I wish TED did more of those scientific talks instead of yet another "inspirational coaching" CRISPR is one viral thing, but how about EM "Impossible" Drive or Recent nano engine...They only seem to be center on AI recently with hosts saying same things over and over again.
Nik you're basically asking them to appeal to a niche audience and ignore other people's interest in things that are not scientific. I appreciateTED being an inclusive platform and providing a variety of subjects to understand.
Once the technology is out, no amount of laws, moratoriums, or policy will prevent it being worked on in every conceivable way, be it rats, rabbits or humans. I don't think it is an inherently bad thing, but no doubt terrible things will happen along the way, out of sight. It is absolutely inevitable.
Y'all, get on board with this technology. I'd like to see my Aunt's Huntington's disease completely eradicated. I see her suffer. There are more people like my aunt that need this DNA editing. Let's not get stuck on super babies and wooly mammoths. Those are petty subjects to those who have little time left to live. The philosophical conversations are critical to understanding but all the talk seems to stymie a potential miracle for someone looking at only a few months or years remaining. The subject makes my heart race with hope but the conversations of morality put dark spots in that hope.
Crisper can lead to the extinction of the human race. The genes pass forever. There’s no going back. Anyone who is edited with crisper should be immidiately steralised. We’ve caused extinction of entire mosquitos species with this tech. Anyone who has their genes edited - should never be allowed to breed ever again. In fact this tech is so dangerous - they should just stop. It’s not worth the risk to humanityZ
It's in all COVID vaccines, to edit the brain, why do you think the slogan of Karl Schwab was " you will have nothing and you will be happy"On his great reset COVID 19?
My mother's side of the family suffered from Huntingtons disease hopefully crispr will cure Huntington's disease I have Huntingtons disease praying for you
Science is hard work. There are people in their particular fields that make great contributions and never get recognized. To those people I would say thank you. You do the human race proud. Maybe you do it for the money, and/or fame, but you know what, if you're helping someone, that makes a difference. So again, thank you
What I don't understand is, when Cas9 cuts the DNA, if it's only broken then shoving the two pieces together sounds right. If I'm mistaken and it cuts OUT a chunk, then I still don't quite grasp what the repair pathways have to do with anything. I did a bit of research, and I think the two pathways being discussed here are HR and NHEJ, but apparently homologous recombination, which is the supposedly more "interesting" repair pathway only occurs during meiosis. Other articles mention CRISPR being able to be applied to non-dividing cells that make up most adult tissue - which is quite obvious, or else it wouldn't be of much use to any living person - so that means it doesn't involve HR. So how does the cell respond when the DNA is cut? Or did I get the whole repair pathway thing wrong? When she said feed it a bit of DNA, does it mean to inject DNA and the cell just happens to find the piece lying around and use it to link the broken bits? Or was it carried with the cas9 protein? Also, apparently if you "blunt" the cutters of cas9, it makes the protein stay in place on the targeted gene and temporarily turns it off. How does that work? Really hope someone watching this knows a bit more about the topic than myself and can help me out a bit. Thanks internet. :)
Things like this have a tendency to simply disappear from the public discourse. Then 10 years later you’ll ask yourself, “hey, whatever happened to crispr?”
I'm 14, and I'm trying to learn as much as I can about genetic engineering before University. If anyone knows of any articles or videos on CRISPR/Cas9 and genetically engineering/alteration please link them, I'd greatly appreciate any and all knowledge on the subject. Thank you!
That's not how that works. In the real world Super powers like comic book heroes would come with EXTREMELY dangerous and destructive side effects. You want skin that can block bullets? Great, but good luck moving, weighing about a ton, and probably being in excruciating pain every time you DO manage to move. Like the best and probably safest super power that can be given with DNA editing is probably a significant immunity to a lot of diseases, reduced rate of aging, and.... Well we could make you glow in the dark, MAYBE but you probably won't be able to turn it off.
When it comes to CRISPR why is everybody going crazy about the wooly mammoth and blue eyes but nobody thinks about the lives it could save by curing diseases ? So excited for this. Imagine you can live happily with your family protected with an efficient healthcare. How peaceful.
When is crispr cast 9 in gene editing going to be available for people that have cancer or something like that and that's all they want to do is to cure it
I hope that lots of good will come of this. I'm concerned that making these genetic changes will be as if you are pushing at the tip of an iceberg without realizing that there's a mountain of ice below the ocean's surface that you can't see yet.
Sure but have you asked mother nature why did she created mosquitos in first place? What was her intension in the domino block building pyramid. If I remove mosquitos, yes birds could feed on ants but if that particular bird expertise on mosquito for 600 millions years, he might have a hard time to only eat ants, which are tricky to catch. Maybe the mating season of that bird coincide with mosquito season. It's like forcing every human on earth to adapt to vegetarism, it will work well for a particular human with blood type B, AB but those who are O+ might feel they get less energy and are less happy eating just veggies, am one of them. With thousands of years, that blood type may disapeared
oh to be perfect and healthy like you. At least you have the luxury of faith and ignorance. Us afflicted however look at the world pragmatic and with eyes open.
2:14 this slide is just wrong! CRISPR is the acronym for clustered regularly interspaced short palindromic repeat sequences. What is labeled as "CRISPR" on the right side is actually a Cas9-Ribonucleoprotein, so the Cas9-protein that does the cleaving combined with the guide-RNA.
