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❤️❤️❤️ life saving information for coronavirus until safe, proven cure is found. Meditation, Prayer and Spiritual Healing: The Evidence From NCBI www.ncbi.nlm.nih.gov/pmc/articles/PMC3396089
Thoughts and prayer improve health. Speak quietly out loud or in normal voice "God, please make my health perfect and eliminate harmful virus. Thank you." Repeat every 1-2 hours (8-16 times a day) as long as the pandemic lasts and until a safe vaccine or cure is available. God is love. This helps. No cost. "A problem exists today regarding some know how to call on God for help while others do not. This loving help is available to all of us regardless of moral character, religious views, and personal beliefs. God does not punish and helps anyone asking correctly. God is love." www.howtocallongodforhelp.com
Social distancing helps prevent infected droplets, splatter, and aerosol particles from entering the lungs and eyes. Reducing viral concentration will give the body better odds at handling infection. First line workers are at high risk because of continuous exposure to the virus, thus greater susceptibility to Covid19. Fever, cough, shortness of breath, and sudden loss of smell and taste are common characteristics of the coronavirus.
Covid19's cytokine storm can cause long term tissue and organ damage and mental health problems. From Mayo Clinic www.mayoclinic.org/diseases-conditions/coronavirus/in-depth/coronavirus-long-term-effects/art-20490351
Masks, face shields, washing hands and disinfecting surfaces prevent spread of this virus. Look into foods high in Vitamin C (avoid harmful synthetic Vitamin C supplements), Vitamin D (20 minutes daily sunlight or Vitamin D supplement with Vitamin K2 to prevent possible calcification from Vitamin supplementation), and zinc. www.webmd.com/lung/news/20200907/too-little-vitamin-d-might-raise-odds-of-coronavirus-infection#1 Healing can happen on many levels. We're not just physical beings. Consciousness, thought, and prayer is not well understood yet plays a major role in healing. We all have a name. Yet modern science can't identify our name by any chemical or physical markers through careful examination of the human body. Our name given to us by parents does not appear to be made of elections, atoms, or molecules. Evidence that consciousness continues after clinical death. ua-cam.com/video/WnoIf2NwaRY/v-deo.html From Scientific American www.scientificamerican.com/article/what-near-death-experiences-reveal-about-the-brain/ www.scientificamerican.com/article/does-consciousness-pervade-the-universe/ Please share. Thank you.❤️❤️❤️
Could you expand the detection for cytokine storm to include a history of lifestyle induced chronic inflammatory responses, with symptoms like insulin resistance/insensitivity, nutritional imbalance in processed carbs, poor recovery due to lack of quality sleep, leaky guts due to high meal frequency, and frequent inactivity? All these can contribute to the comorbidity factor of obesity, yet people who aren't overweight and/or young can still develop these poor health habits.
Can you please tell me the symptoms you would see in a COVID patient with this cytokine storm? As in what a lay person can look for. For instance is a skin reaction a possible overt symptom? Swelling ? Pale skin with blue lacing (almost like blood vessels are showing through)? Rapid heart rate? Bruising without explanation? Just any symptoms that would lead a patient or caretaker to believe this may be a cytokine storm? Thank you
Just had a COVID + patient on the vent. Consistent fever of 104 F for close to 30 hours. Did a CRP which came out > 240. We had to ask pharmacy for Baricitinib PO through the OG tube. Patient eventually expired from sepsis. Great explanation - this is something I've never learned in nursing school
don't worry....here indian doctors dont even know what is the use of dexamethasone....shitty rattu popat indian doctors.....however jholachhap doctors did well in pandemic in rural areas just by giving typhoid medicines which does worked well.
Retired from the ICU world. But learned more about cytokines. As I had cytokine storm. It released squamous cell skin cancer . Antibiotics were given as the inflammation around my head did not go away. The same antibiotics for Lymes Diseases. I have a hx Of Pneumonia and arthritis. COPD. I believe we are all still learning.
I’m so glad I found your channel. You have a very clear and articulate way of explaining things. Unlike most videos on UA-cam. My thoughts is that we have so many drugs at our disposal and all should be looked at. I think a combination therapy much like we do with HIV would be a good mitigator for this virus. Perhaps antivirals early in the disease to reduce viral load and immunomodulators in later stages and of course steroids to reduce inflammation.
Thank you and welcome aboard! I 100% agree with you and in fact so many different therapies are being studied at this point in time that it's tough to even try and keep up with a tiny portion of it all. But I do agree that the best thing we can do for now is to find as many different treatment options from as many different angles and probably use them all together to help aid in recovery and decreasing mortality.
I also agree with you, but why don't we just improve the patient's health so that heavy inflammation doesn't occur in the first place? Oh wait, we couldn't sell all these expensive drugs/treatments anymore? Oops, yeah... now I agree, let's keep the patient's health weak.
Wow, what a fantastic UA-cam video. A million thanks to ICU Advantage. I am a huge fan of yours, sir! Thank you for taking the time it took to make this wonderful production. This is what makes me love UA-cam so much!
Thank you so much Tom! It's always amazing and humbling to hear from everyone on how beneficial these videos are for them, so thank you for taking the time to leave a comment and let me know!
I wish he talked more about the blood test that are done on covid patients, what they mean, how the fluctuate and what can be done when you see the different levels. He did talk a little about this around the 18:00 minute mark
Thanks for the feedback Brandon! I will say when this video was made (early May) we were just barely beginning to understand the basics of what was going on.
@@ICUAdvantage You already said which test to make if You suspect a cytokine storm: - ferritin - CRP = IL- 6 -D dimers and fibrinogen ( coagulopathy - ankle clonic reflex= serotonine syndrome secondary to platelet activation by circulating immunocomplexes. F.Abis MD 17.05.31
This video is brilliant!!!! Understood thoroughly about the cytokines, which was really getting me because I was very confused about the cytokine functions. Thank You !!! Love from Bangladesh. Stay Safe xx
@@ICUAdvantage Honestly I am a 12th grade student(like about to start off my year 12) , so I didn't had much knowledge about cytokines but ur vudeo helped me a lot and this will even help me while im making any presentation. Will you be dropping more videos about cytokines? Cheers!!!
Very informative! My father in law was recently in the hospital due to Covid-19. The doctors ran all of the tests that you had described in your video. I'm on a TNF Blocker (a month now for RA) and recently positive for Covid and am experiencing very mild symptoms no fever as of yet.
I went through a possible cytokine storm. I have 10 autoimmune antibodies. So I got Covid about a month ago. Then my ox was going down. I was admitted to the hosp. and found to have high ferrin levels in the 300 range and D-dimer in the 900 range during this I was desating. 4L in my nose 10 on a rebreather mask. And with all this my ox was 89. So I was sent to another hosp. With a covid ward. I was there 11 days went home on 4L. Doing much better. I had a immune system work up. Found to have immunodificiency missing IgG 2 and 4 subclass dificiency and a Pokeweed mitogen dificiency too. And on the other end autoimmune problems.
All Johns... It is important to us to know that You survived covid in spite of autoimmunity and IgG2 and IgG4 deficiency ! We are still wayting to know to WHICH IgG Subclass the anticov antibodies pertain.
For a topic that is so broad and with many unknown variables- this was an incredible overview and explanation (esp for a newer nurse!) Unfortunately we see many of our patients RAPIDLY go through a progression from ARDS to the huge systemic response, working their way onto CVVH and then unfortunately later to comfort care once the irreversible damage is done. Hope we figure out a way to even just slow the progression so we can treat sooner rather than later!!!
Thank you so much Mattie. I'm glad that I was able to break this complex subject down. When they reach this point, it often seems irreversible. I agree and hope we can figure out something to combat this or prevent this from even happening.
