Methionine Restriction Extends Lifespan: Roles For SCFAs And FGF21, But Not Calorie Restriction
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- Опубліковано 14 жов 2024
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Papers referenced in the video:
Dietary Methionine via Dose-Dependent Inhibition of Short-Chain Fatty Acid Production Capacity Contributed to a Potential Risk of Cognitive Dysfunction in Mice
pubmed.ncbi.nl...
Life-Span Extension in Mice by Preweaning Food Restriction and by Methionine Restriction in Middle Age
pubmed.ncbi.nl...
Changes in the gut microbiome and fermentation products concurrent with enhanced longevity in acarbose-treated mice
pubmed.ncbi.nl...
Methionine-deficient diet extends mouse lifespan, slows immune and lens aging, alters glucose, T4, IGF-I and insulin levels, and increases hepatocyte MIF levels and stress resistance
pubmed.ncbi.nl...
Acarbose, 17-α-estradiol, and nordihydroguaiaretic acid extend mouse lifespan preferentially in males
pubmed.ncbi.nl...
The starvation hormone, fibroblast growth factor-21, extends lifespan in mice
pubmed.ncbi.nl...
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Once again you prove (sort of) that Butyrate is they key to life extension. Love your work, keep it coming.
Thanks Goran. SCFAs are totally underrated in terms of health (and potentially longevity), and will do!
@@conqueragingordietrying123 I am a bit flabbergasted that we don't hear more from the science community regarding SCFA's, all your detailed work regarding this observation clearly shows that there is a connection with SCFA's and longevity. If the SCFA's are made by fermenting fiber in the lower intestines or not, this is really interesting. Extended release Butyrate supplement pill could be the holy grail everyone is looking for?
Great video, have you looked to see how your methionine intake correlates with changes in your epigenetic age and blood bio markers? Looks like Brazil nuts and sardines are the only foods you eat that are considered high methionine.
Thanks Tyler, and not yet, but once I have enough epigenetic data, I'll definitely do that. Sardines (~0.8g/d) and yogurt (0.2g/d) are my largest sources, with smaller contributions from brazil nuts, oats, corn and others each at 0.1g/d..
What does the 0.15% methionine, represent? Cronometer says the RDA is 0.4g. On a 2000c diet, I get 0.9g every day (or 197%) of what's recommended. This is on a vegan diet. Is the 0.15% methionine of the mice study the amount in total grams or of calories consumed? or is it a comparison over the RDA?
0.15% = grams of methionine *4/daily calorie intake. Note that cronometer doesn't have methionine intake for all foods, so you may want to look at your list in cronometer to make sure cronometer shows that data for each food.
There's usually a big difference between the RDA, which is the minimum intended to reduce disease risk, and what's optimal for health and longevity. The RDA wasn't designed for the latter.
@@conqueragingordietrying123 I guess I’m still trying to understand. So are you taking 4 (representing 1.0 gram times 4 calories per gram of methionine consumed) divided by the total calorie intake? So 4/2000, for example, would give you 0.002 or 0.2%? Seems hard to do that in calories and it’s such a small number. So, if I consume 0.9g of methionine on a 2000 calorie diet, would that be 0.9*4/2000, or 0.18%? If so, I guess I’m restricted unless there are lots of items where methionine is underrepresented. I try to only use generic food descriptions and look for the ones with the most numbers filled in.
@@Nof1LongevityQuest You got it exactly, Gail!
@@conqueragingordietrying123 Methionine is 6.06 kcal/g, not 4. See Livesey & Elia 1988. 10.1093/ajcn/47.4.608
@@erastvandoren Thanks Erast Van Doren. Methionine is mentioned 2x in that paper, but I don't see where you're getting 6.06 kcal/g. Can you please explain?
Nice one! Curious about if there’s a comparison between protein restriction and methionine in particular.
Thanks Vedran. I put that data into Part 2 of today's video, but here it is, too: in my data, methionine intake is significantly correlated with overall protein intake (r = 0.94, p=2E-19).
Methylmalonic acid from protein metabolism is affected by b12, folate, and b2 status.
High protein diets don't lower lifespan if you have the right cofactors for metabolism for protein by products and amino acid metabolism.
FGF21 and 23/Klotho are involved in nutrient sensing for phosphorus and calcium. Less to do with high protein or methionine level, more to do with parathyroid hormone and tetrahydrobiopterin function.
Anything moderate is good, thanks for the great content!
You got a riboflavin, p5p, and b12 status to go along with methionine levels.
for the love of God, do a colab with Physionic, you both have amazing data/minds and i bet it would be great.
Thanks sabin cioflec. His channel is new to me, but I'll check it out!
