Meet Your Microglia: Your Brain's Overlooked Superheroes
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- Опубліковано 26 вер 2024
- When talking about the brain, neurons have been dazzling scientists for a long time. But behind every successful neuron is a glial cell - particularly one type of them: microglia.
Hosted by: Brit Garner
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Not all heroes wear capes. Some wear protruding, spidery arms.
Sounds like they're the Judge Dredd of brain cells. Strange super hero for sure!
Imagine wearing your arms
Some way eat the people they rescue
Doc Oc?
and eat brains...
The mitochondria is the powerhouse of the cell
The microglia is the janitor of the brain
The kind of janitor that would be played by Liam Neeson or Jean Claude van Damme in a movie adaptation
@@Fists91 Or Hannibal Lecter (alias Anthony Hopkins) to be more precise.
I work in a glial biology lab and we consistently refer to neurons as useless haha. Without glia, they just die. Ive dropped flasks of glia and they did not care one bit. If I did that with neurons? Instant death
😂 I appreciate this
That's super interesting to hear about
Where do you studyyyy dude. Can I apply to your laboratory
@whesley hynes okay! Please offer yourselves for the cause. Would love to dissect your brain and study microglia, run electrophysiology tests on your neurons😍
@whesley hynes Could you stop copy pasting the same poorly worded comment on all these videos? Once again, my lab uses zero (0) animals, we use all induced pluripotent stem cells from human patients (that consented to sample donation) mind you. But stop railing against people who are trying to do good in the world by using animals to cure horrible diseases. I hope you never get one of the diseases we now have treatments for due to these animal studies, since you probably won't accept this 'immoral' treatment, right? Millions of lives have been saved. And every institute that uses animals has extensive animal care protocols in place to minimize pain, and all animals are taken care of very well.
Thank you all patrons for allowing the rest of us to enjoy these fantastic videos
I laughed way too hard at the image of a nurse noticing a problem with a patient, and therefore proceeding to eat them 😂😂
Give 'em gas.
My brain eats itself. Sounds about right.
yum
Actually this happens all over our body. Take the more popular cousin of Microglia - the Macrophase. It's their job to eat frail or dead cells, but also rebellious (tumorous) and virus infected cells. Macrophase do this many times each day. So here you have it. You eat yourself, all of you.
Your brain is... eating itself... That is terrifying...
Well, bite me has a new slant. 🙄
@Iggy the Mad More like careful remodeling.
It hurt my heart to hear that these important heroes can be permanently altered by trauma
We have first-hand experience in that field. I imagine our microglia are malfunctioning quite badly
@@MaskedNozza just up there eating anything 😂
Be careful, if your heartache persists, it could lead to depression which in turn could permanently damage your microglia. :-P
@@Noukz37 how do you fix them? I have brain on fire!
@@mv8908 I'd say, start with acceptance, then move on to forgiveness and finally gratefulness. Meditate daily 🙂
Such a cool episode and you're so good at making the science fun and easy to follow!
Agreed. Brit is one of my favourite science presenter. This video doesn't feel like 10 minutes at all.
I think this is among the most exciting science developments that have happened in a good while
AMONG?2???2?!!1!!1!1 SUS 😳😳😳😳🤣🤣🤣🤣
Yes! Amazing! How this can lead to new drugs to treat severe anxiety and OCD, without the side effects (excess sleepiness for instance) of SSRIs and SNRIs?
4:00 - That's the reason that babies do that weird jittery shaky movement (which Beck Bennett parodied in the SNL sketch about a CEO with the body of a baby). They have too many synapses so they can't control their bodies and are essentially having constant seizures until their brains prune the synapses to give them better control over their movements.
Whoa
I definitely would appreciate some updated news on this in the future on here.
Yes! Amazing! How this can lead to new drugs to treat severe anxiety and OCD, without the side effects (excess sleepiness for instance) of SSRIs and SNRIs?
I've just seen one paper that was published yesterday on anxiety and OCD related to microglia. Cheers and good luck, from morocco! Please let me know if you find new papers!
That t-shirt is amazing :D
Also wow, this is fascinating! I have learned a lot on this episode
I was so focused on the video that I didn't even notice the shirt
I came to the comments to see if anyone had mentioned where the shirt is from.
If microglia eat unneeded synapses, underactivity in depression may be why you're prone to obsessing over negative thoughts
Yeah, that's my theory. Underactive microglia means lots of dead and harmful connections that don't get removed.
Thus depression, anxiety, ADHD, etc.
@@lilylopnco for anxiety it is more complex
please have a look on an article that was released yesterday on this topic
cheers from morocco!
