I found your video quite helpful for a topic that I am studying in a system dynamics modeling course. I plan to link to your video as a resource in a system dynamics modeling lesson that I am planning.
Between 4 to 5 half-life for a steady state via IV. PO is the slow route of administration and can't be controlled precisely. IV can be controlled for a therapeutic effect to reach a certain/infected area in a short period of time.
Please correct me if I am wrong! ( For oral route administration ) If you start your medication from maintenance dose alone then it would take near 4 half lives to achieve a steady state and to reach that point or therapeutic range earlier doses will just help to reach that level and earlier to that level it didn't have any therapeutic effect as it had not reached therapeutic range. So the earlier dose had no any effect at all to us?
Sort of correct. The loading dose is all about getting to a steady state faster as you suggest. It’s not to say that there is no efficacy at the lower doses or initial doses, but to say that to get full anticipated efficacy, we need to reach a steady state in the blood. This can be complicated by the fact that many medications are cleared quickly from the bloodstream, so what you are trying to achieve is a certain minimum level in order to achieve ongoing effect. Remember, the system is dynamic, so the benefits are also dynamic. Some drugs are all or nothing, but most drugs have some effect even at lower doses.
Loading dose and maintenance dose is similar to the the process of a anesthesiology procedure of induction/loading dose/getting started to being put under sleep or drug reaching affected area in a short period of time and maintenance/keeping under sleep for a period of time/while procedure is being done or continue the process of a therapeutic dosing to fulfill the outcome for said condition.
Bioavailability-- leaves a large amount of drug lost in the body and not used to treat the affected area that are still in the pharmacokinetics process of motion through the body that can cause toxicity until it excretes out. This is when we deal with clearance over elimination.
I’m sorry we never got around to making that video. Medical school was a busy time. In short, bio availability is defined as the amount of the drug that is available to act in the system. Much of the drug in our system is bound to albumin or other molecules that can make it so that, even though it is present in our system, it cannot have any effect on the system. We see this in a lot of ways within the hormones of the body as well. For example, there is testosterone levels, and then there are also bioavailable testosterone levels. And over simplified way to look at it would be to say that total testosterone levels don’t matter, only the bio available testosterone levels do. There’s a lot more nuance to it than that, but that simplified view gives you the basic concept.
Try watching again. The concept is simple. A loading dose has to be larger than a maintenance dose. It takes repeated doses over time until the level in the blood reaches a steady state. Sometimes we use a higher loading dose so that the blood level gets higher faster. We use a lower maintenance dose because we are no longer trying to get the level up, we are only trying to maintain it so a lower dose is all that is required.
Currently studying pharmacokinetics. Really helpful!
Thank you for the kind words. I hope your studies went well.
made it very easy... i was checking your account... suddenly found just one video... hope you will make more.. Thanks
I’m back, and there’s a whole bunch more video where this came from. I hope you’ll still follow us and share with your friends.
I found your video quite helpful for a topic that I am studying in a system dynamics modeling course. I plan to link to your video as a resource in a system dynamics modeling lesson that I am planning.
Thank you so much for linking to our video. I hope it is helpful to you.
Your video ws very helpful....Explanation and the graphs were well done...Thanks!
Thank you for the kind words
Your voice is so clear and comfortable for ear
Thank you!
Between 4 to 5 half-life for a steady state via IV. PO is the slow route of administration and can't be controlled precisely. IV can be controlled for a therapeutic effect to reach a certain/infected area in a short period of time.
Great info.
Nice video making understanding of concepts very easy. Thank you.
Thank you! More great content coming your way.
Please correct me if I am wrong!
( For oral route administration )
If you start your medication from maintenance dose alone then it would take near 4 half lives to achieve a steady state and to reach that point or therapeutic range earlier doses will just help to reach that level and earlier to that level it didn't have any therapeutic effect as it had not reached therapeutic range. So the earlier dose had no any effect at all to us?
Sort of correct. The loading dose is all about getting to a steady state faster as you suggest. It’s not to say that there is no efficacy at the lower doses or initial doses, but to say that to get full anticipated efficacy, we need to reach a steady state in the blood.
This can be complicated by the fact that many medications are cleared quickly from the bloodstream, so what you are trying to achieve is a certain minimum level in order to achieve ongoing effect. Remember, the system is dynamic, so the benefits are also dynamic. Some drugs are all or nothing, but most drugs have some effect even at lower doses.
Loading dose and maintenance dose is similar to the the process of a anesthesiology procedure of induction/loading dose/getting started to being put under sleep or drug reaching affected area in a short period of time and maintenance/keeping under sleep for a period of time/while procedure is being done or continue the process of a therapeutic dosing to fulfill the outcome for said condition.
Thank you!
Bioavailability-- leaves a large amount of drug lost in the body and not used to treat the affected area that are still in the pharmacokinetics process of motion through the body that can cause toxicity until it excretes out. This is when we deal with clearance over elimination.
Great insight
Thank you, great video keep it up sir
Thank you, after a long absence, we are ready to get going again
You referenced a "Bioavailability video" in here. Where is it?
I’m sorry we never got around to making that video. Medical school was a busy time. In short, bio availability is defined as the amount of the drug that is available to act in the system. Much of the drug in our system is bound to albumin or other molecules that can make it so that, even though it is present in our system, it cannot have any effect on the system. We see this in a lot of ways within the hormones of the body as well. For example, there is testosterone levels, and then there are also bioavailable testosterone levels. And over simplified way to look at it would be to say that total testosterone levels don’t matter, only the bio available testosterone levels do. There’s a lot more nuance to it than that, but that simplified view gives you the basic concept.
Outstanding! Thank you.
Thank you!
Why'd you ghost us? No website, no more videos? What happened? This was great, need more.
Medical school kept me far busier than planned. I'm hoping to start making new videos again soon. Any topic you'd like me to cover first?
Otto Shill sexology❤️
Here comes the videos. Check out our updated UA-cam channel and check out our website. Www.shillmed.com
Perfect thank you
You’re welcome. Hope the video helps!
Thank you, very helpful
Thank you!
cheers!
Same to you!
Thanks to you
Thank you so much! More content coming your way!
I really don't understand I just want to cry
Think of it this way. We have to give more up front to get it started. We can give less to maintain once it gets going.
Waste of time... Didnt understand the concept
Try watching again.
The concept is simple. A loading dose has to be larger than a maintenance dose. It takes repeated doses over time until the level in the blood reaches a steady state. Sometimes we use a higher loading dose so that the blood level gets higher faster. We use a lower maintenance dose because we are no longer trying to get the level up, we are only trying to maintain it so a lower dose is all that is required.