Type III hypersensitivity (immune complex mediated) - causes, symptoms & pathology

Поділитися
Вставка
  • Опубліковано 21 лип 2024
  • What is Type III hypersensitivity? Type III hypersensitivity describes when antigen-antibody complexes deposit in the blood vessels and cause subsequent inflammation and tissue damage. Find our full video library only on Osmosis: osms.it/more.
    Join millions of current and future clinicians who learn by Osmosis, along with hundreds of universities around the world who partner with Osmosis from Elseiver to make medical and health education more engaging and efficient. We have unparalleled tools and materials to prepare you for success in school, on your board exams, and as a future clinician. Sign up for a free trial at osms.it/more. If you're interested in exploring an institutional partnership, visit osmosis.org/educators to request a personalized demo.
    Follow us on social:
    Facebook: osms.it/facebook
    Twitter: osms.it/twitter
    Instagram for med: osms.it/instagram
    Instagram for nursing: osms.it/ignursing
    TikTok: osms.it/tiktok
    Linkedin: osms.it/linkedin
    Our Vision: Everyone who cares for someone will learn by Osmosis.
    Our Mission: To empower the world’s clinicians and caregivers with the best learning experience possible. Learn more here: osms.it/mission
    Medical disclaimer: Osmosis from Elsevier does not provide medical advice. Osmosis from Elsevier and the content available on the Osmosis from Elsevier properties (Osmosis.org, UA-cam, and other channels) do not provide a diagnosis or other recommendation for treatment and are not a substitute for the professional judgment of a healthcare professional in diagnosis and treatment of any person or animal. The determination of the need for medical services and the types of healthcare to be provided to a patient are decisions that should be made only by a physician or other licensed healthcare provider. Always seek the advice of a physician or other qualified healthcare professional with any questions you have regarding a medical condition.
    © 2024 Elsevier. All rights reserved.

КОМЕНТАРІ • 127

  • @Ryoko48
    @Ryoko48 5 років тому +396

    I've watched a few of your videos, now everytime I refer to cell degranulation, I have a visual image of a cartoon cell vomiting out granules and enzymes hahahaha. Your illustrations are great

  • @LiquidSwords007
    @LiquidSwords007 4 роки тому +109

    The best thing about this video is that there is special emphasis on the difference between type 2 and type 3, something that confused me a lot

  • @josesolorzano2669
    @josesolorzano2669 5 років тому +63

    "not to play with snakes" that part killed me XD I love these videos so much

  • @syedsaber9666
    @syedsaber9666 Рік тому +16

    3 major differences btw type 2 and type 3
    *Cell surface bound and atigen ab complement system with soluble antigen
    *complement proteins are synthesize in small amount in 2 and in large amount in 3
    *clinical symptoms corresponds to tissue on interacting with antibody in type 2 and in type 3 it is due to deposition of immune comples (ag ab )

  • @ikramzz701
    @ikramzz701 5 років тому +95

    7min more interesting than 1hour and half spent with my teacher in the medical school.

  • @minatsukinana2761
    @minatsukinana2761 4 роки тому +19

    Cant thank you enough *-* I always start with your videos before i read my lectures 💜

  • @osmosis
    @osmosis  5 років тому +94

    Hi everyone, we've updated this video to correct a minor error.

  • @bettinafratto1472
    @bettinafratto1472 3 роки тому +16

    Quick informative and to the point. Great examples and great stress on the differences b/n II and III types. Thank you

  • @gomotsegangngwako6762
    @gomotsegangngwako6762 Рік тому +4

    Detailed yet brief, its brilliant. I watched videos on the three types of hypersensitivity except type 4, can you please direct me to it if its available.

  • @cacarew544
    @cacarew544 5 років тому +6

    Thank u so much. It helps me to have a clearer picture of hypersensitivity

  • @dhuhachouchen6145
    @dhuhachouchen6145 3 роки тому +2

    thank youuuuu your videos made my life as a medical student much easier and fun

  • @dayhanaaldave2193
    @dayhanaaldave2193 4 роки тому

    I really love this, no se me da mucho el ingles, pero sus videos son realmente buenos, todo esta super entendible. Thanks youuu💜

  • @34jayalakshmi36
    @34jayalakshmi36 5 років тому +10

    You r the reason for me to study path...pls upload all pathalogy video

  • @melylacheb
    @melylacheb 9 місяців тому +5

    Life savior as always 🤩✨. I will pass my immunology test this week and u litterally resuled a 1 h lecture in 7 minutes sucessfully 🎉

