I think the confusion between retrospective cohort studies and case-control studies arises because with both approaches, at the point of setting up the study, cases (those with the disease) exist - right now. A retrospective cohort study is like jumping into a time machine and assembling the exposed and non-exposed groups and following them forwards to the present time (when some have become 'cases'). Since we don't have a time machine, historical records are used in RCSs. When assembling the two groups, it is of course critical that we don't know which ones went on to become the present-day cases.
It should be standard practice to require inclusion of all drug contraindications in the cohort matching. If contraindicated you should not be in the study, because that results in a less healthy placebo cohort so obviously the drug cohort will have better results.
so how will you differentiate with case control? both retrospective and case control looks to be the same? both look at past records and both have two groups ,exposed and non-exposed
Thanks a lot. I was having a hard time understanding this. You cleared the confusion.
I think the confusion between retrospective cohort studies and case-control studies arises because with both approaches, at the point of setting up the study, cases (those with the disease) exist - right now. A retrospective cohort study is like jumping into a time machine and assembling the exposed and non-exposed groups and following them forwards to the present time (when some have become 'cases'). Since we don't have a time machine, historical records are used in RCSs. When assembling the two groups, it is of course critical that we don't know which ones went on to become the present-day cases.
It should be standard practice to require inclusion of all drug contraindications in the cohort matching. If contraindicated you should not be in the study, because that results in a less healthy placebo cohort so obviously the drug cohort will have better results.
Perfect... just.. so perfect!
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so how will you differentiate with case control? both retrospective and case control looks to be the same? both look at past records and both have two groups ,exposed and non-exposed
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This cleared things up
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Thank you , this was really helpful
Excellent
too short and too informative. well done!
Succinct yet informative
Thank you...