A complete organized library of all my videos, digital slides, pics, & sample pathology reports is available here: kikoxp.com/posts/5084 (dermpath) & kikoxp.com/posts/5083 (bone/soft tissue sarcoma pathology).
Dr Gardner, I thank you so much for every video you have uploaded so far. I have watched all of them (repeatedly) since the start of my residency (your content helped me through early dermpath). I really enjoy your teaching style and you are more or less the reason I shifted my interest to soft tissue pathology (a field I initially thought was 'far above my paygrade'). Long story short, thank you! Sadly the world is so big and I can't simply come by! Best regards!
Sir Thank you for such Awesome High quality and Dedicated videos. Could you please explain what exactly does "Epithelioid" and " Rhabdoid" Patterns mean, I could not find a good and simple explanation and always tend to struggle with recognising these patterns. Thank you Very Much
Both are morphologic terms describing the cytologic features of a cell. Epithelioid means it looks like an epithelial cell... Round or oval nucleus and abundant cytoplasm. Rhabdoid is a subtype of epithelioid (in my opinion). It has round or oval nucleus and abundant cytoplasm, but the nucleus is at the periphery of the cell not in the center. And usually there is a large globule of dense eosinophilic material next to the nucleus (the globule is an aggregate of intermediate filaments in most cases). Plasmacytoid is very similar and overlaps with rhabdoid.
I don’t think I’ve seen clear cell change in epithelioid sarcoma although maybe it has been reported and I’m just unaware of it. Some cases can have spindled areas although they don’t usually have the marked pleomorphism seen in Undifferentiated pleomorphic sarcoma.
I’m so very sorry for her loss. Most cases of epithelioid sarcoma are random and not inherited. There are rare families that have an inherited SMARCB1 (INI1) gene mutation and people in those families may get a form of epithelioid sarcoma (or related tumor called malignant rhabdoid tumor) as well as multiple nerve tumors called schwannoma. Again those families are very rare with only a handful of such families described to my knowledge. And those families usually have multiple family members with a history of multiple tumors. So unless there is a family history like that, your daughter probably has no greater chance of getting epithelioid sarcoma than you or I do (this is a very rare tumor so the chance of anyone person getting it is extremely low). This is just for educational information of course. Since I am not her doctor I can’t know the full story and I can’t give medical advice. If you have further concerns please speak with her doctor and if there is any concern for a family history that might put her at risk for this tumor, you could see a genetic counselor to discuss genetic counseling. But in the meantime please do not lose sleep over this because those kind of cases are very rare for this tumor. I hope that’s helpful. Best wishes to you and your family and best wishes to peace and emotional healing for your daughter.
I’m sorry but I’ve struggled with speaking too fast my whole life. You can reduce the speed of the video in the settings button in bottom right corner of video.
A complete organized library of all my videos, digital slides, pics, & sample pathology reports is available here: kikoxp.com/posts/5084 (dermpath) & kikoxp.com/posts/5083 (bone/soft tissue sarcoma pathology).
Dr Gardner, I thank you so much for every video you have uploaded so far. I have watched all of them (repeatedly) since the start of my residency (your content helped me through early dermpath). I really enjoy your teaching style and you are more or less the reason I shifted my interest to soft tissue pathology (a field I initially thought was 'far above my paygrade'). Long story short, thank you! Sadly the world is so big and I can't simply come by! Best regards!
A very well demonstrated case! Thank you, Jerad!!
Sir Thank you for such Awesome High quality and Dedicated videos. Could you please explain what exactly does "Epithelioid" and " Rhabdoid" Patterns mean, I could not find a good and simple explanation and always tend to struggle with recognising these patterns. Thank you Very Much
Both are morphologic terms describing the cytologic features of a cell. Epithelioid means it looks like an epithelial cell... Round or oval nucleus and abundant cytoplasm. Rhabdoid is a subtype of epithelioid (in my opinion). It has round or oval nucleus and abundant cytoplasm, but the nucleus is at the periphery of the cell not in the center. And usually there is a large globule of dense eosinophilic material next to the nucleus (the globule is an aggregate of intermediate filaments in most cases). Plasmacytoid is very similar and overlaps with rhabdoid.
@@JMGardnerMD Thank you Very Much sir, very clear explanation. Could you help me out with "organoid pattern " also
Really highly useful points sir...thanku so much
Clear cell area in epithelioid sarcoma
Pleomorphic spindle cells in epithelioid sarcoma .... can we find these areas dr?
I don’t think I’ve seen clear cell change in epithelioid sarcoma although maybe it has been reported and I’m just unaware of it. Some cases can have spindled areas although they don’t usually have the marked pleomorphism seen in Undifferentiated pleomorphic sarcoma.
Very good teaching point
My daughters mother died of this. Is my daughter at risk of it being passed down to her?
I’m so very sorry for her loss. Most cases of epithelioid sarcoma are random and not inherited. There are rare families that have an inherited SMARCB1 (INI1) gene mutation and people in those families may get a form of epithelioid sarcoma (or related tumor called malignant rhabdoid tumor) as well as multiple nerve tumors called schwannoma. Again those families are very rare with only a handful of such families described to my knowledge. And those families usually have multiple family members with a history of multiple tumors. So unless there is a family history like that, your daughter probably has no greater chance of getting epithelioid sarcoma than you or I do (this is a very rare tumor so the chance of anyone person getting it is extremely low). This is just for educational information of course. Since I am not her doctor I can’t know the full story and I can’t give medical advice. If you have further concerns please speak with her doctor and if there is any concern for a family history that might put her at risk for this tumor, you could see a genetic counselor to discuss genetic counseling. But in the meantime please do not lose sleep over this because those kind of cases are very rare for this tumor. I hope that’s helpful. Best wishes to you and your family and best wishes to peace and emotional healing for your daughter.
My nephew has this cancer.?started out in his foot but then it came back in both lungs
I am so very sorry.
Thank you very much
Thanks you, it is very useful video
I have this ...
Thank you so much Dr, Can you speak slowly please ?
I’m sorry but I’ve struggled with speaking too fast my whole life. You can reduce the speed of the video in the settings button in bottom right corner of video.
@@JMGardnerMD i will try my best