Love this woman and how she talks :)
The gestures that go along with the script are ridiculous and downright embarrassing. Somehow she manages to pull them off! She’s a rare sort of person who’s able to act out what the script calls for in a normal, fluid manner. I think most people would look goofy or downright stupid. I don’t think I’m describing what I mean right, but it’s hard to describe.
Besides Hank she's the best complexly host imo, then I would say Michael Aranda
Singing in my head:
"Brain neurons and microglia, glia, ia, eh eh oh" 😅
Microglia, the zombie nurses of the cell world.
Perfect!!!
" gives MS a nasty look.... Gives Microglia a shifty worried look "
my thoughts exactly
Incredible! This makes me want to learn so much more about microglia and glia in general!
As a chronic pain patient I can FEEL how strong glial cells are. The signal of pain gets stuck in the glial cells (the chemicals) and these cells keep producing them giving me an endless sense of pain
uhh
It's weird seeing captain marvel talks about microglia
I heard she was arrested for months in Russia for weed oil, before returning to the WNBA. Impressed that she finds time to discuss science as well.
I like this one a lot. Thank you, SciShow.
I like her too
I feel like this is going to be a huge complex branch of brain health we are going to learn about.
I've just seen one paper that was published yesterday on anxiety and OCD related to microglia. Please let me know if you find new papers! Cheers and good luck to all of us, from morocco!
Wait, no, that doesn't make sense. The synapse is the small gap between one neuron's axon and another neuron's dendrite. It's not a cell in itself. How can the microglia eat a synpase?? Did you mean it eats the involved neurons? That's a bit overkill for just one malfunctioning synapse, isn't it? Or does it severe the neurons' axon and dendrite and eat those? What's going on????
I think the synapse may be the junction made up of the axon, dendrite, and synaptic cleft (which is the gap itself).
@@icejustice6122 This
With all these microorganisms at work in and around you, can you really still feel in control
I remember a movie about this kid who doesn't have enough microglia
Source???? :D
Link?
There are shapeshifting cells in my brain that EAT my neurons?? What if those neurons had some good thoughts in them
You forget stuff in exams 😂
Nice username. Did you get it from Lemony Snicket’s Austere Academy?
@@roneliadelgrange8315 more like Unus Annus
@@roneliadelgrange8315 that's a well known latin phrase... why connect it to some random unknown book?
Thank you. Eggs have the kind of cholesterol that feeds the brain.
6:44 low microglia activity means not enough janitors to clean neurons, means junk will accumulate and damage neurons, leading to the same end result, damaged neurons
Amazing, thank you very much! Very informative ❤️
While watching this, I wondered how microglia would be portrayed in the anime Cells At Work.
So.... microglia.... are basically the cell equivalent of a zombie... eating brains...?
Zombies would be macroglia.
Long story short: microglias can cause some pretty nasty stuff :p
implication to treat anxiety?
My microglia are working on repairing my brain from a recent concussion then
An episode about current information about advances in ASD research would be helpful for those of us in the spectrum.
This.
@whesley hynes thanks for taking the time to comment. Have a lovely evening!
Love her delivery style. Very clear and engaging. 🙂
"shape-shifting housekeepers"(and assassins too probly), gosh, debut of this long lost member of the immune cell family is gonna be glorious in Cells at Work
Oh wow 😮
This was very enlightening. We have multiple personalities as well as a wide range of comorbidities. The current disorders our psychiatrist is looking at are generalised anxiety disorder, social anxiety, panic disorder, OCD, agoraphobia, autism, ADHD, major depressive disorder, bipolar II, PTSD, OSDD / DID, and others that I don't recall. It sounds like microglia could potentially be part of the issues for those with multiple identities like us, especially since there are typically a wide range of comorbidities related to increased stress and anxiety.
It would be interesting to be included in study or research into this. I'll ask our psychiatrist and see if there's anything happening in Australia, but are there any current studies in Australia that you came across while researching for this video?
- Ian
Yeah, and I've seen only one Psychology expert connecting the dots between that and Neurology.
I wonder if there are current areas of research in that.
@@MaximilianBerkmann We will try to find out
I was thinking of DID and how this new information could be useful
Amazing! How this can lead to new drugs to treat severe anxiety and OCD, without the side effects (excess sleepiness for instance) of SSRIs and SNRIs?
@@MaximilianBerkmann I've just seen one paper that was published yesterday on anxiety and OCD related to microglia. Cheers and good luck, from morocco! Please let me know if you find new papers!
I definitely need to hear more about these!!!
This is the coolest episode ever omfg
Thank you so much. I adore your style of presentation.