    • @osmosis
      @osmosis  8 місяців тому

      We hope it went well! 🙏🏼

  • @radhekrishna_lifeline_thak6809
    @radhekrishna_lifeline_thak6809 5 років тому +10

    I LOVE YOU OSMOSIS.... FROM INDIA.. 😀😃😃💟💟💟💟

  • @guljafari3269
    @guljafari3269 4 роки тому +2

    thank you very helpful everytime

  • @ditodewantoros04
    @ditodewantoros04 5 років тому +1

    Sry may i ask, why does neutrofil cant fagocyte immune complex? Thx.

  • @Be1smaht
    @Be1smaht 3 роки тому

    That was great as usual

  • @deffousiheb5031
    @deffousiheb5031 Рік тому

    hi ... first i want to say thank you for your explications .... they'r awsome ... but i have a question .... opsonines will bind to immune complexe or endothelial cells or both ??

  • @abdurrehmantayyab9785
    @abdurrehmantayyab9785 Рік тому +3

    Very good explanation. Sorry to say but i didn't find type 4 hypersensitivity reaction.

  • @elladaye2100
    @elladaye2100 2 роки тому +3

    Such a great video to understand these hypersensitivities

    • @osmosis
      @osmosis  2 роки тому

      Glad you think so, Ella! 😊

  • @emanuele2398
    @emanuele2398 3 роки тому

    Amazing thank you!

  • @allaboutmovies4821
    @allaboutmovies4821 3 роки тому +5

    "Which ultimately teaches a person not to play with snakes" that had me laughing thank you guys.

  • @robertvega5467
    @robertvega5467 3 роки тому +2

    una cosa que haria que muchas nos suscribieramos es que cuando estemos en su plataforma tambien podamos poner subtitulos en español

  • @zubairkkkakar296
    @zubairkkkakar296 2 роки тому

    Very good explanation has been given in this way, it is understandable by explaining ..very nice video very well understood

    • @osmosis
      @osmosis  2 роки тому

      Glad you liked it! 😊

  • @amylouise3789
    @amylouise3789 8 місяців тому

    I am unfortunately suffering from arthritis due to a type III reaction.
    Is there any way to reverse the reaction? I’m about 15 months post the initial onset/reaction to Plavix but still have joint pain!

  • @user-um1fe2fd6b
    @user-um1fe2fd6b 2 роки тому

    Amazing expalantion
    Thank youu really !!

  • @nouhahassam3667
    @nouhahassam3667 3 роки тому +1

    I love you guys , thanks for making it easy and interesting

    • @osmosis
      @osmosis  3 роки тому +2

      Thanks for watching! 🥰🥰🥰

  • @akanshawadekar7430
    @akanshawadekar7430 3 роки тому

    Thank you so much

  • @user-rz6xn4nn2s
    @user-rz6xn4nn2s 5 років тому +1

    Awesome in awesome way

  • @arinarakhteenko579
    @arinarakhteenko579 2 роки тому

    You’ve made awesome videos thank you so much!!

    • @osmosis
      @osmosis  2 роки тому

      Glad you like them! 🙌🏼

  • @Taypha1914
    @Taypha1914 3 роки тому

    Your the GOAT my bro

  • @enoch9019
    @enoch9019 5 років тому +7

    The unsung heroes of UA-cam🙏🏾🙏🏾🙏🏾

  • @zoechang7528
    @zoechang7528 2 роки тому

    So clear and easy to remember with cute image

    • @osmosis
      @osmosis  2 роки тому

      Thanks so much 😊

  • @miranmuslem
    @miranmuslem 11 місяців тому +1

    Thank you for the amazing video!

    • @osmosis
      @osmosis  10 місяців тому +1

      🤓🩺 🙌🏼

  • @lilmamasofly9111
    @lilmamasofly9111 4 роки тому

    Awesome!

