Finally extracting pure Salvinorin A crystals

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  • Опубліковано 12 вер 2024
  • The final conclusion of Salvia Divinorum extraction. May my sanity remain intact after doing this so many times. Enjoy!
    Sources:
    www.iceers.org...
    www.mdpi.com/1...
    pubs.acs.org/d...
    • Doctor Strange - Open ...
    Music: Bensound
    License code: ADCOZPT0Q7J3EE4W

КОМЕНТАРІ • 970

  • @deilach
    @deilach Рік тому +429

    You should make a video where you make acid and go through each step for scientific purposes, of course.

    • @cgyygc5433
      @cgyygc5433 Рік тому +7

      Lmao, if only

    • @remcovanvliet3018
      @remcovanvliet3018 Рік тому +48

      Uhm... I tried reading a paper on acid synthesis once, and I'm quite confident in stating that, if you're not an expert chemist already, you're not even going to understand what you're looking at, let alone be able to reproduce it.
      If only it were that easy...

    • @blunty96
      @blunty96 Рік тому +1

      Frlll

    • @GotTheBestLigma
      @GotTheBestLigma Рік тому +10

      ​@@remcovanvliet3018 also the precursors, I believe they are called ergotlides, are extremely difficult to get

    • @grantking4032
      @grantking4032 Рік тому +7

      Yeah lsd requires ridiculous level of talent not only as a chemist but a mycologist.

  • @That_Chemist
    @That_Chemist Рік тому +481

    "Oh good he's wearing gloves"
    "Oh he's wearing gloves because his hands are cold..."

  • @SetTheCurve
    @SetTheCurve Рік тому +485

    Hot tip: when doing freeze recrystallization, put the hot container in an extremely well insulated vessel like a thermos or styrofoam box, and put that in the freezer. The slower you cool, the bigger your crystals.

    • @robsonez
      @robsonez Рік тому +18

      This makes sense to reduce the speed at which it cools.

    • @goiterlanternbase
      @goiterlanternbase Рік тому +6

      High pressure should also help.

    • @maelgrum
      @maelgrum Рік тому +34

      Very nice tip ! And i can add - put the hot container in an extremely well insulated vessel like a thermos or styrofoam box, and do not put that in the freezer, let it cool slowly to room temperature, then put in fridge and let it cool to fridge temperature, and then put that in freezer. Then you get largest and purest crystals. And use minimum amount of solvent for recrystallization.

    • @maelgrum
      @maelgrum Рік тому +4

      @@timkrause1925 good point ! may be do 2 steps recrystallization - first slow, so most impurities go in mother liquor, and second - fast, so no solvent is trapped in crystals ?

    • @joalsoal1645
      @joalsoal1645 Рік тому +1

      @@goiterlanternbase sounds interesting! I’ve never heard of that

  • @diapysik
    @diapysik Рік тому +331

    What a wild ride, I wouldn't even want to in the same room as that vial but super glad to see your success, really shows that extractions aren't usually as straight forward as they sound on paper.

    • @lucalakic7631
      @lucalakic7631 Рік тому +2

      Couldn't agree more

    • @M_u_t_e96024
      @M_u_t_e96024 Рік тому +3

      I'd eat it ngl

    • @christianterrill3503
      @christianterrill3503 Рік тому +6

      The only way you would trip from it is if you smoked it....I think you would be fine int he same room as itm

    • @3ch0_17
      @3ch0_17 Рік тому +14

      Blink in its direction from a few counties away and you are instantly telephoned into the most mind boggling brain fuck trip you've ever experienced

    • @noodlelynoodle.
      @noodlelynoodle. Рік тому +4

      @@M_u_t_e96024 eating it would destroy it but letting it absorb through the mouth or sinuses would work

  • @Schody_lol
    @Schody_lol Рік тому +76

    “Steven what are you doing in there??”
    “A- Uh... Drugs”

  • @LanceMcCarthy
    @LanceMcCarthy Рік тому +122

    Thank you for the psychopharmacology intro. This was my favorite part of school, the other stuff was so boring. In fact, my psychopharm professor is the one who awarded me a praticum.

  • @rolux4853
    @rolux4853 Рік тому +59

    I’m deathly afraid of what this vial is capable of.
    The secrets of the universe are in that little thing..

    • @supersneakysquirrel
      @supersneakysquirrel Рік тому +3

      😂 facts

    • @jima1135
      @jima1135 3 місяці тому

      I exhaled, blacked out, and apparently said "I'm a traveler of both time and space!", before leaping off the bed and running out of the room

  • @DustyOldBones
    @DustyOldBones Рік тому +129

    This video feels like it could have existed on youtube 15 years ago. Love it, but its only a matter of time until someones mom finds it.

    • @ED-yy4te
      @ED-yy4te Рік тому +5

      Even the intro is from 15 years ago

    • @MagesseT1
      @MagesseT1 Рік тому +5

      🤣 I'm "someone's mom" and found it fascinating!
      Yes, I realize and no, I don't care. The more, the merrier!

    • @1984oner
      @1984oner Рік тому

      ​@°•.Mags.•° hello. How are u doing?

