4. Comparative Genomic Analysis of Gene Regulation

MIT 7.91J Foundations of Computational and Systems Biology, Spring 2014
View the complete course: ocw.mit.edu/7-9...
Instructor: Christopher Burge
Prof. Burge discusses comparative genomics. He begins with a review of global alignment of protein sequences, then talks about Markov models, the Jukes-Cantor model, and Kimura models. He discusses types of selection: natural, negative, and positive.
License: Creative Commons BY-NC-SA
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[@jesseleavitt2818]

MIT, I can't thank you enough for the all of the open course ware! This is some of the best material on computational biology i've come across. I have nothing close in comparison at my local university, and if it wasn't for these courses, I wouldn't have exposure to such great content, so thank you!

[@何雪凝]

Fossil part, MINDBLOWING!!!!! I have always been wondering why repetitive element, as a destablizing thing, haven't been purged by evolution. You gave me such a good answer: because some of them will become regulatory sequences. I love so much how you turn a series of papers into a fascinating evolution story. Professor thank you! MIT thank you!!!

[@sdsa007]

Thanks! very grateful for getting a change to learn this!

[@wenjingma8044]

Thank you for this open lectures! It helps a lot!

[@erikdiaz8892]

I know! It's cool to listen this lecture while writing my PhD proposal!

[@sfmambero]

19:10 comparative genomics

[@paulsimv]

Interesting lecture thank you for publishing

[@wimthiels638]

very interesting, thanks MIT !

[@sfmambero]

12:45 multiple sequence alignment

[@sfmambero]

37:30 Jukes-Cantor model

[@jackc7069]

Where does the log in base 2 come from for the substitution score formula?

[@sfmambero]

9:20 BLOSUM