  • @richardprah1159
    @richardprah1159 Рік тому

    Great Video. But i have a question for you.
    Please you made a statement at 4:09-4-11 minute that DNA is cationic.
    I only Know of DNA being anionic from the peripheral phosphate groups. So why did you made that statement that DNA is cationic? And for that case of me knowing DNA is anionic, there would be repulsion between it and the anionic basement membranes.
    Can you clarify what actually makes the dna bind to the basement membrane even though both are anionic. What really happens. I need an answer for this please

  • @rashamohammad2170
    @rashamohammad2170 3 роки тому

    informative 🍁

  • @nargismalik6293
    @nargismalik6293 2 роки тому

    Thank you for the amazing videos

    • @osmosis
      @osmosis  2 роки тому

      Always our pleasure. Nargis! 🙌🏼

  • @zakayomsigwa2826
    @zakayomsigwa2826 2 роки тому

    I have already subscribed . Thanks, much love from TZ. 🙏🙏🙏🙏🙏

    • @osmosis
      @osmosis  2 роки тому +1

      Thanks for the sub, Zakayo!

  • @dr.manishadeol6561
    @dr.manishadeol6561 5 років тому

    Can u plz tell me about ur osmosis prime?

  • @nouhahassam3667
    @nouhahassam3667 3 роки тому

    what do you mean by saying that complement levels help you to know about the progress of the pathology

    • @user-jj1nm4sx6w
      @user-jj1nm4sx6w 2 роки тому

      I know that the complement system levels help in classifying an autoimmune disease as lupus Erythematous

  • @jadkousa294
    @jadkousa294 Рік тому +1

    Thanks mate, just saved my ass for my upcoming exam xx

    • @osmosis
      @osmosis  Рік тому

      Glad to help, Jad! 😊

  • @mohamudabdulkadir7215
    @mohamudabdulkadir7215 5 років тому +1

    Hi osmosis , why aren't u grouping videos systemic wise at your channel anymore ? Like all videos of CVS in one place and so on.... infectious diseases at one place .
    This will make reaching videos on the same system easier

    • @osmosis
      @osmosis  5 років тому

      Hi Mohamud, thanks for the interest! Check out our playlists here: osms.it/playlist. These playlists include all of our video content, including complete coverage of physiology and pathophysiology. Many of these videos are not available on UA-cam.

    • @Ur1z13l
      @Ur1z13l 5 років тому

      Not cool removing functionality from UA-cam intentionally so people can pay up.

    • @osmosis
      @osmosis  5 років тому +2

      All of the videos we have published on UA-cam are also free to watch on Osmosis.org!

  • @alexandrerebmann203
    @alexandrerebmann203 Рік тому

    Amazing video thank you so much

    • @osmosis
      @osmosis  Рік тому

      Always our pleasure, Alexandre! ❤️

  • @ibrahimmohammed6385
    @ibrahimmohammed6385 4 роки тому +2

    U the man

  • @sumitrajpurohit7657
    @sumitrajpurohit7657 3 роки тому

    Thanks....love from BHARAT ( INDIA)

  • @safalechkhab609
    @safalechkhab609 2 роки тому

    thank u so much that was helpful

    • @osmosis
      @osmosis  2 роки тому

      You're welcome, Safa! 🙌🏼

  • @user-jz2nx6xt3t
    @user-jz2nx6xt3t 3 роки тому

    You mentioned in your previous video about type two hypersensitivity that the antigen antibody complexes are formed!! 😕 if someone can clarify to me i’ll be thankful

    • @doofenshmirtz4474
      @doofenshmirtz4474 3 роки тому +2

      in type 3 hypersensitivity antibodies (IgG/IgM) attach to soluble antigens forming immune complexes that are circulant in the blood. however, in type 2 hypersensitivity tissular/cellular antigens.
      So in both hypersensitivities, there is the formation of antibody-antigen complexes, except un HS3 the complexes are circulant in the blood (immune complexes).
      I hope I helped a little, English isn't my first language x)

    • @user-jz2nx6xt3t
      @user-jz2nx6xt3t 3 роки тому +1

      Ha Thor
      Yeah you helped alot ❤️
      I need to go over my notes again so i can gather it all .. thanks🙏🏻
      (English is not my first language either.. lol )

  • @user-my8ps8iu2h
    @user-my8ps8iu2h 6 місяців тому

    I can't find Type IV hypersensitivity
    Can you diresy me to the link?

  • @doctorjunaid3924
    @doctorjunaid3924 Рік тому

    The post streptococcus glomerulonephritis comes under type 3 hs but my question is in this condition antigen is already bound to cells of kidney,shouldn’t it be considered as type 2 bec like u said immune complexes are not considered if antigen is bound to cells .?Anyone has answer

    • @muhammadmuaziqbal
      @muhammadmuaziqbal Рік тому

      Antibody is bound to streptococcal antigens and the complex get deposited in the glomeruli. It is not type 2 because streptococcal antigen is not bound to kidney cell, it is a soluble antigen in blood, which later gets deposited. That's my understanding. Correct me if I'm wrong..