Rarely on this page, they only post the higher quality ones (well researched and do not break guidelines like marketing a product in the talk). If you want to watch your friend's talk, you can search the Ted event on UA-cam, e.g. TedX(place) or TedX (speaker name).
while the good people who understand genetics are here I have a question , I hear about modifying genes as a future possibility how can you modify every DNA in every cell in the body of life organism . I understand how it can be done to embryos but how can it even be possible for a living organism ?? thanks
Because of cell division the modification spreads. Not a good technique for cells which don't multiple as much, like brain cell, muscles, etc But for those cases, we have just found a way to edit RNA using CRISPR and cas13.
same way, just more cells the virus has to enter, especially the targeted area needing treatment, liver, spine etc... i would imagine. Or even change the edit of our base stem cells so that production will be reflective of the new edited cell. But again im just spitballing.
@6:29 “The devil is in the details.” Very interesting choice of words. There are two types of tomatoes. Naturally grown and GMO (genetically modified organism) aka DNA 🧬 edited. The naturally grown tomato is a product of nature and is not owned by a corporate patent. However, GMO tomato is owned by a corporate patent. Think Monsanto. So the question is, if your DNA is edited by CRISPR technology, who will own you?
The quote is just an English proverb used to remind someone to pay attention to the details, used in a lot of poetry and literature. Regarding the ownership bit, the genetically engineered tomatoes have a patent because they’re commercially sold products, so ofc a company is going to put a patent on tomatoes that were genetically engineered to be better than others, thus potentially outselling any other tomato options available. If humans were to have diseases treated with CRISPR, then it would be a patent on the certain innovations regarding the technology itself (to prevent other competitive pharma companies from being able to use innovative mechanisms themselves), and not anyone who’s gotten those treatments. By the same thought thought process, people who have had certain vaccines would be owned by an entity due to certain vaccines, or parts of them being patented.
What effects would it (And future variations/advancements of it) have on living currently-existing creatures and humans? Like, if you CRISPR a live person to replace whatever genes control hair color, would their hair color slowly start to change because the default/natural state is now say black hair from blonde? Or something more extreme, could CRISPR be applied to transexuals? One of the more extreme but potentially possible examples (Compared to say turning humans into mutant ninja turtles or super soldiers). What are the boundaries of it?
*+Barenur* "We might never get to successfully editing live organisms after all" We already have. Its minor things but the question is more how far we can push it. My bet it really far by how things are looking atm. There are very few deal breakers as of yet.
Human experimentation is a must if you want to see real results in your lifetime. Millions of willing candidates world wide. It's peoples idea of morality is what stands in the way of real human advancement. Ignorant people.. their self righteous idiotic ideas stand in our way of progress.
It'd be a wonderful future to live in where you could take a pill and permanently alter features of yourself (Slowly over time as you grow into them), or make sure your child will grow up resistant to diseases or have vulnerabilities they would have had from your own genes removed. Couple that with stem sell research growing whole new organs and we'll be well on our way to mastering our physical existences. In another generation maybe we'll have nanomachines to fill in the gaps that are left and perhaps achieve an ageless lifespan.
Playing god, you think playing god is ok and that you wont open pandoras box.... you mess with DNA your gonna create something that will not be human anymore, something that could perhaps eat humans and have offspring without a partner.
I'm at a crossroads point in my life .....I'm about to enroll into college and if anyone can help me decide as to whether or not to become a genetic engineer because of crispr.
Mohamed Umar don't be too concerned about picking the exact thing you should study. Pick a field that interests you now and get a broad understanding of as much as you can. If you want some good insight about how your career path will not be a straight line to a defined goal like "genetic engineer", Google "Steve Jobs commencement speech".
Pick something your interested in, not just because of a technique. Techniques come and go especially in science so as long as you have the drive and are interested in the field you will be fine.
To Mohammad Umar I made one big mistakes in my life, I persisted with that mistake, which was to choose a career that reward with money. You have the rest of your life for regret, choose something that is born In you, natural to you, even if your family and friends hate it.
"How can we justify wiping out an entire species that we consider harmful to humans, off the face of the Earth?" You just answered your own question; the species is harmful.
parasites also play a large role within the web of life.. and the food chain, basic science man.. no matter how small it can have a large effect.. chaos theory, butterfly effect, things like that.. at the end of the day its a prey, predator and parasite relationship.. u cant eradicate a whole specie of tigers just coz they are wild and dangerous and can kill humans and other animals.. and that can mean eradicating the whole feline specie.. and humans also harm and threatens other species, we r the only specie that kills for fun.. not for survival
yes gene-editing is exciting. when the strand is broken or torn apart, as such, much like tearing an arm from your body, no matter how many surgeries you get, you cant "get back" to the "original form". this "tearing" event will always a probably in this process.
Not true in 2002 I was studying how they can regrow your arm or whatever you want as long as you have the DNA from the baby being born you could pay 3000 grand a month and cryogenic the belly button cord blood they pulled me out the room told me to never speak of it again or my son wouldn't be able to be born there. I gave other family's the info and they did it most rich. Js
This is such a great video. Amazing topic and I’m glad she is trying to break it down for the masses. We shouldn’t be trying to play with stuff like CRISPR, we should let the scientists do what they do best and if we want to support the research, donate money to labs working with CRISPR.
krickett00 hahaha, you can actually close your eyes and still able to listen to her. She has no demo on stage; albeit there are visuals here and there. In fact, as a scientist she is supposed to look weirder than she should be, lol.
2:13 “it’s a system that we stole from an ancient ancient bacterial immune system”. Can you tell me more on this please. What ancient ancient bacterial immune system?
