Was looking for a source that collects all this information and explains it in a easy to understand way. Better than hunting in multiple books and online and getting lost with memorizing!
on 14:14 i completely lost it. so many things that could be implied there. You are absolutely right! Scientists are mean by giving the same things a gazzilion different names. This is far from the only example where it happens.
Here for reference, instead of going back and forth to my iBooks and pausing. Thank you. Large B cell lymphoma. Large atypical cells positive for cd20, pax5, significant patchy staining for bcl-6. The large cells are negative for ae1/ae3 cd3,c5,cd10, and cyclin d1. Small background lymphocytes show populations that are both cd20 and pax5 positive as well as a population that is cd3 cd5positive. Positive staining for bcl6 may indicate lymphoma of center cell origin.
So what does this mean Absolute CD&+ Lymphocytes (H), CD16+CD56+ Lymphocytes (H), Absolute CD16+CD56+Lymphocytes (H), Absolute CD19+ Lymphocytes (H) My son is six and this is his blood work
If anyone here is studying this subject I would like to ask you some question. To produce antibodies, which cell is involved ? It a fault of the naive B cell ?
A naive B cell activated by an APC either macrophages and has undergone clonal expansion to class switch into the required antibody specific for the antigenic stimulation. So in essence the naive B Cell needs to be activated by presenting Ag to the T helper Cell by MHC class 2 and co stimulatory b7/CD28 interactions leading to clonal expansion and SHM of specific antibodies for the Antigen.
@@benjaminansah-agyei139 Thank you very much. I have a seronegative celiac disease which is now into a refractory celiac type 1/2. Unfortuantely I also have sublinical hypothyroidism with negative Tpo antibodies. I wanted to be tested for Iga or Igg deficiency but it seems that my values were fine. How can I be tested for a naive b cell defects?
I work as an immunologist at JnJ and man this is crazy helpful. Always need a refresher.
I've never seen a teacher explaining this. Life could be a lot easier if they all had that simple idea.
Was looking for a source that collects all this information and explains it in a easy to understand way. Better than hunting in multiple books and online and getting lost with memorizing!
on 14:14 i completely lost it. so many things that could be implied there. You are absolutely right! Scientists are mean by giving the same things a gazzilion different names. This is far from the only example where it happens.
Thank you for your concise explanation. my question is, can cells be double positive for cd 4 or cd 8 without being positive for cd45
Did you learn since what CD19 role is for? I have chronic reactivating EBV and my CD19 marker is high.
Like all gems, these lectures are hidden. Salute to Maureen!
Here for reference, instead of going back and forth to my iBooks and pausing. Thank you.
Large B cell lymphoma. Large atypical cells positive for cd20, pax5, significant patchy staining for bcl-6. The large cells are negative for ae1/ae3 cd3,c5,cd10, and cyclin d1. Small background lymphocytes show populations that are both cd20 and pax5 positive as well as a population that is cd3 cd5positive. Positive staining for bcl6 may indicate lymphoma of center cell origin.
I actually didn't find any perfect explanation.. You really helped me a lot
10:54 So what you're saying is pembrolizumab (PD-1 receptor antibody) is basically like a "T-cell red bull" that keeps them going for longer?
how comes this does not have more views! AWESOME VID. thx!
That's truly useful, Thanks a lot for presenting such a brilliant lesson.
So what does this mean
Absolute CD&+ Lymphocytes (H),
CD16+CD56+ Lymphocytes (H),
Absolute CD16+CD56+Lymphocytes (H),
Absolute CD19+ Lymphocytes (H)
My son is six and this is his blood work
Following- did you get results?
Thank you so much doc.This will help me a lot with my steps exams, appreciations !
Hi Maureen what does a High CD4/CD8 Ratio Mean?
Outstanding presentation! Thank you 🙏
are also eosinophils induce in class switching from IgE to IgA with il 5 ?
For a moment I was like why would anyone review CD marker pens. My bad. Thanks for the video.
Amazing
amazing explanation
If anyone here is studying this subject I would like to ask you some question.
To produce antibodies, which cell is involved ? It a fault of the naive B cell ?
A naive B cell activated by an APC either macrophages and has undergone clonal expansion to class switch into the required antibody specific for the antigenic stimulation. So in essence the naive B Cell needs to be activated by presenting Ag to the T helper Cell by MHC class 2 and co stimulatory b7/CD28 interactions leading to clonal expansion and SHM of specific antibodies for the Antigen.
@@benjaminansah-agyei139 Thank you very much. I have a seronegative celiac disease which is now into a refractory celiac type 1/2.
Unfortuantely I also have sublinical hypothyroidism with negative Tpo antibodies.
I wanted to be tested for Iga or Igg deficiency but it seems that my values were fine.
How can I be tested for a naive b cell defects?
I don't know what to say but you are an awesome memory cell
Thank you very much! Very useful!
Omg this was soo helpful.. THanks a ton.. 😊
Superb 🎉
thank you so much for the review.
You should get a Nobel!
that is not how it works..
Good video, I found it very useful!
You're a godsend!!!
You are just amazing thank u ❤
u r amazing u r grear
Amazing, thank you so much!
Nice 👍
Thank you soooo much!
Thank you
I love love love this
Sensational
Hero's work! :)
Thank youuuuuuu