Type III hypersensitivity (immune complex mediated) - causes, symptoms & pathology

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  • Опубліковано 16 гру 2024

КОМЕНТАРІ • 132

  • @Ryoko48
    @Ryoko48 5 років тому +436

    I've watched a few of your videos, now everytime I refer to cell degranulation, I have a visual image of a cartoon cell vomiting out granules and enzymes hahahaha. Your illustrations are great

  • @LiquidSwords007
    @LiquidSwords007 4 роки тому +120

    The best thing about this video is that there is special emphasis on the difference between type 2 and type 3, something that confused me a lot

  • @osmosis
    @osmosis  6 років тому +99

    Hi everyone, we've updated this video to correct a minor error.

  • @josesolorzano2669
    @josesolorzano2669 6 років тому +67

    "not to play with snakes" that part killed me XD I love these videos so much

  • @ikramzz701
    @ikramzz701 5 років тому +100

    7min more interesting than 1hour and half spent with my teacher in the medical school.

  • @syedsaber9666
    @syedsaber9666 Рік тому +17

    3 major differences btw type 2 and type 3
    *Cell surface bound and atigen ab complement system with soluble antigen
    *complement proteins are synthesize in small amount in 2 and in large amount in 3
    *clinical symptoms corresponds to tissue on interacting with antibody in type 2 and in type 3 it is due to deposition of immune comples (ag ab )

  • @minatsukinana2761
    @minatsukinana2761 4 роки тому +19

    Cant thank you enough *-* I always start with your videos before i read my lectures 💜

  • @melylacheb
    @melylacheb Рік тому +6

    Life savior as always 🤩✨. I will pass my immunology test this week and u litterally resuled a 1 h lecture in 7 minutes sucessfully 🎉

    • @osmosis
      @osmosis  Рік тому

      We hope it went well! 🙏🏼

  • @enoch9019
    @enoch9019 5 років тому +8

    The unsung heroes of UA-cam🙏🏾🙏🏾🙏🏾

  • @34jayalakshmi36
    @34jayalakshmi36 6 років тому +10

    You r the reason for me to study path...pls upload all pathalogy video

  • @dhuhachouchen6145
    @dhuhachouchen6145 4 роки тому +2

    thank youuuuu your videos made my life as a medical student much easier and fun

  • @bettinafratto1472
    @bettinafratto1472 4 роки тому +16

    Quick informative and to the point. Great examples and great stress on the differences b/n II and III types. Thank you

  • @abdurrehmantayyab9785
    @abdurrehmantayyab9785 2 роки тому +5

    Very good explanation. Sorry to say but i didn't find type 4 hypersensitivity reaction.

  • @radhekrishna_lifeline_thak6809
    @radhekrishna_lifeline_thak6809 6 років тому +10

    I LOVE YOU OSMOSIS.... FROM INDIA.. 😀😃😃💟💟💟💟

  • @cacarew544
    @cacarew544 6 років тому +6

    Thank u so much. It helps me to have a clearer picture of hypersensitivity

  • @jinuannasabu1242
    @jinuannasabu1242 9 місяців тому +4

    Pls upload type IV

  • @gomotsegangngwako6762
    @gomotsegangngwako6762 Рік тому +4

    Detailed yet brief, its brilliant. I watched videos on the three types of hypersensitivity except type 4, can you please direct me to it if its available.

  • @allaboutmovies4821
    @allaboutmovies4821 4 роки тому +5

    "Which ultimately teaches a person not to play with snakes" that had me laughing thank you guys.

  • @susanahernandez6893
    @susanahernandez6893 9 місяців тому

    The differences between type 2 and 3, are: complement proteins are synthesize in small amount in 2 and in large amount in 3, clinical symptoms corresponds to tissue on interacting with antibody in type 2 and in type 3 it is due to deposition of immune comples (ag ab ). And the inmune complexes get in the blood vessel, depending in different features: the size of the inmune complexes, the isotype of the Ig, characteristics of the blood flow, the quantity of the inmune complexes and the antigen load (which is possitive).