    • @TimNurTV
      @TimNurTV Рік тому

      I’m someone’s dad and I love salvia it’s the most based substance in existence

  • @oliverhorgs2298
    @oliverhorgs2298 Рік тому +93

    Holy fuck the madman actually managed to pull it off, congratulations! Your channel is fucking incredible❤

  • @Crowbars2
    @Crowbars2 Рік тому +163

    1:55 - Just a _slight_ correction. Although many classical psychedelics are agonists of the 5HT2A receptor, it's actually the 5HT2A-mGluR2 complex, an oligomerized receptor complex consisting of both the 5HT2A receptor and the mGluR2 (metabotropic glutamate receptor 2) receptor that is responsible for psychedelic effects. There are drugs out there like Lisuride which acts as a partial agonist of 5HT2A, but doesn't result in psychedelic effects because it only binds to the uncomplexed 5HT2A receptor. The uncomplexed 5HT2A receptor has a similar, yet distinct, binding pocket when compared to the complexed 5HT2A receptor in the 5HT2A-mGluR2 complex. So, a drug that binds to 5HT2A doesn't necessarily mean that it's a psychedelic drug, but there's a good chance it will be.

    • @sciencething1449
      @sciencething1449 Рік тому +21

      pharmacology is so incredibly confusing yet incredibly interesting

    • @Crowbars2
      @Crowbars2 Рік тому +21

      @@sciencething1449 Yeah, this whole "it's not the 5HT2A receptor, it's actually a 5HT2A receptor complex" thing confused the fuck out of me when I first heard it. Then, I went to a lecture on receptor dimers at university and it started to make sense. Basically, GPCR's (G-protein coupled receptors), can join with other receptors to make a dimerized receptor i.e. a combination of 2 or more receptors. They can have similar effects to each receptor on it's own, but they can also have effects that are completely different.
      It's an emerging field of research. It's so big, and we currently know very little. Like, if activating the 5HT2A-mGluR2 complex can result in psychedelic effects, who knows what effects messing with other dimers can result in?

    • @sciencething1449
      @sciencething1449 Рік тому +5

      @@Crowbars2 very interesting i did not know this at all, does the dimerizing happen automatically like how does that work? When do the receptors decide to do that?

    • @Crowbars2
      @Crowbars2 Рік тому +21

      @@sciencething1449 I think that the mechanism of how/why GPCR's dimerize is currently unknown for certain, but it's a hot topic of research. Expert opinions range from "omg these particular GPCR's never dimerize" to "Of course all GPCR's function as dimers."
      What we do know is that the way that these GPCR's dimerize is through linking of certain domains (extracellular domain, transmembrane domain, c-terminal tail) from each GPCR through disulfide bonding, and non-covalent bonding. This also explains how a dimerized receptor can have different pharmacology. If the binding pocket is located on the extracellular domain in each GPCR, and the receptor dimer involves two extracellular domains linking together, that could change the shape of the binding pocket and mean different ligands can affect the dimerized receptor compared to the undimerized receptor.
      The GABA-B receptor is quite interesting in this regard, because it can only function as a heterodimer of GABA-B1 and GABA-B2 receptors, and the mechanism of how this occurs is known. GABA-B1/B2 have minimal function on their own, and they need to dimerize to make the final GABA-B receptor, and there's a very particular mechanism to it's production.
      GABA-B1 and GABA-B2 are encoded by two separate genes (the genes are called "GABBR1" and "GABBR2"). When the GABA-B1 mRNA is produced from the gene, the mRNA then enters the endoplasmic reticulum, where it is converted to protein, the GABA-B1 receptor, and inserts itself into the membrane of the endoplasmic reticulum.
      But on the GABA-B1 receptor, there's a particular protein sequence which causes it to be retained in the endoplasmic reticulum until a finished GABA-B2 receptor comes along, which causes a conformational change in both receptors. This leads to both receptors subunits linking together through the c-terminus tails, producing the completed GABA-B receptor. The conformational change in the receptor also allows amyloid precursor protein (APP) to bind to it, which causes the finished GABA-B receptor to form a vesicle, releasing the completed GABA-B dimer from the endoplasmic reticulum, and be shuttled to the cell membrane.
      Since dimerization is necessary for the function of GABA-B, this could just be a way of ensuring both receptors dimerize into a functional receptor. Maybe other receptors can dimerize just by being close together on the cell membrane. Maybe there are other mechanisms of dimerization with other receptors. Unfortunately, we don't know for certain.

    • @sciencething1449
      @sciencething1449 Рік тому +5

      @@Crowbars2 geez thanks for the essay lmao. Im asuming you are studying this? anyway very interesting, this motivates me to look deeper into pharmacology to try and understand half the words you are saying haha

  • @luka6575
    @luka6575 Рік тому +86

    Science is so crazy. The mechanics and organic chemistry is fascinating. Even though this is not my type of pace, I can appreciate the beautiful synthesis.

    • @chemdelic
      @chemdelic  Рік тому +9

      It really is!

    • @oitthegroit1297
      @oitthegroit1297 Рік тому +7

      ​@@chemdelic You should take the Salvinorin A and turn it I to Salvinorin B ethoxymethyl ether, it's more potent than Salvinorin A and the effects last for 2 to 3 hours instead of 30 minutes.

