Thank you for the work you do. I know you are speaking mainly to physicians but you are helping MM patients and their spouses/caregivers to make informed decisions about their care. You inspired me (my husband is 53 and has MM) to do a deep dive on the Determination Study and figure out what is best for my husband and our family.
Exactly - from the patient's point of view is all this Twitter back and forth good or bad? On one hand, open discussion is good like getting a whole bunch of second opinions. On the other hand getting a whole bunch of second opinions that create doubt leads to a sense that nobody has a clue what the hell they're doing!
I am a Family Physician. I listen to most of your conent because I like the way you think. Just as you find trouble in your area of expertise, I find it in mine.
After they realized that monkeypox, like AIDS, affected only a certain protected population, they had to scrap their plans of making it the new covid. Hard to make people terrified of something they know they won't get because they know they don't stick their pee pee where the sun don't shine.
As a layperson: Thank you for going through the time and trouble of decoding these studies! However, if I were a MM patient who wanted to enter a clinical trial in search of a possible cure or treatment, I'd be more despondent than ever, and seek alternative medicine, palliative care and hospice options for relief.
A lot of good takeaways in this video from nitty gritty like what can mend the problem (changes in education, less corruption)... to big picture ideas like irresponsibility & making room for regulators.
*oh, thank goodness! so it is just myeloma twtr makes things up!* that is a relief. bc i thought id seen some questionable things across fields. thought id even engaged in few! but i prefer feeling this way. =). fine entry. _JC
Mom got this in 1994 at age 57. She was given 3-5 years, she lived 3. No stem cell transplant at that time for this. Never heard of MM before that and now I feel like I hear about it a lot. There seems to be a lot more they can do now-i know of people who have had it and are still with us many years later, thankfully. Wish I still had her :(
I work in the oncology drug development field and deeply appreciate the education you’re providing. I’ve also thoroughly enjoyed your commentaries on covid. This is completely anecdotal, but prior to COVID and the mass vaccination campaign, I had zero family members with breast cancer and no breast cancer in my family. As of today, my 3rd aunt and now my 39 year old sister-in-law have been diagnosed with localized breast cancer. I do not have an excessively large family, so this represents the majority of women in my family going from healthy, no cancer to having breast cancer in the last 2 years. Obviously now we know covid vaccination has an impact on menstruation. Is there any emerging data on a possible association between mRNA vaccination and breast cancer?
I honestly don't understand a lot of this, so I don't even know why I listen. If I ever get cancer, I don't know if this info will help me to make treatment decisions for myself. Yet I keep listening. Maybe it's because my mom is a retired oncology nurse who spent the latter part of her career in home health care, mainly caring for oncology patients. She left the oncology unit at the hospital when her favorite oncologist left the field. I think it was sometime in the late 1980s or early 1990s. He followed a protocol that had great success, but the pharmaceutical company stopped making one of the drugs that was most successful for whatever cancer. This is a small city, so none of the oncologists specialized in one form of cancer to the exclusion of others. And according to Mom, who participated in compiling the data sent to CDC, this region had the highest number of cancer cases in the US. Word about that got around, so a local newspaper columnist talked to some official at the local health department to get the scoop. And according to the local health department, we didn't have the highest number of cancer cases, we just had the highest number of cancer deaths. Either way, it ain't good, but Mom insisted it was both -- first, the most cases, then after Dr. B. left, the most deaths. At that time there was only one cancer treatment hospital, as the other local hospital had taken on all maternity deliveries. That was the agreement the two hospitals came to when the Baby Boom ended and it was decided that only one obstetrics unit was needed in town. Since then the obstetrics hospital set up an oncology unit, but it's not very good, so I hear. Patients start off on the treatment protocol, go into remission, then quickly the cancer comes back, and the oncologists don't return phone calls. One patient said she desperately reached out to a hospital in the nearest big city, and they accepted her as a patient. She phoned her local oncologist to have her records transferred, and lo and behold he personally called her back to have her come in to discuss treatment options. She listened to the options and got it in writing, then took it to the big city oncologist. He told her that was an out of date treatment option, and went over the one he uses. He told her it would buy her maybe 6 months. Well, it's been a couple years, and she's still doing pretty well. She's enjoying her final years, treasuring each good moment. Her newest great grandchild is her motivation. He wasn't even born when she started this new treatment, and he's almost 2 years old now. But it is expensive, that's for sure.
Do some trials with large economic implications as u did with teclistamab. Maybe look at adagrasib review - 11% gr5 AEs don’t look so good on a second in class KRAS drug
Quick question but important I think with all the sudden cardiac deaths) my husband who had sudden afib after the you know what and EF of 25/30% Is now having to go for a lexiscan.. my concern is with this drug induced stress test (my understanding of it) has anyone noticed more sudden cardiac arrest results upon performing this test than before… with patients who have taken the v?
