First, a great talk, respect to both of the guys! Said that, one comment to the "Greenland shark argument" against the "thermodynamic principle of aging" @ 40:15 by a biology-interested physicist: 1. That incredible long-living creature is a shark, i.e. a primitive fish not a mammal. 2. As all fish it is ectothermal and live in the deep arctic sea, where the water - and therfore the sharks body - temperature is 0...4 centigrade, which is 30...40 K less than our body temperature. 3. As a very rough rule of thumb chemical reactions double in speed for every 10 K, of course depending on the activation enthalpy of that reaction. 4. Compared to humans that give it a 2^ 3 ... 4 ~10 ( one order of magnitude) slower metabolism. Everything else kept constant, it the shark should live an order of magnitude longer, so instead of our humanly 80 years it should be 800 years, which comes close to the age estimate of the animal. It even reaches reproductive age similar (for the cold environment) about 10 times slower than we, at age 150. So the Greenland shark is rather an argument for the thermodynamics than against it. The true argument against the thermodynamic principle of aging is that the germline, the gamets, somehow escape the entropy that decays the somatic cells.
My mother never exercised. Was diminutive around 4’11. Controlled her eating , never ate a large meal. Slept at least 8 hours a night. Gave birth to 10 children .Smoked rarely when young . Biggest problem was osteoporosis. No diabetes or Bp problems. Read 2 books a week for years. Great memory . Lived to 100. Died in nursing home for therapy for osteoporosis issue. Died suddenly caused by food poisoning in nursing home!
First, a great talk, respect to both of the guys!
Said that, one comment to the "Greenland shark argument" against the "thermodynamic principle of aging" @ 40:15 by a biology-interested physicist:
1. That incredible long-living creature is a shark, i.e. a primitive fish not a mammal.
2. As all fish it is ectothermal and live in the deep arctic sea, where the water - and therfore the sharks body - temperature is 0...4 centigrade, which is 30...40 K less than our body temperature.
3. As a very rough rule of thumb chemical reactions double in speed for every 10 K, of course depending on the activation enthalpy of that reaction.
4. Compared to humans that give it a 2^ 3 ... 4 ~10 ( one order of magnitude) slower metabolism. Everything else kept constant, it the shark should live an order of magnitude longer, so instead of our humanly 80 years it should be 800 years, which comes close to the age estimate of the animal. It even reaches reproductive age similar (for the cold environment) about 10 times slower than we, at age 150.
So the Greenland shark is rather an argument for the thermodynamics than against it.
The true argument against the thermodynamic principle of aging is that the germline, the gamets, somehow escape the entropy that decays the somatic cells.
My mother never exercised. Was diminutive around 4’11. Controlled her eating , never ate a large meal. Slept at least 8 hours a night. Gave birth to 10 children .Smoked rarely when young . Biggest problem was osteoporosis. No diabetes or Bp problems. Read 2 books a week for years. Great memory . Lived to 100. Died in nursing home for therapy for osteoporosis issue. Died suddenly caused by food poisoning in nursing home!
Great interview