The system was originally found in bacteria that use it as an immune response against viruses that would infect them. Viruses can't replicate without a host, because they are so simple they don't have the necessary molecular machinery. During infection, viruses inject genetic material like DNA into cells, hijacking the host to make more viruses. An infected bacteria can capture a piece of this virus DNA and store it into its genome like a file to recognize this virus in the future, sort of analogous to how our immune system makes antibodies to recognize a virus after we've been infected. This bacterial genome region is called the CRISPR locus. Over time bacteria will have many different DNA fragments as they are passed on as the bacteria multiplies. Part of the CRISPR locus are Cas enzymes that cut DNA, and they are guided by these stored virus DNA (and repurposed by researchers like in this video). Should an already encountered virus inject its DNA into this bacteria, the Cas enzyme will recognize this DNA and cut it, preventing the virus from infecting the bacteria.
Michael Steinwand, excellent explanation Michael thank you. In watching a videos by Jennifer Doudna she makes the claim of being the “co-inventor” of CRISPER Cas9. This seems an extreme arrogance on her part in that it appears that all that happened is that they noted how this function worked and then copied it and then began utilising it for their own nefarious purposes. What would you say? Oh yes, as you might discern, I did a bit of research to answer my own question after I asked it.
@@paulcowdroynon-noxiouschan3971 Likely she was referring to her patent claim with another scientist Emmanuelle Chapentier as co-inventors, against the Zhang group at the Broad Institute, and using that legal terminology. Many molecular biology tools are first discovered in living organisms, altered and repurposed. It takes a lot of intellectual work to figure out all the pieces and how it all works, and I won't downplay how hard that is. This level of science is often the result of whole teams of labs, so while it's individual scientists who often become most famous, look for those who use "we" a lot more than "I", because they likely didn't do it alone.
Michael Steinwand, how ever many “we” they come up with, and even if they take the more humble approach in appreciative recognition of what they but have “discovered” and not themselves “invented”, they still have developed only a tiny picture of how this particular function fits into the ‘whole’ picture of health and wellbeing of the human race. But on that extremely limited perception basis do they then proceed to fight to patent the use and most likely abuse of this identified function to attempt to ‘take control of evolution and crack creation’ to restate JD’s own stated intentions in her book. And then to blindly surge forward, once they gain control of it via a patent, it in a way so as to assume to think they can improve on something they ‘know’ but a tiny fraction about. Already I note that Cas9 is now about to be out done by CRISPR Cpf1. It seems to me yet another presentation of the blind leading the blind leading all who follow straight into a waiting pit. I am now reading JD’s book “A Crack In Creation”, a new power to control evolution. You should hear her right from the get go claiming that it be “her breath” and “her voice” be the ‘one’ who ‘rightly’ gets to take this thing forward. Even her co-author of the book is ‘justified’ as being placed aside because ‘her experience’ be the primary thing here. Do you think she will now change her name to Gene-I-Confer Do-U-DNA? I predict that her book in retrospect will be seen as ‘A Crack At Creation’, not ‘A Crack in Creation. And that such view will rightly humiliate the woman who but thought she could attempt it with success. Because she certainly does need a rather big slice of humble pie well before she assumes to take on such a role. I think the lady in this video said it right. What they now are fighting to patent they but stole. What a foundation upon which to go forward. Doomed to failure thank God. By the way Michael, what is your interest and roll in these things. You seem to have a good working knowledge respecting it?
Ellen says, "...It is the system that we stole from an ancient, ancient viral immune system." She sounds like she knows a lot of important details. How do viruses have ancient immiune systems? She has somehow spoken inaccurately, but to what is she referring to by "ancient, ancient viral immune system". I think she has informed us of something around for a very, very long time. Remember what ancient Spartans were said to do with babies that cried? - They were thrown to their deaths. It seems long ago people knew something strange about how babies have evolved into technical innovations of babies that is know being done with improving genetic engineering. Ellen seems to be speaking in a made up way, but she also seems partly enlightened.
She is right in that most of us work for a living ... just so that the few can play god. Monopolizing on great discovers using a 'Patent' defeats the whole premise of civilized Law. We need to modernize our collective thinking patterns to account for everyone on the planet ... their contribution and share in the rewards.
As a biotechnologist I think that while the patent mentality is unfortunately still prevalent, lots of us are moving towards an open collective mindset; from community bio-hack spaces, to open access journals and open source projects. The biotech community is becoming less corporate.
Vaughn Utube ah man, it does suck. But if X person puts in X amount of work, they should be rewarded. I do think the whole system needs an overhaul. I am not certain if genes that exist in nature or found later to exist should be patentable. Should the patent last so long? I don't have the answers, just the questions :)
Oh yeah I agree, if person X puts in the time they should be compensated for it. The problem is when he makes too much. Let say 1 billion for instance. They probably deserve it? ... but then every year after that, he'll make $300 million more or less just on interest alone. And so for generations ( or till the next war ) we'll be enslaved by these individuals just generating and protecting their growing wealth (and diminishing precious time we could have used discovering something else for the benefit of man/woman kind) ... it's stupid and we all need to put an end to it.
Patents are necessary; without them, incentive for innovation will be lower (Not gone, obviously, but do not underestimate the power of financial incentive). What is not necessary is for patents to become the brand protector for immortal companies, which is what they are now thanks to companies like Disney.
Stop with your playing god bullshit. Its fucking science. Go live In the forest and avoid all 'gods' inventions. Or better yet go to mid east where ppl pray all day.
I can't find the exact biological process for how CRISPR is used in designer babies to bring forwards a desired characteristic. Can someone please help
I suspect that Crispr will become so cheap that is can be done on a kitchen table. It just needs one person who believes it is possible. And that person will be backed by the entire human population, and they will make it free and accessible for all and everyone. This is inevitable.
Man can this fix my hair? or more precisely the absence of hair on my head? i kinda went half bald at 17 (completely bald now) and goddamn did it hurt.