Interesting enough, now I am completing "anatomy and physiology" playlist :p , one video per day :p
And just started learning about them .
(From the "crash course" channel )
Wow... this is crazy interesting!!! Another reminder of how little we know.
Awesome video Brit, as per usual, informative and interesting. I love that shirt!! All I can hear in my mind now is James Woods saying “need a bigger boat” 😂🤣
Brains are sooooo complicated!! who new i had so much going on upstairs.
yes but very important!
These channels are my adulthood bill nye the science guy show 😆
"Eat the problem" sounds like I was doing things right all this time already!
I appreciate how you use scientific naming along with metaphors to facilitate understanding. I'm in the midst of a discussion on the benefits to this technique for teaching.
This might help explain why and how Long COVID often produces neurological problems ! 1. Long COVID usually means ongoing cytokine storms or overactivity. 2. Cytokines get into the brain, thanks to microglia, as indicated in the middle of this video. 3. Maybe they do neurological damage there.
What an excellent episode. Great breakdown of information and cautioning of information
Phenomenal video, thank you
Sounds like neurons evolved to avoid being eaten by microglia.
Neat to know about them!
You guys should do an episode on astrocytes; there have been recent studies that suggest astrocyte size and diversity is responsible for human intelligence!
Do microglia ever get full and have to call another one in to eat for them?
Funky macrophages. There's similar in mammalian ovarian tissue. Microglia activity in different areas of the CNS, would have different affects and different symptoms
There was a study many years ago that found that blocking PKR, an important immune signaling molecule, caused mice to exhibit what appeared to be perfect recall. This was also associated with apparently asymptomatic microseizures. Sounds like maybe the lack of PKR interfered with the microglia pruning new memories 🤔
Awesome video, such good information
Aside from John Green, Brit Garner and Reid Reimers are my favourite hosts from SciShows, CrashCourses and PBS channels. Seems like they're actually talking to me when they're speaking, which I guess is the ultimate compliment for a host. :-)
It is indeed! Many thanks 😊 -Brit
@@natureleague Aww
This is the best.
Thanks!
Very good episode!
If depression is associated with both overactive and underactive microglia, does that not suggest that there might be different forms of depression that are similar in their superficial presentation, but are extremely different in how they function on a neurological level, and might require very different treatment?
Thank you for talking about this!
The childhood stress causing issues with glia, could that be part of my wife’s chronic migraines ?
Microglia: the zombies of the brain
Awesome stuff
thank you for all the sources! looking forward to doing some reading up on this topic
ML libraries developers should notice and add neuron eating layers as a new way to traind DNNs.
Soooo... Nurse zombies? "Are you all right, dear? No? OK, then... BRAINS!"
Great presenter and interesting video!
Really excellent video! The presentation was a bit fun, too.
Amazing! How this can lead to new drugs to treat severe anxiety and OCD, without the side effects (excess sleepiness for instance) of SSRIs and SNRIs?
Whenever I think about Neurons and Glial cells doing their job, I wonder - am I myself?
Soooo we could say,,,,the microglia is a powerhouse of the brain?
yes please!
Really good video 👍👍👍
Amazing!
So far as I'm concerned, it is magic.
I have an urge to go back and find a vhs copy of the blob for reference
Beware the Blob!
In this episode I noticed less trimming of micro-pauses. The information was thus less time-dense and the pauses almost left me with the time to think and digest the information. Good work. Pass the info to the others.
I kept hearing Mike Birbiglia
So they’re basically the ninja maids of the cell world! :D
amazing video
I like her attitude dwl lolololo and she is still factua
Spidery Blobby Things is going to be the name of my Celtic-Hot Jazz band.
Hey! I eat my problems, too!
Twinsies! 😃
😭
Oh boy. My poor, poor microglia.
Child(neuron):"Mom, i think something is wrong with me"
A few moments later
Mom(microglia): chomp chomp chomp, slurp, DELICIOUS!
Microglias are like my mom, really hard-working, custodial, and literally overpowered
That Megalodon shirt is cool
Your shirt is really cool
That is one cool t-shirt 😄
MS: hehe maybe I'll kill those next
Depression: it doesn't matter, we're gonna die anyway
Anxiety: but what if it eats everything! We need to do something ASAP
That was really engrossing, MashaAllah
Soooo... they're the Judge Dredd of brain cells? Judge, jury, _and_ executioner! "I am the law." 🤣
Shark!
Well after watching this video some of my neurons know there's something that might eat them just because... spooky
Glia...Yep, mine must be messed up.
If only I could get rid of all my problems, by just eating them up :(
awesome