Great presentation with great visuals. Very concise and informative...gave a great summary of the Cytokine Storm response. Thank you so much for posting !!
Wow this is fascinating, really hoping the think tanks working on this will be able to find out what causes the immune response ramp up when these situations happen. Thank you for the video✌️
Thank you for putting out videos like this for our education when covid hit my home I really need nothing about it other than we practice prevention we were always working so when it hit home my son got nervous he had it pretty bad and he was basically covered free by the time he went to the hospital but he was just frightened they told him he had ammonia gave him prednisone and antibiotics by the third day of taking the meds I had to call 911 the hospitalized them intubated him and he died I was shocked what happened I went to the hospital information portal and found out that they had given him a wrong diagnosis how do I know that I read the details on the report 40 years old no underlying conditions vitals were good breathing a doctor that checked his lung set the lungs were clear x-ray said that the findings were vague in other words they were not sure yet the last doctor that released them said covet pneumonia all because she saw colvin assumed that he had in the morning yeah when she was looking at was a recovery covid patient the residual effects of covid she should have sent him home with covid information and follow up with his doctor he would have been a life now if she would have done that instead she send them to his death by lowering his immune system and letting that covert take over now the lawyers here will not touch cover cases and all I can do is want people do your research I'm sure they're good hospitals out there but not like Banner hospital emergency room here in Glendale
Amazing explanation!!! Could you please leave some references??? Because I will probably show it to my colleagues and it would’ve been great to show them with the evidence! Thanks in advance, your content is awesome.
I don't leave references as I don't intend the videos to be used as reference material, but more as a. guide for ideas and information. Honestly some of what I talk about is from personal experience and some comes from many different sources in research for my videos.
This is a good overview. Living in a demography that has little CoVid, but lots of fear, our system has decreed that all CoVid persons under investigation at our hospital get daily ferritin, CRPs, and D - dimers. As it still takes 24 to 48 hours to get their CoVid tests back, the average negative patient gets 2 of these panels. The waste in lab cost is unbelievable. I spend my time basically deleting these pre programmed orders in low probability patients. These markers indicate death and I am not overwhelmed by the available therapies. If you can't effectively treat it, why look for it and I would argue there is little proven effective treatment. I tried to order Kineret for one patient and the system refused.
Perhaps the overload of ferritin is due to Iron deficiency. And the Increase CRP and D-Dimer is a result of a poorly functioning immune system mainly caused by vitamin D deficiency.
Can you explain why the protocols being used around the world by doctors such as Dr Zelenko (and others) are helpful in preventing the cytokine storm to begin with? Ivermectin HCQ along with steroids and antibiotics, high dose vitamins C,D, zinc and quercitin have effectively kept people out of the hospital with EARLY treatment. Those who don’t start treatment early May end up in the hospital only to be met with an onslaught of invasive and ineffective treatment like ventilation and remdesivir, which is so hard on the kidneys, putting an already compromised patient at further risk. Would the early treatment regime be effective in late treatment after the cytokine storm has already begun?
FANTASTIC presentation 🙌🙌! Thank you 🙏 You might want to look up the recent trial done in Spain that used l-arginine, l-glutamine and vitamin C, in which kept severe Covid PT’s from death. I know it’s non pharmaceutical, but being a functional medicine nutricuticalist…it’s my chosen course of action.
Thank you! So glad you like these videos I put together! 😃 And that's a great suggestion. I don't think I've covered the waveforms too extensively in any of my past videos, so I'll add that to the todo list. Thanks so much for the suggestion and for watching.
Thanks for another great lesson! You really put everything together clearly. I'm a vet, and have been thinking about the parallels between Covid19 in humans and feline coronavirus infections in cats. Feline Enteric Conoravirus (FECoV) produces a mild diarrhea illness in the vast majority of infected cats, but in small percentage of cases (a mostly younger cats) the virus mutates to a more virulent form - the Feline Infectious Peritonitis virus - which basically spreads via macrophages and results in a cytokine storm. Severe peritonitis and sometimes pleuritis occurs (wet form) or pyogranulomatous reactions occur in multiple organs (dry form) resulting in death. FIPV's are always directly genetically related to the FECoV in a given cat population, but also, it is the latter virus that spreads between cats. Can't help but wonder if similar mutation of the SARS CoV2 occurs in some people is causing the severe form of COVID19. Wonder if any genetic analysis of virus isolated from severely ill patients compared to virus from asymptomatic or mildly ill individuals has or is being done?
I hadn't heard much on any recent genetic analysis, but I know early on there were some early mutations mainly around ease of infectivity, which is the mutation that dominated in the US. I haven't follow that closely over the past few months so it would be interesting to read up on more. Thanks for the comment and glad you enjoyed the video! I appreciate the insight. I have practically zero knowledge of the animal world. 😊
Does anyone have and link to patients who have survived this.. my uncle is on the edge of death and this is possibly happening to him all in a week. We are so scared for him. The Dr. Mentioned possibly going to be flown to Santa Clara for help with this if it occurs which It very much may ... I love this man and he doesn't deserve this
It has been over a year from the end of 2019, the strategies for COVID in terms of treatment and management seems have not achieved as much breakthrough as the positive cases seen among vaccinated patients. The more expensive the treatment is, the more applauds heard. I wonder how the third world countries have achieved better outcomes compared to their developed counterparts. This is a world of matrix.
Love this video! It seems that some success against COVID-19 has been had using Stem Cells under compassionate use, and a 300 patient phase 3 trial is now underway in US. If this is successful, would be great to see a video on just how these cells work against the virus - or against the cytokine storm. And how these cells also seem to initiate repair of damage caused by the virus.
Thanks for letting me know about that. I honestly hadn't heard anything about stem cells, but honestly theres so much right now its hard to keep up with all that is happening. I'll have to look in to it more and perhaps a future video. Thank you!
@@ICUAdvantage Your'e welcome. Just a st a bit more info in case it helps: the trial is using Mesenchymal Stem Cells produced by Mesoblast Ltd and is being run at Mt Sinai with many other hospitals involved. A link to the trial: clinicaltrials.gov/ct2/show/NCT04371393 . Cheers and keep up the great work!
I would love to see how many patients with poor outcomes have gene polymorphisms involving genes like PGC 1 alpha, and possibly have a mitochondrian dysfunction that may make them more susceptible to these poor outcomes. Have a suspicion that this area is possible culprit to at least a subset of these outcomes. Any thoughts?
decrease viral load, use anti viral medications or antibody treatment in early stage, use anti-inflammatory or steroid during cytokine storm, also pay attention to anticoagulant treatment need, prevent more patient need intubation and ventilator, plus support treatment, O2.
But.. but my president told me to drink bleach or whatever Alex Jones is selling! Sorry I knew this is outdated, just reflecting on the stupidity of the times for future generations. If that happens to be a thing. 🤞
Hello, can you please give me all the information in the video in the form of a pdf or ppts file because I need it in a research for the Faculty of Pharmacy.
Really informative lecture and could be understood easily. Thank you very much for nice lecture.I think it will really helpful for me when treating my patient as a doctor working in COVID 19 Patient treating unit,
Had a question for you...do you think that people with Autoimmune diseases and are on immunosuppressants to treat them are at a lesser risk of getting the Cytokine storm response?
Great question! I think its a strong maybe. We don't have any evidence of that yet, but as I mentioned in here, they are looking at many different medications that are used for autoimmune disorders to try and prevent and lessen the degree of the cytokine storm seen.
