Linking number. Again, applying writhe greater than 0 will cause the right handed helix to twist more in right handed side causing increase in number of twist and Linking number.
I may be wrong. Please explain 🙏🏻
I think here the negative and positive sign when calculating only shows the direction of turning with respect to the original clock/aniti clock twisting of DNA.
By definition negative supercoiling usually refers to when DNA is un winded whereas positive supercoiling is when DNA is condensed further.
But here cause the linking number can't be changed and is kept constant we use -(negative) or +(positive) signs to maintain the ratio between twists(Tw) and writhe(Wr).
( As Lk = Tw+ Wr)
So even if a strand of DNA which in RH in nature is being twisted clockwise it's supercoiling would still be positive as the number of twists (in equation) decreases and to maintain constant Lk we're required to add writhe (Wr) hence making it positive.
This is what I understand,do provide info if I made a mistake.
Just like how DNA in humans is stored via coiling around histone proteins,it's by definition an ex of positive supercoiling and we can say that here the number of twists might be decreasing as it's writhe is increasing (coiling around histone proteins).
So as per equation Wr would be + as twist might be decreasing in number but still decreasing of twists doesn't equal DNA not condensing as it is being coiled into smaller size.
I.e, just cause number of twists are decreased doesn't mean condensing isn't happening.
Very Nice Explanation! 👍👏
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#highschoolbiology
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ac coil radioactive frequency multilooping energy momemtum flow at superconductivity speed
that negative electomagetism loop
Trank you !!
Wrong info
Write show amount of coiling.
5 + three writhes is 8.
Now 8 time s we need to open both strands.
Your example change lk to again 5 that is again definition of lk
하이고 어렵다 ㅠ