  • @goldenlight2277
    @goldenlight2277 2 місяці тому

    It was very understable and captured the whole essence of the concept. 14th Oct 2024. Many thanks.

  • @elladaye2100
    @elladaye2100 3 роки тому +3

    Such a great video to understand these hypersensitivities

    • @osmosis
      @osmosis  3 роки тому

      Glad you think so, Ella! 😊

  • @alaaadel8900
    @alaaadel8900 3 роки тому +3

    *اللَّهُمَّ صَلِّ عَلَى سَيِّدِنَا مُحَمَّدٍ نُورِ الْأَنْوَارِ وَسِرِّ الْأَسْرَارِ وَسَيِّدِ الْأَبْرَارِ، وَزَيْنِ الُمرْسَلِينَ الْأَخْيَارِ وَأَكْرَمِ مَنْ أَظْلَمَ عَلَيْهِ اللَّيْلُ وَأَشْرَقَ عَلَيْهِ النَّهَارُ، وَعَدَدَ مَا نَزَلَ مِنْ أَوَّلِ الدُّنْيَا إِلَى آخِرِهَا مِنْ قَطْرِ الْأَمْطَارِ ،وَعَدَدَ مَا نَبَتَ مِنْ أَوَّلِ الدُّنْيَا إِلَى آخِرِهَا مِنَ النَّبَاتِ وَالْأَشْجَارِ صَلَاةً دَائِمَةً بِدَوَامِ مُلْكِ اللَّـهِ الْوَاحِدِ الْقَهَّارِ.**اللهم صل على سيدنا محمد وعلى اله وصحبه وسلم تسليما كثيرا عدد خلقك و رضا نفسك وزنة عرشك ومداد كلماتك و عدد ما كان وعدد ما سيكون وعدد الحركات والسكون.*

  • @guljafari3269
    @guljafari3269 5 років тому +2

    thank you very helpful everytime

  • @jadkousa294
    @jadkousa294 2 роки тому +1

    Thanks mate, just saved my ass for my upcoming exam xx

    • @osmosis
      @osmosis  2 роки тому

      Glad to help, Jad! 😊

  • @sumitrajpurohit7657
    @sumitrajpurohit7657 3 роки тому

    Thanks....love from BHARAT ( INDIA)

  • @robertvega5467
    @robertvega5467 4 роки тому +2

    una cosa que haria que muchas nos suscribieramos es que cuando estemos en su plataforma tambien podamos poner subtitulos en español

  • @miranmuslem
    @miranmuslem Рік тому +1

    Thank you for the amazing video!

    • @osmosis
      @osmosis  Рік тому +1

      🤓🩺 🙌🏼

  • @zoechang7528
    @zoechang7528 2 роки тому

    So clear and easy to remember with cute image

    • @osmosis
      @osmosis  2 роки тому

      Thanks so much 😊

  • @115afreen3
    @115afreen3 6 років тому +25

    Don't play with the same snake twice 🐍🐍

    • @crystalss8354
      @crystalss8354 5 років тому

      anfere sompink متتت😂😂😂

  • @shards8300
    @shards8300 3 роки тому +2

    life saver of med and dent students

    • @osmosis
      @osmosis  3 роки тому

      Glad to be of help! 😊

  • @richardprah1159
    @richardprah1159 Рік тому

    Great Video. But i have a question for you.
    Please you made a statement at 4:09-4-11 minute that DNA is cationic.
    I only Know of DNA being anionic from the peripheral phosphate groups. So why did you made that statement that DNA is cationic? And for that case of me knowing DNA is anionic, there would be repulsion between it and the anionic basement membranes.
    Can you clarify what actually makes the dna bind to the basement membrane even though both are anionic. What really happens. I need an answer for this please

  • @dayhanaaldave2193
    @dayhanaaldave2193 4 роки тому

    I really love this, no se me da mucho el ingles, pero sus videos son realmente buenos, todo esta super entendible. Thanks youuu💜

  • @nouhahassam3667
    @nouhahassam3667 3 роки тому +1

    I love you guys , thanks for making it easy and interesting

    • @osmosis
      @osmosis  3 роки тому +2

      Thanks for watching! 🥰🥰🥰

  • @Be1smaht
    @Be1smaht 4 роки тому

    That was great as usual

  • @Taypha1914
    @Taypha1914 3 роки тому

    Your the GOAT my bro

  • @そよ風ナシマ
    @そよ風ナシマ 3 роки тому

    Amazing expalantion
    Thank youu really !!

