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Thank you for sharing your views about the potential dangers of high-THC cannabis. While the concerns you raise are valid and align with the growing body of evidence on cannabis use risks, it's essential to consider a balanced perspective rooted in current science and clinical practice. High THC concentrations in cannabis can indeed increase the risk of adverse mental health outcomes, including anxiety, depression, and even psychosis, particularly in individuals who are vulnerable due to genetic predispositions or other mental health conditions. Research indicates that prolonged or heavy use of cannabis with high THC levels may elevate these risks​​. That said, it's also important to note that cannabis use and its effects are highly individualized. For many individuals, it can be safely used under medical supervision for legitimate therapeutic purposes, such as chronic pain or spasticity in multiple sclerosis​. This highlights the necessity of regulated medical cannabis programs to ensure safe and effective use. Your mention of cannabis-induced psychosis is critical. Substance-induced psychosis, including that caused by cannabis, typically resolves after cessation of use. However, chronic use in genetically predisposed individuals can act as a precipitant for more enduring psychotic disorders​​. Public education, harm reduction strategies, and access to mental health support are vital. If you or someone you know is affected by cannabis use or has concerns, connecting with healthcare professionals, especially those specializing in addiction medicine, can provide tailored guidance. Thank you for contributing to this crucial conversation. It's through informed discussions that we can better understand and address the complexities surrounding substance use.

Thank you for sharing your experience and concerns-it's a big step to acknowledge the impact cocaine use and other health factors can have on your body. Chronic cocaine use, particularly when combined with conditions like obesity, high blood pressure, and swelling in your legs, can indeed put significant strain on your cardiovascular system. Cocaine can elevate blood pressure, increase the risk of heart attacks, and worsen existing conditions like lymphedema or edema. It’s encouraging to hear that you recognize how much better you feel with regular exercise and clean eating-these habits can make a significant difference in your overall health. However, addressing your cocaine use is crucial to improving your health outcomes. You might consider reaching out to a healthcare professional or addiction specialist to explore support options tailored to your needs. They can help with a comprehensive plan that addresses your substance use, weight management, and cardiovascular health. If you can, take a look at out latest episode on Mediterranean Diet ua-cam.com/video/N1MhdwacExY/v-deo.html Remember, seeking help is a sign of strength, and with the right support, it’s possible to turn things around. You’ve got this! 💪❤

Thank you! Will try to do!

Thank you for sharing your experience. It’s clear you’ve been through a lot, and benzodiazepine withdrawal can indeed be a daunting and complex process, especially after long-term use. It's important to acknowledge that withdrawal symptoms and risks vary widely depending on the individual and their specific circumstances. For someone in your position, a slow, medically supervised taper is often the safest approach. Working closely with a healthcare provider who specialises in addiction medicine or withdrawal management can help reduce risks and manage symptoms effectively. They can also explore other supportive treatments and strategies to make the process as safe and comfortable as possible. If you haven’t already, consider reaching out to a healthcare professional or support group that understands the challenges of benzodiazepine withdrawal. You don’t have to face this alone, and there are resources and people who can help guide you through this journey safely. Your experience is a vital reminder of how challenging this process can be, and we’re committed to providing information and support to those navigating it. Thank you again for your courage in sharing your story.

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Thank you for sharing your experience! It sounds like you’re making a lot of changes to support your sleep and ADHD management. Many people find that transitioning off medications like Klonopin can impact sleep, so it’s great to hear you’re trying options like magnesium glycinate and melatonin. As for CBD, some find it helpful in promoting relaxation, which may support sleep, especially during challenging transitions. However, it's essential to consult with a healthcare provider before adding it, especially given your recent medication changes. Wishing you restful nights and continued success with Clonidine!

Thank you for tuning in! That “gimme, gimme, gimme” effect of dopamine can be a powerful driver in addiction. As Dr. Armstrong explained in the episode, dopamine creates a strong urge to repeat behaviours that give us a reward, even if we don’t necessarily like the behaviour itself. Managing it often involves addressing the underlying triggers and building alternative, positive habits that stimulate dopamine in healthier ways. Therapy, mindfulness techniques, and structured routines can be helpful strategies to gradually “turn off” that impulsive craving and reduce its hold over time.

Glad it was helpful!