My mom was recently diagnosed with Covid and she has an autoimmune disorder (Multiple Sclerosis). She did have a cytokine storm and was treated with Tocilizumab for it. Fortunately, the drug worked for her and she has now recovered.
As a patient's family, how can you get real information on how your loved one is doing when hospitalized? I want to know what his lab results are for these specific Cytokine Storm markers (IL6, CRP) but nurses and hospitalists do not discuss this kind of information!
Multiple issues with that: a) time b) lack of understanding/ knowledge (of staff; yes, I did say that) c) lack of understanding of non-medical ppl (some concepts are pretty difficult to explain, heavily depends on edu background)
So, can vaccines make the situation worse since mRNA vaccines will present the spike protein on human cell surfaces? Can it trigger an autoimmune-like response?
such a complex sytem and phenomen like this ... can not be explane better. i wanted to send you a part of my hearth for your share-able brain.. thank you...
My Mom is currently in ICU with cytokine storm per her DR. They are wanting to go cytosorb to help but she’s declining to do it. Has anyone had a patient to overcome this? I’m looking for any help I can get.
I have had a patient with positive PCR for COVID 19 showing mosaic attenuation for a few days followed by an abrupt onset of pic of COVID related HRCT findings filling up the initially trans radiant areas of mosaic attenuation noted . This happens by day 3 or 4 following the initial CT.
hello can you update this soon, or have you already? I would love to see what you have found as far as what is working well or has worked well, such as ivermectin? and timing of certain drugs:) thank you so much!!
I had covid the beginningof 2020.It was very mild but I had an annoying cough. The one lasting problem I have is my memory.I started taking Prevogen. It helps a little. Any suggestions????
I'm a lay person but I've been hearing about Exosome Germ Theory. Is this the same or related to Cytokine Storm idea? Possibly the idea that Viruses don't exist. Didn't Kary Mullis hint toward this concerning HIV/ AIDS? Thanks
May I ask your opinion on the theory of cytokine storms potentially being induced by adjuvants in vaccines that patients received prior to becoming infected with COVID-19?
This is so detailed. I think I'm having something somewhat similar of a reaction to mold. I've suddenly been diagnosed with 2 or 3 autoimmune disorders. I feel miserable. I can't seem to convince anyone in my home that this is a mold issue. Anybody know of a specific test for mold exposure? I could go to an allergist, but I already know that I'm very allergic to mold. Considering covid 19, I'm not really wanting to start immunosuppressive drugs.
Thank you for your very informative but easy to follow description of the new covid 19 virus. It's very much appreciated. The actual display of bright colours is great too!
It seems that the evidence is pointing towards using procalcitonin as a potential biomarker for severity of COVID. They've found that levels were 4 times higher in those with severe infections and seem to correlate to infection severity, and then decrease as the disease improves.
Very informative but I wish you had better news on the treatment side! I have Alpha-1 Antitrypsin Deficiency so am concerned about the virus causing a cytokine storm for me if I am infected. I have been unable to find discussion of any correlation between the deficiency and deaths due to COVID/Cytokine storm. Any comment?
ICU Advantage,there is this clinic in my city that are treating covid patients with Oxiris blood filter and they've been successful with almost all the patients that they've treated. Can you elaborate on that please or make a video to explain it.
Interesting that you mention this. I was just reading about a new study using an inline filter for ECMO patients that is similar and works by adsorbing cytokines. I did a quick look and the filter you mentioned looks to be newly approved in the US and is run as a filter set that is a part of Gambro's CRRT machines. Other CRRT filters have had this adsorption property with cytokines, but this looks to be something new. I was already considering doing a video regarding the ECMO filter, but now may just make one covering both. Thanks for the info. Are you in the US where you are seeing this used?
Thank you Very Much for this Informative Overview of Cytokines and the Cytokine Storm! Will you also Cover Chemokines, Especially those Contributing to the Cytokine Storm? Have a Marvellous week! Cheers!
Linus C Chemokines direct inflammatory cells ( granulocytes, monocytes, macrophages and T and B lymphocytes to the region infected to induce inflammation that kills infective agents (viruses bacteria, parasites,fungi, sting poisons. F Abis MD, ESM 17.05.21
Linus C Thank You for this precise description of the course of Your Covid, particulary for Your mention of reduced levels of IgG subclasses. We still do not know if the reduction in IgG subclasses is a defect in production or if those IgG are consumed during Your response to the infection. Let dose Your IgG subclasses when You feel healed. If the four classes result in the normal range or are elevated = immune response. If both of Your IgG are low= production defect due to loss of funtion of the implicated genes. Please let us know !
Excellent video, possibly apoptosis is a response to pyroptosis in the respiratory, inflammation is nothing new, intermittent release of viral particles creates an intermittent release of antibodies viral infected cell burst may create immune cell burst release multiple antibodies in return more immune cells would be required at area of infection for specific antibodies or proteins to attach to becoming receptors, with the delay of the thymus producing specific neutralizing binding antibodies- cells carrying these antibodies may come as a storm possibly bursting while capillaries leading to the respiratory are constricted from fluid and waste buildup restricting delivery of larger immune cells through the capillaries. Whats interesting recently dr drbeen did a lecture on the Bradykinin storm and located at the capillaries.
consider the properties of the cell Coronavirus hijacks , the time frames of utilizing the properties and the various types of cells hijacked. immune cells are mobile and antibodies are not , the immune cells main function is to contain, the mathematics of counts between antigens antibodies and cells the amount of antibodies that become tcell receptors and or bind with the virus , the viral count in the bloodstream comparing to the respiratory determining if enough cells are being delivered to the infection area , with the possibility of viral spread through mitosis given the location of viral transcripts within an infected cell maybe previous to Coronavirus hijacking the cell property of producing antibodies in various numbers or none at all a mass of viral replications released at once compared to intermittent release of viral replications, one virus may be capable of utilizing cells properties compared to another virus , timelines of infected cell burst and immune cell burst immune cell burst possibly releasing multiple antibodies and the bloodstream route restriction leading to the infected area constricted delaying delivery of both antibodies and cells to the infected area , until a pathway is created by the infection with the bloodstream it is difficult for an effective immune response given the bloodstream respiratory barrier, possible immune reaction like sneezing is hijacked by the virus when it can reduce viral load, a lot of antibodies throughout the bloodstream without virus replications in the bloodstream could mean the antibodies didn't get delivered to the infected area but were released prematurely(not in growth sence) with a timeline of the cell, the cells already at an infected area would need specific proteins to bind with iggs to make specific antibodies or receptor , the cytokine storm may carry the specific antibody protein to the infected area, unless specific antibodies or cells are delivered in convalescent plasma then there may not be an effective immune response
Thank you for this video! It helped me to understand cytokine storm better. What do you think about Edaravone for COVID-19-treatment? Can it be possible candidate for prevention lethal complications and for treatment COVID-19? I've heard edaravone can block both cytokine and free-radicals' storm.
Great and informative video! Can you please explain why fever in cytokine storm is so hard to manage/treat , and why person usually doesn't respond to antipiretic medicine (sorry for my english). Thank you.
Well! Does it mean that plasma therapy could be the best option right now for COVID patients, because the immune system is not actively suppressed by recieving the plasma from others but the triggers for cytokine storm are reduced overall ??
Post covid female 23yr old_Crp 78mg/l, ,S.ferritin 59ng/ml, Ddimer 0.85 ug/ml... Highly inflammed cervical lymph nodes, now no fever (very high fever for past 4 days)... Please advise... Presently on amoxyclauv
It was informative, but falls short of the mark. It would be nice if this gentleman would educate his viewers on the role Vitamin D3, cholesterol and magnesium play in the prevention of cytokine storm. In addition it would also be a good thing to note how zinc inhibits covid from utilizing rna dependant rna polymerase, and therefore preventing the viruse's attempt to replicate. Vitamin D3 influences and promotes IL-4 and 10, thereby directing the immune system to take the non-cytokine storm pathway. Anyhow, still an informative video, and thank you.