When are they going to start using crisper cast 9 Gene editing for people with HIV I got the disease when I was 18 I've had it for 34 years all people want to do is to be healthy when will it be available in the United States and their doctors offices what year taking a chance of getting cured is better than death thank you
"we all have a responsibility " to not let them do anything to our bodies with it until they know exactly what they're doing and cells no longer are compared to as " black boxes".
The title is very misleading. She only explained how CRISPR works and what the real cost and difficulty is. She didn't explain what impact it can have on our lives, which is by far the most important question for non-scientists. The other TED talk about CRISPR was much better: "Gene editing can now change an entire species -- forever"
All I've got to say is Einstein was right. We need to establish common ownership and democratic control of the collective product of our labour. CRISPR is a product of human labour. Turning it into a privately owned/sold commodity will turn its few owners into the rulers of the immense majority, the producers of the wealth of nations.
We need to focus on self human evolution and environmentally helpful species strengthening so they can withstand our impact on this world. One day we can bring back extinct animals but for now we need to focus on our survival which is hanging half way off of a cliff
I wish TED did more of those scientific talks instead of yet another "inspirational coaching"
CRISPR is one viral thing, but how about EM "Impossible" Drive or Recent nano engine...They only seem to be center on AI recently with hosts saying same things over and over again.
Yeah I do too... I see the inspirational coaching talks as filler really. TED is just another media publisher after all.
Easier to make money off inspiration speeches than it is anything based off intelligence
Ted is becoming what the history channel became: unrelated stuff
Nik you're basically asking them to appeal to a niche audience and ignore other people's interest in things that are not scientific. I appreciateTED being an inclusive platform and providing a variety of subjects to understand.
They are focusing on explained cutting edge science, not some half baked bullshit like the EM drive.
Once the technology is out, no amount of laws, moratoriums, or policy will prevent it being worked on in every conceivable way, be it rats, rabbits or humans. I don't think it is an inherently bad thing, but no doubt terrible things will happen along the way, out of sight. It is absolutely inevitable.
Y'all, get on board with this technology. I'd like to see my Aunt's Huntington's disease completely eradicated. I see her suffer. There are more people like my aunt that need this DNA editing. Let's not get stuck on super babies and wooly mammoths. Those are petty subjects to those who have little time left to live. The philosophical conversations are critical to understanding but all the talk seems to stymie a potential miracle for someone looking at only a few months or years remaining. The subject makes my heart race with hope but the conversations of morality put dark spots in that hope.
catherine lake +
mi mama tambien sufre de esta enfermedad
Crisper can lead to the extinction of the human race. The genes pass forever. There’s no going back. Anyone who is edited with crisper should be immidiately steralised. We’ve caused extinction of entire mosquitos species with this tech. Anyone who has their genes edited - should never be allowed to breed ever again.
In fact this tech is so dangerous - they should just stop. It’s not worth the risk to humanityZ
It's in all COVID vaccines, to edit the brain, why do you think the slogan of Karl Schwab was " you will have nothing and you will be happy"On his great reset COVID 19?
My mother's side of the family suffered from Huntingtons disease hopefully crispr will cure Huntington's disease I have Huntingtons disease praying for you
It's staggering how far along technology has come in my life time. I couldn't imagine this technology as a child....
Were you a kid in the 90s? Because that's when covid was edited in a lab by a computer...
Lol, you probably have no idea it’s was used on you with the fake vax
It's been around they just don't tell the slaves they give you and I sports Hollywood entertainment.
Science is hard work. There are people in their particular fields that make great contributions and never get recognized. To those people I would say thank you. You do the human race proud. Maybe you do it for the money, and/or fame, but you know what, if you're helping someone, that makes a difference. So again, thank you
I know alot because of kurzgesagt
same they are brilliant
Thoughty2 and Vsauce for me.
And don't forget PBS Space Time!
In a nutshell
vsauce, thoughty2, kurzgesagt, and now TED
I love how she summarized it all up into the final statement.
I want a mammoth steak but only if it's CRISPIER.
Don't give them any ideas. They'll bring mammoth back just to make it a menu item.
HigherPlanes sounds good to me
Eli Mager Why, though.
Yummo
@@HigherPlanes So be it.
What I don't understand is, when Cas9 cuts the DNA, if it's only broken then shoving the two pieces together sounds right. If I'm mistaken and it cuts OUT a chunk, then I still don't quite grasp what the repair pathways have to do with anything. I did a bit of research, and I think the two pathways being discussed here are HR and NHEJ, but apparently homologous recombination, which is the supposedly more "interesting" repair pathway only occurs during meiosis. Other articles mention CRISPR being able to be applied to non-dividing cells that make up most adult tissue - which is quite obvious, or else it wouldn't be of much use to any living person - so that means it doesn't involve HR. So how does the cell respond when the DNA is cut? Or did I get the whole repair pathway thing wrong? When she said feed it a bit of DNA, does it mean to inject DNA and the cell just happens to find the piece lying around and use it to link the broken bits? Or was it carried with the cas9 protein? Also, apparently if you "blunt" the cutters of cas9, it makes the protein stay in place on the targeted gene and temporarily turns it off. How does that work? Really hope someone watching this knows a bit more about the topic than myself and can help me out a bit. Thanks internet. :)
I love this. Dare I say a faster delivery. Superb delivery by the way. You ladies know how to speak. Thank you
Its kind of bummer to think my generation will be the last generation to NOT benefit from CRISPR..
Things like this have a tendency to simply disappear from the public discourse. Then 10 years later you’ll ask yourself, “hey, whatever happened to crispr?”
bhec7715 gets hidden
@@bhec7715 not CrisPr. Actually in progress.
SpinazFou
yeah...
2 years they said...
