Understanding Angiogenesis through Retinopathy

Air date: Wednesday, April 15, 2009, 3:00:00 PM
Category: Wednesday Afternoon Lectures
Description: Proliferative vascular disease of the retina is a major cause of blindness in children (retinopathy of prematurity), in middle aged adults (diabetic retinopathy) and in the elderly (age-related macular degeneration). Oxygen-induced retinopathy in the mouse is a model system for both retinopathy and angiogenesis. Understanding the oxygen-regulated factors acting on the immature retina and those factors normally supplied by the in utero environment and missing after premature birth from helps define critical pathways in normal vascular development, vascular loss and neovascularization. With this model we have explored the role of Hif regulated factors such as VEGF and erythropoietin in vascular survival and the role of omega long chain polyunsaturated fatty acids and IGF-1 missing after preterm birth.
The NIH Director's Wednesday Afternoon Lecture Series includes weekly scientific talks by some of the top researchers in the biomedical sciences worldwide.
Runtime: 00:52:33
Author: Smith, Lois.
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