    • @McFwoupson
      @McFwoupson Рік тому +3

      @@oitthegroit1297 cursed chemical

  • @swampmonkey420
    @swampmonkey420 Рік тому +12

    Nile Red has some competition! another great video bruv, Thanks!

  • @MaoTao
    @MaoTao Рік тому +49

    Salvinorin A is such an underrated compound. I'm willing to bet that the majority of people who dislike Salvia did so because they did little to no research on the substance. They probably expected a euphoric high similar to cannabis, and I can't even blame them. Due to dumb drug laws, Salvia was marketed as an incense not for human consumption which meant they couldn't list the correct dosages, causing people to fill a whole bowl of the stuff when all they really needed was a small pinch.
    I think the best way to use Salvia is as a tool to explore consciousness while letting go of all expectations. The moment you expect an outcome is the moment the drug turns on you.

    • @MisterNiles
      @MisterNiles 9 місяців тому

      I'm so glad that when I got into Salvia, there was already a dosing guide on the dmt nexus. Using a scale with a sane level salvia extract (~10x) was a game changer for me. The other game changer was discovering that salvia in a changa mix was amazing. A guaranteed ticket to carnival/circus land.

    • @jima1135
      @jima1135 3 місяці тому

      @@MisterNiles I don't know if Erowid is still a site, but that's what I used to use in my misguided youth for dosage recommendations.

  • @multiarray2320
    @multiarray2320 Рік тому +23

    i dont know anything about chemistry but you somehow managed to be in the top 2 of my favorite youtube channels (sebastian lague is the other one). you have a unique style and i like that.

  • @antonetwas2415
    @antonetwas2415 Рік тому +13

    I love the *purely informational* video you posted about, how to make salvinorin crystal👍
    And your video quality is getting really good👀

  • @hotrodlincolnx
    @hotrodlincolnx Рік тому +103

    Salvia was by far at the top of my favorite trip list. I always explain it as a 5 minute LSD trip, it honestly feels like hours, last time I ended up in a snow bank. Make sure to have a good trip sitter, a lot can happen in 5-10 mins.

    • @MirrorcatYT
      @MirrorcatYT Рік тому +21

      you are fn crazy then lol salvia was a horrible horrible experience for me and i love me some L

    • @CD3WD-Project
      @CD3WD-Project Рік тому +2

      DMT ?

    • @EddieTheH
      @EddieTheH Рік тому +20

      ​@@gstein123 I agree, it's a completely different box of frogs to LSD.

    • @ChemEDan
      @ChemEDan Рік тому +4

      @@EddieTheH Box of frogs 🐸 love it

    • @dazultra2000
      @dazultra2000 Рік тому +16

      Once had some 5x extract and it made my skin crawl but not much else. Then I won some 60x extract and thought "why not?". Whoosh. I thought I was 6 years old again on my way to school on a snowy day. I could feel the icy cold metal of a lamppost (in reality my glass containing water device). It felt so real. No trace of current reality was left. Then, after an unknown amount of time I was back and totally freaked out by what happened. Not a bad experience but enough to make me NEVER want to try it again.

  • @79obrien
    @79obrien Рік тому +14

    Salvia has a bad reputation but I think it's because most people had no idea what they were getting into. It's effects are powerful and peculiar.

    • @MisterNiles
      @MisterNiles 9 місяців тому +2

      Most people didn't even consider using a scale.That may have helped.
      I would love to try salvinorin A extract because I hate the smell and tasteof the leaves so much. I have a feeling the trip would be less dysphoric if I didn't have to experience that taste.

    • @johnmaccallum7935
      @johnmaccallum7935 Місяць тому +1

      Peculiar is a great description and I'm no stranger to brain candy but don't care to relive this treat

    • @79obrien
      @79obrien Місяць тому

      @@johnmaccallum7935 yeah if people want something intense that will actually feel meaningful then DMT derived from Mimosa is the way to go. I don't even recommend people use 5 MeO DMT for intense experience

  • @scottm2553
    @scottm2553 Рік тому +12

    Recommendation: flash chromatography column packed with lab grade clean cotton, clean sand, charcoal. Boom. Edit: check out this book: Techniques in Organic Chemistry: Miniscale, Standard Taper Microscale, and Williamson Microscale This is what I used for ochem back in my undergrad program. It's a solid manual on techniques and is cheap now.

  • @digitalmind4700
    @digitalmind4700 Рік тому +2

    Hello dear friend
    My main field is electronics technician and graphic design
    But due to my interest in chemistry, I am also active in this field
    I saw that you used devices and funnels for filtration several times
    I don't think there is a need for so much complexity
    A 20 ml syringe
    Remove the piston
    Squeeze a piece of cloud or Kleenex tissue
    Push the tissue into the syringe until it reaches the outlet
    Press it with a tool that is not sharp
    Now pour activated carbon up to 1 cm
    And now dissolve the crystal in water
    and pour into the syringe
    Put the piston in place and press gently
    and over
    I used it many times in the extraction of ephedrine and so on
    The result was excellent
    be happy

  • @EndEverEsports
    @EndEverEsports Рік тому +5

    Instant subscription. Salvia was one of my babies. Glad to see them grow.