My mom died of Multiple Myeloma back in 1973. Why not focus on the cause of this disease. It’s been 50 yrs! I’d seen her eat raw meat, at my dads request, she ate baking yeast thinking that was good for her. She was only 54 and I was 20 back then. I decided back then we are each responsible for our health, I will never submit myself to Chemo. After all this time, Im sure it’s our diets that contribute to Cancer. Good put such amazing fruits and veggies on this planet and warned us what not to eat. Every time we eat something inferior it replaces the opportunity to eat something healthy. All the billions donated to cancer research has benefit very little. Focus on preventing along with….. now what are we going to do for this patient!
What do you think is the best maintenance plan for someone in remission? Currently, my dad is doing Faspro alone and his M spike is starting to creep back up.
I believe I heard you say in a video that over 90% of children have already had (or maybe been exposed to) covid. I'm looking for that data. Can you or someone point me in the right direction? :)))
I think most doctors don't really know what he is talking about. Evidence-based medicine is supposed to be a sieve to clarify medical issues via the scientific method. For me, the "evidence-based" part has now become an enterprise unto itself, some sort of statistical plaything in which "experts" in their field spew all kinds of interpretations to obfuscate the data. The better an 'expert' is on this game, the more confused an average doctor becomes, the doctor some sort believes he/she cannot really understand all these complicated reasonings and statistical methods, resign to accept words of 'experts in the field' as dogma.
I love these types of pure information videos. I want more videos like this, pure information with the study’s backing it up.
Thank you for the work you do. I know you are speaking mainly to physicians but you are helping MM patients and their spouses/caregivers to make informed decisions about their care. You inspired me (my husband is 53 and has MM) to do a deep dive on the Determination Study and figure out what is best for my husband and our family.
Exactly - from the patient's point of view is all this Twitter back and forth good or bad? On one hand, open discussion is good like getting a whole bunch of second opinions. On the other hand getting a whole bunch of second opinions that create doubt leads to a sense that nobody has a clue what the hell they're doing!
Often, many of the people do not have a clue.
Welcome to the internet
Glad we are starting to expand medical issues beyond CoVid. And what happened to Monkeypox?
Don’t ask, don’t tell.
They could not make it the new coof.
I am a Family Physician. I listen to most of your conent because I like the way you think. Just as you find trouble in your area of expertise, I find it in mine.
After they realized that monkeypox, like AIDS, affected only a certain protected population, they had to scrap their plans of making it the new covid. Hard to make people terrified of something they know they won't get because they know they don't stick their pee pee where the sun don't shine.
It's homophobic to ask about monkey pox.
As a layperson: Thank you for going through the time and trouble of decoding these studies! However, if I were a MM patient who wanted to enter a clinical trial in search of a possible cure or treatment, I'd be more despondent than ever, and seek alternative medicine, palliative care and hospice options for relief.
Wish I had the statistical chops this guy has!
A lot of good takeaways in this video from nitty gritty like what can mend the problem (changes in education, less corruption)... to big picture ideas like irresponsibility & making room for regulators.
Thanks for this. This was a remarkably informative plenary talk.
*oh, thank goodness! so it is just myeloma twtr makes things up!* that is a relief. bc i thought id seen some questionable things across fields. thought id even engaged in few! but i prefer feeling this way. =). fine entry. _JC
Mom got this in 1994 at age 57. She was given 3-5 years, she lived 3. No stem cell transplant at that time for this. Never heard of MM before that and now I feel like I hear about it a lot. There seems to be a lot more they can do now-i know of people who have had it and are still with us many years later, thankfully. Wish I still had her :(
I work in the oncology drug development field and deeply appreciate the education you’re providing. I’ve also thoroughly enjoyed your commentaries on covid. This is completely anecdotal, but prior to COVID and the mass vaccination campaign, I had zero family members with breast cancer and no breast cancer in my family. As of today, my 3rd aunt and now my 39 year old sister-in-law have been diagnosed with localized breast cancer. I do not have an excessively large family, so this represents the majority of women in my family going from healthy, no cancer to having breast cancer in the last 2 years. Obviously now we know covid vaccination has an impact on menstruation. Is there any emerging data on a possible association between mRNA vaccination and breast cancer?