@@Samuel-qc7kg it's already used in eradicating rats in a US state. Well it was just approved. Lol
I'm 14, and I'm trying to learn as much as I can about genetic engineering before University. If anyone knows of any articles or videos on CRISPR/Cas9 and genetically engineering/alteration please link them, I'd greatly appreciate any and all knowledge on the subject. Thank you!
Good luck!
Use the internet dumbass
Read 'A crack in creation' Book
I think watching videos like these first will build base knowledge and then you can go futher in depth with text books or courses etc. Gl.
You can read this Research Paper entitled Cas 9 as a versatile tool for engineering biology by Prashant Mali, kevin MEsvelt and George M Church
thanks to kurzgesagt, i know what she's talking about... well most of it
LU39 samee
Exactly!
LU39 lol Same after watching that I watched another one and now I’m here
Me 2 they are amazing
I love Kurzgesagt
I've never heard of it but it sounds delicious.
I want crisper flavored cheez-its
I think we should bring back the wooly mammoth, but like a miniature one the size of a small dog
ᕕ( ᐛ )ᕗ I agree let’s make it happen
I have one, they've been around a while now
@@monajo855 if you don’t sin then Jesus died for nothing
I am kind of wondering if any natural disease mechanisms were able to utilize Cas9 or similar sequences...prior to the patent filings.
6:30 Do we need to know all these reasons why. It's better to classify wich one does what. Eventually the reasons why will become clear.
yeah , yeah , just give me super powers ^^
The power of one extra chromosome.
Do you think that you really pour all of your super powers to fulfill it if you get it?
That's not how that works. In the real world Super powers like comic book heroes would come with EXTREMELY dangerous and destructive side effects. You want skin that can block bullets? Great, but good luck moving, weighing about a ton, and probably being in excruciating pain every time you DO manage to move. Like the best and probably safest super power that can be given with DNA editing is probably a significant immunity to a lot of diseases, reduced rate of aging, and.... Well we could make you glow in the dark, MAYBE but you probably won't be able to turn it off.
well faster regeneration and slow aging is good enough . i"ll have more time to practice my ninja skills . oh night vision may be very handy too :P
each of those possible superpowers would come with an enhanced cancer risk - do you want to end up like deadpool?
1:43 - "That's how it works" ....... Nice graphic animation of how CRISPR works.
When it comes to CRISPR why is everybody going crazy about the wooly mammoth and blue eyes but nobody thinks about the lives it could save by curing diseases ? So excited for this. Imagine you can live happily with your family protected with an efficient healthcare. How peaceful.
Crispr can eradicate entire species. It’s somewhat dangerous and needs regulation
When is crispr cast 9 in gene editing going to be available for people that have cancer or something like that and that's all they want to do is to cure it
I hope that lots of good will come of this. I'm concerned that making these genetic changes will be as if you are pushing at the tip of an iceberg without realizing that there's a mountain of ice below the ocean's surface that you can't see yet.
wipe out the goddamn mosquitoes
just need one guy to do it without telling anyone and then its too late - what are they going kill all the GM mosquitoes HaHa.
Who will feed the birds and the spiders?
Alberto Humova the other insects.
we should wipe out plasmodium. mosquitoes also suffer from malaria.
Sure but have you asked mother nature why did she created mosquitos in first place? What was her intension in the domino block building pyramid. If I remove mosquitos, yes birds could feed on ants but if that particular bird expertise on mosquito for 600 millions years, he might have a hard time to only eat ants, which are tricky to catch. Maybe the mating season of that bird coincide with mosquito season.
It's like forcing every human on earth to adapt to vegetarism, it will work well for a particular human with blood type B, AB but those who are O+ might feel they get less energy and are less happy eating just veggies, am one of them. With thousands of years, that blood type may disapeared
there's one quastion ib my mind. If we use SCISPR-CAS in human body, will our immune system react to foreign protein CAS9?
"u cant just do this in your kitchen" as im doing my crispr experiments in my kitchen
But why is it 20 base pairs on the RNA instead of 21? How could a stop codon work if the anticodon can't bond?
5:25 So your saying its relatively cheap. Like SpaceX falcon 9 vs Atlas V cheap?
It's not a coincidence that she said the devil is in the details....and that's very scary
Hannah Reid I noticed that too. Also, the fact that she said you can stuff extras in and she said "kind of like a Trojan horse"...
oh to be perfect and healthy like you. At least you have the luxury of faith and ignorance. Us afflicted however look at the world pragmatic and with eyes open.
@@No1More1Mr1Nice1Guy1 But you can't approach the word with openness of mind?
@@demetriusflenory2385 i suspect we differ greatly on our interpretations of 'openness of mind'
@@No1More1Mr1Nice1Guy1 Indeed
I’m so excited for the future
2:14 this slide is just wrong! CRISPR is the acronym for clustered regularly interspaced short palindromic repeat sequences. What is labeled as "CRISPR" on the right side is actually a Cas9-Ribonucleoprotein, so the Cas9-protein that does the cleaving combined with the guide-RNA.
True but she has to dumb it down for everyone.
Will this work for a living adult?
my friend had a ted talk this weekend, when do ted talks usually get posted
Rarely on this page, they only post the higher quality ones (well researched and do not break guidelines like marketing a product in the talk). If you want to watch your friend's talk, you can search the Ted event on UA-cam, e.g. TedX(place) or TedX (speaker name).
Michael Rosche hm still can't find it so idk
SharkmasterD Then they havn't posted it, try facebook.
Thank you for this educational video!
Y'all go to Kurzgesagt it has the cutest animations and you really do pay attention to what the beautiful voice of a British man is saying ☺️
7:03 does anyone know who the girl is who got cured of leukemia?