I read somewhere on Twitter that the patients of Ebola experienced this cytokine storm before their deaths. The writer of the tweet said the cytokine storm is our body's last effort to beat the pathogen/virus, causing death after the pathogens are all terminated. What are your thoughts about this? Is it the same for the case Covid-19 and other illnesses caused by viruses?
Many diseases can actually lead to a cytokine storm. We even see it to some degree with the flu. The exact process and cytokines involved can vary from disease to disease though. I don't know if I'd consider it the body's last effort though as it really is the body's normal system sent in to an abnormal overdrive. This isn't how it was designed to fight so I think I view it more of a disorder than a last hope move by the body.
@@ICUAdvantage (pretend that you shrunk down to microscopic size) & standing inside a blood vein/arteries. I cannot for the life of me find any animation or illustration of this point of view. of the cytokine storm effect. Some Accurate and Real recorded video would be fantastic.
Very interesting. I am bow working on aproject to see is tetrahydrocannabinolacid, and CB1 and 2 could be effective in some way. I have a similar condition but no cytokine storm, but an inflammatory condition cause by an issue of the immune system not shutting off, of the digestive tract called IBD, specifically Crohn's disease. (Please pardpn the typos as this keyboard has been recently presenting probems). Crohn's as you probably know is an autoimmune disprder that is genetic, environmenta; and dieter;ated. Have you looked also into perjas the 'imabs' such as infliximab, vedolizumab, etc? These are quite common in the control of Crohn's. I am assuming this might help before any cytokine storm as these medicines are generally immunosuppressant. Just a passing thought.
Are people with myeloproliferative neoplasms more at risk for cytokine storms since the JAK2 mutation leads to higher levels of circulating pro-inflammatory cytokines? I did hear that Novartis is doing a clinical trial for the MPN drug Jakafi to see if it will help mitigate the cytokine storm.
Honestly I'm not sure. I think having higher levels of the pro inflammatory cytokines would certainly be concerning though. I'll have to look in to that. Thanks for the question Laura.
A great overview. Not seeing much that really works on these pts, they pretty much follow the course to the bitter end. I've been hearing some voices about vitamin D, how would vD meets this process, if it does at all?
Pyroptosis of infected cells may be followed by a similar immune response of apoptosis in respiratory or the bloodstream, intermittent release of viral transcripts followed by intermittent release of immune transcripts or replications, each results in a different immune response or reaction, immune host cells produced for immune transcripts to bind with. With the buildup of waste and fluids restricts blood flow through the capillaries into the lungs resulting in the restriction of an effective immune response if any as well as restricting gas exchanges, cell bursting(pyroptosis) occurring in the respiratory outside the bloodstream makes it more difficult for antibodies to be delivered to the respiratory given the bloodstream respiratory barrier without a pathway for antibodies to enter the respiratory antibodies may not be present in the respiratory until a pathway is created from damage and bleeding occurs, damaged infected cells bursting or infected cells intermittently releasing viral transcript(replications) in the respiratory can be delivered with co2 into the bloodstream previous to tissue damage creating antibodies, specific antibodies may not be created until transcripts enter the blood and tissue
does cytokine storm occur depending on the severity of a dse ? how about cough or cold is there a cytokine storm there ? since Cytokine storm is not a hallmark for covid19 only. pls anybody elaborate what you know thanks in advance
Dear ICU advantage, thanks alot for sharing these interesting videos. they are really excellent ! I have a question: is there different types of Cytokine storms? if yes how is it possible to distinguish them? for example is there any differences btw Hpercytokinemia by COVID-19 patients and H5N1 infected patients? if there is no differences, why there is no traetment till now? the SARS-COV-2 crisis should not happen in this scale, should it? why is it becoming suddenly a worldwide disaster but H5N1- virus was contolled easily without social contact restrictions ? Good luck!
Thanks so much for this interesting video! In which patients can cytokine storm happen? In all patients? Is there any information, how many cases of Covid-19 are associaed with Cytokine storm ?
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❤️❤️❤️ life saving information for coronavirus until safe, proven cure is found.
Meditation, Prayer and Spiritual Healing: The Evidence
From NCBI www.ncbi.nlm.nih.gov/pmc/articles/PMC3396089
Thoughts and prayer improve health.
Speak quietly out loud or in normal voice
"God, please make my health perfect and eliminate harmful virus. Thank you." Repeat every 1-2 hours (8-16 times a day) as long as the pandemic lasts and until a safe vaccine or cure is available. God is love. This helps. No cost. "A problem exists today regarding some know how to call on God for help while others do not. This loving help is available to all of us regardless of moral character, religious views, and personal beliefs. God does not punish and helps anyone asking
correctly. God is love."
www.howtocallongodforhelp.com
Social distancing helps prevent infected droplets, splatter, and aerosol particles from entering the lungs and eyes. Reducing viral concentration will give the body better odds at handling infection. First line workers are at high risk because of continuous exposure to the virus, thus greater susceptibility to Covid19. Fever, cough, shortness of breath, and sudden loss of smell and taste are common characteristics of the coronavirus.
Covid19's cytokine storm can cause long term tissue and organ damage and mental health problems.
From Mayo Clinic www.mayoclinic.org/diseases-conditions/coronavirus/in-depth/coronavirus-long-term-effects/art-20490351
Masks, face shields, washing hands and disinfecting surfaces prevent spread of this virus. Look into foods high in Vitamin C (avoid harmful synthetic Vitamin C supplements), Vitamin D (20 minutes daily sunlight or Vitamin D supplement with Vitamin K2 to prevent possible calcification from Vitamin supplementation), and zinc.
www.webmd.com/lung/news/20200907/too-little-vitamin-d-might-raise-odds-of-coronavirus-infection#1
Healing can happen on many levels. We're not just physical beings. Consciousness, thought, and prayer is not well understood yet plays a major role in healing. We all have a name. Yet modern science can't identify our name by any chemical or physical markers through careful examination of the human body. Our name given to us by parents does not appear to be made of elections, atoms, or molecules. Evidence that consciousness continues after clinical death.
ua-cam.com/video/WnoIf2NwaRY/v-deo.html
From Scientific American
www.scientificamerican.com/article/what-near-death-experiences-reveal-about-the-brain/
www.scientificamerican.com/article/does-consciousness-pervade-the-universe/
Please share. Thank you.❤️❤️❤️
Could you expand the detection for cytokine storm to include a history of lifestyle induced chronic inflammatory responses, with symptoms like insulin resistance/insensitivity, nutritional imbalance in processed carbs, poor recovery due to lack of quality sleep, leaky guts due to high meal frequency, and frequent inactivity? All these can contribute to the comorbidity factor of obesity, yet people who aren't overweight and/or young can still develop these poor health habits.
Qqq
Can you please tell me the symptoms you would see in a COVID patient with this cytokine storm? As in what a lay person can look for. For instance is a skin reaction a possible overt symptom? Swelling ? Pale skin with blue lacing (almost like blood vessels are showing through)? Rapid heart rate? Bruising without explanation? Just any symptoms that would lead a patient or caretaker to believe this may be a cytokine storm? Thank you
Dupixent seems to impact the cytokine storm. Has anyone dies while taking Dupixent?