I honestly don't understand a lot of this, so I don't even know why I listen. If I ever get cancer, I don't know if this info will help me to make treatment decisions for myself. Yet I keep listening. Maybe it's because my mom is a retired oncology nurse who spent the latter part of her career in home health care, mainly caring for oncology patients. She left the oncology unit at the hospital when her favorite oncologist left the field. I think it was sometime in the late 1980s or early 1990s. He followed a protocol that had great success, but the pharmaceutical company stopped making one of the drugs that was most successful for whatever cancer. This is a small city, so none of the oncologists specialized in one form of cancer to the exclusion of others. And according to Mom, who participated in compiling the data sent to CDC, this region had the highest number of cancer cases in the US. Word about that got around, so a local newspaper columnist talked to some official at the local health department to get the scoop. And according to the local health department, we didn't have the highest number of cancer cases, we just had the highest number of cancer deaths. Either way, it ain't good, but Mom insisted it was both -- first, the most cases, then after Dr. B. left, the most deaths. At that time there was only one cancer treatment hospital, as the other local hospital had taken on all maternity deliveries. That was the agreement the two hospitals came to when the Baby Boom ended and it was decided that only one obstetrics unit was needed in town. Since then the obstetrics hospital set up an oncology unit, but it's not very good, so I hear. Patients start off on the treatment protocol, go into remission, then quickly the cancer comes back, and the oncologists don't return phone calls. One patient said she desperately reached out to a hospital in the nearest big city, and they accepted her as a patient. She phoned her local oncologist to have her records transferred, and lo and behold he personally called her back to have her come in to discuss treatment options. She listened to the options and got it in writing, then took it to the big city oncologist. He told her that was an out of date treatment option, and went over the one he uses. He told her it would buy her maybe 6 months. Well, it's been a couple years, and she's still doing pretty well. She's enjoying her final years, treasuring each good moment. Her newest great grandchild is her motivation. He wasn't even born when she started this new treatment, and he's almost 2 years old now. But it is expensive, that's for sure.
As a layperson, I love this
Please make your video window smaller, so you are not covering your slide content.
great ep!!!
Great job. Where was this effective, hard-hitting, pointed mockery of all the faux covid BS?
More of this! Love it ❤
so good......as usual thanks
Great discussion!
Thanks, that was very interesting one!
Do some trials with large economic implications as u did with teclistamab. Maybe look at adagrasib review - 11% gr5 AEs don’t look so good on a second in class KRAS drug
I can"t see -read behind your image ! Please !
9:10 leadtime (scaner) bias & a def switch (classic). _JC
Quick question but important I think with all the sudden cardiac deaths) my husband who had sudden afib after the you know what and EF of 25/30%
Is now having to go for a lexiscan.. my concern is with this drug induced stress test (my understanding of it) has anyone noticed more sudden cardiac arrest results upon performing this test than before… with patients who have taken the v?
My mom died of Multiple Myeloma back in 1973. Why not focus on the cause of this disease. It’s been 50 yrs! I’d seen her eat raw meat, at my dads request, she ate baking yeast thinking that was good for her. She was only 54 and I was 20 back then. I decided back then we are each responsible for our health, I will never submit myself to Chemo. After all this time, Im sure it’s our diets that contribute to Cancer. Good put such amazing fruits and veggies on this planet and warned us what not to eat. Every time we eat something inferior it replaces the opportunity to eat something healthy. All the billions donated to cancer research has benefit very little. Focus on preventing along with….. now what are we going to do for this patient!
Fasting is supposed to be good for preventing cancer as well.
Awesome analysis
Isn't fewer blisters at mile 3 a good thing? Not the end goal of course, but absent any other information, isn't this a good thing?
Thalidomide may have additional activity not seen in newer more expensive imids
What do you think is the best maintenance plan for someone in remission? Currently, my dad is doing Faspro alone and his M spike is starting to creep back up.
The analogies are killing me. Lmao Rudyard Kipling
And it"s only for advanced users - unfortunately !
I believe I heard you say in a video that over 90% of children have already had (or maybe been exposed to) covid. I'm looking for that data. Can you or someone point me in the right direction? :)))
As a general internist, I have no idea what words you are saying. For that reason, I'm out.
I think most doctors don't really know what he is talking about. Evidence-based medicine is supposed to be a sieve to clarify medical issues via the scientific method. For me, the "evidence-based" part has now become an enterprise unto itself, some sort of statistical plaything in which "experts" in their field spew all kinds of interpretations to obfuscate the data. The better an 'expert' is on this game, the more confused an average doctor becomes, the doctor some sort believes he/she cannot really understand all these complicated reasonings and statistical methods, resign to accept words of 'experts in the field' as dogma.
Randomized controlled studies are bunk.
Why did VP think the jabs had good data when they first came out?
Still pushing the poison jabs Vinay?
Still molesting little boys, Mr Marito?