  • @UkrainianBazooka
    @UkrainianBazooka Рік тому +5

    this has been a great experience, i'm glad you brought us along for the whole ride!

  • @ashcroftttt
    @ashcroftttt Рік тому +13

    If you have access to a -80°C freezer or some dry ice it helps tremendously with the wax/chlorophyll issue, extract is light lime instead of dark green. Also just realized it was like 15 years ago that I last did this extraction, damn, time does fly...

    • @lindboknifeandtool
      @lindboknifeandtool Рік тому

      Where do you buy liquid nitrogen?

    • @thedude4795
      @thedude4795 Рік тому

      @@lindboknifeandtool uhh... thats something differerent

    • @lindboknifeandtool
      @lindboknifeandtool Рік тому

      @@thedude4795 I know but I’m in the right place, and casting a wide net.

    • @crowe6961
      @crowe6961 Рік тому

      @@lindboknifeandtool Check welding supply companies. You need to have a container that's actually rated for it, of course.

  • @twistedsphere
    @twistedsphere Рік тому +2

    i will enjoy this video for the next six weeks that it exists on youtube. best channel ever.

  • @johnmcclane4430
    @johnmcclane4430 Рік тому +5

    It is always fun seeing the iterative process at work.

  • @patrickcarpenter6258
    @patrickcarpenter6258 Рік тому +2

    This channel is so GOOD! Thank you for posting these fun educational videos

  • @marvindiagne237
    @marvindiagne237 Рік тому +3

    i did not expect such a good yield from an extraction with so many potential for loses

  • @rileymerson8781
    @rileymerson8781 Рік тому +21

    Hey chemdelic! Would you perhaps consider a kratom extraction video? I’d love to see how you tackle that one ! It’s a much less legal grey area for than salvia!

    • @chemdelic
      @chemdelic  Рік тому +23

      Yes I can

    • @freehat2722
      @freehat2722 Рік тому +1

      @@chemdelic I'm mildly curious, but this takes the cake. I would certainly watch that.

    • @SheikhN-bible-syndrome
      @SheikhN-bible-syndrome Рік тому +2

      ​@@chemdelic yeah if you can get around all the Wax and fats they have and are able to make a pure product that would double your sub count over night lol only time I was able to get a clean product was to use dry acetone and let it soak over night then filter the top clean part it made a brown crystal that looked amazing but sadly every extract I've made or bought isn't as strong as taking the hole powder itself 😔 but finding a way to make it easier on the stomach is my goal because it sits so heavy in my stomach it makes it hard to eat and you just feel like shit when you drink it it's so bitter

    • @apdwilly4632
      @apdwilly4632 Рік тому +1

      Omg this would be amazing

    • @dirtyhiggins5484
      @dirtyhiggins5484 Рік тому +1

      ​@@SheikhN-bible-syndrome I take the powder with oblate paper (Blate Papes), making there no taste to worry about. I have used them for a few years and use them for all my powder supplements. They are great

  • @ecilimE
    @ecilimE Рік тому +3

    Never heard of this crystal yet I'm so proud of you.

  • @adriaanbazelmans4809
    @adriaanbazelmans4809 Рік тому +1

    This is quickly becoming my favorite UA-cam channel

  • @faksake1630
    @faksake1630 Рік тому +8

    very simple and clean video :)
    i expected little harder process of extraction but this piece of cake.
    but yea as you said this is more like nexus guide than yt video xDDD
    and proud to say this year is my 10th year of continuous mimosa extracts :D

  • @MrBradshawbenjamin
    @MrBradshawbenjamin Рік тому +1

    congratulations! Your product looks beautiful, and this seems to me like an excellent conclusion to this series.

    • @freehat2722
      @freehat2722 Рік тому

      Conclusion? I'm just getting warmed up to him.

    • @MrBradshawbenjamin
      @MrBradshawbenjamin Рік тому

      @@freehat2722 I meant to the Salvinorin A series.

  • @olutukko2681
    @olutukko2681 Рік тому +3

    Interesting. I've been meaning to do something similar, and then see how it would work on blotterpapers so one wouldn't need to chew on a horribly tasting leaves on order to get a longer trip.

    • @ZaynneThaWook
      @ZaynneThaWook Рік тому +2

      You could put this in a vape cart potentially

  • @dillaques
    @dillaques Рік тому +2

    Awesome video series bro! Great to see the activated charcoal and methanol recrystallization work so beautifully. That charcoal column had me laughing 😂

  • @jelenahegser445
    @jelenahegser445 Рік тому +9

    I feel you so mutch with the aktivated charcole issue, I had the exact same problem with an extraction I did, only difference: I had a Hand crank centrifuge... yeah my arms were unuseable for an houre or so after turning the the centrifuge with my pure muscle power... again and again...