"Thank you for your input. It’s important to clarify that the association between marijuana use and cardiovascular events isn't straightforward. While there is some evidence suggesting that marijuana can affect heart rate and blood pressure, leading to potential cardiovascular risks, the direct link to heart disease needs more comprehensive research to be conclusively established. Regarding car accidents, attributing them to cardiac events due to marijuana use oversimplifies a complex issue. Most traffic fatalities involve multiple factors, including but not limited to, impairment from various substances, driver error, and vehicle conditions. We appreciate your engagement with the topic, and we encourage further discussion based on scientific research and data. Let's keep exploring these subjects with the depth and nuance they require." If you are a medical professional or curious, we just completed a webinar on Cannabis Prescribing. You can see the replay here meducate.com.au/webinars

Temperature: Change your body temp to change your distress level. Hold an ice cube or take a cold shower to shock your system into calmness. Intense Exercise: Channel that stress into physical activity. Run, do burpees, or dance like you're in a music video. It's about exhausting your body to quiet your mind. Paced Breathing: Slow it down. Breathe in deeply for 5 seconds, hold, then exhale for 7. It's like yoga, but without the mat. Progressive Muscle Relaxation: Go from tense to relaxed, muscle by muscle. It's like a body scan but with the intent to release all that pent-up tension. Remember, these TIPP techniques are your toolkit for when life gets too spicy, no pills necessary. Keep it simple, keep it effective!

Additional Techniques: Mindfulness and Meditation: Practice being present in the moment. This can involve simple activities like mindful eating, focusing on the sensations of a single raisin as mentioned in some therapeutic techniques, or formal meditation sessions. Acceptance: Understand that some discomfort is part of life. Learning to accept these moments without fighting them can reduce suffering. This doesn't mean you like or want the feeling, but you acknowledge it without judgment. Self-Soothing Activities: Engage in activities that are comforting and nurturing. This could be listening to music, reading, crafting, or any hobby that makes you feel calm and grounded. Social Connectivity: Talk to someone you trust. Sometimes, just voicing your feelings can alleviate their intensity. However, as some X posts suggest, be mindful of the company you keep when you're not feeling great. Regulate Your Nervous System: Daily practices like going for walks, cold showers, or even EFT tapping as suggested on X, can help keep your baseline stress levels lower. Cognitive Techniques: Challenge and reframe negative thought patterns. If you find yourself ruminating, consider if there's another way to view your situation, inspired by the philosophy of thinkers like Epictetus mentioned in X posts. Routine: Establishing a daily routine can provide a sense of normalcy and control when internal states are turbulent. Limit Stimulants: As one X post wisely advises, watch your substance use. Caffeine, nicotine, and especially more potent substances can exacerbate mood swings. Remember, these strategies require practice, and their effectiveness can vary from person to person. It's also beneficial to learn these skills when you're not in crisis so that they're easier to apply when you are. If you find these techniques insufficient, or if you're struggling significantly, consider seeking guidance from a therapist who can provide personalized strategies or further explore why non-pharmacological approaches might not be enough on their own.

this one might be useful ua-cam.com/video/_cW4Ezqn318/v-deo.html

Thank you for your feedback on the recent Cracking Addiction episode. I appreciate your passion for discussing distress tolerance techniques, and I understand your concerns. It seems there might have been a misunderstanding about the episode's focus. Let me clarify a few points. The episode aimed to provide a comprehensive overview of managing distress and anxiety, especially in the context of substance use disorders. In clinical practice, the goal is to equip individuals with multiple tools to cope with distress, including both pharmacological and non-pharmacological approaches. This is particularly true when severe distress might escalate to situations where safety becomes a concern, or in clinical settings where withdrawal or anxiety management can benefit from temporary medical support. Here’s how we integrate both approaches: Psychological Strategies: Techniques like Dialectical Behavior Therapy (DBT) are central to managing distress without medication. Skills like TIPP (Temperature, Intense Exercise, Paced Breathing, and Progressive Muscle Relaxation) are proven to help in acute moments of distress. We actively support and teach these techniques and encourage their use in daily practice. The use of TIPP, as part of DBT, has been shown to be highly effective in calming the body's stress response, especially when emotions feel overwhelming. Pharmacological Support: For some individuals, distress can reach levels where it severely impacts functioning or becomes dangerous (e.g., risk of self-harm during withdrawal). In such cases, short-term use of medications (e.g., diazepam for acute anxiety or withdrawal symptoms) can provide crucial relief. These are not first-line or long-term solutions but can play a vital role in a comprehensive treatment plan. We emphasize that these medications should only be used under medical supervision, following careful assessment, and as part of a broader strategy that includes therapy and skill-building. Holistic and Personalized Care: Our episodes and educational content aim to balance these approaches, reflecting real-world clinical practice. Patients and healthcare professionals benefit from understanding all available tools so they can tailor approaches based on individual needs. For example, some may rely solely on DBT techniques, while others, especially during the acute phase of withdrawal or high distress, might need temporary pharmacological support to engage effectively in therapy. To your point about labeling, it’s crucial for us to communicate that our approach is inclusive of both behavioral therapies and appropriate, evidence-based pharmacological interventions. The goal is to bridge gaps between different care modalities, not to lean exclusively on one side. If you’d like to delve deeper into non-pharmacological strategies, I’d be more than happy to dedicate an episode solely to DBT techniques like TIPP, mindfulness practices, and other self-soothing skills. It’s important to us that the podcast serves as a resource for varied perspectives, and your feedback helps us ensure it continues to meet the needs of all listeners. Thank you again for your candid input. I hope this clarification helps, and I’d love to hear your thoughts on how we can make future episodes more aligned with your expectations. Warm regards, Dr. Ferghal Armstrong

