Berberine: Liver and Metabolic Health
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- Опубліковано 9 лют 2023
- Berberine: Liver and Metabolic Health
Talk #1 on Berberine: ua-cam.com/users/liveGbn0ZTlgMo0
Berberine is a magical molecule with a vast array of effects. Today we will focus on the mechanism of the impact of BBR on liver and glucose levels.
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Disclaimer:
This video is not intended to provide assessment, diagnosis, treatment, or medical advice; it also does not constitute provision of healthcare services. The content provided in this video is for informational and educational purposes only.
Please consult with a physician or healthcare professional regarding any medical or mental health related diagnosis or treatment. No information in this video should ever be considered as a substitute for advice from a healthcare professional.
URL list from Sunday, Feb. 10 2023
Berberine is an insulin secretagogue targeting the KCNH6 potassium channel | Nature Communications
www.nature.com/articles/s4146...
AMP-activated protein kinase - Wikipedia
en.wikipedia.org/wiki/AMP-act...
Frontiers | Cerebral Gluconeogenesis and Diseases
www.frontiersin.org/articles/...
Phosphoenolpyruvate carboxykinase - Wikipedia
en.wikipedia.org/wiki/Phospho...
Gluconeogenesis - Wikipedia
en.wikipedia.org/wiki/Glucone...
Metformin - Wikipedia
en.wikipedia.org/wiki/Metformin
Sterol regulatory element-binding protein 1 - Wikipedia
en.wikipedia.org/wiki/Sterol_...
The Role of Mammalian Target of Rapamycin (mTOR) in Insulin Signaling - PMC
www.ncbi.nlm.nih.gov/pmc/arti...
mTORC1 activates SREBP-1c and uncouples lipogenesis from gluconeogenesis | PNAS
www.pnas.org/doi/10.1073/pnas...
Insulin Signaling Pathway | Antibodies.com
www.antibodies.com/insulin-si...
Regulation of SREBP by insulin signaling pathway | Download Scientific Diagram
www.researchgate.net/figure/R...
The role of the KATP channel in glucose homeostasis in health and disease: more than meets the islet - PMC
www.ncbi.nlm.nih.gov/pmc/arti...
Frontiers | Glucose-lowering effect of berberine on type 2 diabetes: A systematic review and meta-analysis
www.frontiersin.org/articles/...
ATP-sensitive K+ channels in pancreatic beta-cells. Spare-channel hypothesis - PubMed
pubmed.ncbi.nlm.nih.gov/2452107/ - Розваги
You’re constant admonition to ‘consult your doctor’ doesn’t hold the same weight as it did prior to CVD. Now we’re wide awake to what we’re dealing with, and that the vast majority of ‘doctors’ are essentially paid hitmen!
Thank you for sharing and explaining this to us. It is greatly appreciated!
legalised drug pushers !!
Just keeping his channel on you tube and keeping from getting sued. He has to say consult your doctor--if you can find one that knows what he/she is doing.
As a 50-something with near type 2 diabetes, Berberine has made miraculous impact in just 4 weeks of taking daily. This little natural molecule is God send 🙏😊❤
Thanks! I have been taking berberine for a year. Along with major changes to my diet, taking berberine has helped me lose weight and lowered my A1C from 5.3 to 5.2. A few months ago, I switched to dihydraberberine.
I have been taking Berberine for 6 months and it has been a miracle for me. I am taking it for weightloss. The weight has literally been melting off after taking this. It helps me by working as an appetite suppressant, this helps me maintain a caloric deficit. It also gives me energy. I take 1000 MG. I started with 500 MG and it did not work as well. I have not had any side effects. I absolutely love this vitamin. I suggest mixing it with a keto or low carb zero sugar diet. That is if you seek to use this for weight loss.
i was taking 500 mg a day for a few years but my naturopath suggested i up it to 1000 mg a day. she said the studies were done with 1500 mg. i take it for blood sugar control & it works for that but i also lost a few pounds with bumping it up. it seems to work better for me if i take it 1/2 hour before meals.
Its not a vitamin. Its a plant
What brand do you take?
What brand do you take?
@@mariecallahan9975I take Thorne, because I trust them to produce high quality products. But I think any reliable brand would do.
I've been taking Berberine for several years (for all properties Dr. Been discussed). It's also popular among the "anti-aging biohackers", along with Metformin and Rapamycin.
I put my wife on it about a year ago. We had to buy a Powder Scale in order to take the correct dosage. My Wife and I are taking Bitter Melon to control blood sugar.
Milk Thistle works great along side Berberine.
Did you find scientific foundation explaining effect of Berberine as "anti-aging" agent
Most physicians would not know what berberine does let alone the drug interactions... Basically you are on your own in the US if you are taking it.
Many things they don't know. nac or natto they never heard of till I brought it up. Made them Google it lol.
Might be better off doing own research
@@Broken4forever interestingly, my daughter in Australia had NAC recommended to her by her doctor during and after her 3rd bout with Covid. Could it be that some doctors are listening?