  • @Ryan.Kooper
    @Ryan.Kooper 2 місяці тому

    Salvia was the only compound I experimented with as a teenager that would give a very different response per plant. Such a wide array of strengths and effects

  • @andreasflensmark8616
    @andreasflensmark8616 Рік тому +3

    The amount of "professionel" lab equipment is really nice to see in a home lab

  • @sadtown
    @sadtown Рік тому +2

    I'm proud of you son. Keep up the good work

  • @highlander723
    @highlander723 Рік тому +3

    another way you could have done that decanting was by using a funnel with a small size filter fret plugged with diatomaceous earth. another way would be old fashioned filter paper with a slight vacuum pump 2 micron will clean it up nicely.

  • @mysticrider76
    @mysticrider76 Рік тому +1

    I am so sensitive to Sally D, that I tend trip HARD on small doses of dried leaf extract. It definitely changed my way of thinking after a few very deep spiritual trips. When you say you will see God, I can back that 100% I can't imagine where pure Salvia would put me. It's my 3rd favorite psychedelic and for me, comes nowhere near the same as shrooms or LSD. Salvia is on it's own plateau. It's get the most respect from me.
    Love the video - great stuff!
    ~New sub 😊👍

    • @Ormodius3751
      @Ormodius3751 Рік тому

      Please stop using drugs. It's mat be illegal in your area.

  • @peterdebelianow-mm7tw
    @peterdebelianow-mm7tw Рік тому +3

    Idea for next video: decarboxylation of tryptophan with spearmint oil

  • @lexinexi-hj7zo
    @lexinexi-hj7zo 6 місяців тому +1

    I have done every substance. And Salvia is the most crazy, Crazier then K. I watched the ceiling of my friend room open up peel down the center and splash down the walls like wabes as I went into another dimension of time and space, thought my whole life before was just a dream and now I was awake.

  • @clrwtrmusic
    @clrwtrmusic Рік тому +30

    Hey if you could put chemical list and necessary equipment list, that would be helpful 😎🧪

    • @chemdelic
      @chemdelic  Рік тому +12

      I will put in the comments later!

    • @Sxultv
      @Sxultv Рік тому +1

      @@chemdelic lol

    • @SafetyLucas
      @SafetyLucas Рік тому +2

      Bruh he literally said everything he did in the video

    • @clrwtrmusic
      @clrwtrmusic Рік тому +1

      @@SafetyLucas I know it’s just easier for organization and setup purchase

    • @freehat2722
      @freehat2722 Рік тому

      If you use CC option it should help transcribe most of it.

  • @randykitchleburger2780
    @randykitchleburger2780 Рік тому +4

    Oh my God it's a Kappa agonist!? Trippy AF for sure

  • @Karanps
    @Karanps Рік тому

    I feel each and every person here is so interesting to be a part of this channel.

  • @scottm2553
    @scottm2553 Рік тому +8

    You may want to clarify at the end that the mg scale a lot of people use off amazon isn't good enough. You need like a $10,000 dollar scale to measure safely for sub miligram measurements and it needs to be properly calibrated.

    • @user-ro9md9wp3j
      @user-ro9md9wp3j Рік тому +3

      yeah a safer way to dose it would be to measure out like 50 mg with a cheap scale, dissolve that in some quantity of ethanol, and then dose it volumetrically onto blotter paper or some kind of plant matter for smoking. That way if your scale is a little bit off it won't make a big difference.

    • @scottm2553
      @scottm2553 Рік тому

      ​@@user-ro9md9wp3j That's a good idea!

  • @GyzelE
    @GyzelE Рік тому +1

    A had a ton of this stuff back when it was legal. Very, very fun times!

  • @TheBackyardChemist
    @TheBackyardChemist Рік тому +11

    a concentrated DMSO solution of this would be terrifying

    • @freehat2722
      @freehat2722 Рік тому

      Ah ha ty. I was thinking menthol as it's much more available (like my front yard). I made a similar post.

    • @freehat2722
      @freehat2722 Рік тому

      Only problem: both are soothing for pain. So is capsaicin, which I would find somewhat necessary for a "banish to hell" effect. Hypothetically speaking. All in good fun.

  • @ben-jinni6799
    @ben-jinni6799 Рік тому +1

    I've watched this video at least 4 times already. Please make more videos like this of other medicinal plants

  • @That_Chemist
    @That_Chemist Рік тому +3

    10:58 our boy lifts weights

    • @chemdelic
      @chemdelic  Рік тому +2

      Not only is That Chemist smart, but also very observational!!

    • @That_Chemist
      @That_Chemist Рік тому

      @@chemdelic I used to have them on my hands - not anymore lmao

    • @user255
      @user255 Рік тому

      It could also be due excessive masturbation. We just cannot know.

  • @jeanious2009
    @jeanious2009 Рік тому

    Nice!! Salvia completely tore up my ego, gave me new look and perception to life. Respectfully tried it about 4 times and disrespectfully 1. All it takes is one bad trip to learn to respect salvia and salvia will treat you right.

  • @btd6vids
    @btd6vids Рік тому +4

    Thanks for the tutoria-
    I mean educational video not meant to be tried at home!