Just had a COVID + patient on the vent. Consistent fever of 104 F for close to 30 hours. Did a CRP which came out > 240. We had to ask pharmacy for Baricitinib PO through the OG tube. Patient eventually expired from sepsis. Great explanation - this is something I've never learned in nursing school
don't worry....here indian doctors dont even know what is the use of dexamethasone....shitty rattu popat indian doctors.....however jholachhap doctors did well in pandemic in rural areas just by giving typhoid medicines which does worked well.
1 year later this information is even more important that it was during release! Great job thank you!
True
I searched for something you might have done on the Immune System.? You are an excellent teacher.
Thank you so much! I don't actually have any videos on the immune system yet.
You too found him awesome?
Retired from the ICU world. But learned more about cytokines. As I had cytokine storm. It released squamous cell skin cancer . Antibiotics were given as the inflammation around my head did not go away. The same antibiotics for Lymes Diseases. I have a hx Of
Pneumonia and arthritis. COPD. I believe we are all still learning.
I’m so glad I found your channel. You have a very clear and articulate way of explaining things. Unlike most videos on UA-cam. My thoughts is that we have so many drugs at our disposal and all should be looked at. I think a combination therapy much like we do with HIV would be a good mitigator for this virus. Perhaps antivirals early in the disease to reduce viral load and immunomodulators in later stages and of course steroids to reduce inflammation.
Thank you and welcome aboard! I 100% agree with you and in fact so many different therapies are being studied at this point in time that it's tough to even try and keep up with a tiny portion of it all. But I do agree that the best thing we can do for now is to find as many different treatment options from as many different angles and probably use them all together to help aid in recovery and decreasing mortality.
I also agree with you, but why don't we just improve the patient's health so that heavy inflammation doesn't occur in the first place?
Oh wait, we couldn't sell all these expensive drugs/treatments anymore?
Oops, yeah... now I agree, let's keep the patient's health weak.
Wow, what a fantastic UA-cam video. A million thanks to ICU Advantage. I am a huge fan of yours, sir! Thank you for taking the time it took to make this wonderful production. This is what makes me love UA-cam so much!
Thank you so much Tom! It's always amazing and humbling to hear from everyone on how beneficial these videos are for them, so thank you for taking the time to leave a comment and let me know!
This comment of yours makes a huge fan of you too... I like people who don't hide what they feel... Hahaha
Thank you so much for your videos they really assist me in providing the best care to my ICU patients.
Really glad to hear this! Happy to help!
In Sri Lanka, anesthetic consultants use drugs like MMF, Prednisolone and many others as you mentioned. Thank you for this very informative lesson.
I wish he talked more about the blood test that are done on covid patients, what they mean, how the fluctuate and what can be done when you see the different levels. He did talk a little about this around the 18:00 minute mark
Thanks for the feedback Brandon! I will say when this video was made (early May) we were just barely beginning to understand the basics of what was going on.
@@ICUAdvantage You already said which test to make if You suspect a cytokine storm:
- ferritin
- CRP = IL- 6
-D dimers and fibrinogen ( coagulopathy
- ankle clonic reflex= serotonine syndrome secondary to platelet activation by circulating immunocomplexes.
F.Abis MD 17.05.31
@@ezzovonachalm7534anyway you can help me understand how my sister can ask her doctor to check for this please.
This video is brilliant!!!! Understood thoroughly about the cytokines, which was really getting me because I was very confused about the cytokine functions.
Thank You !!!
Love from Bangladesh. Stay Safe xx
Yay!! So glad this video helped out! There really is SOOOOO much more to cytokines and I barely scratched the surface in this video tho.
@@ICUAdvantage Honestly I am a 12th grade student(like about to start off my year 12) , so I didn't had much knowledge about cytokines but ur vudeo helped me a lot and this will even help me while im making any presentation.
Will you be dropping more videos about cytokines?
Cheers!!!
Very informative! My father in law was recently in the hospital due to Covid-19. The doctors ran all of the tests that you had described in your video. I'm on a TNF Blocker (a month now for RA) and recently positive for Covid and am experiencing very mild symptoms no fever as of yet.
Glad to hear it has been mild for you Trisha. Hoping for a speedy recovery for you and your father in law.
I went through a possible cytokine storm. I have 10 autoimmune antibodies. So I got Covid about a month ago. Then my ox was going down. I was admitted to the hosp. and found to have high ferrin levels in the 300 range and D-dimer in the 900 range during this I was desating. 4L in my nose 10 on a rebreather mask. And with all this my ox was 89. So I was sent to another hosp. With a covid ward. I was there 11 days went home on 4L. Doing much better. I had a immune system work up. Found to have immunodificiency missing IgG 2 and 4 subclass dificiency and a Pokeweed mitogen dificiency too. And on the other end autoimmune problems.
All Johns...
It is important to us to know that You survived covid in spite of autoimmunity and IgG2 and IgG4 deficiency !
We are still wayting to know to WHICH IgG Subclass the anticov antibodies pertain.
For a topic that is so broad and with many unknown variables- this was an incredible overview and explanation (esp for a newer nurse!) Unfortunately we see many of our patients RAPIDLY go through a progression from ARDS to the huge systemic response, working their way onto CVVH and then unfortunately later to comfort care once the irreversible damage is done. Hope we figure out a way to even just slow the progression so we can treat sooner rather than later!!!
Thank you so much Mattie. I'm glad that I was able to break this complex subject down. When they reach this point, it often seems irreversible. I agree and hope we can figure out something to combat this or prevent this from even happening.
Great presentation with great visuals. Very concise and informative...gave a great summary of the Cytokine Storm response. Thank you so much for posting !!
You are very welcome! I appreciate you taking to time to leave such a great comment!
This has helped me to understand another condition and it's potential cause. Thank you.
Awesome, glad to have helped!
That was awesome and extremely helpful! Thank you so much for teaching this in such a clear and easy way!
You're very welcome!
Wow this is fascinating, really hoping the think tanks working on this will be able to find out what causes the immune response ramp up when these situations happen. Thank you for the video✌️
Thank you. This was the best explanation I have come across.
Great to hear!
Thank you for putting out videos like this for our education when covid hit my home I really need nothing about it other than we practice prevention we were always working so when it hit home my son got nervous he had it pretty bad and he was basically covered free by the time he went to the hospital but he was just frightened they told him he had ammonia gave him prednisone and antibiotics by the third day of taking the meds I had to call 911 the hospitalized them intubated him and he died I was shocked what happened I went to the hospital information portal and found out that they had given him a wrong diagnosis how do I know that I read the details on the report 40 years old no underlying conditions vitals were good breathing a doctor that checked his lung set the lungs were clear x-ray said that the findings were vague in other words they were not sure yet the last doctor that released them said covet pneumonia all because she saw colvin assumed that he had in the morning yeah when she was looking at was a recovery covid patient the residual effects of covid she should have sent him home with covid information and follow up with his doctor he would have been a life now if she would have done that instead she send them to his death by lowering his immune system and letting that covert take over now the lawyers here will not touch cover cases and all I can do is want people do your research I'm sure they're good hospitals out there but not like Banner hospital emergency room here in Glendale
Amazing explanation!!! Could you please leave some references??? Because I will probably show it to my colleagues and it would’ve been great to show them with the evidence! Thanks in advance, your content is awesome.
I don't leave references as I don't intend the videos to be used as reference material, but more as a. guide for ideas and information. Honestly some of what I talk about is from personal experience and some comes from many different sources in research for my videos.
This is a good overview. Living in a demography that has little CoVid, but lots of fear, our system has decreed that all CoVid persons under investigation at our hospital get daily ferritin, CRPs, and D - dimers. As it still takes 24 to 48 hours to get their CoVid tests back, the average negative patient gets 2 of these panels. The waste in lab cost is unbelievable. I spend my time basically deleting these pre programmed orders in low probability patients. These markers indicate death and I am not overwhelmed by the available therapies. If you can't effectively treat it, why look for it and I would argue there is little proven effective treatment. I tried to order Kineret for one patient and the system refused.
you're a hero!
