Honestly one of the most enthusiastic teachers I've ever encountered. Not only do you tend to keep me interested in this complex subject, you seem to perfectly know everything you talk about, which is something most professors miss. Cheers!
Having read the Guyton, the Boron, Ganong and much more shit, you are the only one stating precisely that the water that would otherwise dilute the interstice will directly get into the vasa recta. THANK YOU. I was assuming this but it's good to actually having HEARD it. I kiss your glabella
Oh my!!! You explain this the best!!! And I love that you don't make assumptions. Thank you for stating the rule,that 200mosmoles is the max gradient that can be created by the NKCC cotransporter and that the water that diffuses is immediately picked up by the vasa recta. Great job!God bless you
I am an A level Biology teacher from Pakistan and I had been looking for a resource to prepare my class. I went through a lot of books and numerous videos, but couldn't find anything that would just make me go Tada! And then I found this. Thank you very much, Madam.
Shout out from Belgium to Wendy Riggs for her amazing, amusing and clarifying way she talks about anatomy and physiology! Helping me through my study of pharmaceutical sciences
I love you! Literally every other video or source on this takes for granted that it is understood that 200 mOsm gradient must be established at each level, which left me completely confused about the gradient in the interstium was created when i completely understood how it is created in the lumen of the loop. Thank you so much!
Hi wendy, Im absolutely loving this lecture series. Im just wondering, as I'm from Australia and am aware that there are a few terminology differences, is 'isosmotic' interchangeable for 'isotonic'? My lecturers have used 'tonic' in isotonic, hypertonic and hypotonic when discussing the osmolarity of something and I'm assuming you're talking about the same thing. Just wanted to make sure i guess! Thanks! you really know how to make human physiology an engaging and fascinating domain.
+Josh Jorgensen Hey Josh-- couldn't help it- I had to respond! Isotonic and Isosmotic are NOT the same thing...isotonic describes a solution based on how the solution affects a cell...while isosmotic simply compares concentrations between two things. (If they have the same concentration, they are isosmotic. If a CELL doesn't change, the solution is also isotonic.) This is tricky-- but I have a lecture on this too: ua-cam.com/play/PL5GRRRmaGVqUASeRrzWFlmqoj2xPcWoXI.html Hope it isn't too late!
So the medullary gradient doesn’t get washed away is because of the vasa recta that water goes to it Because if order was just reabsorbed into the interstitial fluid the osmolarity won’t be maintained high
there is mistake when it was 300 in the ascending thick loop and interstitium it was 400 you said some change should be inside but it didnot change in interstium and change was presented in the loop only and you then said as difference is here 200 so no need of change. kindly check and correct. correction needed at video timing 6.30-6.31.
Hi thank you for these videos, they are amazing. I just have one question. You say that water reabsorbed through the descending henle tube gets immediatly washed away by the cuntercurrent capillary. But why doesnt the solutes also get washed away ? Because if that were the case, the interstitium osmolarity would not rise and there would be no gradient.
Every time a solute particle is picked up by the vasa recta (which it is!)-- the ALH pumps more solute into the interstitial space to replace it. Forever. (VERY GOOD QUESTION. A common source of misconception!)
I thinks its due to the length of the loop of Henle (and the flow of filtrate through the nephron). as the filtrate only gets more concentrated in the descending limb, it only spend a finite amount of time in there and therefore only a finite amount of water is taken out of it. by the time it gets to the hairpin, its reached 1200mOsm. as it ascends again, Na+ is pumped out which = less concentrated.
The fact that my prof put your video in their lecture shows how good of a teacher you are.
Honestly one of the most enthusiastic teachers I've ever encountered. Not only do you tend to keep me interested in this complex subject, you seem to perfectly know everything you talk about, which is something most professors miss. Cheers!
Having read the Guyton, the Boron, Ganong and much more shit, you are the only one stating precisely that the water that would otherwise dilute the interstice will directly get into the vasa recta.
THANK YOU. I was assuming this but it's good to actually having HEARD it. I kiss your glabella
Ditto. Having read so many books and literally 50 odd videos, this was the only one to state the basic chemical fact.
Oh my!!! You explain this the best!!! And I love that you don't make assumptions. Thank you for stating the rule,that 200mosmoles is the max gradient that can be created by the NKCC cotransporter and that the water that diffuses is immediately picked up by the vasa recta. Great job!God bless you
I am an A level Biology teacher from Pakistan and I had been looking for a resource to prepare my class. I went through a lot of books and numerous videos, but couldn't find anything that would just make me go Tada! And then I found this. Thank you very much, Madam.
