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MCB 182: Introduction to Genomics lecture videos Course playlist: ua-cam.com/play/PLpzXFzEHUCQdveBWm63MbUdGK_t0Nt23F.html Chapters: 0:00 Introduction 5:36 Protein-protein interactions 22:59 Genetic interactions 38:23 Regulatory interactions 46:48 Co-expression networks 1:09:59 Inferring important genes from networks

MCB 182: Introduction to Genomics lecture videos Course playlist: ua-cam.com/play/PLpzXFzEHUCQdveBWm63MbUdGK_t0Nt23F.html Chapters: 0:00 Introduction 7:03 DamID, nuclear lamina 21:04 Chromatin Conformation Capture (3C) tech 23:40 3C 25:41 4C 27:40 Hi-C 43:06 TADs 54:09 identifying loops

MCB 182: Introduction to Genomics lecture videos Course playlist: ua-cam.com/play/PLpzXFzEHUCQdveBWm63MbUdGK_t0Nt23F.html Chapters: 0:00 Introduction 12:39 RNA selection 23:30 RNA read mapping 41:13 Principal Components Analysis 45:47 Batch effects 55:53 scRNA-seq 1:14:52 10x Chromium Single Cell Gene Expression

MCB 182: Introduction to Genomics lecture videos Course playlist: ua-cam.com/play/PLpzXFzEHUCQdveBWm63MbUdGK_t0Nt23F.html Chapters: 0:00 Introduction 16:10 Histone modifications 26:23 CUT&RUN 30:37 DNA methylation 40:19 Chromatin accessibility (ATAC-seq, CUT&RUN) 55:45 Chromatin states 1:22:09 MPRA 1:46:18 Peak calling 1:50:37 Hypothesis testing

MCB 182: Introduction to Genomics lecture videos Course playlist: ua-cam.com/play/PLpzXFzEHUCQdveBWm63MbUdGK_t0Nt23F.html Chapters: 0:00 Introduction 5:03 ChIP-seq 23:48 Relative, absolute entropy 50:33 Sequence logos, position weight matrices (PWMs)

MCB 182: Introduction to Genomics lecture videos Course playlist: ua-cam.com/play/PLpzXFzEHUCQdveBWm63MbUdGK_t0Nt23F.html Chapters: 0:00 Introduction to alignments 7:36 Gap penalties in alignments 14:14 Local alignments 18:20 Dot plots

MCB 182: Introduction to Genomics lecture videos Course playlist: ua-cam.com/play/PLpzXFzEHUCQdveBWm63MbUdGK_t0Nt23F.html Chapters: 0:00 Introduction 4:48 siRNA 23:09 Site-directed mutagenesis 25:56 Double-stranded break repair pathways and editing systems 30:12 CRISPR/Cas9 56:07 Genome-wide CRISPR screens 1:03:07 Gene ontology (GO) 1:05:34 Gene set enrichment analysis (GSEA)

MCB 182: Introduction to Genomics lecture videos Course playlist: ua-cam.com/play/PLpzXFzEHUCQdveBWm63MbUdGK_t0Nt23F.html Chapters: 0:00 Introduction 11:56 Applications: Genome assembly and resequencing 17:07 Short vs long read sequencing 19:32 Sanger sequencing 24:35 Shotgun sequencing 28:31 Bacterial artificial chromosomes 37:19 Illumina 1:05:36 Long read sequencing introduction 1:11:46 PacBi...

(2022) MCB 182: Introduction to Genomics lecture videos Course playlist: ua-cam.com/play/PLpzXFzEHUCQdveBWm63MbUdGK_t0Nt23F.html Chapters: 0:00 Introduction 13:13 Contents of the genome 17:05 Review of transcriptional regulation 29:50 Repetitive sequences

A brief introduction to the genetics of complex traits, and how they differ from e.g. Mendelian disorder genetics. MCB 182: Introduction to Genomics lecture videos Course playlist: ua-cam.com/play/PLpzXFzEHUCQdveBWm63MbUdGK_t0Nt23F.html

An introduction to confounding factors such as population structure and ethnicity that commonly lead to inflation (detection of 'excess associations') of GWAS results. MCB 182: Introduction to Genomics lecture videos Course playlist: ua-cam.com/play/PLpzXFzEHUCQdveBWm63MbUdGK_t0Nt23F.html

An introduction to GWAS analysis methods for continuous phenotypes using linear regression. Also, an introduction to the concepts of effect size and statistical significance (or goodness of fit) in the context of GWAS. MCB 182: Introduction to Genomics lecture videos Course playlist: ua-cam.com/play/PLpzXFzEHUCQdveBWm63MbUdGK_t0Nt23F.html

Brief introduction into the problem of identifying causal variants, from association signals detected in GWAS. MCB 182: Introduction to Genomics lecture videos Course playlist: ua-cam.com/play/PLpzXFzEHUCQdveBWm63MbUdGK_t0Nt23F.html

MCB 182 Lecture 12.8 - PCA for analysis of population structure in GWAS, multiple hypothesis testing

MCB 182 Lecture 12.4 - Q-Q plots, types of genetic architectures of complex traits

A deeper look at how population structure is detected, visualized, and corrected for in GWAS. MCB 182: Introduction to Genomics lecture videos Course playlist: ua-cam.com/play/PLpzXFzEHUCQdveBWm63MbUdGK_t0Nt23F.html

MCB 182 Lecture 12.10 - Epistasis, missing heritability in GWAS

MCB 182 Lecture 12.3 - GWAS for binary phenotypes

MCB 182 Lecture 10.3 - Chromatin conformation capture (3C, 4C) assays

MCB 182 Lecture 9.8 - Analysis goals of scRNA-seq

MCB 182 Lecture 11.2 - Protein-protein interaction (PPI) networks

MCB 182 Lecture 11.4 - Regulatory interaction networks

MCB 182 Lecture 9.7 - Introduction to single cell RNA sequencing (scRNA-seq)

MCB 182 Lecture 10.7 - Chromatin looping, loop extrusion model

MCB 182 Lecture 10.4 - Chromatin conformation capture (Hi-C) assays

MCB 182 Lecture 10.5 - Visualization of Hi-C data, bias in the Hi-C assay

MCB 182 Lecture 9.9 - scRNA-seq technologies

MCB 182 Lecture 9.3 - RNA-seq read mapping strategies

MCB 182 Lecture 9.6 - ncRNA (miRNA, lncRNA, eRNA)