Great video. Very clearly presented and informative. Just one point to consider regarding the sodium concentration in secondary hyperaldosteronism. Due to congestive heart failure (one of the common causes of secondary hyperaldosteronism), patients often become sodium and water overloaded due to increased renin and thus aldosterone release. The increased renin occurs becuase of reduced effective intravascular volume which is sensed in the kidney as you clearly outline. The reabsorption of sodium and thus water leads to hypervolaemia which we see clinically by a raised JVP and peripheral oedema in some patients. However, angiotensin II also stimulates ADH secretion from the posterior pituitary gland as well as renin secretion from the kidney. ADH acts differently to aldosterone and results in water (but not sodium) reabsorption in the collecting duct. Therefore, although patients with heart failure for example are often sodium overloaded (due to the effect of hyperaldosteronism), the disproportionately greater reabsorption of water means that the patient actually can have low sodium concentration in the extracellular fluid (hyponatremia) due to the dilution effect of increased water intake.
Laid in the hospital after successful surgery. Less than 24 hours since the tumour and gland removed and already there has been significant improvement.
Hi. Can you explain what happens to the levels of angiotensin 1 and 2 in conns syndrome? Renin is obviously low due to primary hyperaldosteronism. Thanks
+Edwin Celso Vilca Pajares, Thank you, we're glad you found this video tutorial helpful. Please check out our other videos and feel free to share them with others :)
I have high Aldosterone (2x-3x normal max value) and severe hypertension BUT normal renin, normal Na+ and normal K+ and no protein in my urine, no cerosis, no adrenal tumors. I've gone to many doctors and they are clueless..:/ would appreciate any ideas as to what I might have.
I know it's been a couple years, but I have the same issues. I've now been on Spiro and clonidine patches for a long while and my BP is under control. How are you doing?
I have conn's. Clean diet but spironolactone retains the potassium loss. This or eplerenone is the drug of choice. Alongside controlled bloodwork to monitor potassium levels and kidney function. I nearly died from the potassium loss. I'm lucky.
Great video. Very clearly presented and informative. Just one point to consider regarding the sodium concentration in secondary hyperaldosteronism. Due to congestive heart failure (one of the common causes of secondary hyperaldosteronism), patients often become sodium and water overloaded due to increased renin and thus aldosterone release. The increased renin occurs becuase of reduced effective intravascular volume which is sensed in the kidney as you clearly outline. The reabsorption of sodium and thus water leads to hypervolaemia which we see clinically by a raised JVP and peripheral oedema in some patients. However, angiotensin II also stimulates ADH secretion from the posterior pituitary gland as well as renin secretion from the kidney. ADH acts differently to aldosterone and results in water (but not sodium) reabsorption in the collecting duct. Therefore, although patients with heart failure for example are often sodium overloaded (due to the effect of hyperaldosteronism), the disproportionately greater reabsorption of water means that the patient actually can have low sodium concentration in the extracellular fluid (hyponatremia) due to the dilution effect of increased water intake.
You must be a genius. Very clear explanation. Thanks
Wow, you explained it so concisely-yet so simply as well. Thank you
Fezile Gabellah, How are you doing ? We hope you succeeded very well.
Good vid1
One correction:
s-Na+ will be normal as the Na+ reabsorption will be neutralized by the concomittant H20 reabsorption.
no one can make it any more easy, thank you :)
Laid in the hospital after successful surgery. Less than 24 hours since the tumour and gland removed and already there has been significant improvement.
thank god i clicked on your link. very excited to see what you have to offer. stay fit.
Really helps to understand. Thanks.
Very clear and concise. Thank you!
Really well explained. Thank you and well done.
Always great lectures, thank you so much
Consider teaching
very easy to follow and great explanation thank you
Short and simple bro ✌️
Great lecture. Thank you
Brilliant presentation
fantastic video, thank you!
you are a good teacher
fantastic video
explained very well
good job
love it, thanks a lot for ur time
If u can.post for D.insipidus and SIADH .. Would be great !
Hi. Can you explain what happens to the levels of angiotensin 1 and 2 in conns syndrome? Renin is obviously low due to primary hyperaldosteronism. Thanks
Really your explication is very good. Made Easy is tru
+Edwin Celso Vilca Pajares, Thank you, we're glad you found this video tutorial helpful. Please check out our other videos and feel free to share them with others :)
I have high Aldosterone (2x-3x normal max value) and severe hypertension BUT normal renin, normal Na+ and normal K+ and no protein in my urine, no cerosis, no adrenal tumors. I've gone to many doctors and they are clueless..:/ would appreciate any ideas as to what I might have.
Maria C check medications! These may be a contributing cause?!
How you doing right now
I know it's been a couple years, but I have the same issues. I've now been on Spiro and clonidine patches for a long while and my BP is under control. How are you doing?
Thank you
Very nice.
beautifully explained. thank you
Thank you so much - wonderful seriously.
Great video, what diet is recommended for patients. I would imagine, DASH diet, low sodium, high potassium. What about water intake. 😊😊😊
I have conn's. Clean diet but spironolactone retains the potassium loss. This or eplerenone is the drug of choice. Alongside controlled bloodwork to monitor potassium levels and kidney function. I nearly died from the potassium loss. I'm lucky.
How can I get your rest videos plzzzzzz???????
Great lecture!
Great lecture thanks ! :)
thank you so much .very helpful
Awesome.. Really helpfull thanx a lot :))
perfect explanation tnx
Very nice!
very very thxu i understand your lecture ...........god bless you....
How can I get your rest visions plz........?????????????????
THANKS!
what does escape phenomenon mean???
Thank you so much
in primary hyperaldosterinoism the Na will be normal dt Aldosterone escape metabolism.
what abt mineralocorticoid escape phenomenon?
Thank you 🙏🏽
very good
Thanks, very good explanation and simple, dude!
excellent
superbbbbbbbbb sir...
nice one
God bless you
It Is better than CTO
Tq
No one
Great video! Thank you!
thank you