  • @deffousiheb5031
    @deffousiheb5031 Рік тому

    hi ... first i want to say thank you for your explications .... they'r awsome ... but i have a question .... opsonines will bind to immune complexe or endothelial cells or both ??

  • @mdzahikhalid404
    @mdzahikhalid404 6 років тому +2

    Nice lecture.u already mention in early vedeos hyper 1 , hyper 2 hyper 3....i am from india....hyderabad

  • @zubairkkkakar296
    @zubairkkkakar296 2 роки тому

    Very good explanation has been given in this way, it is understandable by explaining ..very nice video very well understood

    • @osmosis
      @osmosis  2 роки тому

      Glad you liked it! 😊

  • @akanshawadekar7430
    @akanshawadekar7430 3 роки тому

    Thank you so much

  • @Lina-hi5ji
    @Lina-hi5ji 6 років тому +3

    Thank you Osmosis. Love from Peru

  • @emanuele2398
    @emanuele2398 4 роки тому

    Amazing thank you!

  • @mohamudabdulkadir7215
    @mohamudabdulkadir7215 6 років тому +1

    Hi osmosis , why aren't u grouping videos systemic wise at your channel anymore ? Like all videos of CVS in one place and so on.... infectious diseases at one place .
    This will make reaching videos on the same system easier

    • @osmosis
      @osmosis  6 років тому

      Hi Mohamud, thanks for the interest! Check out our playlists here: osms.it/playlist. These playlists include all of our video content, including complete coverage of physiology and pathophysiology. Many of these videos are not available on UA-cam.

    • @Ur1z13l
      @Ur1z13l 6 років тому

      Not cool removing functionality from UA-cam intentionally so people can pay up.

    • @osmosis
      @osmosis  6 років тому +2

      All of the videos we have published on UA-cam are also free to watch on Osmosis.org!

  • @alexandrerebmann203
    @alexandrerebmann203 2 роки тому

    Amazing video thank you so much

    • @osmosis
      @osmosis  2 роки тому

      Always our pleasure, Alexandre! ❤️

  • @arinarakhteenko579
    @arinarakhteenko579 2 роки тому

    You’ve made awesome videos thank you so much!!

    • @osmosis
      @osmosis  2 роки тому

      Glad you like them! 🙌🏼

  • @user-rz6xn4nn2s
    @user-rz6xn4nn2s 5 років тому +1

    Awesome in awesome way

  • @nargismalik6293
    @nargismalik6293 2 роки тому

    Thank you for the amazing videos

    • @osmosis
      @osmosis  2 роки тому

      Always our pleasure. Nargis! 🙌🏼

  • @zakayomsigwa2826
    @zakayomsigwa2826 3 роки тому

    I have already subscribed . Thanks, much love from TZ. 🙏🙏🙏🙏🙏

    • @osmosis
      @osmosis  3 роки тому +1

      Thanks for the sub, Zakayo!

  • @foxykira2005
    @foxykira2005 2 роки тому

    You're website is down?

    • @osmosis
      @osmosis  2 роки тому +1

      Hi! We don't get to regularly check our comments here but you may send us an email (support@osmosis.org) anytime and our team will be glad to assist you with your concerns. 🙏🏼

  • @amylouise3789
    @amylouise3789 Рік тому

    I am unfortunately suffering from arthritis due to a type III reaction.
    Is there any way to reverse the reaction? I’m about 15 months post the initial onset/reaction to Plavix but still have joint pain!

  • @nouhahassam3667
    @nouhahassam3667 3 роки тому

    what do you mean by saying that complement levels help you to know about the progress of the pathology

    • @헤린송-o7i
      @헤린송-o7i 3 роки тому

      I know that the complement system levels help in classifying an autoimmune disease as lupus Erythematous

  • @ditodewantoros04
    @ditodewantoros04 6 років тому +1

    Sry may i ask, why does neutrofil cant fagocyte immune complex? Thx.