We have done a few eps on DBT ua-cam.com/video/H6pLc7BbY7Q/v-deo.html ua-cam.com/video/kRYMgkHmuTM/v-deo.html ua-cam.com/video/FEG0x53uSnE/v-deo.html ua-cam.com/video/ojvxrQsN2FY/v-deo.html ua-cam.com/video/89NAXzio_wc/v-deo.html

Firstly, suggesting a mix of baclofen and pregabalin right after stopping GHB (gamma-Hydroxybutyric acid) with a "go to sleep and deal with diazepam later" approach is like fighting fire with a bit more fire and hoping everyone just takes a nice nap instead of catching alight. Baclofen: It's a muscle relaxant and has been explored for its potential in reducing withdrawal symptoms from various substances, including GHB. Its use in GHB withdrawal might help due to its action on GABA-B receptors, somewhat similar to GHB's effects, but it's not a straightforward solution. Pregabalin: This drug acts on calcium channels, reducing the release of neurotransmitters like glutamate. It's used for anxiety and neuropathic pain, and yes, theoretically, it could ease some withdrawal symptoms due to its anxiolytic effects. However, using it to treat GHB withdrawal could be akin to swapping one dependency for potential another, albeit less intense, issue. In reality, GHB withdrawal should be managed under medical supervision with a tailored approach that might indeed include medications like baclofen or benzodiazepines, but with careful monitoring, not just a "set and forget" strategy. And pregabalin? That might be for the aftermath, dealing with residual anxiety or pain, not the acute phase of withdrawal.

I fucking wish I read this comment before. I am on the evening of day 2 of 0ml per day. I was using 1.7-2ml every hour. And at least a ml most hours for 3 years 3 days ago did 1ml every hour (wasn't great) 2 days sgo (with diazepam) 0.5ml at 7/12:30/17:30/29:30 And I felt fine ! Xanax and sleep Cold turkey from then. But I read about toxins from calcium buildup like excitoxicitiy or something and pregabilin needs to be usedm

Thank you for sharing your experience. Cannabis withdrawal can indeed be quite challenging, especially if you were using heavily. It's common for symptoms to peak in the first week and can last around two weeks, although some people notice improvement within the first week itself. Symptoms may include anxiety, irritability, sleep disturbances, and cravings. These are all part of the body's process of readjusting after regular use. It will get better, but if symptoms are too intense or persistent, seeking support from a healthcare professional could be helpful for managing the process more comfortably​​.

Cannabis withdrawal is a real phenomenon that can occur with heavy or prolonged use, even if it wasn’t widely recognized in the past. The symptoms are linked to changes in the brain's endocannabinoid system due to regular exposure to THC, the active ingredient in cannabis. While there may be concerns about additives or contaminants in some cannabis products, withdrawal symptoms are primarily due to the body's adaptation to THC itself, rather than added substances​​. Medical cannabis, like any regulated product, is subject to quality standards, but natural cannabis can still cause withdrawal for frequent users. It’s more likely that increased awareness and stronger cannabis strains today are making withdrawal symptoms more noticeable.

Shaking and sweating are common symptoms of cannabis withdrawal, especially after stopping heavy use. These symptoms result from the body's effort to rebalance itself after being accustomed to regular cannabis exposure. While most people experience withdrawal symptoms peaking within the first week and improving after two weeks, some symptoms, like sweating and shaking, can persist longer for certain individuals. The prolonged symptoms could be due to the severity of dependence, individual factors like metabolism, or even underlying health conditions that might be exacerbated by withdrawal. If these symptoms are persistent or worsening, seeking medical advice would be wise, as additional support might help manage the withdrawal more effectively​​.