  • @jinuannasabu1242
    @jinuannasabu1242 4 місяці тому

    Pls upload type IV

  • @alaaadel8900
    @alaaadel8900 2 роки тому +3

    *اللَّهُمَّ صَلِّ عَلَى سَيِّدِنَا مُحَمَّدٍ نُورِ الْأَنْوَارِ وَسِرِّ الْأَسْرَارِ وَسَيِّدِ الْأَبْرَارِ، وَزَيْنِ الُمرْسَلِينَ الْأَخْيَارِ وَأَكْرَمِ مَنْ أَظْلَمَ عَلَيْهِ اللَّيْلُ وَأَشْرَقَ عَلَيْهِ النَّهَارُ، وَعَدَدَ مَا نَزَلَ مِنْ أَوَّلِ الدُّنْيَا إِلَى آخِرِهَا مِنْ قَطْرِ الْأَمْطَارِ ،وَعَدَدَ مَا نَبَتَ مِنْ أَوَّلِ الدُّنْيَا إِلَى آخِرِهَا مِنَ النَّبَاتِ وَالْأَشْجَارِ صَلَاةً دَائِمَةً بِدَوَامِ مُلْكِ اللَّـهِ الْوَاحِدِ الْقَهَّارِ.**اللهم صل على سيدنا محمد وعلى اله وصحبه وسلم تسليما كثيرا عدد خلقك و رضا نفسك وزنة عرشك ومداد كلماتك و عدد ما كان وعدد ما سيكون وعدد الحركات والسكون.*

  • @sachitpatil9061
    @sachitpatil9061 4 роки тому

    Perfect

  • @susanahernandez6893
    @susanahernandez6893 4 місяці тому

    The differences between type 2 and 3, are: complement proteins are synthesize in small amount in 2 and in large amount in 3, clinical symptoms corresponds to tissue on interacting with antibody in type 2 and in type 3 it is due to deposition of immune comples (ag ab ). And the inmune complexes get in the blood vessel, depending in different features: the size of the inmune complexes, the isotype of the Ig, characteristics of the blood flow, the quantity of the inmune complexes and the antigen load (which is possitive).

  • @malathali8658
    @malathali8658 3 роки тому

    عاشت ايدكم

  • @115afreen3
    @115afreen3 5 років тому +26

    Don't play with the same snake twice 🐍🐍

    • @crystalss8354
      @crystalss8354 5 років тому

      anfere sompink متتت😂😂😂

  • @Nothing-es5nk
    @Nothing-es5nk 5 років тому

    Awesome

  • @Kyujinie
    @Kyujinie 2 роки тому

    thank u so much

    • @osmosis
      @osmosis  2 роки тому

      You're welcome, Alex! 😊

  • @mdzahikhalid404
    @mdzahikhalid404 5 років тому +2

    Nice lecture.u already mention in early vedeos hyper 1 , hyper 2 hyper 3....i am from india....hyderabad

  • @EMTako
    @EMTako 2 роки тому +1

    Most important lesson, don’t play with snakes. Lolz

  • @foxykira2005
    @foxykira2005 Рік тому

    You're website is down?

    • @osmosis
      @osmosis  Рік тому +1

      Hi! We don't get to regularly check our comments here but you may send us an email (support@osmosis.org) anytime and our team will be glad to assist you with your concerns. 🙏🏼

  • @farazahmadnoor6840
    @farazahmadnoor6840 Рік тому

    @osmosis... Plz check why this video isn't playable

    • @osmosis
      @osmosis  Рік тому

      Hi Faraz! If you're having issues with our videos, kindly contact support@osmosis.org so that our team can better assist you. 🙏🏼

  • @zamraabdi3561
    @zamraabdi3561 5 років тому

    I love u keeep going is the only channel that i'm easy to understand the videos 😍😍😍😍😘😘😘😘

  • @ShahzaibAli-og6st
    @ShahzaibAli-og6st 2 роки тому

    Good

    • @osmosis
      @osmosis  2 роки тому

      Thanks, Shahzaib! 🙏🏼

  • @Lina-hi5ji
    @Lina-hi5ji 5 років тому +3

    Thank you Osmosis. Love from Peru

  • @shards8300
    @shards8300 3 роки тому +2

    life saver of med and dent students

    • @osmosis
      @osmosis  3 роки тому

      Glad to be of help! 😊

  • @anabyakhan160
    @anabyakhan160 2 роки тому +1

    Which ultimately teach the person not to play with snakes 😂😂😂😂😂 that was good

  • @penelopelambson9128
    @penelopelambson9128 4 роки тому

    Need a hard copy of this.