This is true I asked my doctor he had no clue
@@techadsr very few.
I’ve been taking berberine for about 6 months and was very happy to learn the details of the mechanism of action. Thank you!
Did you take it for a particular health issue or for general health maintenance?
@@republiccooper, my HgbA1c was 5.6 and to improve digestion.
@@areugnat5484 What has your experience been?, if you feel comfortable to share.
@@republiccooper Positive. No adverse reactions. The HgbA1c dropped 2 points.
@@areugnat5484 great!
Thanks for getting back to this Dr Sayed. I read all I could find years ago and am very interested in a deeper understanding.
Absolute wonderful.
Thanks a lot.
INVALUABLE - I’m soooo THANKFUL to you!!
Thank you for all this wonderful information.
Wow! Thank you so much! May you be blessed!
Thanks for being so scientific & detailed.
Wonderful!!! Thank you Dr. Been. Looking forward to hearing more of berberine's many benefits.
🇬🇧🙏This is simply magnificent! How many pathways and mechanisms ! Love it ! Thank you Dr. Mobeen 🥰🙏🙏🙏
Excellent lecture. Thank you
Great show! Thank you.
Thank You for the breakdown...
I recently started taking Berberine to help manage Blastocystis hominis, a parasite. Great to hear that it happens to work in other areas as well. Thanks for such a clear presentation of the mechanism of action. Still searching for how it works on blasto.
Wonderful presentation. Love your art, clear explanations, and topic. Blessings on your head, Dr B!
Congratulations from a colleague from Portugal!
Very informative thank you doc
My pleasure
I did see a study also mentioning a bit of help with ApoB which I thought was odd, I have high Apob but I eat high fat low carb and my ldl is high though my trigs and stuff are all low. It's nice to see berberine helps lower apob,raise hdl lower ldl and trigcylerides as well.
Thank You 👍👍👍
Wonderfull lecture.... Thank you so much
Thank you!
You're welcome!
Thanks forever for delving so deeply into berberine....also looking forward to the side effects video....want to take it...but have some concerns re past experience
Thank you so much for the information on berberine! I really appreciate these talks. 😊
Thanks!
@Di Dz I am so sorry for your loss. Hope to see you back here soon.
I have been taking berberine for years. It works for very nicely for me.
This supplements elevate your liver enzymes?
Thank you..
It would be nice if doctors even knew what berberine is!
It's Awesome sir 🙏
Basically what is desired from Berberine is increased energy. Since my metabolism seems OK at this point I will take akg so it is easier to stand after sitting and lower frailty.
thank you
🤔Comment, much appreciate that this talk explains mechanisms behind berberine’s effects. Glad to see an explanation. Miraculous! I had wondered about berberine because of coincidental personal experience with some supplement. I’d noticed that I felt much better, much healthier, more energy, even clearer thinking, when taking certain supplements that happened to include berberine along with other ingredients. Additionally, I lost unhealthy weight and got less sick. I hadn’t been interested in berberine but as I noticed that the supplement which included it had me feeling better whereas the ones that didn’t weren’t having such an effect, including looking better since others commented when I had taken it for a while, I thought that ingredient might be important. Although not certain, I have no way to definitively verify that was the factor, berberine seemed to be the key. Later, that supplement was no longer sold. It seemed quite effective. Even if it was a placebo (doubtful as I hadn’t noted that it was included when I started noticing the effect, and hadn’t noted originally that it wasn’t included in the other supplements), I miss the supplement. It’s too bad. The mechanism is interesting.
Just take plain Berberin.
So, it technically disrupts energy pathways on multiple levels, which forces the cells to change their behavior. Compared to fasting it works whether the liver tries to compensate or not. On the other hand, it speeds up processes but does not let them get finished, which probably means a lot of unused metabolites just floating around (=a massive workload for kidneys).
I would label it as a good shock therapy if your metabolism is in disarray, but a weird thing to consume daily if your body is in a good condition.
I've always been told to take it in monthly cycles. Not personally knowing the reasoning. Just advice from someone I trust on key health topics.
@@InHisName999 that applies o everything, even types of food.
Regarding the decrease in mRNA production and protein synthesis, are there any concerns of other (needed) proteins and enzymes being hindered? Very good presentation!
Thes ternative solutions are fine and should be required for physicians. Although big pharma can’t patient.
Q. How does the cell use up all this excess glucose now coming into the cell as it cannot be converted to fatty acids or does it only take what it needs through glut4?
Thank you for the excellent explanation. What are your thoughts about taking berberine while on HRT?
Hi Doc, so my question is Berberine good for a fatty liver when also including this study? In science direct..".The short-term effects of berberine in the liver: Narrow margins between benefits and toxicity"......this is a 2022 study.....notes "However, safety concerns also arise because all effects occur at similar concentrations and there is a narrow margin between the expected benefits and toxicity. Even mild inhibition of gluconeogenesis is accompanied by diminutions in oxygen uptake and ammonia detoxification and increases in the NADH/NAD+ ratio. " Thanks for your opinion as this stuff can be very complicated.