Perhaps the overload of ferritin is due to Iron deficiency. And the Increase CRP and D-Dimer is a result of a poorly functioning immune system mainly caused by vitamin D deficiency.
Can you explain why the protocols being used around the world by doctors such as Dr Zelenko (and others) are helpful in preventing the cytokine storm to begin with? Ivermectin HCQ along with steroids and antibiotics, high dose vitamins C,D, zinc and quercitin have effectively kept people out of the hospital with EARLY treatment.
Those who don’t start treatment early May end up in the hospital only to be met with an onslaught of invasive and ineffective treatment like ventilation and remdesivir, which is so hard on the kidneys, putting an already compromised patient at further risk.
Would the early treatment regime be effective in late treatment after the cytokine storm has already begun?
@@Elsie144k It would be nice if ICU Advantage would reply to your comment.
Thank you for explaining! Great info to look out for my pts.
Awesome! Glad you liked it and found it useful. Stay safe!
I love too... I have been documenting this topic... Cytokines are scarier than anything out there if produced uncontrollably in the body...
FANTASTIC presentation 🙌🙌! Thank you 🙏 You might want to look up the recent trial done in Spain that used l-arginine, l-glutamine and vitamin C, in which kept severe Covid PT’s from death. I know it’s non pharmaceutical, but being a functional medicine nutricuticalist…it’s my chosen course of action.
absolutely love your videos.. you're great at what you do! Could you do a video on a line / cvp wave forms explained? (if you haven't already)
Thank you! So glad you like these videos I put together! 😃 And that's a great suggestion. I don't think I've covered the waveforms too extensively in any of my past videos, so I'll add that to the todo list. Thanks so much for the suggestion and for watching.
Thanks for another great lesson! You really put everything together clearly. I'm a vet, and have been thinking about the parallels between Covid19 in humans and feline coronavirus infections in cats. Feline Enteric Conoravirus (FECoV) produces a mild diarrhea illness in the vast majority of infected cats, but in small percentage of cases (a mostly younger cats) the virus mutates to a more virulent form - the Feline Infectious Peritonitis virus - which basically spreads via macrophages and results in a cytokine storm. Severe peritonitis and sometimes pleuritis occurs (wet form) or pyogranulomatous reactions occur in multiple organs (dry form) resulting in death. FIPV's are always directly genetically related to the FECoV in a given cat population, but also, it is the latter virus that spreads between cats. Can't help but wonder if similar mutation of the SARS CoV2 occurs in some people is causing the severe form of COVID19. Wonder if any genetic analysis of virus isolated from severely ill patients compared to virus from asymptomatic or mildly ill individuals has or is being done?
I hadn't heard much on any recent genetic analysis, but I know early on there were some early mutations mainly around ease of infectivity, which is the mutation that dominated in the US. I haven't follow that closely over the past few months so it would be interesting to read up on more.
Thanks for the comment and glad you enjoyed the video! I appreciate the insight. I have practically zero knowledge of the animal world. 😊
Thank you so much for such a detailed description of the content. Really appreciate it.. 👏👏👏👏
My pleasure 😊 Glad you enjoyed it!
Does anyone have and link to patients who have survived this.. my uncle is on the edge of death and this is possibly happening to him all in a week. We are so scared for him. The Dr. Mentioned possibly going to be flown to Santa Clara for help with this if it occurs which It very much may ... I love this man and he doesn't deserve this
What is role of lactate dehydrogenase in covid 19 investigation ?
It has been over a year from the end of 2019, the strategies for COVID in terms of treatment and management seems have not achieved as much breakthrough as the positive cases seen among vaccinated patients. The more expensive the treatment is, the more applauds heard. I wonder how the third world countries have achieved better outcomes compared to their developed counterparts. This is a world of matrix.
5% of the continent Africa has been vaccinated yet the first world countries with money are getting boosters and being pushed on children….
Love this video! It seems that some success against COVID-19 has been had using Stem Cells under compassionate use, and a 300 patient phase 3 trial is now underway in US. If this is successful, would be great to see a video on just how these cells work against the virus - or against the cytokine storm. And how these cells also seem to initiate repair of damage caused by the virus.
Thanks for letting me know about that. I honestly hadn't heard anything about stem cells, but honestly theres so much right now its hard to keep up with all that is happening. I'll have to look in to it more and perhaps a future video. Thank you!
@@ICUAdvantage Your'e welcome. Just a st a bit more info in case it helps: the trial is using Mesenchymal Stem Cells produced by Mesoblast Ltd and is being run at Mt Sinai with many other hospitals involved. A link to the trial: clinicaltrials.gov/ct2/show/NCT04371393 . Cheers and keep up the great work!
I would love to see how many patients with poor outcomes have gene polymorphisms involving genes like PGC 1 alpha, and possibly have a mitochondrian dysfunction that may make them more susceptible to these poor outcomes. Have a suspicion that this area is possible culprit to at least a subset of these outcomes. Any thoughts?
🤷🏻♂️
Two q’s:
Is there any way to predict who may be at greater risk for CS?
Are vaccinated people more or less likely to have a CS response?
@@pjgreen1786 based on what?
decrease viral load, use anti viral medications or antibody treatment in early stage, use anti-inflammatory or steroid during cytokine storm, also pay attention to anticoagulant treatment need, prevent more patient need intubation and ventilator, plus support treatment, O2.
But.. but my president told me to drink bleach or whatever Alex Jones is selling! Sorry I knew this is outdated, just reflecting on the stupidity of the times for future generations. If that happens to be a thing. 🤞
loved the video. super informative!
there were some messing spots in my mind, but I've got the whole picture now. thank you :)
Glad I could help!
Better than teachers at my Med School.
Wow, thank you!
Very informative vedio. Thanks
Amazing information.. really helpful in ongoing pandemic.
Hello, can you please give me all the information in the video in the form of a pdf or ppts file because I need it in a research for the Faculty of Pharmacy.
Many people do not even believe that it is real. Great video thanx for the education.
Thank you and glad you liked it!
Really informative lecture and could be understood easily. Thank you very much for nice lecture.I think it will really helpful for me when treating my patient as a doctor working in COVID 19 Patient treating unit,
Had a question for you...do you think that people with Autoimmune diseases and are on immunosuppressants to treat them are at a lesser risk of getting the Cytokine storm response?
Great question! I think its a strong maybe. We don't have any evidence of that yet, but as I mentioned in here, they are looking at many different medications that are used for autoimmune disorders to try and prevent and lessen the degree of the cytokine storm seen.
My mom was recently diagnosed with Covid and she has an autoimmune disorder (Multiple Sclerosis). She did have a cytokine storm and was treated with Tocilizumab for it. Fortunately, the drug worked for her and she has now recovered.
As a patient's family, how can you get real information on how your loved one is doing when hospitalized? I want to know what his lab results are for these specific Cytokine Storm markers (IL6, CRP) but nurses and hospitalists do not discuss this kind of information!
Each hospital is different, but each should have a process for obtaining medical records. You could ask about and look in to that.
Multiple issues with that: a) time b) lack of understanding/ knowledge (of staff; yes, I did say that) c) lack of understanding of non-medical ppl (some concepts are pretty difficult to explain, heavily depends on edu background)
So, can vaccines make the situation worse since mRNA vaccines will present the spike protein on human cell surfaces? Can it trigger an autoimmune-like response?