First off, congrats on hitting the two-week mark! That's like climbing Mount Everest in the world of withdrawals, and you're already at base camp two. Now, about that elusive sleep... it's like that one friend who says they'll show up to the party but never does, right? Here's the deal: Your body's throwing a bit of a tantrum because it misses its green buddy, but guess what? You're in the detox phase where your brain is basically relearning how to hit the hay without its herbal lullaby. Here are some not-so-boring tips to possibly help you catch those Zs: Create a Sleep Sanctuary: Make your bedroom so inviting that even your insomnia would want to take a nap. Think dark, cool, and gadget-free. Yes, that means your phone too. The Pre-Sleep Routine: Engage in something so dull that it makes watching paint dry seem like the Super Bowl. Reading the terms and conditions of software updates might just do the trick. Exercise: But not right before bed. Tire yourself out earlier in the day. Maybe chase a frisbee like you're a dog at the park - that'll wear anyone out. Avoid the Stimulants: Coffee, sugar, and late-night conspiracy theory videos. They're the trio that'll keep you up like it's their job. Herbal Tea: Not that herb, but something like chamomile or valerian root. They're like the boring but effective cousins of your previous leafy pal. Mindfulness or Meditation: Try some guided sessions. Picture yourself in a place where sleep is as abundant as reality TV shows about finding love. Remember, this phase is temporary - like fashion trends or a viral dance move. Your sleep cycle will normalize. Your brain's just got to remember how to do its job without the green nudge. Keep going strong! You're doing something incredibly tough, and every hour of sleep you manage to snag is a victory. Here's to hoping your nights get longer and your sleep gets deeper. And remember, if all else fails, count sheep, or better yet, count the reasons why being sober rocks - starting with not having to deal with munchies-induced grocery bills. Hang in there, champ! 🌜✨

Glad it was helpful!

Your comment on melatonin's antioxidant properties is well-supported and highlights its complex and powerful roles in protecting cells from oxidative stress. Melatonin not only directly scavenges free radicals but also enhances the body's own antioxidant defenses, particularly by upregulating enzymes like SOD and GPx. Moreover, its role in mitochondrial protection and the antioxidant actions of its metabolites further extends its protective effects. These mechanisms showcase why melatonin is widely studied for its potential benefits beyond sleep regulation, especially in the context of oxidative stress-related conditions.

It’s great that you're sharing your experience! Recovery approaches vary greatly, and what works for one person may not for another. Steffon Barkload’s program sounds interesting, especially with its emphasis on pacing yourself and rewiring your mindset. I’d encourage others to explore options that resonate with them, but also recommend checking in with healthcare professionals to ensure any method aligns with your overall health, particularly when dealing with alcohol addiction. Thanks for contributing your thoughts to the discussion!

Ah, the old "blunt" truth about the cost of habits, eh? Here's a thought: maybe it's time to invest that money in something that doesn't go up in smoke... like a piggy bank shaped like a giant blunt, for irony's sake. Keep on cracking that addiction; your wallet will thank you by getting pleasantly plump!

@@medheads yes sir!! Thank you

Thank you for sharing your experience. It sounds like you're going through a really tough time right now, and it's great that you're reaching out for support. Even though you don't feel you have an addictive personality and have managed your use over the years, it's important to remember that cannabis withdrawal can still be challenging, especially if your body has developed a tolerance or dependency. The symptoms you're describing-like difficulty sleeping, anxiety, irritability, and physical discomfort-are common during cannabis withdrawal and can be quite intense, particularly in the first couple of weeks. You mentioned it's been seven days since you stopped using cannabis, which is a significant milestone. The good news is that while these symptoms are tough, they are typically temporary. Most people find that symptoms peak in the first week or so and then gradually start to improve. However, everyone's experience is different, and some symptoms, like sleep disturbances, might linger a bit longer. It's encouraging to hear that you're determined to handle it and that you're looking forward to feeling better. In the meantime, here are a few tips that might help ease the process: Stay Hydrated and Nourished: Eating balanced meals and staying hydrated can help your body cope with withdrawal. Exercise: Gentle physical activity, like walking or yoga, can help reduce stress and improve sleep. Relaxation Techniques: Practices like deep breathing, meditation, or mindfulness can help manage anxiety and agitation. Seek Support: If you find the symptoms overwhelming, it might be helpful to talk to a healthcare professional or counselor, especially if you continue to struggle after a few weeks. Remember, it's okay to ask for help, and there are professionals who can provide support tailored to your needs. You're doing something really positive for your health by stopping cannabis, even if it doesn't feel like it right now. Hang in there, and take it one day at a time-things will get better.

