The Search for New Antibiotics
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- Опубліковано 28 вер 2024
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Naowarat (Ann) Cheeptham, a Professor at Thompson Rivers University, describes her research of exploring caves to find new species of bacteria and fungi that can produce the next generation of life-saving antibiotics.
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Animated by: Jorge Cham
Produced by Piled Higher and Deeper in partnership with The Cheeptham Laboratory at Thompson Rivers University. Funding provided by the TRU Internal Research Fund for Scholarship and Scholarly Teaching (IRFSST) and the Society for Applied Microbiology Public Engagement Fund.
Featuring: Naowarat (Ann) Cheeptham faculty.tru.ca/...
Image sources: Kent Watson, Cheeptham Lab; mightybackgrounds.com
1:52 "My students and I go to de caeeev". Not trying to be offensive, I laughed a lot and I'm not sure why.
My spoken English is also not good, but I can feel her passion in her voice. She loves her job. In Science, that's far more important than having a good voice.
Her accent grows on me..
Some comments are not needed. Their mouths are making their ears deaf. Great work Ann! A great accent forces people to listen instead of hear. The people who hear you will never become great.
these videos are excellent!
aww this is a cool video.. the way you talk in english has ALOT of character.. its very funny yet still gets the message across clearly.. you're a very good communicator of ideas and concepts! i enjoyed this video.. tnx :)
(cont.) new molecules, and that is that bacteria can be used later to do the chemical synthesis of the substance of interest, and help mass production.
Ann (the Professor interviewed) is originally from Thailand. :)
I never knew about that... very fashinating! thk a lot ;)
Yeah, I suspected that the speaker was a Thai
Saludos de un tailandes :D
well, I think you're right about the compter power to date, but molecular modeling can help us design an active molecule. Most of the antibiotics have a small size compared to proteins, even vancomycin and daptomycin which have peptidic nature are not super big as a protein is. I don't like the vid because it misleads this area, because, YES we can find a totally new structure to use as a new drug. I believe that the vid fails to explain the main reason to find a microorganism to explore (Cont.)
Great topic and good video, but I gotta say, the narration made it difficult to listen to.
I say that as someone for whom English isn't a first language either.
Ha! So Profs follow PhD Comics too? XD
computers CAN know that: it's called molecular modeling
can you get antibiotics resistance by just eating meat,eggs and milk?
+Anna Stepashkina no there is no such thing is antibiotic resistance, however you can get disease with contaminated food, especially spoiled ones, the most dangerous and hard to detect of which are dairy products that have lots of sweet because sugar mask the spoiling and provide very nice situation for viruses that allows for it...once in the stomach because the digestive system cannot process it faster than the viruses multiply. This is how most deadly deceases and the less dangerous diabetes come into being! So beware of dairy sweets like hard to tell spoiled ice cream!
+Yours Truly I don't think that is what Anna meant. Some bacteria have developed an immunity to antibiotics and bacteria are constantly sharing genes. The antibiotic resistance is a very real problem if bacteria that can resist it become too prevalent.
Dr. Oz:silverstorm1000 give an ex. of bacteria that develop immunity, once a bacteria always a bacteria, penicillin will always kill bacteria in its purest form, it is not the bacteria but the disease that reach a point of contamination that it can no longer be cured.
Trisha takanawa
It's not the accent that bothered me.. She spoke very clearly.. It was the poor editing and cutting spaces between the words that made the whole speech unnatural..
cute accent :3
This was probably the worst human voice I ever heard.
urgh that voice.....
Golden Question: Why arent the "good" bacteria finding new "holes" in the bad bac?
That accent, it's Thai right? XD
To all those bitching about accents - never ever work in a general, non specialised job like retail in a major city in Australia. I moved for university and had to adapt for what is basically nearly the whole world's worth of accents in under a year or i could never work. It's not that hard. Get over it.
Would it really be that hard to get a native English speaker to narrate? This is not a racist comment, which seems to be the knee-jerk reaction below. It is grating and very off-putting. I bet many people would not listen to the video because of that fact. Why be so discerning with the animation and not the narration?
This is so cute, superhero bacteria!!!!!
Don't complain about the narration lol.
Holy fucking shit this is hilarious!!
"They became resistant to current antibiotics so we need to find new antibiotics"
Unless scientists understand the resistance mechanism and manipulate it through epigenetics/gene therapy, we will still have to wait 25 more years for new antibiotics with loads of side effects
Just saying Genetics > Microbiology
Your view is wildly optimistic. There are billions of possible combinations of atoms that could be synthesized. A computer cannot know how these new compounds interact with microorganisms. Rational drug design is about finding a molecule that fits a particular known protein - a process far less difficult than new drug design for an unknown target. The only viable way to find out whether a compound will be active is through testing. Computer antibiotics ? Not any time soon, MM notwithstanding.
She cannot even get the chemical structure of penicillin correct! So how does she expect to find new compounds?
That was interesting! And yes, I've wondered why so many children develop allergies which were rare in older generations. Apparently, trying to protect them in cleaner environments, their parents make them more vulnerable. They haven't been expsed to bacterias and haven't developed the necessary antibodies.