I was thinking about this as well....
yes it does and it will lead to death. You can google what Professor Dolores Cahill says about it.
Unlikely
such a complex sytem and phenomen like this ... can not be explane better. i wanted to send you a part of my hearth for your share-able brain.. thank you...
Thank you so much!
Haha have😂 you've made my weekend...
My Mom is currently in ICU with cytokine storm per her DR. They are wanting to go cytosorb to help but she’s declining to do it. Has anyone had a patient to overcome this? I’m looking for any help I can get.
I have had a patient with positive PCR for COVID 19 showing mosaic attenuation for a few days followed by an abrupt onset of pic of COVID related HRCT findings filling up the initially trans radiant areas of mosaic attenuation noted . This happens by day 3 or 4 following the initial CT.
I religiously follow your channel.❤️
Haha thanks Zerin! Glad to have you around and glad you enjoy the videos! 🙂
this is an excellent explanation clarifying a complex topic
I really tried my best to break it down simply! Glad you enjoyed it Rebekha!
Just started the Wim Hof breathing method, I wonder what kind of cytokines are released, hopefully the anti inflammatory. Does anyone know ?
hello can you update this soon, or have you already? I would love to see what you have found as far as what is working well or has worked well, such as ivermectin? and timing of certain drugs:) thank you so much!!
I may loop back around to this topic again, but I honestly have so much stuff on the todo list right now.....
I had covid the beginningof 2020.It was very mild but I had an annoying cough. The one lasting problem I have is my memory.I started taking Prevogen. It helps a little. Any suggestions????
Thank you. You have made it simple and clear! Good job👍
Awesome to hear this Sara. Glad you liked it!
I'm a lay person but I've been hearing about Exosome Germ Theory. Is this the same or related to Cytokine Storm idea? Possibly the idea that Viruses don't exist. Didn't Kary Mullis hint toward this concerning HIV/ AIDS? Thanks
May I ask your opinion on the theory of cytokine storms potentially being induced by adjuvants in vaccines that patients received prior to becoming infected with COVID-19?
This is so detailed. I think I'm having something somewhat similar of a reaction to mold. I've suddenly been diagnosed with 2 or 3 autoimmune disorders. I feel miserable. I can't seem to convince anyone in my home that this is a mold issue. Anybody know of a specific test for mold exposure? I could go to an allergist, but I already know that I'm very allergic to mold. Considering covid 19, I'm not really wanting to start immunosuppressive drugs.
Get Hepa filters, and if you own the house, start looking at suspect areas, particularly behind baseboards.
If you got the vaccine then this is the reason for your immune system issues! Wake up
try ozone nasal suplexation. or h202 nebulizer
Good overview of I.I.R.
former combat medic. subscribed.
Right on! Former Infantry myself. Glad to have you on board and welcome.
This is wonderful information and review! Thank you
Awesome!
Thank you for your very informative but easy to follow description of the new covid 19 virus. It's very much appreciated. The actual display of bright colours is great too!
So glad you liked it and thank you so much for taking the time to leave such an awesome comment!
Most useful and very clear video. Thanks for the presentation.
Glad it was helpful!
Thanks x sharing. What's about Procalcitonin level in cytokine storm? Would u mind to talk about it.
It seems that the evidence is pointing towards using procalcitonin as a potential biomarker for severity of COVID. They've found that levels were 4 times higher in those with severe infections and seem to correlate to infection severity, and then decrease as the disease improves.
Very informative but I wish you had better news on the treatment side! I have Alpha-1 Antitrypsin Deficiency so am concerned about the virus causing a cytokine storm for me if I am infected. I have been unable to find discussion of any correlation between the deficiency and deaths due to COVID/Cytokine storm. Any comment?
I'm sorry I just don't have any info on that to be able to comment logically.
ICU Advantage,there is this clinic in my city that are treating covid patients with Oxiris blood filter and they've been successful with almost all the patients that they've treated. Can you elaborate on that please or make a video to explain it.
Interesting that you mention this. I was just reading about a new study using an inline filter for ECMO patients that is similar and works by adsorbing cytokines. I did a quick look and the filter you mentioned looks to be newly approved in the US and is run as a filter set that is a part of Gambro's CRRT machines. Other CRRT filters have had this adsorption property with cytokines, but this looks to be something new. I was already considering doing a video regarding the ECMO filter, but now may just make one covering both. Thanks for the info. Are you in the US where you are seeing this used?
@@ICUAdvantage would love a vid!
Tnx for nice elabaratio on time demanding topic. this is Nazma from Bangladesh.
Thank you Nazma!
Thank you Very Much for this Informative Overview of Cytokines and the Cytokine Storm!
Will you also Cover Chemokines, Especially those Contributing to the Cytokine Storm? Have a Marvellous week! Cheers!
Ill throw them on the todo list
Wow thanks! Amazing video! Love it!
Just a quick question: Are chemokines a different group or just a subgroup of cytokines?
Thank you so much Linus! Chemokines are a small subgroup of cytokines. Glad you enjoyed the video and thanks for leaving a comment!
Linus C
Chemokines direct inflammatory cells ( granulocytes, monocytes, macrophages and T and B lymphocytes to the region infected to induce inflammation that kills infective agents (viruses bacteria, parasites,fungi, sting poisons.
F Abis MD, ESM 17.05.21
Linus C
Thank You for this precise description of the course of Your Covid, particulary for Your mention of reduced levels of IgG subclasses. We still do not know if the reduction in IgG subclasses is a defect in production or if those IgG are consumed during Your response to the infection.
Let dose Your IgG subclasses when You feel healed.
If the four classes result in the normal range or are elevated = immune response.
If both of Your IgG are low= production defect due to loss of funtion of the implicated genes.
Please let us know !
Excellent video, possibly apoptosis is a response to pyroptosis in the respiratory, inflammation is nothing new, intermittent release of viral particles creates an intermittent release of antibodies viral infected cell burst may create immune cell burst release multiple antibodies in return more immune cells would be required at area of infection for specific antibodies or proteins to attach to becoming receptors, with the delay of the thymus producing specific neutralizing binding antibodies- cells carrying these antibodies may come as a storm possibly bursting while capillaries leading to the respiratory are constricted from fluid and waste buildup restricting delivery of larger immune cells through the capillaries. Whats interesting recently dr drbeen did a lecture on the Bradykinin storm and located at the capillaries.
Thank you so much an interesting perspective. It will be interesting to see what we learn as time goes on.
@@ICUAdvantage yes lots to learn, humans survival instincts are in overdrive with good reason
consider the properties of the cell Coronavirus hijacks , the time frames of utilizing the properties and the various types of cells hijacked. immune cells are mobile and antibodies are not , the immune cells main function is to contain, the mathematics of counts between antigens antibodies and cells the amount of antibodies that become tcell receptors and or bind with the virus , the viral count in the bloodstream comparing to the respiratory determining if enough cells are being delivered to the infection area , with the possibility of viral spread through mitosis given the location of viral transcripts within an infected cell maybe previous to Coronavirus hijacking the cell property of producing antibodies in various numbers or none at all a mass of viral replications released at once compared to intermittent release of viral replications, one virus may be capable of utilizing cells properties compared to another virus , timelines of infected cell burst and immune cell burst immune cell burst possibly releasing multiple antibodies and the bloodstream route restriction leading to the infected area constricted delaying delivery of both antibodies and cells to the infected area , until a pathway is created by the infection with the bloodstream it is difficult for an effective immune response given the bloodstream respiratory barrier, possible immune reaction like sneezing is hijacked by the virus when it can reduce viral load, a lot of antibodies throughout the bloodstream without virus replications in the bloodstream could mean the antibodies didn't get delivered to the infected area but were released prematurely(not in growth sence) with a timeline of the cell, the cells already at an infected area would need specific proteins to bind with iggs to make specific antibodies or receptor , the cytokine storm may carry the specific antibody protein to the infected area, unless specific antibodies or cells are delivered in convalescent plasma then there may not be an effective immune response
Can it trigger q form of menigitis .. aseptic meningitis? Csf protein levels are high. ?