  • @danielsiebert5714
    @danielsiebert5714 9 місяців тому +1

    Nice work. There are simpler methods, but given how potent a substance this is, I don’t want to spell out Salvinorin A Extraction for Dummies here. Hint: the easiest, but not most productive, methods I have tried are basically just like recrystallization, but starting with leaf powder. The change in solvent temperature and volume does most of the work. Extract the leaf powder into a solvent that you would use as a solvent for recrystallizing salvinorin A (ethanol works well). Maybe do two 24-hour macerations. Filter the combined extracts, then boil down to concentrate (how much to concentrate here is important, but you’ll have to experiment). Put the concentrate in the fridge for a day or two. Then filter off the crystals. They can then be washed in boiling hexanes. Then in boiling distilled water. They should be quite clean at this point, but you can purify further by recrystallizing in ethanol.

  • @Iwantcaps
    @Iwantcaps Рік тому +3

    Chemdelic always posting bangers

  • @eve_squared
    @eve_squared Рік тому +2

    Roll up a filter paper and stuff it in the bottom end of the funnel then add the charcoal on top of that, maybe even wrap a second filter paper around the bottom and tie it/ rubber band it (maybe a bad idea when working with some solvents)

  • @GranulatedStuff
    @GranulatedStuff Рік тому +4

    Did it once....My main trip was awesome. My job in life was to lay on my back in a meadow while stamping out multi-coloured 'crazy paving' slabs out of the gooey stream that was flowing overhead....
    However , the off-ramp was so horrifying that I can't bring myself to try it again...I believed I'd being held captive and sedated for 6 months and I 'realised' that the sedation was wearing off giving me a chance to escape. I somehow managed to get up, stagger down some stairs and out into the street. I felt like I was moving through electrified gel.

  • @brayancamargo2048
    @brayancamargo2048 Рік тому +2

    Me and my girl were keeping up with your extractions on this since the first video, she laughed so hard at the yield you finally managed to recover😭 ay but that’s chemistry in a nutshell mam

    • @robsonez
      @robsonez Рік тому +4

      58mg at 1mg being a mythic dose? Sounds like a good yield to me

    • @brayancamargo2048
      @brayancamargo2048 Рік тому

      @@robsonez learning curve things brother 🫡💯

  • @simpleman806
    @simpleman806 Рік тому +5

    If you happen to be in a situation where you run out of methanol, you can pick some up at an auto parts store or a truck stop. It's listed as air brakes antifreeze.

  • @BenjaminMaggi
    @BenjaminMaggi Рік тому +1

    Boy, every time someone talks Salvia it throws me back to my wildest hallucinations I've ever had, scary shit and you made pure crystals are you mad ??? It's very cool I'm an engineer but I always wanted to be a chemist I want to start doing extractions

  • @charlesalberti563
    @charlesalberti563 Рік тому +4

    This but extracting DMT from mimosa hostilis would be dope AF.
    Got some root bark powder I've been meaning to give it a go at . Confident I could it but wouldn't mind some extra references!

    • @granderondeproductions3286
      @granderondeproductions3286 Рік тому

      I wouldn't admit to that. but, hey I'm not a lawyer. All I can say is good luck... its an intense drug.

    • @charlesalberti563
      @charlesalberti563 Рік тому +1

      @@granderondeproductions3286let me just start with I appreciate you looking out homie, but to your first point,I live without masters. If they want to come lock me in a cage then they will, I will not censor, hide, or change anything about myself to appease some pseudo overlords. I am hurting no one and I am proud of my actions, I will always do them in the light.
      To your second point yeah I've done it a handful of times and you're 100% right in that it's intense, words fail to describe what is experienced on the deemz. Last time I did it a voice told me to stop for a while, you'll know when it's time to come back, and its time to come back.
      Im a lab tech and a coworker did the extraction for me last time but I think I need to remove the training wheels

    • @user-rw2pq8te7x
      @user-rw2pq8te7x Рік тому +3

      cybs tek was super easy

    • @electronium6378
      @electronium6378 Рік тому

      @@charlesalberti563 DEA watching this 👀👀👀👀👀

    • @charlesalberti563
      @charlesalberti563 Рік тому

      @@electronium6378 who cares? You go live in fear I'll live without it

  • @RaraAvis1138
    @RaraAvis1138 Рік тому

    This was fascinating and so appreciated! I love watching well explained demonstrations - thank you!

  • @lefroy1
    @lefroy1 Рік тому +3

    Is the removal of the chlorophyll in rhe latter stages just for aesthetic reasons, or does it mess with the efficacy of the product?

    • @chickenmonger123
      @chickenmonger123 Рік тому +3

      I’m not chemist, but if you don’t get it out, it seems unlikely to crystallize properly. Regardless I’ve performed extractions, and getting chlorophyll out is something you want, it could interfere with the steps after it.

    • @chemdelic
      @chemdelic  Рік тому +6

      You can smoke the leaves directly and you would have effects from the Salvinorin A. It mainly is an isolation of the psychoactive compound. It just changes the style of consumption as leaves are less concentrated and this is WAY more concentrated. Though mine mainly was for aesthetic reasons. Plus it is much easier to dose when you have the exact isolation of a pure compound rather than an unknown concentration with impurities!