  • @user-gn2un1de9n
    @user-gn2un1de9n 5 місяців тому

    From where i get this notes ??????????

    • @osmosis
      @osmosis  5 місяців тому

      Hi! We have high-yield notes that you can access over at osmosis.org 😊

  • @sweetta2596
    @sweetta2596 2 роки тому

    I just graded 30%/100 cuz of this video. I told to teacher that serum sickness can cause of snake, and he said that "serum sickness causing of snake is impossible. It's other reaction of snake toxicity, u're so wrong." :( guys which one is right ? pls respond me

  • @Arendt-Foucault
    @Arendt-Foucault 4 роки тому

    Hahahahaha.. which will ultimately teach a person NOT TO PALY a SNAKE 🤣

  • @fadiwassouf739
    @fadiwassouf739 Рік тому +1

    Moral of the story: don't play with snakes

  • @mewmannamwem6087
    @mewmannamwem6087 3 роки тому

    Bro... my university's "homework giver" sucks .... !@#$ .... why i dont have teachers like this :/

  • @mahesm2604
    @mahesm2604 5 років тому

    There is no playlist ???😐😐😐

    • @osmosis
      @osmosis  5 років тому

      Hi Human, thanks for the interest! Check out our playlists here: osms.it/playlist. These playlists include all of our high-yield content, not just the videos available on UA-cam.

    • @mahesm2604
      @mahesm2604 5 років тому

      Thank you so much 😊😊😊

  • @lucian6257
    @lucian6257 Рік тому

    Where is type4?🥺

  • @suriosha
    @suriosha 2 роки тому

    ♥️

  • @adamstonebraker5532
    @adamstonebraker5532 6 місяців тому

    yo dawg, I heard you like antibodies, so we put antibodies on your antibodies! -Xzibit on serum sickness, probably

  • @76sohamingavale42
    @76sohamingavale42 Рік тому

    Full form of PAN anyone???

  • @happypaul7966
    @happypaul7966 2 роки тому

    serum sickness usmle

  • @ahmedhesham2096
    @ahmedhesham2096 2 роки тому

    Don't play with snakes, noted

  • @Everydayimmoonwalkin
    @Everydayimmoonwalkin Рік тому

    Pls don’t tell me type 4 needs that subscription thing

  • @nablesbenarous9682
    @nablesbenarous9682 7 місяців тому

    🇩🇿🇩🇿🇩🇿🇩🇿

  • @khuziwesithole6719
    @khuziwesithole6719 Рік тому

    Why do the cells look so evil😂😂😂😂😂😂

  • @user-jj1nm4sx6w
    @user-jj1nm4sx6w 2 роки тому

    This video is so incomplete and somethings are not explained good ..

    • @osmosis
      @osmosis  2 роки тому

      Hi! Thanks for your feedback. We'd love to hear more from you as to how we can improve our content. If you can, please get in touch with support@osmosis.org 🙏🏼

  • @blackyme2889
    @blackyme2889 3 роки тому

    which will teach a person not to play with snikes 😂😂😂

  • @MusicIsMyLife31x
    @MusicIsMyLife31x Рік тому

    no type 4? T__T ahh

  • @jinsu0504
    @jinsu0504 Рік тому

    text goes on and on 40 pages of gibberish and this guy explains the whole chapter and then some more in just 7 minutes... sigh.

    • @osmosis
      @osmosis  Рік тому

      We hope that our video was able to help, Matthew! 🙏🏼

  • @bluemoon78296
    @bluemoon78296 Рік тому

    Please speak slower

    • @osmosis
      @osmosis  Рік тому

      Sorry about this, Sandra. You may adjust the playback speed of the video by clicking in the cog icon/settings button on the lower part of the video player. 🙏🏼

  • @ghassanauf8103
    @ghassanauf8103 4 роки тому

    Try to read your lecture slowly , the best way to learn is teaching , and you’re teaching nothing

  • @leena02nu76
    @leena02nu76 Рік тому

    sounds like Type 4 doesn’t exist to him🥲