@@aniksamiurrahman6365 for me it's ai, I've been working my way for the past 2 years, gained a lot of knowledge and theory , now I want to get a degree
In the ESM2 paper it was shown that you don't need MSA at all for generating structures, just some embeddings obtained from a masked token task pretrained RoBERTa are quite suitable.
We live in some very interesting times, indeed. Thank you for this video! Just a few notes, and maybe you can address them in a next video. Apparently it's not capable of working with any ligands, just a subset provided by the AI vendor. Also, it seems a ligand with many rotary bonds might be overwhelming for pair representation matrix. Still, many people think this new version will most likely help make important leaps for the drug design industry.
I guess this channel will always be my favorite! I just learned about pair representations on NanoRooms and now I know an application and a prediction about the future of AI tools 🤯
Yeah I can see how once you do away with the "triangles" or any other modeling of the relatedness of neighboring amino acids, the data about the evolutionary history of the molecule would not be as important as it was before. It's crazy that you can get atom-by-atom predictions in molecules as big as protein complexes in reasonable computational time. If I had to guess, a goal for the next decade in protein structure algorhythms would be to turn an input that's like "I want a protein that catalyzes this reaction under these conditions" and it spits out a hybrid protein sequence that does that, predicting the speed of the reaction.
I just read a Book of Manfred Spitzer about AI. AlphaFold was also mentioned but not fully explained in detail. He mentioned those triangels forming the proteins backbone. But not how they are arranged and that there be so many. 😅
I'm 45. I see all the illnesses in the Boomers, the next generation up, and it kinda freaks me out. And those even older, who are stuck at home or in care homes. I visited my grandmother in one, and that is not how her long life should have ended. Hopefully, this and all the other models being implemented will have transformed the industry by the time I'm the age where I could be facing their illnesses. Fingers crossed!
Perfect overview - just the right level of background and detail. I suspect that non-drug protein / molecule design will have a much bigger impact than novel drugs only for the wealthiest few % of all humans. (Drugs aren't going to fix rapacious capitalism and inequality)
@@miskee11 But sir le graphene! Le superconductors at room temperstures! Le heckin nuclear fusion?! We need more billions of units of currency to make those things real (for real this time, promise)
Your last videos got me curious and started looking at Alphafold and am now seriously considering making it my goal to work in that field. Thank you 🎉
That's awesome! I'd love to hear more if you do go down that path! My email is on my "about" page
AI or Biology?
@@aniksamiurrahman6365 for me it's ai, I've been working my way for the past 2 years, gained a lot of knowledge and theory , now I want to get a degree
I wouldn't if I were you, there will be no jobs thanks to alphafold itself.
@@FindingCreatures Its exactly the other way. More things are possible for Biotech industries now, and thus more opportunity.
In the ESM2 paper it was shown that you don't need MSA at all for generating structures, just some embeddings obtained from a masked token task pretrained RoBERTa are quite suitable.
Fascinating. I really learned something, which says something about your ability to teach, because this is not my wheelhouse
Thank you so much for sharing your insights into this! You have a real gift for seeing and explaining things
Good stuff Mithuna keep it coming!
Glory to He Jiankui HIV Free Africa and this year Laureates!
We live in some very interesting times, indeed. Thank you for this video! Just a few notes, and maybe you can address them in a next video. Apparently it's not capable of working with any ligands, just a subset provided by the AI vendor. Also, it seems a ligand with many rotary bonds might be overwhelming for pair representation matrix. Still, many people think this new version will most likely help make important leaps for the drug design industry.
Thanks!
Another great video on alpha fold. Thanks!
I guess this channel will always be my favorite! I just learned about pair representations on NanoRooms and now I know an application and a prediction about the future of AI tools 🤯
Maybe it can fold proteins, but AI can never predict the connections that Mithuna will come up with next!
This is really high quality video. Great job
Great video, you have a great way of explaining complicated concepts!
Concise and understandable. Thanks!
Yeah I can see how once you do away with the "triangles" or any other modeling of the relatedness of neighboring amino acids, the data about the evolutionary history of the molecule would not be as important as it was before. It's crazy that you can get atom-by-atom predictions in molecules as big as protein complexes in reasonable computational time. If I had to guess, a goal for the next decade in protein structure algorhythms would be to turn an input that's like "I want a protein that catalyzes this reaction under these conditions" and it spits out a hybrid protein sequence that does that, predicting the speed of the reaction.
These are fantastic explanation. many thanks for this.
I just read a Book of Manfred Spitzer about AI. AlphaFold was also mentioned but not fully explained in detail. He mentioned those triangels forming the proteins backbone. But not how they are arranged and that there be so many. 😅
what a time to be alive!
Two Minute Papers? Love that channel
@@LookingGlassUniverse yesss!!!
Great understanding...Thank you so much
Not related to the video but I really love your handwriting
that chair looks really comfortable
Great stuff - Im so excited about AF3. I think new ML techincs will boost whole science and inventions.
You are so awesome. Well explained
Interesting. The MSA and pairing system is like the attention mechanism of LLM. Maybe next would be more data for self attention?
You got me interested in this subject, although I don't know why.
I think that all the advancements in tech at the moment are due to our capacity to see smaller and smaller.
awesome explanation!
Thanks a lot! 😀
Wow. I know a little about the protein-folding problem and you and your explanation of AlphaFold are unputdownable. Subscribed.
"merely" astonishing
I'm 45. I see all the illnesses in the Boomers, the next generation up, and it kinda freaks me out. And those even older, who are stuck at home or in care homes. I visited my grandmother in one, and that is not how her long life should have ended.
Hopefully, this and all the other models being implemented will have transformed the industry by the time I'm the age where I could be facing their illnesses. Fingers crossed!
Perfect overview - just the right level of background and detail.
I suspect that non-drug protein / molecule design will have a much bigger impact than novel drugs only for the wealthiest few % of all humans.
(Drugs aren't going to fix rapacious capitalism and inequality)
Drugs fix illnesses, not politics
Alpha Fold 3 looking good
i loved this!
I feel very uncomfortable regarding AI, especially generative AI but your recent videos have changed my feelings somewhat.
The only discomfort I feel is, due to these AIs, we might never discover the underlying physics. Researchers might just stop working on them.
Đơn giản ko?
Going to be fun times in the future. At least for drug companies
Since when does she cover AI content, what happened to the physics from her Ph.D?
Physics has been stuck for a hundred years. AI and crypto are what actually matter now.
@@miskee11Crypto? It went nowhere at least 5 yrs ago. Soon might lose it's usefulness in speculation as well.
@@miskee11 you may be interested in a video by physicist Angela Collier titled "a physicist responds: physics has done very little for like 70 years"
@@miskee11 But sir le graphene! Le superconductors at room temperstures! Le heckin nuclear fusion?! We need more billions of units of currency to make those things real (for real this time, promise)
@@dr.tafazzi The Industrial Revolution and its consequences have been a disaster for the human race.
Tats
First?!
Ok
Bah! I am waiting for SigmaFold 😎
/s