Case Study: Discovery of an early diagnostic biomarker for NASH

Nonalcoholic steatohepatitis (NASH) is a complex, multifactorial metabolic disorder, influenced by both genetic and environmental factors. While genetic variants linked to NASH heritability have been discovered, our understanding of the pathophysiology that underlies progression from NAFLD to NASH is still incomplete. This case study describes the discovery of a small molecule biomarker that provides an early diagnostic for NASH by predicting disease development more than 10 years in advance.