Awesome explanation! Thank you!
So glad to hear this Allison! Thank you!
Thank you for this video! It helped me to understand cytokine storm better.
What do you think about Edaravone for COVID-19-treatment? Can it be possible candidate for prevention lethal complications and for treatment COVID-19? I've heard edaravone can block both cytokine and free-radicals' storm.
I have found my new role model!
😂 Glad you liked it!
Thank you. You help me so much at feeling confident and prepared in my ICU.
Great and informative video!
Can you please explain why fever in cytokine storm is so hard to manage/treat , and why person usually doesn't respond to antipiretic medicine (sorry for my english). Thank you.
because there is a deficiency in nutrient.
If the new covid19 hypothesis suggests bradykinin storm....doesn’t lisinopril cause in increase in bradykinin??
Interesting point. It does potentiate bradykinin. It will be nice when one day we have a good grasp on this disease.
Simple way to explain complicated processes.keep it up .👍
Thanks a lot 😊I appreciate hearing that and I'll definitely have more coming!
Is neutrophilia in covid-19 associated with dysregulated immune system and cytokine storm?
Well! Does it mean that plasma therapy could be the best option right now for COVID patients, because the immune system is not actively suppressed by recieving the plasma from others but the triggers for cytokine storm are reduced overall ??
Great information!! Thank you!
Post covid female 23yr old_Crp 78mg/l, ,S.ferritin 59ng/ml, Ddimer 0.85 ug/ml... Highly inflammed cervical lymph nodes, now no fever (very high fever for past 4 days)... Please advise... Presently on amoxyclauv
How was your treatment?
It was informative, but falls short of the mark. It would be nice if this gentleman would educate his viewers on the role Vitamin D3, cholesterol and magnesium play in the prevention of cytokine storm. In addition it would also be a good thing to note how zinc inhibits covid from utilizing rna dependant rna polymerase, and therefore preventing the viruse's attempt to replicate. Vitamin D3 influences and promotes IL-4 and 10, thereby directing the immune system to take the non-cytokine storm pathway. Anyhow, still an informative video, and thank you.
Thank you, very concise and informative
Glad it was helpful!
You too like conciseness, yeah!
Wow, this is powerful information.thanks a lot.
Glad to help!
Also from vaccine, the same cytokine storm can appear.
fantastic lecture
I read somewhere on Twitter that the patients of Ebola experienced this cytokine storm before their deaths. The writer of the tweet said the cytokine storm is our body's last effort to beat the pathogen/virus, causing death after the pathogens are all terminated. What are your thoughts about this? Is it the same for the case Covid-19 and other illnesses caused by viruses?
Many diseases can actually lead to a cytokine storm. We even see it to some degree with the flu. The exact process and cytokines involved can vary from disease to disease though.
I don't know if I'd consider it the body's last effort though as it really is the body's normal system sent in to an abnormal overdrive. This isn't how it was designed to fight so I think I view it more of a disorder than a last hope move by the body.
@@ICUAdvantage thank you so much for replying! I really love your video and how you explained things. You just earned one subscriber 😇
Can we get some video of a FPV (First Person View) of the Cytokine storm?
Not sure I understand what you're asking for?
@@ICUAdvantage (pretend that you shrunk down to microscopic size) & standing inside a blood vein/arteries. I cannot for the life of me find any animation or illustration of this point of view. of the cytokine storm effect. Some Accurate and Real recorded video would be fantastic.
Is there an estimated % of patients that experience this phenomenon?
Not true, unvaccinated husband experienced cytokine storm and went into ICU. Thankfully, he survived
Very interesting. I am bow working on aproject to see is tetrahydrocannabinolacid, and CB1 and 2 could be effective in some way. I have a similar condition but no cytokine storm, but an inflammatory condition cause by an issue of the immune system not shutting off, of the digestive tract called IBD, specifically Crohn's disease. (Please pardpn the typos as this keyboard has been recently presenting probems). Crohn's as you probably know is an autoimmune disprder that is genetic, environmenta; and dieter;ated. Have you looked also into perjas the 'imabs' such as infliximab, vedolizumab, etc? These are quite common in the control of Crohn's. I am assuming this might help before any cytokine storm as these medicines are generally immunosuppressant. Just a passing thought.
Are people with myeloproliferative neoplasms more at risk for cytokine storms since the JAK2 mutation leads to higher levels of circulating pro-inflammatory cytokines? I did hear that Novartis is doing a clinical trial for the MPN drug Jakafi to see if it will help mitigate the cytokine storm.
Honestly I'm not sure. I think having higher levels of the pro inflammatory cytokines would certainly be concerning though. I'll have to look in to that. Thanks for the question Laura.
A great overview.
Not seeing much that really works on these pts, they pretty much follow the course to the bitter end.
I've been hearing some voices about vitamin D, how would vD meets this process, if it does at all?
Thank you Rachel. There is still so much to learn about this disease unfortunately. Hopefully soon we will have a good grasp and good treatment plan.
thank you for explanations in a simple way. Would you mind to tell what program you used for writings on the slide/video?
Thank you so much. I use an iPad. I screen cast my Mac and have Adobe Photoshop open and write with the Apple Pencil.
Hi, do u think deficiency of glycine which is unable to stop cytocine reaction?
I'm not really sure. I hadn't heard anything about that.
Pyroptosis of infected cells may be followed by a similar immune response of apoptosis in respiratory or the bloodstream, intermittent release of viral transcripts followed by intermittent release of immune transcripts or replications, each results in a different immune response or reaction, immune host cells produced for immune transcripts to bind with. With the buildup of waste and fluids restricts blood flow through the capillaries into the lungs resulting in the restriction of an effective immune response if any as well as restricting gas exchanges, cell bursting(pyroptosis) occurring in the respiratory outside the bloodstream makes it more difficult for antibodies to be delivered to the respiratory given the bloodstream respiratory barrier without a pathway for antibodies to enter the respiratory antibodies may not be present in the respiratory until a pathway is created from damage and bleeding occurs, damaged infected cells bursting or infected cells intermittently releasing viral transcript(replications) in the respiratory can be delivered with co2 into the bloodstream previous to tissue damage creating antibodies, specific antibodies may not be created until transcripts enter the blood and tissue
does cytokine storm occur depending on the severity of a dse ? how about cough or cold is there a cytokine storm there ? since Cytokine storm is not a hallmark for covid19 only. pls anybody elaborate what you know thanks in advance
Is it possible for a 3year old to have cytokines syndrome/storm without ever having Covid-19?
Absolutely.
Dear ICU advantage, thanks alot for sharing these interesting videos. they are really excellent ! I have a question: is there different types of Cytokine storms? if yes how is it possible to distinguish them? for example is there any differences btw Hpercytokinemia by COVID-19 patients and H5N1 infected patients? if there is no differences, why there is no traetment till now? the SARS-COV-2 crisis should not happen in this scale, should it? why is it becoming suddenly a worldwide disaster but H5N1- virus was contolled easily without social contact restrictions ? Good luck!
Thanks so much for this interesting video! In which patients can cytokine storm happen? In all patients? Is there any information, how many cases of Covid-19 are associaed with Cytokine storm ?
love the channel. Subbed
Sweet! Thanks so much and glad to have you on board Sean!