متا ينزل للسوق Teixobactin
i'm love your explanation
As Kramer would pronounce fungi "fun-ghai"
I'm not an expert and 500 characters is painfully few, but in evolution we need to distinguish between mutations (random; often unhelpful; can create new genes) and selection (non-random; requires existing genes). Antibiotic resistance is mostly based on old, formerly uncommon genes that we unintentionally selected for. Waiting for new genes via mutations would be terribly slow, but we can instead seek out and select for "new" old genes that create other antibiotics -- exactly what Ann is doing.
YOU PEOPLE ARE NUTS! Knowledge coming to you and all you care about is accents. She and her accent may save your perfectly spoken life some day!!!!! You may have to "Thank you" and she and her accent may say "yur weekcom" but your alive to criticize....so I guess that what count :) Must be nice to be so perfect....
It's only a four minute summary of her research. She couldn't possibly get into every detail, so "can not know that" is probably just the short way of saying that the technology isn't there yet. I doubt she's a "narrow minded" person. No need to plead "OP pls" as if they've committed themselves to ignorance - give the crew at PhD Comics a little credit.
To say that a computer "Can not know that" is needlessly narrow minded. The interactions between complex molecules is, admittedly, a difficult thing to simulate. None the less, there ARE projects that are making great headway into this emerging field. Please don't shut this avenue out in your own mind, OP, as I think it'll result in saved time and lives.
Modeling a molecule is a far cry from modeling a protein. Typically a computer attempting to model a protein can only extrapolate from previously known structures and it isn't always right. The number of permutations is staggering, far more than even computers can analyze reasonably at this time.
I'm not believing that they have committed themselves to ignorance, just voicing concern that the possibility exists. It did come across as dismissive of said technology, to me. My own misinterpretation? Possibly, but the concern remains.
You must have had only English speaking friends and professors. Most of the scientific community does not speak English at all. My biochemistry professor's accent is leaps and bounds worse.
Antibiotics are substances produced by the fungi and bacteria, not the fungi and bacteria themselves. So you can't get a fungal infection by using antibiotics derived from fungi...
Very interesting..the lady sound like buk lao...
Ann...your narration Rocks! And your job too.
This was great love the voice, and the info have a great week. See ya'll next time. :-)
Nope. That was just me. Jorge Cham (the creator of PHD Comics) is Panamanian :-P
Not to mention theres no money in it at the moment...
She has an accent, but she is pretty articulate and well spoken.
Loved the voice and the animations, very informative.
Annoying narration - Speak from ur mouth not nose
Annoying name - Use another name, not that one.
the difference is, the video was posted to be enjoyed by all and it fails at doing so due to her voice
sonicbouy
That's your opinion, though. Everyone does enjoy it, expect for the very few of you that can't get past an accent. Srsly, it's 2014.
+sonicbouy Are you serious?!
Purel will be the bane of humanity
Great topic.
Plus I love your voice, it makes it nicer!
Just fyi, calling someone's voice annoying is impolite.
Her voice sounds like the Windows voice synthesizer
Very raw and untrained voice. Too hard to listen.
so, in thailand, is spanish the spoken language?
Thank you so much for sharing this vid.
Your work is exciting and beneficial, and you explain it well.
Simply Love it :D My next research will be this ;)
Well done Prof Ann and thank you for your work and sharing it with us.
Gosh, she sounds like a coooool person
loved the narrator's enthusiasm!
amazing :) I didn't know there had been such a long pause in antibotic discoveries. Good to know science has combined medicine, microbiology and extreme sports into saving people :D Who said science was boring?
your explanation is funny. :)
interesting
...no capes!
cool stuff
The main problem, of having a lack of working Antibiotics, have happened cause that bacteria become resistant when exposed to them at large scale.
And many of Antibiotics have the "nice" side effect that livestock will grow faster and fetter if applied... caused to waste potential heal potential for short term economic interests.
Also the pharmacological industry stated and I quote here: "Would not making *_enough_* profit from it". So that wasn't a decision made not to research new Antibiotics because there would be no profit, but there would be not enough to satisfy their greed...
Hi :3
Time...
Japanese ?? I found the narration good
+Know India No. Her last name is "Ann", which is likely the Southern deviation of a Chinese last name.
Nvm..."Ann" is probably a quick name. The professor is Thai. You guys probably should look up her publications; she's very well studied in the cave microbiomes and has several review papers on the subject
Love your channel! Keep the great work!
im not racist but WTF, who makes a production value video with this type of narration?!?! Please redo in English by English
That person that commented is dumb as fuck. Im a minority and i still cant understand or follow what shes saying. Ur right man, they should of had someone with a clearer voice talk about this subject
This world.
It is all lost.
Say what you want, the rhythm of the speech not the accent makes it rather unpleasant to listen to. Some oratory exercises and off-recorder preparation would improve a lot.
***** shut the hell up and quit trying to break down everything i said into details. Here much simpler for your mind:
"Its hard to follow this lady talking on a highly intellectual topic, please have someone else will better control of the English language narrate it please"