Iranian Foreign Policy: Prospects for Change

The January protests in the streets of Tehran highlighted a set of economic and political frustrations currently felt by the Iranian people.
While Iran’s government faces challenges in addressing these frustrations with domestic policy, the country’s foreign policy stance and actions have remained largely the same since the 1979 revolution.
What can be identified as the key current foreign policy priorities in 2018 for Iran? And what avenues for potential reform and change are there going forward, in particular, in regards to relations with its neighbours and the US?
And is the perceived prioritization of national security and self-defence over other foreign policy initiatives the largest obstacle to potential changes in Iran’s agenda?