  • @rashamohammad2170
    @rashamohammad2170 3 роки тому

    informative 🍁

  • @anabyakhan160
    @anabyakhan160 2 роки тому +1

    Which ultimately teach the person not to play with snakes 😂😂😂😂😂 that was good

  • @ibrahimmohammed6385
    @ibrahimmohammed6385 4 роки тому +2

    U the man

  • @EMTako
    @EMTako 3 роки тому +1

    Most important lesson, don’t play with snakes. Lolz

  • @MAON2000
    @MAON2000 3 роки тому

    عاشت ايدكم

  • @salmanafisah-l6g
    @salmanafisah-l6g 2 місяці тому

    can 1 get the source?

  • @doctorjunaid3924
    @doctorjunaid3924 2 роки тому

    The post streptococcus glomerulonephritis comes under type 3 hs but my question is in this condition antigen is already bound to cells of kidney,shouldn’t it be considered as type 2 bec like u said immune complexes are not considered if antigen is bound to cells .?Anyone has answer

  • @user-jz2nx6xt3t
    @user-jz2nx6xt3t 4 роки тому

    You mentioned in your previous video about type two hypersensitivity that the antigen antibody complexes are formed!! 😕 if someone can clarify to me i’ll be thankful

    • @doofenshmirtz4474
      @doofenshmirtz4474 4 роки тому +2

      in type 3 hypersensitivity antibodies (IgG/IgM) attach to soluble antigens forming immune complexes that are circulant in the blood. however, in type 2 hypersensitivity tissular/cellular antigens.
      So in both hypersensitivities, there is the formation of antibody-antigen complexes, except un HS3 the complexes are circulant in the blood (immune complexes).
      I hope I helped a little, English isn't my first language x)

    • @user-jz2nx6xt3t
      @user-jz2nx6xt3t 4 роки тому +1

      Ha Thor
      Yeah you helped alot ❤️
      I need to go over my notes again so i can gather it all .. thanks🙏🏻
      (English is not my first language either.. lol )

  • @ouz314
    @ouz314 2 місяці тому +1

    Where is type lV

  • @lilmamasofly9111
    @lilmamasofly9111 5 років тому

    Awesome!

  • @Themiseriedmo
    @Themiseriedmo 10 місяців тому

    From where i get this notes ??????????

    • @osmosis
      @osmosis  10 місяців тому

      Hi! We have high-yield notes that you can access over at osmosis.org 😊

  • @EstherOkebule
    @EstherOkebule 11 місяців тому

    I can't find Type IV hypersensitivity
    Can you diresy me to the link?

  • @Kyujinie
    @Kyujinie 2 роки тому

    thank u so much

    • @osmosis
      @osmosis  2 роки тому

      You're welcome, Alex! 😊

  • @sachitpatil9061
    @sachitpatil9061 4 роки тому

    Perfect

  • @Official-VickyKhanna
    @Official-VickyKhanna 2 місяці тому

    Good

    • @osmosis
      @osmosis  2 місяці тому

      Thanks! ❤️

  • @ShahzaibAli-og6st
    @ShahzaibAli-og6st 2 роки тому

    Good

    • @osmosis
      @osmosis  2 роки тому

      Thanks, Shahzaib! 🙏🏼

  • @fadiwassouf739
    @fadiwassouf739 Рік тому +1

    Moral of the story: don't play with snakes

  • @dr.manishadeol6561
    @dr.manishadeol6561 5 років тому

    Can u plz tell me about ur osmosis prime?