Oh! Thank YOU for these kind words, friend! I'm glad this helps.
Shout out from Belgium to Wendy Riggs for her amazing, amusing and clarifying way she talks about anatomy and physiology! Helping me through my study of pharmaceutical sciences
I love you! Literally every other video or source on this takes for granted that it is understood that 200 mOsm gradient must be established at each level, which left me completely confused about the gradient in the interstium was created when i completely understood how it is created in the lumen of the loop. Thank you so much!
what does she mean with "you're gonna have too muck leakiness, you can't maintain that"?
Omg thank you sooo much!!! Very helpful!!! Read and watched so many vifeos but none explained the process as detailed as you!!!!
Just have to say what a GREAT job you've done with videos 7 & 8! Great way to supplement my med school lectures on this concept!
From now on ... You are my favorite DOC
Just one word: brilliant!
Your explanations are so clear and explicit! Thank you so much!
Very explicit ,and clear.
Well done,thank you :-)
You're like so cool. Thanks to you I am going to be able to write a fantastic theory exam tomorrow. :)
You're such a good teacher! Thank you!!
Hi wendy, Im absolutely loving this lecture series. Im just wondering, as I'm from Australia and am aware that there are a few terminology differences, is 'isosmotic' interchangeable for 'isotonic'? My lecturers have used 'tonic' in isotonic, hypertonic and hypotonic when discussing the osmolarity of something and I'm assuming you're talking about the same thing. Just wanted to make sure i guess!
Thanks! you really know how to make human physiology an engaging and fascinating domain.
+Josh Jorgensen Hey Josh-- couldn't help it- I had to respond! Isotonic and Isosmotic are NOT the same thing...isotonic describes a solution based on how the solution affects a cell...while isosmotic simply compares concentrations between two things. (If they have the same concentration, they are isosmotic. If a CELL doesn't change, the solution is also isotonic.) This is tricky-- but I have a lecture on this too: ua-cam.com/play/PL5GRRRmaGVqUASeRrzWFlmqoj2xPcWoXI.html Hope it isn't too late!
So the medullary gradient doesn’t get washed away is because of the vasa recta that water goes to it
Because if order was just reabsorbed into the interstitial fluid the osmolarity won’t be maintained high
This is exactly right!
Thank you , you just saved ma life
A great teacher😍😍😍🤩🤩🤩🤩
there is mistake when it was 300 in the ascending thick loop and interstitium it was 400 you said some change should be inside but it didnot change in interstium and change was presented in the loop only and you then said as difference is here 200 so no need of change. kindly check and correct. correction needed at video timing 6.30-6.31.
Totally helpful, so gonna write da exam real good ✌️ 👍
Hi thank you for these videos, they are amazing.
I just have one question. You say that water reabsorbed through the descending henle tube gets immediatly washed away by the cuntercurrent capillary. But why doesnt the solutes also get washed away ? Because if that were the case, the interstitium osmolarity would not rise and there would be no gradient.
If I remember correctly, my prof. said in the lecture, this would be due to different flow (diff. speed) in the resp. segments of the capillaries
thank you this was great and helpful
Liked and subscribed. Thank you so much I luv u 😭😘
عشتي 🌸☺️ شرح رائع
dude you're amazing
Thank yooooo so much !
Won't the solute be picked up by the vasa recta??? If so, why won't the concentration in the interstitial fluid goes down ??
Every time a solute particle is picked up by the vasa recta (which it is!)-- the ALH pumps more solute into the interstitial space to replace it. Forever. (VERY GOOD QUESTION. A common source of misconception!)
@@wendy-riggs ohhh..... ok", I understand now. Thank you for the explanation !!! 😊😊😊
Thanks a lot..
what makes it stop at 1200 mOsm?
I have the same question in mind!
I thinks its due to the length of the loop of Henle (and the flow of filtrate through the nephron). as the filtrate only gets more concentrated in the descending limb, it only spend a finite amount of time in there and therefore only a finite amount of water is taken out of it. by the time it gets to the hairpin, its reached 1200mOsm. as it ascends again, Na+ is pumped out which = less concentrated.
Thank you! :)
good lesn thnk u..
I like your videos - your audio is hard on my ears
😍😍😍😍
i love u
Love you mam where are you i want to meet you :(
this sucks