I had a strange side effect, my neck started hurting - my shoulders, like a mast cell response. I have also developed reactive hypoglycemia. I dont know if the hypoglycemia is connected, but I definately had a reaction.
I found out that I had to buy a Powder Scale in order to take the correct dosage of Berberine. Bitter Melon helps a lot with blood sugar.
Pharmacology question. Is there evidence of prescription Sodium-glucose inhibitors conflicting with Beberine that unregulates these channels.
Thanks, long time follower. Keep up the great work. Sam Q.
It's such a powerful drug, but mostly unknown to doctors since they can't prescribe it and there are no billing codes they can use. I think I did talk to a doctor about it, and he said "what's that?" and that he would prescribe me metformin if I wanted. There are some issues with metformin, though, and I'm not sure the risks outweigh the rewards. The only thing about all this I don't like, is forcing the cell into an emergency, survival mode, where it only produces the most important enzymes. That's why Dr Brad Stanfield (another YT MD influencer) was saying to only take berberine on non exercise days, which makes it a pain since every day is an exercise day for me. I think I lost weight when I was taking it (every 3 days o so) but I do too many things and don't keep track of them, so can't tell cause and effect.
Why on noon- exercise days?
What about TD1, insulin dependence & resistance?
curious as to why you did not mentioned the impact of berberine on the microbiome and ultimately its ability to reduce post prandial endotoxemia that drives the type 2 diabetes . As you most likely aware the both Chinese medicine and Ayurvedic medicine has been using berberine for GI issues and ultimately solving the root cause of the metabolic issues that stem from the dysbiosis and post prandial endotoxemia...the mechanisms you describe can all be improved via reduction of endotoxemia...Thoughts?
I took 1200mg today. I want to see whether it causes Hypoglycemia.
Husband has cirrhosis of the liver and I am hoping this supplement will help him. After being on Lactulose for hepatic encephalopathy, his A1C went up quite a bit. Of course, doctors all say supplements do nothing. Enjoy your videos. thank you
Take TUDCA not this
Is there a brand you recommend?
Thank you. According to your explanation, therocally, it is good to take berberine before meal in order to diminish quickly blood sugar level but also during fasting period in order to avoid neoglucogenesis to happen?
Is there effect from berberine to liver hemangioma?
Thank you once again for your great gifts to humanity, Dr King Been. You are a star shining light on mechanisms obscure to many of your peers. What a thinker/inspiration you are as you challenge further medical knowledge and research hypotheses and developments for humanity’s wellbeing. 29:04. This would be interesting to test using Dr VAShiva cytosolve system simulations. 31:55
Have you checked into high dose Thiamine therapy for long covid?
Dr Marik's HAT sepsis protocol uses Thiamine - is it possible we have not fully exploited B1's benefits? See EONutrition - great explanation of mechanisms. A person may have NORMAL B1 levels and still benefit from high-dose B1 therapy.
What is the natural remedy to shrink fibroidsin the uterus
is Berberine good or bad for you liver ?
If ATP production is decreased in the mitochondria, wouldn't that result in decrease energy levels?
Excuse me Doctor, but are you going to present the in-vitro study on Nattokinese? They found that it destroyed the Spike protein.
Can you add link
Can I take berberine if Im takin isotretinoin?
I wonder if decreases Mtor due to activating ampk will lower muscle growth
Inositol same
Can bernerine be used for people who are NOT diabetic or pre-diabetic? I’m not on any medications. Thank God. I just want to know if it’s also good for normal healthy people?
So how much should we take?
10mg/kg divided into 2 or 3 doses per day (from studies on berberine) - generally about 250 mg three times a day for someone 160lbs, take with meals..
@@terfalicious thank you!
No doctor on the planet will ever discuss Berberine with you.
You have to go to a functional medicine doctor or a naturopath.
NATUROPATHS DO💯
@@47retta Seems like some allopathic docs are coming around to food and supplements, mostly vitamins but at least mine aren't throwing a fit when they see my supplement list.
@@47retta i had 2 different naturopaths recommend berberine to me. when i told my GP i was taking it, she had to look it up on the net.
Im a pathologist and take this supplement.
I have collagenous colitis.
I'm wondering if the Berberine is helping with it. Sure seems to be better since I started 500mg
Also called microscopic colitis.
Can people who are in antidepressants take Berberine?
Sure... if you want to unalive yourself. 😳
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Merci !
Not just beautiful doctor 🎉
Don't bother with doctors , go naturopath or a herbalist to info on berberine.
My ALT level before Covid was 12, year after Covid it's 37. GP hasn't reacted to that change and I'm freaking out what causes that spike - cancer ? which I know post covid people develop.
Watch or read Dr..Fung The Cancer Code.