Thank you for sharing your perspective on GHB. It's clear that you have strong feelings about how this substance is perceived and regulated. It's important to recognize that GHB, like many substances, has both potential therapeutic uses and significant risks. While it has been investigated for various medical applications, including the treatment of certain types of addiction, PTSD, and sleep disorders, its potential for abuse and the severe consequences of misuse-such as respiratory depression, unconsciousness, and even death-are well-documented. These risks are the primary reasons why GHB is tightly regulated and its use is carefully controlled in many countries, including Australia. The conversation around substances like GHB is indeed complex, involving both public health considerations and the interests of various stakeholders, including pharmaceutical companies. It's also true that the pharmaceutical industry plays a significant role in the development and regulation of medications, sometimes leading to contentious debates over drug policy and access. However, it's critical to approach the use of any substance with caution, especially those with a high potential for misuse. The goal should always be to balance the potential benefits of a drug with its risks, ensuring that it is used safely and effectively under proper medical supervision. If GHB or any other substance is to be used therapeutically, it must be done within a framework that minimizes harm and maximizes the potential for positive outcomes. Thank you again for your comment, and for engaging in this important conversation. If you or someone you know is considering the use of GHB or is dealing with substance use issues, I strongly recommend consulting with a healthcare professional to explore safe and effective treatment options.

Thank you for your insightful comment and for engaging with our podcast. You raise an important point about the complexity of GHB withdrawal and the need for precise treatment protocols. Understanding the exact substance used and employing a titration step-down method, as you mentioned, is indeed critical. Clinical data supports this approach over a cold turkey method with benzodiazepines alone, highlighting the importance of tailored withdrawal management plans. Your perspective is valuable, and we appreciate your commitment to deepening the conversation around addiction treatment.

Thank you for sharing your experience with Methadone! It’s great to hear that it’s working for you. Unfortunately, stigma can indeed be a significant challenge, even among healthcare professionals. It’s essential to continue raising awareness and educating about the benefits of evidence-based treatments like Methadone. Keep advocating for yourself and others, and know that there are many in the medical community who support and understand the value of these therapies. Stay strong!

Glad you enjoyed it

Thank you for sharing your thoughts. It's clear you have strong feelings about Alcoholics Anonymous (AA), and it's important to discuss these concerns openly. It's true that AA doesn’t work for everyone. Different approaches work for different people, and it's essential to find what suits you best. If AA’s focus on powerlessness and a higher power doesn't resonate with you, there are other evidence-based options available, such as cognitive-behavioral therapy (CBT), motivational interviewing, and medications that can help with addiction management. Feeling demeaned or guilted can be incredibly counterproductive in any recovery process. Recovery should be about empowerment and finding strength, not feeling broken or powerless. If the concept of a higher power doesn't align with your beliefs, alternatives like SMART Recovery, which focuses on self-empowerment and self-reliance, might be a better fit for you. It's important to explore different paths and find a support system that respects your values and helps you feel strong and in control of your recovery journey. Everyone's path to recovery is unique, and what matters most is finding what works for you and fosters your well-being.

Thank you for reaching out with your question. Anxiety and depression can indeed sometimes be manifestations of underlying conditions such as Attention Deficit Disorder (ADD) in adults. Misdiagnosis or missed diagnosis of ADD can occur because its symptoms often overlap with those of mood disorders like anxiety and depression. If you're experiencing worsening anxiety and depression, it may be worth discussing the possibility of ADD with your healthcare provider. Proper evaluation and diagnosis are key to developing an effective treatment plan. Always consult with a professional for personalized medical advice. For more detailed information on this topic, you can visit search our channel on mental health and ADD or visit our website meducate.com.au

Thank you for your question about methadone. Methadone is not derived from the morphine molecule, nor is it an antispasmodic. Methadone is a synthetic opioid, classified as a full mu-opioid receptor agonist, and is primarily used in opioid agonist therapy to manage opioid dependence and chronic pain. Its chemical structure is different from that of morphine, and it doesn't contain a propylamine group derived from morphine. Methadone’s pharmacological profile includes properties that help reduce withdrawal symptoms and cravings in individuals with opioid use disorder. It's important to consult healthcare professionals for detailed information on methadone and its uses.

