Semaglutide vs. Tirzepatide for Weight Loss: Which works better?

On this episode of the She’s Healthy podcast your host and Nurse Practitioner, Lori Aikman, looks at the research to see…
Which is better for weight loss semaglutide (Wegovy) or tirzepatide (Zepbound)?
If you're a woman who is struggling to lose weight, maybe all the things you used to do like diet and exercise aren't working and you're looking for more. If you're considering taking one of these medications to help your stubborn weight loss, this is an episode you won't want to miss.
Key Takeaways:
Mechanism of Action: Lori reviews how both semaglutide and tirzepatide work to induce weight loss. If you missed the details, check out the first episode for an in-depth discussion.
Approval Timeline: Semaglutide received FDA approval for treating obesity before tirzepatide. Tirzepatide was FDA approved for obesity on 11/8/23.
Clinical Trials: Explore the results of the STEP trials, focusing on semaglutide's effectiveness for obesity. Learn about the SURPASS trials that studied tirzepatide's impact on patients with diabetes, and get a sneak peek into the upcoming SURMOUNT trials examining tirzepatide's efficacy for obesity in both diabetic and non-diabetic patients.
Pharmaceutical Source: Both semaglutide and tirzepatide injections are products of the renowned pharmaceutical company, Eli Lilly.
Prescribing Guidelines: Understand the obesity prescribing guidelines, emphasizing that these medications are intended for individuals with a BMI greater than 30 or a BMI greater than 27 with weight-related comorbidities such as diabetes, pre-diabetes, high blood pressure, high cholesterol, cardiovascular disease, etc.
SURMOUNT-1 Trial: Delve into the findings of the SURMOUNT-1 trial, exploring the effectiveness of various tirzepatide doses compared to a placebo for weight loss. Discover that weight loss increases with higher doses of tirzepatide.
Comparison Study: Gain insights from the study "Weight loss with subcutaneous semaglutide versus other glucagon-like peptide 1 receptor agonists in type 2 diabetes." Find out how tirzepatide outperformed semaglutide, dulaglutide, exenatide, and liraglutide in terms of weight loss.
Appetite Reduction: Uncover takeaways from the study "Tirzepatide Reduces Appetite, Energy Intake, and Fat Mass in People With Type 2 Diabetes."
Cost-Effective Options: Lori suggests a cost-effective alternative - getting these medications from a compounding pharmacy.
Whether you're on a weight loss journey or simply curious about these medications, Lori provides valuable insights to guide your decisions. Tune in to the She’s Healthy podcast and stay informed about optimizing your health in your 30s and 40s!
Curious about working with Lori? Click here to book a 15 Minute Connection Call: crownexecutivehealth.practice...
Check out the website: www.queenbeemedicine.com
Follow us on Instagram:
/ queenbeemedicine
/ loriaikman

[@lashawnward340]

Thks. Very informative 😊

[@MegaBrandon3]

Thank you

[@victoriachanel2493]

In your opinion, is it better to inject in your stomach area or your thigh area? Thanks!❤

[@soniar.4324]

How can I contact your practice? I’m interested

[@lori.aikman]

You can use this link to book an interest call: p.bttr.to/3JfDizB
Look forward to chatting with you!

[@jward3961]

I have the option of being on one of these from a weight loss clinic in the state I live in through a compounding pharmacy because of insurance refusing to pay for the name brand. My question would be the prices are triple for tirzepitide for max dose compared to semaglutide. If the most you can afford is 5 mg a wk of the tirzepitide is it going to be more or the same effectiveness at weight loss as the 2.4 mg a wk of semaglutide? 5 mg tirzepitide is double the cost of the semaglutide 2.4 mg there.

[@lori.aikman]

@@jward3961​​⁠ the doses are not an equal. As in 1 mg of Semaglutide is not equal to 1 mg of Tirzepatide. Semaglutide 0.25mg is equivalent to Tirzepatide 2.5mg. Tirzepatide is typically more expensive even through compound pharmacies, but the data shows it’s more effective.

[@privatbruker5905]

To be honest they are about the same, for maximizing results I would advice starting off with 10 000 steps daily increase it week from week 500+1000
And aim for high protein diet, low fat and abit of carbs around when you workout and abit after but healthy carbs.
I used wegovy to lose 25kg of fat and get absolutely shredded to the bone 😤 8-10% fat % also gained muscle

[@lori.aikman]

Thank you for your input! Sounds like you probably had some good muscle mass and good metabolic function to begin with. Someone with high blood sugar and insulin may not want to add in carbs that early and it can take a few months before the weight really starts moving. I definitely agree with getting in plenty of protein and building muscle to accelerate results! The research shows semaglutide and tirzepatide are NOT the same and tirzepatide causing significantly more weight loss.