Layla Richards
"How can we justify wiping an entire species that is harmful to humans off the face of the planet?" That question answers itself.
while the good people who understand genetics are here I have a question , I hear about modifying genes as a future possibility how can you modify every DNA in every cell in the body of life organism . I understand how it can be done to embryos but how can it even be possible for a living organism ?? thanks
last shadow By using viruses that infect your organism, as she said it's not easy.
Because of cell division the modification spreads. Not a good technique for cells which don't multiple as much, like brain cell, muscles, etc But for those cases, we have just found a way to edit RNA using CRISPR and cas13.
same way, just more cells the virus has to enter, especially the targeted area needing treatment, liver, spine etc... i would imagine. Or even change the edit of our base stem cells so that production will be reflective of the new edited cell. But again im just spitballing.
I know from experience that humans have a great way of taking great things and turning them into nightmares
Yes just look at what they're doing with it now lol
Excellent talk on a new discovery.
I feel like this is a really interesting thing but very very dangerous due to mistakes or people weaponizing it.
@6:29 “The devil is in the details.” Very interesting choice of words.
There are two types of tomatoes. Naturally grown and GMO (genetically modified organism) aka DNA 🧬 edited.
The naturally grown tomato is a product of nature and is not owned by a corporate patent.
However, GMO tomato is owned by a corporate patent. Think Monsanto.
So the question is, if your DNA is edited by CRISPR technology, who will own you?
C19 has allowed 90% of people to be MRNA edited
The quote is just an English proverb used to remind someone to pay attention to the details, used in a lot of poetry and literature.
Regarding the ownership bit, the genetically engineered tomatoes have a patent because they’re commercially sold products, so ofc a company is going to put a patent on tomatoes that were genetically engineered to be better than others, thus potentially outselling any other tomato options available.
If humans were to have diseases treated with CRISPR, then it would be a patent on the certain innovations regarding the technology itself (to prevent other competitive pharma companies from being able to use innovative mechanisms themselves), and not anyone who’s gotten those treatments.
By the same thought thought process, people who have had certain vaccines would be owned by an entity due to certain vaccines, or parts of them being patented.
@@anthonydo9945 Have you researched what’s in these CV-19 vaccines?
Great storytelling!
Where this treatment is available in India
What effects would it (And future variations/advancements of it) have on living currently-existing creatures and humans? Like, if you CRISPR a live person to replace whatever genes control hair color, would their hair color slowly start to change because the default/natural state is now say black hair from blonde? Or something more extreme, could CRISPR be applied to transexuals? One of the more extreme but potentially possible examples (Compared to say turning humans into mutant ninja turtles or super soldiers).
What are the boundaries of it?
*+Barenur* "We might never get to successfully editing live organisms after all"
We already have. Its minor things but the question is more how far we can push it.
My bet it really far by how things are looking atm. There are very few deal breakers as of yet.
Human experimentation is a must if you want to see real results in your lifetime. Millions of willing candidates world wide. It's peoples idea of morality is what stands in the way of real human advancement. Ignorant people.. their self righteous idiotic ideas stand in our way of progress.
What Whatwhat
I agree.
Hopefully they wont choose for all of us
It'd be a wonderful future to live in where you could take a pill and permanently alter features of yourself (Slowly over time as you grow into them), or make sure your child will grow up resistant to diseases or have vulnerabilities they would have had from your own genes removed. Couple that with stem sell research growing whole new organs and we'll be well on our way to mastering our physical existences. In another generation maybe we'll have nanomachines to fill in the gaps that are left and perhaps achieve an ageless lifespan.
Kate Apples
That's only 10-15 years away at this rate of progress though. And that might be a conservative estimate on my part.
At least partly.
"You need a lab"
-So does Meth
Meth doesn't need a lab.
oh okay then good point Kellen Ruppee says no lab required everyone I guess that's that.
@@eattoast6378 Mind you that this technology is so basic even morons like Kellen will have access to it.
@@Abraxis86 You said meth needs a lab. I said meth does not need a lab. Why does this upset you? I didn't insult you.
Playing god, you think playing god is ok and that you wont open pandoras box.... you mess with DNA your gonna create something that will not be human anymore, something that could perhaps eat humans and have offspring without a partner.
I'm at a crossroads point in my life .....I'm about to enroll into college and if anyone can help me decide as to whether or not to become a genetic engineer because of crispr.
When you finish you degree this tech is going to be outdated and HATED by people. Good luck!
***** similarly with GMO. "NOBODY" wants "new GMOs" (plants or animals).
Mohamed Umar don't be too concerned about picking the exact thing you should study. Pick a field that interests you now and get a broad understanding of as much as you can. If you want some good insight about how your career path will not be a straight line to a defined goal like "genetic engineer", Google "Steve Jobs commencement speech".
Pick something your interested in, not just because of a technique. Techniques come and go especially in science so as long as you have the drive and are interested in the field you will be fine.
To Mohammad Umar
I made one big mistakes in my life, I persisted with that mistake, which was to choose a career that reward with money.
You have the rest of your life for regret, choose something that is born In you, natural to you, even if your family and friends hate it.
Can It change hair texture?
"How can we justify wiping out an entire species that we consider harmful to humans, off the face of the Earth?"