@@medheads I think we all know it hits opioid receptors. But there's a reason. Btw, sorry to say but Your mistaken about the Spasmolytic. The precusor's name is Recipavrin.( Synonym is Diphenyl butane) It has smooth muscle-relaxing properties. (Prevents spasms). Now .. u could argue that all they did was revive functions back to its predecessor, the phenanthren. That means it's an OPEN CHAIN OF MORPHINE. But we know for certain it's made from a Spasmotic( stomach muscle relaxant). Again it's called Recipavrin which is a SYNONYM FOR Methadone Intermediate's IUPAC Name: Cyano dimethylamino Diphenyl butane. Another is Trimethyl Diphenyl butanamide/butane. PS: not trying to embarrass u on ur channel but I took a screenshot in case it gets deleted. If u disagree explain why . More than just it hits the same receptors, there's a reason. H2O hits your mu receptors too. It hits every receptor in your body, water. But if u disagree that's saying centuries of hard working chemists & research vs UH-uh...,NO!!.

Let's break it down: ....."I think we all know it hits opioid receptors. But there's a reason. Btw, sorry to say but Your mistaken about the Spasmolytic. The precursor's name is Recipavrin. (Synonym is Diphenyl butane). It has smooth muscle-relaxing properties. (Prevents spasms)."..... Accuracy: Partially correct. Methadone is known to act on opioid receptors as a full mu agonist​​. You mention a precursor named "Recipavrin," synonymous with "Diphenyl butane," and attributes smooth muscle-relaxing properties to it, implying spasmolytic effects. However, the specific mention of Recipavrin is not well-documented in common pharmacological texts. Methadone does have some smooth muscle relaxant properties due to its opioid receptor activity, but "Recipavrin" is not a widely recognized term in the context of methadone synthesis. ....."Now .. u could argue that all they did was revive functions back to its predecessor, the phenanthrene. That means it's an OPEN CHAIN OF MORPHINE."..... Accuracy: Incorrect. Methadone is not a phenanthrene derivative but rather a diphenylheptane. It is structurally distinct from morphine and other phenanthrene opioids​​. ...."But we know for certain it's made from a Spasmotic (stomach muscle relaxant). Again it's called Recipavrin which is a SYNONYM FOR Methadone Intermediate's IUPAC Name: Cyano dimethylamino Diphenyl butane. Another is Trimethyl Diphenyl butanamide/butane.".... Accuracy: Partially correct. The term "Cyano dimethylamino Diphenyl butane" seems to be an attempt to describe a methadone precursor, possibly the intermediate compound used in methadone synthesis. Methadone synthesis involves intermediate compounds, but the exact terms and descriptions here are somewhat imprecise. The description does reflect some of the chemical complexity involved in methadone synthesis​​. ...."PS: not trying to embarrass u on ur channel but I took a screenshot in case it gets deleted. If u disagree explain why. More than just it hits the same receptors, there's a reason. H2O hits your mu receptors too. It hits every receptor in your body, water. But if u disagree that's saying centuries of hard working chemists & research vs UH-uh...,NO!!.".... Accuracy: Misleading. While methadone's primary action is on mu-opioid receptors​​, the claim about water (H2O) hitting mu receptors is scientifically inaccurate. Water does not interact with opioid receptors or any specific neural receptors in the same manner that methadone or other opioids do. Conclusion: Agree: Methadone acts on mu-opioid receptors, and there is complexity in its synthesis involving intermediate compounds with specific chemical properties. Disagree: The structural and functional descriptions provided (such as the link to phenanthrene and the term "Recipavrin") are either incorrect or not well-documented. Additionally, the claim about water interacting with mu receptors is incorrect. Thanks for interacting..

​@@medheads Yes, I've heard of Diphenyl Heptane . Now u Kno The carbon rings of Morphine molecule are made of Hexane. Regarding one being on right: Hexanol , the top : Hexane(alkane) and left is a Phenol. I do believe originally on the morphine molecule there are "chiral centers". Heptane I think is a chiral of Hexane. But interestingly aside I always wondered what the function of Methadone causes it's analgesic character ??? Does this mean Heptane is analgesic ??? Or the other part butanone (butanol alcohol) ??? & Is it 2-propanol as well ??? The amine group dimethylamino ?? Methanol ?? All These were my original questions or curiosities.

