An overview of CAR T-cell therapies in the treatment of patients with MCL

Nilanjan Ghosh, MD, PhD, Levine Cancer Institute, Charlotte, NC, discusses the use of CAR-T therapy for patients with mantle cell lymphoma (MCL). There is a clear unmet need for patients with MCL who have failed treatment with BTK inhibitors. Two CAR T-cell therapies have recently been approved in MCL: brexucabtagene autoleucel (brexu-cel) based on the results of the ZUMA-2 study (NCT02601313) and lisocabtagene maraleucel (liso-cel) based on the TRANSCEND study (NCT02631044). Whilst there are barriers to the administration of CAR-T therapies, these approvals are promising for patients with relapsed/refractory (R/R) MCL. This interview took place at the 29th Congress of the European Hematology Association (EHA) in Madrid, Spain.
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