  • @Sweetapopp
    @Sweetapopp 3 роки тому

    I just graded 30%/100 cuz of this video. I told to teacher that serum sickness can cause of snake, and he said that "serum sickness causing of snake is impossible. It's other reaction of snake toxicity, u're so wrong." :( guys which one is right ? pls respond me

  • @zamraabdi3561
    @zamraabdi3561 6 років тому

    I love u keeep going is the only channel that i'm easy to understand the videos 😍😍😍😍😘😘😘😘

  • @farazahmadnoor6840
    @farazahmadnoor6840 Рік тому

    @osmosis... Plz check why this video isn't playable

    • @osmosis
      @osmosis  Рік тому

      Hi Faraz! If you're having issues with our videos, kindly contact support@osmosis.org so that our team can better assist you. 🙏🏼

  • @Nothing-es5nk
    @Nothing-es5nk 5 років тому

    Awesome

  • @khuziwesithole6719
    @khuziwesithole6719 2 роки тому

    Why do the cells look so evil😂😂😂😂😂😂

  • @Arendt-Foucault
    @Arendt-Foucault 4 роки тому

    Hahahahaha.. which will ultimately teach a person NOT TO PALY a SNAKE 🤣

  • @penelopelambson9128
    @penelopelambson9128 5 років тому

    Need a hard copy of this.

  • @mewmannamwem6087
    @mewmannamwem6087 4 роки тому

    Bro... my university's "homework giver" sucks .... !@#$ .... why i dont have teachers like this :/

  • @lucian6257
    @lucian6257 2 роки тому

    Where is type4?🥺

  • @anasbendahou7722
    @anasbendahou7722 15 днів тому

    Type 4 😢

  • @ahmedhesham2096
    @ahmedhesham2096 2 роки тому

    Don't play with snakes, noted

  • @blackyme2889
    @blackyme2889 3 роки тому

    which will teach a person not to play with snikes 😂😂😂

  • @76sohamingavale42
    @76sohamingavale42 2 роки тому

    Full form of PAN anyone???

  • @adamstonebraker5532
    @adamstonebraker5532 11 місяців тому

    yo dawg, I heard you like antibodies, so we put antibodies on your antibodies! -Xzibit on serum sickness, probably

  • @Everydayimmoonwalkin
    @Everydayimmoonwalkin Рік тому

    Pls don’t tell me type 4 needs that subscription thing

  • @happypaul7966
    @happypaul7966 2 роки тому

    serum sickness usmle

  • @헤린송-o7i
    @헤린송-o7i 3 роки тому

    This video is so incomplete and somethings are not explained good ..

    • @osmosis
      @osmosis  3 роки тому

      Hi! Thanks for your feedback. We'd love to hear more from you as to how we can improve our content. If you can, please get in touch with support@osmosis.org 🙏🏼

  • @suriosha
    @suriosha 3 роки тому

    ♥️

  • @mahesm2604
    @mahesm2604 6 років тому

    There is no playlist ???😐😐😐

    • @osmosis
      @osmosis  6 років тому

      Hi Human, thanks for the interest! Check out our playlists here: osms.it/playlist. These playlists include all of our high-yield content, not just the videos available on UA-cam.

    • @mahesm2604
      @mahesm2604 6 років тому

      Thank you so much 😊😊😊

  • @jinsu0504
    @jinsu0504 2 роки тому

    text goes on and on 40 pages of gibberish and this guy explains the whole chapter and then some more in just 7 minutes... sigh.

    • @osmosis
      @osmosis  2 роки тому

      We hope that our video was able to help, Matthew! 🙏🏼

  • @MusicIsMyLife31x
    @MusicIsMyLife31x 2 роки тому

    no type 4? T__T ahh

  • @nablesbenarous9682
    @nablesbenarous9682 Рік тому

    🇩🇿🇩🇿🇩🇿🇩🇿

  • @bluemoon78296
    @bluemoon78296 Рік тому

    Please speak slower

    • @osmosis
      @osmosis  Рік тому

      Sorry about this, Sandra. You may adjust the playback speed of the video by clicking in the cog icon/settings button on the lower part of the video player. 🙏🏼

  • @ghassanauf8103
    @ghassanauf8103 4 роки тому

    Try to read your lecture slowly , the best way to learn is teaching , and you’re teaching nothing

  • @leena02nu76
    @leena02nu76 Рік тому

    sounds like Type 4 doesn’t exist to him🥲

  • @safalechkhab609
    @safalechkhab609 2 роки тому

    thank u so much that was helpful

    • @osmosis
      @osmosis  2 роки тому

      You're welcome, Safa! 🙌🏼