What do YOU think about the two syntheses? Let me know in the comments! Massive thank you to all channel supporters! instagram.com/totalsynthesis_official/; www.patreon.com/totalsynthesis
4 mg, from 96 kg after 10 columns, and then you have to convince the NMR guys to make good 2D spectra... Thank you for putting huge effort into another brilliant video!
The ingenuity of synthetic chemists never ceases to amaze... Also doing this work.must be a great test of your resilience and character..just think of the many days and months in the lab when all reactions are failing... can be quite soul destroying.
Great video. That purification process the first group did to obtain the natural product from fruit was insane. It was like comically long. I wouldn't want to be the person to have to do all of that hahah. Very impressive. Not to mention those total syntheses were definitely wild rides. Also very impressive.
In The Rych-guy's synthesis, the enol ether D-A reaction is actually very interesting! DBU first deprotonates the unsaturated ketone at the delta-position, then the silyl group captures the oxygens. Then a very facile [1,5]-H migration happens before the cycloaddition, so if you deuterates the ketone alpha-H, you will find it in the single bridge in the product. Came across this in a quiz, and missed it
Maybe I’m being dumb, but should there not be another carbon in the transition state at 5:08? After the diels-alder, the ring on the left seems to be 5 membered, but based on the transition state, it ought to be 4 membered. Also great video, super interesting!
5:37 is it just me or is there an extra carbon coming in out of nowhere for that ring. I’m not too good with organic synthesis but I’m counting more carbons in the diels alder product than there is before the reaction. Am I completely missing something?
@@totalsynthesis right but we are thinking in the right direction. If I drop dead right now I could die knowing we are on the right road. This will only be available to the rich for a while but that's why you befriend a good chemist!
I'm in awe at the patience of this creator.. If you draw out reaction schemes in chem draw, I'm humbled. I'd predict this molecule class would be toxic with all those epoxides.
We may think about how the enzyme in organism that create so much complex molecules with only one stereoisomer they want. That is a good reason that we protect the environment, not to challenge ourselves to acheive the works of the enzymes. All organisms are the master of organic chemist, right?
😂 I hope the first step was ok? For the other stepy, I intentionally did not show every detail or talk too much theory so the video doesnt get too long
@@totalsynthesis not your fault at all! And yes, I did see the ester disconnection. But when it went into the ring contraction pinacol rearrangement my head started hurting.
What do YOU think about the two syntheses? Let me know in the comments!
Massive thank you to all channel supporters! instagram.com/totalsynthesis_official/; www.patreon.com/totalsynthesis
must admit, as a high school student, i barely understood anything yet i found it quite amusing. I'm in awe. chemistry is wonderful.
same lmfao
4 mg, from 96 kg after 10 columns, and then you have to convince the NMR guys to make good 2D spectra... Thank you for putting huge effort into another brilliant video!
The ingenuity of synthetic chemists never ceases to amaze...
Also doing this work.must be a great test of your resilience and character..just think of the many days and months in the lab when all reactions are failing... can be quite soul destroying.
Oh for sure, few things are worse than trying the same step/ reaction for months without success!
The plants man .. the real chemists. They didn't use any glassware or expensive chemicals 😂
I am in awe of chemists
As someone whos doing their bachelors thesis in bioorganic chemistry rn, i’m just in awe… long way to go but wow, if it isn’t worth the ride
Good luck on your thesis 💪
Outstanding!
Thank you!!
Damn! You outdid yourself again. That second synthesis was insane.
Keep up the good work.
Thanks!
Wow just found this channel, what a phenomenal content! I love it, subscribed instantly :)
Awesome man, thanks!
Great video. That purification process the first group did to obtain the natural product from fruit was insane. It was like comically long. I wouldn't want to be the person to have to do all of that hahah. Very impressive. Not to mention those total syntheses were definitely wild rides. Also very impressive.
Thanks mate! I've literally just published a new video that covers quite some chemistry if you are interested!
Always a pleasure. Here's one for the algo
Great content, thank you.
Thanks!
In The Rych-guy's synthesis, the enol ether D-A reaction is actually very interesting! DBU first deprotonates the unsaturated ketone at the delta-position, then the silyl group captures the oxygens. Then a very facile [1,5]-H migration happens before the cycloaddition, so if you deuterates the ketone alpha-H, you will find it in the single bridge in the product. Came across this in a quiz, and missed it
Amazing video as always ❤
🔥🔥🔥
How would you synthesize Alstoscholactine and Alstolaxepine?
Maybe I’m being dumb, but should there not be another carbon in the transition state at 5:08? After the diels-alder, the ring on the left seems to be 5 membered, but based on the transition state, it ought to be 4 membered.
Also great video, super interesting!
Yea very well spotted, they lost one carbon in that drawing :)
Interesting video could you please send me a link to the Illusionism A rat study I would like to check out that paper
Illisimonin A: www.sciencedirect.com/org/science/article/abs/pii/S1523706021016321
Jiadifenolide: pubs.acs.org/doi/10.1021/ol9021029
5:37 is it just me or is there an extra carbon coming in out of nowhere for that ring. I’m not too good with organic synthesis but I’m counting more carbons in the diels alder product than there is before the reaction. Am I completely missing something?
Yes, the authors drew the intermediate just prior to the rxn with a carbon less! (just a slip up)
I have a degenerative brain disease. It's in it's early stages but scary non the less. This is a huge leap in my opinion. Where do I donate?
These molecules are unfortunately years away from pre-clinical research, let alone clinical! All the best
@@totalsynthesis right but we are thinking in the right direction. If I drop dead right now I could die knowing we are on the right road. This will only be available to the rich for a while but that's why you befriend a good chemist!
I'm in awe at the patience of this creator.. If you draw out reaction schemes in chem draw, I'm humbled.
I'd predict this molecule class would be toxic with all those epoxides.
fantastically insightful video as always, quick question do you work in the field of synthetic organic chemistry?
Not anymore!
I hope enzyme chemistry could be used more... so many harsh solvents and reagents.
We may think about how the enzyme in organism that create so much complex molecules with only one stereoisomer they want. That is a good reason that we protect the environment, not to challenge ourselves to acheive the works of the enzymes. All organisms are the master of organic chemist, right?
I would prefer the natural isolation if i was going to ingest🎉
I love organic chemistry and I can't follow literally anything in this retrosynthesis.
😂 I hope the first step was ok?
For the other stepy, I intentionally did not show every detail or talk too much theory so the video doesnt get too long
@@totalsynthesis not your fault at all! And yes, I did see the ester disconnection. But when it went into the ring contraction pinacol rearrangement my head started hurting.
And I thought strychnine synthesis was hard 😂😂😂