@@conqueragingordietrying123 He is not that well known but has a sharp mind and has awesome study reviews. You two overlap on some stuff but not on another, would be a cool conversation and you both get exposure.
Can 10g glycine supplementation per day emulate methionine restriction?
not sure
I think chris masterjohn talks about this a lot, glycine and glynac have showed better lifespan+better inflammatory markers. From my point of view methionine increases the needs for cofactors but is overall healthy. Most people are just glycine deficient, and paired up with too much methionine it leads to unhealthy results.
Also you get a lot of scfa from ketosis and there are several studies that show you don't need fiber and that your body can have higher inflammation from it, we are not herbivores. This study is poop :))
What evidence do you have that humans are not herbivores? We certainly are not carnivores. My guess is that humans evolved to be omnivores, like bears.
@@jamesherried9269 There is no suggestion of going pure herbivore in the video
@@conqueragingordietrying123 Yes, I listened to the entire video. I made that reply in response to one of the other comments, in which it was stated that humans are not herbivores, and that eating fiber isn't that important for humans.
Don't know how you concluded they weren't calorie restricted if they were significantly leaner on low methionine even if food volume was higher. Either they consumed less calories (possible since diet composition would be significantly different with such low protein) or they were more active.
We would need a direct comparison of CR vs CR + MetR to see if methionine restriction has an independent effect
Eating more food = not calorie restricted-the only thing that differed between diets was methionine intake. I agree about a direct comparison of CR vs CR + MetR to see.
@@conqueragingordietrying123 They must have either eaten fewer calories or used up more calories. Thermodynamics dictates there is no other way
@@bobbobson4030 Yes of course-they didn't eat fewer calories, but instead, thermogenesis was likely increased. For example, see:
pubmed.ncbi.nlm.nih.gov/28096260/
Bryan Johnson is doing a calorie and methionine restriction. He looks a bit uncanny now compared to before and supplements with testosterone to counteract the current deficiency.
I'm waiting.
How does this work with human beings?
Some of that is the Patreon-specific video, i.e the balance between methionine/protein intake and muscle mass in people...
So methionine restriction can be achieved using a predominately vegan diet.
It would have to be a low-protein vegan diet, but I'm not sure that would translate into optimal health in people. For me, I favor a balance between methionine intake, overall protein intake, and muscle mass:
www.patreon.com/posts/methionine-whats-75488565
@@conqueragingordietrying123 ua-cam.com/video/RiJAUNNgsSU/v-deo.html
Well I’m not changing my diet, so what do I have to take to achieve lower Methionine?
Oh, that’s right I won’t learn any conclusions here unless I pay money for a Patreon. Figures.
For this video, I temporarily added an extra Patreon tier that included my methionine intake data. I've since deleted that tier.
The conclusions are for you to decide in terms of limiting methionine intake or not. There's plenty of free content (at my expense) on this channel for others to decide if it's valuable or not.
@@conqueragingordietrying123Low protein. high dairy fat keto combined with a strict 20:4 IF and 72 hour bulletproof FMD cycles would be the gold standard for restricting the amino acid pool and Mtor Activity. - Meat based KD sprinter
> I’m not changing my diet ... I won’t learn any conclusions here ...
Hmm...
Is it then correct to say that a ketogenic diet reduces methionine?
ketogenic diet can be formulated in a lot of different ways, methionine is part of protein and most protein is in animal meat. So a high animal meat+fat diet is ketogenic, but so is a avocado/nuts/olive oil/veggies diet that is very low. Ketosis is just high--ish fat low carbs low/medium protein.
@@sabincioflec8413 thank you for the reply (sorry for my delayed reply). So in short: low carb, high fat, lowish protein would be better to decrease methionine and improve lifespan
@@andrewf.7813 yeap, now how to go about it, meaning what's healthy to eat it's heard to know exactly. Methionine seems to be balanced by glycine, so if you eat enough collagen ( that contains glycine ) it shouldn't be that bad for you.
A body not creating more tissue or less fighting inflammation will live longer.... it's kind of obvious, for some people meat and fish is critically needed to help them fight the illness, eating not enough might just prove to be dramatically damaging the repair functions of the cells. Just my 2 cents here.. Let me know what you think...
By no means am I anti-animal foods-sardines and yogurt are staples in my daily diet. But, the question is, how much/how often? For some, an almost all-animal diet can be optimal, whereas for others, that may not be the case. The key is blood testing (and testing other objective measures) to find out.
Did methionine restriction reduce homocystiene
Not in my case
methyl-B12 has the strongest correlation with lower homocysteine in my data, currently taking it
Also increased choline and folate intake, re-testing on 11/27
@conqueragingordietrying1797 choline was linked pretty conclusively to spread of prostate cancer,
Well eggs were, the scientists tried to make a case against choline.
This plant based guy