You just answered your own question; the species is harmful.
parasites also play a large role within the web of life.. and the food chain, basic science man.. no matter how small it can have a large effect.. chaos theory, butterfly effect, things like that..
at the end of the day its a prey, predator and parasite relationship.. u cant eradicate a whole specie of tigers just coz they are wild and dangerous and can kill humans and other animals.. and that can mean eradicating the whole feline specie..
and humans also harm and threatens other species, we r the only specie that kills for fun.. not for survival
Don’t want to sound edgy butttttt “I am become death, destroyer of worlds” Now........ die despasquitos 😂
Well, that would disturb the environmental cycle or the food chain resulting in some severe consequences...
humans are harmful to so many species and I don't see anyone inventing tech that can wipe us off the face of Earth
@@mitalilal6215 wow?? You must not love yourself. Sad
5:41 oh ya? what if I like to do it on kitchen table...
She is so real i love it
Thanks dear for such a beautiful explaination
Thank U and God bless U
I want to work with these things. What do I need to study?
Awesome Explanation mam😊
Anyone who is worried about CRISPR needs to consider what government has done to people.
Add a dose of 5g and call us done.
hmmm is there any posibility to bring back lost hair or not to loss hair mostly in men.🤔
I think CRISPR deserved a better presentation.
Azureim yess this speech and speaker were a bit dull. If you haven’t already watch this, search up “CRISPR in a nutshell”
This was like watching someone give a talk about Napster in 1998
What is the success rate?
yes gene-editing is exciting. when the strand is broken or torn apart, as such, much like tearing an arm from your body, no matter how many surgeries you get, you cant "get back" to the "original form". this "tearing" event will always a probably in this process.
Not true in 2002 I was studying how they can regrow your arm or whatever you want as long as you have the DNA from the baby being born you could pay 3000 grand a month and cryogenic the belly button cord blood they pulled me out the room told me to never speak of it again or my son wouldn't be able to be born there. I gave other family's the info and they did it most rich. Js
At times my back hurts. Is it possible too... with CRISPR??? O.o
Really amazing lecture, than you.
But I'm the best life form.
Chuck Norris ... is it true that you never cry but instead sweat from the eyes?
lmao!
Cas 9 is skin editing system?
Very nice talk
This is such a great video. Amazing topic and I’m glad she is trying to break it down for the masses. We shouldn’t be trying to play with stuff like CRISPR, we should let the scientists do what they do best and if we want to support the research, donate money to labs working with CRISPR.
和訳ありがとうございます。とても勉強になります。
Was the piece of hair by her cheek bothering anybody else? lol
so annoying and strange looking
krickett00 hahaha, you can actually close your eyes and still able to listen to her. She has no demo on stage; albeit there are visuals here and there.
In fact, as a scientist she is supposed to look weirder than she should be, lol.
Parisiii I think you just don't like trans women.
NOT UNTIL I READ YOUR COMMENT LMAO
I didn't notice it before I read this comment! What's funny is that I thought it was her microphone...
The anthropomorphization really helped me understand
2:13 “it’s a system that we stole from an ancient ancient bacterial immune system”. Can you tell me more on this please. What ancient ancient bacterial immune system?
The system was originally found in bacteria that use it as an immune response against viruses that would infect them. Viruses can't replicate without a host, because they are so simple they don't have the necessary molecular machinery. During infection, viruses inject genetic material like DNA into cells, hijacking the host to make more viruses. An infected bacteria can capture a piece of this virus DNA and store it into its genome like a file to recognize this virus in the future, sort of analogous to how our immune system makes antibodies to recognize a virus after we've been infected. This bacterial genome region is called the CRISPR locus. Over time bacteria will have many different DNA fragments as they are passed on as the bacteria multiplies. Part of the CRISPR locus are Cas enzymes that cut DNA, and they are guided by these stored virus DNA (and repurposed by researchers like in this video). Should an already encountered virus inject its DNA into this bacteria, the Cas enzyme will recognize this DNA and cut it, preventing the virus from infecting the bacteria.
Michael Steinwand, excellent explanation Michael thank you. In watching a videos by Jennifer Doudna she makes the claim of being the “co-inventor” of CRISPER Cas9. This seems an extreme arrogance on her part in that it appears that all that happened is that they noted how this function worked and then copied it and then began utilising it for their own nefarious purposes. What would you say? Oh yes, as you might discern, I did a bit of research to answer my own question after I asked it.
@@paulcowdroynon-noxiouschan3971 Likely she was referring to her patent claim with another scientist Emmanuelle Chapentier as co-inventors, against the Zhang group at the Broad Institute, and using that legal terminology. Many molecular biology tools are first discovered in living organisms, altered and repurposed. It takes a lot of intellectual work to figure out all the pieces and how it all works, and I won't downplay how hard that is. This level of science is often the result of whole teams of labs, so while it's individual scientists who often become most famous, look for those who use "we" a lot more than "I", because they likely didn't do it alone.
Michael Steinwand, how ever many “we” they come up with, and even if they take the more humble approach in appreciative recognition of what they but have “discovered” and not themselves “invented”, they still have developed only a tiny picture of how this particular function fits into the ‘whole’ picture of health and wellbeing of the human race. But on that extremely limited perception basis do they then proceed to fight to patent the use and most likely abuse of this identified function to attempt to ‘take control of evolution and crack creation’ to restate JD’s own stated intentions in her book. And then to blindly surge forward, once they gain control of it via a patent, it in a way so as to assume to think they can improve on something they ‘know’ but a tiny fraction about. Already I note that Cas9 is now about to be out done by CRISPR Cpf1. It seems to me yet another presentation of the blind leading the blind leading all who follow straight into a waiting pit. I am now reading JD’s book “A Crack In Creation”, a new power to control evolution. You should hear her right from the get go claiming that it be “her breath” and “her voice” be the ‘one’ who ‘rightly’ gets to take this thing forward. Even her co-author of the book is ‘justified’ as being placed aside because ‘her experience’ be the primary thing here. Do you think she will now change her name to Gene-I-Confer Do-U-DNA? I predict that her book in retrospect will be seen as ‘A Crack At Creation’, not ‘A Crack in Creation. And that such view will rightly humiliate the woman who but thought she could attempt it with success. Because she certainly does need a rather big slice of humble pie well before she assumes to take on such a role. I think the lady in this video said it right. What they now are fighting to patent they but stole. What a foundation upon which to go forward. Doomed to failure thank God. By the way Michael, what is your interest and roll in these things. You seem to have a good working knowledge respecting it?
