New Study: Hormone Therapy & Heart Disease | Diet & Exercise | Mark Scholz, MD | PCRI
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- Опубліковано 15 чер 2024
- Weight Training Protocol: pcri.org/sky-2/2017/9/19/fitn...
Androgen-deprivation therapy and risk of death from cardio-vascular disease in prostate cancer patients: a nationwide lithuanian population-based cohort study: www.tandfonline.com/doi/full/...
Hormone therapy (that is, reducing a man's testosterone to near zero) is one of the most daunting parts of prostate cancer treatment for men, and a new study has demonstrated that men on hormone therapy have a higher incidence of heart disease and diabetes. However, hormone therapy can be essential in cases of advanced disease to prevent prostate cancer mortality, and it is also useful for improving cure rates in men with intermediate- to high-risk prostate cancer that is assumed to be at least mostly localized. Moreover, while the side effects of hormone therapy can be profound, they are usually temporary if they are well-managed, which makes it an attractive option when compared to other modalities with risks of permanent side effects. Here, Dr. Scholz explains that the increased risks of diabetes and cardiovascular disease from hormone therapy are largely related to the accelerated weight gain and muscle loss that oftentimes occurs if a man does not change his habits to compensate for his reduced testosterone (especially diet and exercise with emphasis on resistance training). He also provides strategies for mitigating the rest of the long list of side effects that come when a man's testosterone is suddenly reduced to negligible.
0:09 Recently, there was a study involving 13,000 men that found increased cardiovascular risks with men on hormone therapy versus men without hormone therapy. Can you explain?
3:48 The study found that the cardiovascular risks from hormone therapy is highest in older men. How should older patients manage this risk?
5:32 Does the cardiovascular risks from hormone therapy go away once the hormone therapy has stopped?
6:28 To what extent does hormone therapy affect memory?
7:44 How do you weigh the risks and benefits of hormone therapy?
9:20 What are some tips for men to mitigate the side effects of hormone therapy?
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Wow, you guys always hit the nail on the head. I was an avid walker/hiker averaging 6 miles a day and then was diagnosed cT3bNxM0 Gleason 8. 44 days IMRT and 28 months ADT dropped my stamina AND interest 80%. BP shot up to 160/110! After 9 months ADT and a BMI increased to 35, I could barely walk up stairs, and diagnosed with cardiomyopathy w/WMA, (presumed silent heart attack) Wish I had followed your weight training advise and fought my disinterest in exercising. Tomorrow is another day to start fresh! Thank you for all your advise/info during my journey.
I’m so sorry to hear this, my husband is about to start ADT along with IMRT, is your heart condition reversible? May I ask how old you are? My husband is 67 and has a very physical job, now I am worried 😟
@@rgiernet Hello. I'm 66 but, I retired at 62 due to health issues from a 40 year cooking career. I spent two years "regaining" my health, but was set back by treatments. ADT saps more than your labito. Physical and mental fatigue can make every day a struggle. Pushing yourself to diet and exercise is important. PCRI is an invaluable resource. All their advice/info has been right on!
I had an organ transplant to get rid of cancer. Then got diagnosed with Prostate Cancer. Gleason 3+5. I did about 52 treatments of Radiation then was advised 2 years ADT. I took a 6 month shot of Eligard. Was supposed to get 3 more shots. Told the Doctor No More. It has been 11 months since my shot and effects still have not wore off. There is no way anyone can convince me I need more of that stuff.
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Yep I fill for you
Great to see Dr Schultz stating the obvious of evidence based medicine. Guys please try to stay as fit as you can throughout life, eat sensible food. We cannot select the illnesses we get but we can try to stay fit, thus helping recovery.
I went on Eligard after stage 4 prostate cancer diagnosis. I lost my muscle strength over a period of a year. No more Eligard for me.
It's been 6 months that I been on hormone therapy and did do exercises that did help out. I only wish you had put the 'weight training protocol 6 months ago! It wood have done me a lot of good Ithink,happy to have it now and will try it out.
Thanks!
I have been on hormone therapy for the last 9 months due to prostate Cancer with bone metastases. With pain in waist and fatigue , is weight lifting exercise safe with weak bones?
Sir my PSA levels are between 4.5 to 6.2.prostrate volume is 75 gms.8 to 10 times urination.no burning no pain. I am taking urimax D .nubph capsules.DRE no modules found.is it necessary to go for biopsy
Hello sir..following your channel for a long time..my dad is having gleason score 5+5 ..metastasis in multiple skeletal bone nd base of bladder..he is post abiraterone,bicalutamide,bilateral orchidectomy,enzalutamide and post docetaxel 6 cycles..now he is MCRPC ..he is started on honvan now..what do you suggest..is lutetium therapy an effective option or shall i think abt cabaxitaxel..main concern is bilateral pedal edema due to lymph node obstruction iliac and inguinal plus scrotal swelling..dad went into malignant hypertension episode on 29th july,by god's grace he survived but had to undergo DJ stenting as he went into AKI..left kidney is non functional now...whats the plan you can suggest?
Can hormone therapy cause a decrease in the red blood cell counts?
That is interesting as I have heart disease and a pacemaker but nothing was ever said when I found I had prostate cancer that had spread to my lymph nodes all the way up my spine. Put me on hormon therapy and now with bad hot flashes give me angina pain. Which will I die of first?
What about intermittent hormone blocking? What is the shortest length of time one can be on hormone blockers? ( 3 months?) abdominal lymph node metastasis post surgery gleason 9.
Hello, we are not able to answer case questions on our comment section but we can help you through our Helpline who can speak with you either by phone or email. Here is the link to contact them: pcri.org/helpline
Can orchidectomy substitute ADT/HT?
Specially when it comes to side effects in persons having other health issues, like someone who has severe coronary artery disease (CAD).
Side effetcs:
Hot flashes - Fatigue - Loss of libido - Weight gain - Gynecomastia - Osteoporosis and bone density loss - Mood changes and depression - Memory and cognitive changes - Anemia - Metabolic changes - Muscle loss - Cardiovascular risks, heart attacks and strokes.
Hoping PCRI Dr. Scholz can respond and answer it
With depravation therapy you would also be lowering the patient’s estradial which is heart protective..
I am 62 and have advanced prostate cancer which has spread to my bones. Currently halfway through chemo and on monthly hormone injections. My doctor says that I will need to have hormone injections for the rest of my life.
An alternative that no one seems to discuss is orchiectomy...or castration.
I am considering this as I am not keen on having hormone therapy for the rest of my life. Any thoughts on this, or is it taboo?
As far as I know you'll have the same problems. With ADT or castration, that's what my oncologist told us.
@@chein33 Thanks for your reply...my main concern is that I am retired and really can't afford the monthly costs of getting hormone injections.
I am curious to hear from anyone who has had this procedure. Cheers.
Good luck mister Roy Take care Man hope you be fine fast !
She asks what I call "intelligent questions." 🤔😊
This is correct. Hormone therapy also causes adrenal gland issues causing cortisol levels elevated which is not good.
My age is 84 yrs
Very confusing. He said men who do NOT take testosterone gain weight and have an increase in blood pressure. So how does that equate to men taking testosterone having an increase in heart attacks and strokes. He totally lost me.