To answer your follow-up questions, I need to clarify several points about the structure of methadone, its relationship to morphine, and what contributes to its analgesic properties. Clarifying Points: Chemical Structure of Morphine and Methadone: Morphine: Morphine is a naturally occurring alkaloid with a specific structure that includes several functional groups and chiral centers. It has a pentacyclic structure with a phenol group, an ether bridge, and several chiral centers. Methadone: Methadone is a synthetic opioid with a different structure from morphine. It belongs to the diphenylheptane class, not the morphinan class (which includes morphine). Chirality and Structure: Chiral Centers in Morphine: Morphine indeed has multiple chiral centers, which are critical for its biological activity. Chirality in Methadone: Methadone also has a chiral center, leading to two enantiomers: (R)-methadone and (S)-methadone. The (R)-enantiomer is primarily responsible for the analgesic effects. Heptane vs. Hexane: Hexane: A simple alkane with six carbon atoms (C6H14). Heptane: An alkane with seven carbon atoms (C7H16). structurally unrelated to hexane in terms of chirality or function. Chirality: Neither hexane nor heptane are inherently chiral molecules. Chirality arises from carbon atoms bonded to four different groups, which is not the case in simple alkanes like hexane or heptane. Analgesic Properties of Methadone: Methadone's analgesic properties are not due to heptane, but rather its overall molecular structure and how it interacts with the opioid receptors. The key features contributing to its analgesic effects include: Binding to Mu-Opioid Receptors: Methadone, particularly its (R)-enantiomer, binds strongly to mu-opioid receptors, mimicking the action of endogenous opioids and producing analgesia​​. Long Half-Life: Methadone has a long half-life, leading to prolonged analgesic effects. Chemical Groups in Methadone: Diphenyl Heptane Structure: This refers to the methadone backbone, which includes two phenyl rings attached to a heptane chain. Amine Group (Dimethylamino): Methadone includes a dimethylamino group, which is essential for its activity. Methanol: While methadone does not contain methanol, it is important to distinguish methanol (a simple alcohol) from methadone’s more complex structure. Specific Questions: Does Heptane Confer Analgesic Properties? Answer: No, heptane itself does not have analgesic properties. The analgesic effect of methadone is due to its overall structure and its interaction with opioid receptors. Role of Butanone (Butanol Alcohol) and 2-Propanol: Answer: Methadone does not contain butanone or 2-propanol. Its analgesic properties are not related to these groups. The essential groups for methadone’s activity are the phenyl rings and the dimethylamino group. Role of Dimethylamino Group: Answer: The dimethylamino group is crucial for the binding of methadone to the opioid receptors, contributing significantly to its analgesic properties​​. Summary: Methadone’s analgesic properties are primarily due to its ability to bind to mu-opioid receptors, a function driven by its overall molecular structure, particularly the presence of its phenyl rings and the dimethylamino group. The heptane backbone provides structural support but is not directly responsible for analgesic effects. Methadone is effective due to its specific interactions at the receptor level, rather than the presence of simple hydrocarbons like hexane or heptane. I hope this answers your great questions. Thanks for watching and your feedback. Please subscribe :-)

Diazepam is often used in withdrawal management to help ease symptoms and provide comfort, under medical supervision. It’s important to consult with healthcare professionals for the safest and most effective treatment options. If you have any concerns or questions, discussing them with your doctor can help you understand the best approach for your situation.

Thank you for sharing your insights on cannabis withdrawal. Tapering can indeed be an effective strategy, especially for managing symptoms like insomnia. Implementing such a tapering schedule in an inpatient setting can be challenging but not impossible with proper medical supervision. Involving healthcare professionals to oversee the tapering process and provide necessary support can significantly improve outcomes. Cannabis dependency is often underestimated, and your comments highlight the importance of a comprehensive approach to treatment.

@@medheads thanks for the reply, and apologies for the spelling mistakes, the perils of commenting on your phone!

Couldn’t disagree more

Thank you for sharing your thoughts! Tobacco can indeed alter the experience of using cannabis by interacting with its effects. While some people might find that it moderates and prolongs the high, it's important to note that combining substances can also introduce additional health risks. Always use caution and consider consulting with a healthcare professional about your substance use.

