CAR T Cell Therapy and Lupus
Вставка
- Опубліковано 12 кві 2024
- In this video, Dr. Donald Thomas, clinical rheumatologist and author of The Lupus Encyclopedia, shares the latest science behind this emerging lupus therapy and its promise of drug-free remission.
Special thanks to our sponsors Tin Rocket, Blue-eyed Crow Studio, 7-Minute Cinemas and PhRMA for their generous support in making this video possible.
Note: Since the video taping (as of April 2024), additional data have been published, and at least 43 SLE patients have been reported treated with CAR-T cell therapy. Almost all developed mild, easy-to-treat cytokine release syndrome (most common symptom was fever).
What a great talk! Thanks!
Thanks for your comments; glad you enjoyed it! Please, share it with everyone you know.
Thank you!
Thank you! Share it with anyone else you might think could use this information.
Great talk! How did the anti-SSA antibody patient on cd19 CART benefit from therapy, if they did not have reduction in anti-SSA antibodies? (28min mark)
Since the video taping (as of April 2024), additional data have been published, and at least 43 SLE patients have been reported treated with CAR-T cell therapy. Almost all developed mild, easy-to-treat cytokine release syndrome (most common symptom was fever).
Therefore, Dr. Thomas retracts his statement in the video regarding Novartis' CAR-T therapy. Thus far, their results appear to have similar safety and efficacy as other products).
Updated report can be seen here: www.lupusencyclopedia.com/car-t-cell-therapy-for-lupus/
Hi, Great video. Does Dr. Donald have an opinion on CD19 antibodies or CD19 T-cell engagers? I know CD19 CAR-T has most data, but may be restrictive to patients. thx!
I have a question
How does the b cells come back after 90 days if cart cells are still in the system trying to eliminate them
CAR-T programmed cells attach to and kill only cells for which they recognize . More mature B-cells have CD-19 molecules on their surface so they are all destroyed. However, the most immature cells in the bone marrow that can become mature B-cells are still present and they reproduce, repopulating the body with important B-cells to fight off infections. However, so far, they are not producing bad lupus antibodies like anti-dsDNA. That is why the scientists call it "resetting the immune system." However, cells producing anti-SSA are still alive, probably the most mature B-cells called plasma cells, so we have a lot to learn. Also, could the immature cells that do not contain CD-19, could they become abnormal again, producing bad lupus antibodies? Only time will tell as we follow these patients over time.
HI, we asked this question of Dr. Thomas and here is his answer. "The CART T programmed cells attach to and kill only the cells for which they are designed to recognize - the more mature B cells that have CD-19 molecules on their surface. So they are all destroyed. However, the most immature cells in the bone marrow that can become mature B cells later are still present and they reproduce, repopulating the body with important B cells to fight off infections. However, so far, they are not producing bad lupus antibodies like anti-dsDNA. That is why the scientists call it 'resetting the immune system.' However, cells producing anti-SSA are still alive, probably the most mature B-cells called plasma cells [which are not all killed off]. So we have a lot to learn. Also, could the immature cells that do not contain CD-19 become abnormal again, producing bad lupus antibodies? Only time will tell as we follow these patients over time." Thanks for asking this question!
@@kaleidoscopefightinglupus thankyou very much. A very dear person of mine have bad lupus. This can save her
@@shalevsaada7596 Good luck to her!!
What about RA
Hi, cancer treatments are still the most common use of CAR T cell therapies, but there is some research for RA. You can find out more from the NIH here (scroll down the page): www.ncbi.nlm.nih.gov/pmc/articles/PMC10328598/
We hope this helps!
The KFL Team
@@kaleidoscopefightinglupusThank you
There is also a study in RA patients that did well. At the moment, the number of studies and treated patients is really growing... it is an exciting time for possibly better therapies for autoimmune disorders