Ellen says, "...It is the system that we stole from an ancient, ancient viral immune system." She sounds like she knows a lot of important details. How do viruses have ancient immiune systems? She has somehow spoken inaccurately, but to what is she referring to by "ancient, ancient viral immune system". I think she has informed us of something around for a very, very long time. Remember what ancient Spartans were said to do with babies that cried? - They were thrown to their deaths. It seems long ago people knew something strange about how babies have evolved into technical innovations of babies that is know being done with improving genetic engineering. Ellen seems to be speaking in a made up way, but she also seems partly enlightened.
She is right in that most of us work for a living ... just so that the few can play god. Monopolizing on great discovers using a 'Patent' defeats the whole premise of civilized Law. We need to modernize our collective thinking patterns to account for everyone on the planet ... their contribution and share in the rewards.
As a biotechnologist I think that while the patent mentality is unfortunately still prevalent, lots of us are moving towards an open collective mindset; from community bio-hack spaces, to open access journals and open source projects. The biotech community is becoming less corporate.
Vaughn Utube ah man, it does suck. But if X person puts in X amount of work, they should be rewarded. I do think the whole system needs an overhaul. I am not certain if genes that exist in nature or found later to exist should be patentable. Should the patent last so long? I don't have the answers, just the questions :)
Oh yeah I agree, if person X puts in the time they should be compensated for it. The problem is when he makes too much. Let say 1 billion for instance. They probably deserve it? ... but then every year after that, he'll make $300 million more or less just on interest alone. And so for generations ( or till the next war ) we'll be enslaved by these individuals just generating and protecting their growing wealth (and diminishing precious time we could have used discovering something else for the benefit of man/woman kind) ... it's stupid and we all need to put an end to it.
Patents are necessary; without them, incentive for innovation will be lower (Not gone, obviously, but do not underestimate the power of financial incentive). What is not necessary is for patents to become the brand protector for immortal companies, which is what they are now thanks to companies like Disney.
Stop with your playing god bullshit. Its fucking science. Go live In the forest and avoid all 'gods' inventions. Or better yet go to mid east where ppl pray all day.
I want to take this therepy/ treatment pl
I can't find the exact biological process for how CRISPR is used in designer babies to bring forwards a desired characteristic. Can someone please help
A new book just came out called CRISPR People. Try there.
Will this work with genetic mutation that are hereditary and then inhibits certain enzymes to be produced in the body??
I suspect that Crispr will become so cheap that is can be done on a kitchen table. It just needs one person who believes it is possible. And that person will be backed by the entire human population, and they will make it free and accessible for all and everyone. This is inevitable.
You don't need a professional lab, you just need the equipment and necessary skill
This reminds me of some of the missions in the show travelers
"Adaptation Is a sigh of Intelligence"... Well, this relationship is more close that I thought.
Can we reverse aging?
awesome!
@@danishajaib1923 yes but it's hard and will take alotta time
No we cannot. Not significantly but crispr scientist are working on this. Look up David Sinclair he's a geneologist for that study.
I expected to learn more
Amazing an scary at the same time. In love with technology!!!!
marry it then
Someone please put her the sunglasses 9:43
I take my hat off with that last minutes...
about the Wooly mammoth: currently the climatic conditions might not be good for that. if the new ice age will appear, the chances might be higher ;P
Man can this fix my hair? or more precisely the absence of hair on my head? i kinda went half bald at 17 (completely bald now) and goddamn did it hurt.
When are they going to start using crisper cast 9 Gene editing for people with HIV I got the disease when I was 18 I've had it for 34 years all people want to do is to be healthy when will it be available in the United States and their doctors offices what year taking a chance of getting cured is better than death thank you
Larry Price they did it, search for Lulu and Nana, the chinese newborn girls genetically modificated in IVF
"we all have a responsibility " to not let them do anything to our bodies with it until they know exactly what they're doing and cells no longer are compared to as " black boxes".
I don’t care if it succeeds also. NO!
Fantastic!
on our road to make Frankenstein :)) its awesome
The title is very misleading. She only explained how CRISPR works and what the real cost and difficulty is. She didn't explain what impact it can have on our lives, which is by far the most important question for non-scientists.
The other TED talk about CRISPR was much better: "Gene editing can now change an entire species -- forever"
she is there to confuse people more, and let them think that is very god/positiv using CRISPR!!!!! She is scient.
"... the devil is in the details...put stuff in like a Trojan horse"
🎯
What do you know about phenotypic revolutions?
Well this made me less confident in the astraz vac. ...
How much would it cost to set up my own lab?
All I've got to say is Einstein was right. We need to establish common ownership and democratic control of the collective product of our labour. CRISPR is a product of human labour. Turning it into a privately owned/sold commodity will turn its few owners into the rulers of the immense majority, the producers of the wealth of nations.
the kurzgesagt is best channel on youtube
Patent a technology when there are so many unknown consequences ? Seriously 😶
When she said "making better models...", who thought, for a second, she thought fashion models?
eugenics is a weapon. always has been always will be
Everything can be a weapon
We need to focus on self human evolution and environmentally helpful species strengthening so they can withstand our impact on this world. One day we can bring back extinct animals but for now we need to focus on our survival which is hanging half way off of a cliff