Your friend's situation is concerning and multi-faceted. Combining cocaine, alcohol, and high amounts of energy drinks poses significant health risks, especially for someone who is already underweight. Here are the key issues and potential interventions to consider: Substance Interaction and Health Risks: Cocaine and Alcohol: This combination can form a substance called cocaethylene, which increases the risk of cardiovascular issues, liver damage, and sudden death more than using either substance alone​​​​. Energy Drinks: High caffeine intake can exacerbate the cardiovascular strain from cocaine and alcohol use, leading to increased heart rate, blood pressure, and potential heart complications​​. Underweight Concerns: Being underweight can indicate malnutrition, which can be worsened by the appetite-suppressing effects of cocaine and the empty calories from alcohol and energy drinks​​. Physical and Mental Health Impact: Malnutrition and Dehydration: Your friend might be missing essential nutrients, which can affect their overall health and ability to recover from substance use. Alcohol and cocaine use can also lead to dehydration and electrolyte imbalances​​. Psychiatric Symptoms: Substance use can lead to or worsen mental health issues such as anxiety, depression, and psychosis. For instance, cocaine withdrawal can lead to severe depressive episodes and psychotic symptoms​​​​. Immediate Actions and Support: Medical Assessment: Encourage your friend to seek medical help immediately for a full assessment. This should include a nutritional evaluation, cardiovascular check, and mental health screening​​. Hydration and Nutrition: Encourage small, frequent meals that are nutrient-dense and easy to digest. Hydration with water or electrolyte solutions is also crucial​​. Cocaine and Alcohol: This combination can form a substance called cocaethylene, which increases the risk of cardiovascular issues, liver damage, and sudden death more than using either substance alone​​​​. Energy Drinks: High caffeine intake can exacerbate the cardiovascular strain from cocaine and alcohol use, leading to increased heart rate, blood pressure, and potential heart complications​​. Underweight Concerns: Being underweight can indicate malnutrition, which can be worsened by the appetite-suppressing effects of cocaine and the empty calories from alcohol and energy drinks​​. Encourage your friend to seek medical help immediately for a full assessment. This should include a nutritional evaluation, cardiovascular check, and mental health screening​​. Encourage small, frequent meals that are nutrient-dense and easy to digest. Hydration with water or electrolyte solutions is also crucial​​. Reducing or eliminating energy drinks can help decrease the cardiovascular strain and potential for caffeine-related anxiety and sleep disturbances​​. Long-term Support and Resources: The combination of cocaine, alcohol, and energy drinks, along with being underweight, requires immediate medical attention. Support your friend in seeking professional help and making healthier lifestyle choices to address both the substance use and nutritional deficiencies.

Thank you for sharing your experience. It's great to hear that you found a path that worked for you! Methadone maintenance can be a vital tool for many, but transitioning to morphine for tapering off completely clearly made a significant difference for you. Your journey is an inspiring reminder that there are multiple pathways to recovery, and finding the right approach can lead to lasting change. Well done on your success!

Regarding the question about the use of gabapentin in GHB withdrawal, gabapentin can be a useful adjunct in managing withdrawal symptoms. Gabapentin, primarily used for its anticonvulsant and analgesic properties, can help alleviate some of the neurological and musculoskeletal symptoms associated with GHB withdrawal, such as anxiety, insomnia, and muscle pain.

Hey bro I had GHB withdrawal from weeks of use and I took pregablin which is a stronger version of gabapentin and I was able to go to the gym. It really helped alleviate the most serious of symptoms

Thank you for sharing your perspective. It's important to recognise that everyone's experience with addiction is different. Cannabis withdrawal can be challenging for some people, and it's okay to seek help. Working out and staying hydrated are great tips for overall well-being, but professional medical advice can provide safe and effective support when needed. Let's respect everyone's journey towards recovery.

While it's true that benzodiazepines like diazepam (Valium) carry a risk of dependence, they are sometimes used in short-term, carefully monitored settings to manage acute withdrawal symptoms, including those from cannabis.

Indeed, Clonidine, when discontinued abruptly, can cause rebound hypertension, even in patients without a prior history of hypertension. This phenomenon, which you have encountered in ICU settings, occurs because Clonidine suppresses sympathetic outflow; sudden withdrawal can lead to a significant surge in blood pressure. It's crucial to taper Clonidine gradually under medical supervision to mitigate this risk. If a patient presents with severe hypertension after stopping Clonidine, reintroducing the medication, as you mentioned, can help stabilize their blood pressure. Always consult a healthcare provider before making changes to Clonidine treatment to ensure safe management of the medication.

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Ghb withdrawal is actually rather tame compared to heroin or benzo withdrawal .. benzo withdrawal is like ghb withdrawal x10

@@brianmeen2158 let's agree to disagree on that one. Maybe we are just made different.

unless u get BAClofen/ pregabalin

True

Hope it helps. Take care

Yes it can be extremely difficult. Best wishes, stay strong.

ok