    • @oliverhorgs2298
      @oliverhorgs2298 Рік тому +1

      Makes it gunky and gooey and tastes pretty bad chlorophyll kinda sucks for tryna get pure crystals or really anything that doesn't look like black/green tarry paste

    • @radomane
      @radomane Рік тому +1

      Probably don’t want to inhale the vaporized chlorophyll. On the other hand the chance of introducing a more toxic impurity through the extraction seems high for the general caliber of chemists doing this extraction. Most of the videos I’ve seen the product looks more like dried leaves than extract.

    • @lefroy1
      @lefroy1 Рік тому

      Thanks to all, that makes sense, and congratulations @Chemdelic. Been interesting following you on this journey.
      I don't envy trying to dose 1mg of yr crystal. ;-) gl.

  • @MisterLucidDreamer
    @MisterLucidDreamer 7 місяців тому

    What an ambassador of Her Spirit xD ! Love it : )))

  • @goiterlanternbase
    @goiterlanternbase Рік тому +3

    7:12 Don't worry. I would do half of the things different🤣
    Like not using Aceton, like at all.
    Like filtering every pull straight on. Look what you pour out of the bottle and how green it is, after the night. That is caused by all the stuff, you did not filter out straight.
    Pull time of 3 times one minute, is 2 times and 57 seconds to long. It's plant material. Just grow/buy 20% more of it, to cover the losses.
    Get Salvia leafs, not powder. Powder is only good for a vitamin rich smoothie.

  • @randykitchleburger2780
    @randykitchleburger2780 Рік тому +2

    Finally! Great job!

  • @justinwatson1510
    @justinwatson1510 Рік тому +2

    The opening clip was a pretty faithful recreation of how I would describe my salvia experience, minus the certainty that I was being pulled into some sort of giant deli slicer.

  • @joshbevill1770
    @joshbevill1770 Рік тому

    I really like the way you narrated this video.

  • @stepdoc
    @stepdoc Рік тому +2

    Holy shit bruh. I thought biochem was useless but i understood the entire intro 😭

  • @ediefreddie5438
    @ediefreddie5438 Рік тому +2

    Legend says the table is still high from all the spills

  • @k2___2
    @k2___2 Рік тому

    just found the channel and im loving it!

  • @APF3LKUCH3NLP
    @APF3LKUCH3NLP Рік тому

    I just discovered your channel and im in love with you

  • @ZiessRides
    @ZiessRides Рік тому +1

    Some people see "machine elves" on DMT. I'm pretty sure that vial at the end is how you become one. Good lord. Great video.

  • @user-nr7ls1uj2q
    @user-nr7ls1uj2q Рік тому

    Thank you! Chemistry is such a beautiful world!

  • @stevensims3342
    @stevensims3342 Рік тому

    I had the wildest trip on some 20x back in the day. Some Bob Marley song was playing as I held my breath, slowly the walls began to swell and contract to the beat of the song while what he was saying related to what was happening for a bit until I looked to my left and I saw the corner of a very large book (like a corner triangle blending into the background of the garage we were in). The edges were lined in gold and suddenly it opened up about halfway then pages began to fall. I was gazing into the same reality I was in on each page that passed, each was slightly different. Not entirely different, like objects and such but different possible courses for that night other than what happened though it was all still in the garage. This all happened very fast but as I was looking into the large corner of a book and as I was realizing what it was looking deeper, it stopped. When it stopped, everyone in that "potential reality" turned to look at me in a manner like "What are you doing looking at this? You should net be seeing this 🤨" then the trip ended. It was amazing though slightly unsettling at that specific moment when they looked back at me.

  • @emil30w
    @emil30w Рік тому +1

    can't wait for you to craft Acid !

  • @harliethomas1378
    @harliethomas1378 Рік тому +1

    I have no interest in making recreational drug to psychedelics but I find this synthesis absolutely fascinating along with all the quirks that inevitably come along while trying to do it

    • @julianprzybysawski8543
      @julianprzybysawski8543 Рік тому +2

      It's not a synthesis, it's an extraction from plant matter.

    • @harliethomas1378
      @harliethomas1378 Рік тому

      @@julianprzybysawski8543 Yes true. And that thought went through my mind after I pushed it lol

  • @bassaddict1988
    @bassaddict1988 Рік тому +2

    Salvinorin felt for me like my skeleton was jumping out of my skin while a high speed train was rushing through my room. And well, that was far below a real high dose. Such a crazy compound.

  • @andrewrogers9236
    @andrewrogers9236 2 місяці тому

    Interesting video, I’ve smoked salvia extract, crazy stuff. I noticed this extraction is very similar to a DMT extraction using Mimosa Hostilis root bark. Done it a few times, I doubt you could show that process on your channel though lol. Cool how easy it is

  • @_boch
    @_boch Рік тому

    you know the day is good when new chemdelic video comes out

  • @smoothmovez
    @smoothmovez Рік тому

    I hope there's another more to come. Just found channel. Extremely interesting

  • @Schnippen_Schnappen1
    @Schnippen_Schnappen1 Рік тому +1

    I’m terrified of salvia. Never smoked enough to break through but just the threshold effects made me NOPE! and got a panic attack. That is crazy makes DMT look like a joke

  • @Amipotsophspond
    @Amipotsophspond 7 місяців тому

    so you should use a french coffee press in a ice bath on top of your stir plate for your cold extraction. you can pull the plunger in and out while you are pouring and the solvent really gets around your solid. if the steel mesh is not fine enough you can just buy more steel meshes and use them one of them at a time to get even espresso fineness out.

