Transdermal Selegiline: Mechanism of Action

Among the pharmacological options for MDD treatment, selegiline stands out, particularly in its transdermal form. Transdermal selegiline offers a novel approach to delivering this medication, promising efficacy with reduced side effects.
Transdermal administration offers an alternative route for drug delivery, bypassing the gastrointestinal system and delivering the medication directly into the bloodstream through the skin. In the case of selegiline, this method of delivery has been optimized to provide steady plasma concentrations while minimizing the risk of adverse effects.
But what exactly is its mechanism of action?
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