The main challenge to longevity is that the epigenetic clock is uniform among all tissues. If there had been more heterogeneity, then immunotherapy would be all that's needed to target the older cells. Indeed, if healthier and younger cells/tissues are introduced, the immune system will identify it as foreign and attack it. Therefore, immunosuppressants are necessary. Only then will gene therapy be effective. Immunotherapy must be used to kill stem cells because they identify older/unhealthy cells as self. Then radiation therapy can kill off other types of cells. Finally, stem cell therapy can be used to supply younger/healthier cells. After enough iterations, the immune system will redifine what's self. Then it will no longer be necessary to use immunosuppressants. A new protein-signalling paradigm will be in place. For residual old/unhealthy cells, memory b cells can be used to target them. This will only work when young/healthy cells predominate.
Great summary of scientific Aging background, work, and future directions! A must watch for anyone interested in the field - too bad the title is scary and uninformative, don't get turned off by it!
Is there any thoughts around tissues and organs that don't regenerate? I'm thinking about how we have a certain amount of elastin in our bodies and we stop producing it. Can that be regenerated
Russian Elon Musk (Пшеничный) was tortured to death in a prison by FSB agents who wanted to extort him for money. Yuri lives in Canada. This is just an unfortunate reality of modern Russia that many Western people don't realize, just how bad the situation is, and just how much worse authoritarianism is compared to even most feeble democracies. Russia could have been a major player in the science of human advancement. But history took other turn. You can't be an Elon Musk in Russia in 2024.
Great presentation.
The main challenge to longevity is that the epigenetic clock is uniform among all tissues. If there had been more heterogeneity, then immunotherapy would be all that's needed to target the older cells. Indeed, if healthier and younger cells/tissues are introduced, the immune system will identify it as foreign and attack it. Therefore, immunosuppressants are necessary. Only then will gene therapy be effective.
Immunotherapy must be used to kill stem cells because they identify older/unhealthy cells as self. Then radiation therapy can kill off other types of cells. Finally, stem cell therapy can be used to supply younger/healthier cells.
After enough iterations, the immune system will redifine what's self. Then it will no longer be necessary to use immunosuppressants. A new protein-signalling paradigm will be in place.
For residual old/unhealthy cells, memory b cells can be used to target them. This will only work when young/healthy cells predominate.
Great summary of scientific Aging background, work, and future directions! A must watch for anyone interested in the field - too bad the title is scary and uninformative, don't get turned off by it!
wow you posted this video right after we won 2nd place on the foresight event such a coincidence
who is we and does that mean I'm missing out by not watching something else?
Is there any thoughts around tissues and organs that don't regenerate? I'm thinking about how we have a certain amount of elastin in our bodies and we stop producing it. Can that be regenerated
Good lecture but Audio is bad . Shame
Very interesting, let me know when you need me to be a test subject. =D
Hurry. I'm 51.
this has to go ppl who have lost their lives at a young age due to illness - like destroyed multiple tissues not just for someone who has
like russian Elon Musk
Russian Elon Musk (Пшеничный) was tortured to death in a prison by FSB agents who wanted to extort him for money. Yuri lives in Canada. This is just an unfortunate reality of modern Russia that many Western people don't realize, just how bad the situation is, and just how much worse authoritarianism is compared to even most feeble democracies.
Russia could have been a major player in the science of human advancement. But history took other turn. You can't be an Elon Musk in Russia in 2024.
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