  • @verylowpoly
    @verylowpoly Рік тому

    Someone's doing cool Salvia Science in 2023? Holy moly, bro. I haven't seen anyone do serious work with Salvia for as long as it's bad reputation clouded peoples interest in it. Subbed

  • @mikerope5785
    @mikerope5785 Місяць тому

    The other realm is eerily nostalgic, you will be lectured to by familiar and diminuitive yet towering entities, taught things that everyone knows, but delivered in an unfamiliar fashion, with a sense of forboding imminent hilarity. Time will mischievously appear to run backwards with feet, rather than forward with hands.

  • @Ryan.Kooper
    @Ryan.Kooper 2 місяці тому

    I didn’t think about freezing material and solvent, definitely a smart move. Also didn’t think about dewaxing the fats off

  • @Gajsu1
    @Gajsu1 Рік тому +1

    So i've been doing some activated charcoal cleanings of the solutions in my workplace and the solution you got at 9:55 can be easily cleaned if you just took it into a 25ml syringe and pushed it through 0.45um hydrophobic PTFE filter that you put on top of the syringe, these are pretty cheap and very effective at removing charcoal. Also remember to pre-wet the filter with methanol.

  • @nicknorthcutt7680
    @nicknorthcutt7680 2 дні тому

    "You will be seeing god if you decide to do this" lmaoo exactly 💯🤣

  • @gratefuldoge8598
    @gratefuldoge8598 Рік тому

    I am loving this era of chemists
    Bring Synth to a home near you!

  • @thedude4795
    @thedude4795 Рік тому

    omg, this channel HOW DID I MISS YOU?

  • @s_bt_iwtf
    @s_bt_iwtf Рік тому +2

    "It's important to not use too much of the solvent and or too little"
    Only salvia can make too much and too little occur simultaneously.

  • @Shorty50
    @Shorty50 Рік тому

    wow i do love some good old chemistry Great work dude!

  • @sammacleod7950
    @sammacleod7950 Рік тому +1

    The crystals probs take longer to dissolve because of the lower free energy (more stability) of the crystal structure vs crude product with less crystallinity because of impurities disrupting the crystallisation. Or maybe it´s just smaller particle size!

  • @minkorrh
    @minkorrh Рік тому +1

    Having experienced the other reality that is salvia, I can only shake my head and chuckle at why anyone would want to concentrate this stuff and make it any more powerful than it already is lol.

    • @EYESLAPJEWS
      @EYESLAPJEWS Рік тому

      Exactly they made some Taffy/waxy 100 x potent and even more than that look like some purple goo and all you need to do is take one bong rip and you'll be so high when you're done tripping you'll realize that it made you stupid and you never want to touch it ever again

  • @Zaekk
    @Zaekk Рік тому

    Oh man how did I not know about this channel.
    Haha I love the ending, yeah I was thinking "oh man that's like 100 doses".

  • @nazofalltrades
    @nazofalltrades Рік тому

    You have the same energy as sam o’nella academy

  • @Yokai.Wakukhan
    @Yokai.Wakukhan Рік тому

    you are a true legend in my book bro man

  • @Mason_Earle
    @Mason_Earle Рік тому

    Fantastic. Please do a cactus extraction vid!

  • @A3Kr0n
    @A3Kr0n Рік тому

    You'll try it a couple of times and be done.
    Congratulations! You have another reality to compare this one to!

  • @PunkIAm
    @PunkIAm Рік тому +1

    Yes, just do all of it, Gone in a place yet to be found, but not around -Salvia

  • @ubza1234
    @ubza1234 Рік тому

    I have a fun tech for you to try which works really really well. After your first 3 acetone washings, filter with coffee filter and then a second filtration step with tightly packed cotton wool in a funnel. Rinse cotton with acetone.
    Here's the difference: add water to the acetone in a 3:1 ratio into a large jar. Water:acetone. Mark the level on the jar. Bring the solution to around 50 degrees and leave at this temperature with the top open for a week so that all the acetone can evaluate out but it will leave the water behind. Every day, to up the water to your level. Excess water is best.
    The crystals will crash out, as they are highly soluble in acetone,but not in water, so once the acetone is removed, they crash out as hair like needles. The plant fats and chlorophyll Will mostly stay soluble in the water. Some may form a green scum at the top, but that's fine. Carefully decent the solution. Feel free to leave some of the water in there, if it cannot be removed without disturbing the crystals. Add some water to wash the crystals, and leave to settle out. Decent. Repeat if necessary. There you go, it's basically a 3 step process straight to crystal without any nasty chemicals. Because the process is basically self cleaning, there isn't really as much need to use ice cold acetone either, although it can make things a little less messy.
    I'd love for you to try that one! I've found it pretty good ☺

  • @datura_boof
    @datura_boof Рік тому +1

    i did this when i was 16 in highschool. good stuff m8