Відео

I am a chemical engineer, but believe me, methadone cannot be produced with these ingredients

Thankssssssssss

Thanks sir

U just made it more boring

Isn't methadone like a man made Ketone Body ?

Thank you very much sir 🙏

Sir sulfamerazine,celecoxib,Thioguanine pr synthesisi bna do plz.....

Sir.. Please send your contact details...i want to discuss regarding Mefnamic acid manufacturing in plant...now am manufacturing mef ..i want to improve and new route

You are great... Make more like this... & Requesting on reducing other voice problems please

Sir very good video sir I learn we find starting material by breaking the structure of drug But sir I find difficulty in learning adrnerggic receptor and adrnerggic drugs

And what's difference between structure activity relationship and quantative structure activity relationship

Sir please make playlist unit wise medicinal chemistry so that in order every body can watch it and clear concepts

Very good video sir filled with medicinal chemistry knowledge

Awesome video sir I now know how to study medicinal chemistry in my college sir complette 3 units I didn't understand anything

Great lecture! Thank you.

Very very informative vedio sir. Thank u sir

👌

Thank you very much sir for such wonderful demonstration.

i saw many more videos but the concept that u cleard was legendary

Nice sir

Wow...thank you Sir..thank you so much

Your teaching style is passionate..really helpful.

Awesome explanation sir

After watching a diversified lecture I found ur lecture that is prefect😁

Thank you sir for your contribution, I am a PhD candidate and I am so much interested in incorporating 3d QSAR. You have given me enough guidelines. My problem now is how to get the softwares for building this model. I hope you will guide on how to get it. Thanks.

Hello sir when you upload your next video of electronic parameters

Thank you soo much sir

Sir g please in slow motion

Thank you sir..it is very helpful What is the purpose of test set?

Sir nice teaching.

Awesome and very helpful video

Thanks a lot sir keep uploading 😃

😍

absolute legend, you have my respect.

Very well explained 👌

Thanks sir

Very very thanks sir.

Hi, can you please explain this method, is it any good? I have no access to TLC so have you any idea on reaction times etc. Any information would be gratefully received, thanks in advance. Synthesis of 7-chloro-5-phenyl-1H benzo[e][1,4]diazepin2(3H)-one (nordiazepam) (1) To a vigorously stirred of 2-amino-5-chloro benzophenone (0.232 g, 1 mmol), chloro acetyl chloride (1.2 mL, 2 mmol) was added drop wise at room temperature under solvent-free conditions during 30 min and the progress of reaction was monitored by TLC. After completion of the reaction, NH4OAc (0.23 g, 3 mmol) and K2CO3 (0.42 g, 3 mmol) were added to the mixture at room temperature under solvent-free conditions and stirred for 2.5 h. When the reaction was completed, as it was shown by TLC, the water (30 mL) was added and the product was filtered off, washed with more water (2 9 100 mL) and dried. The product was obtained in high yield and purity (94 % yield) and was used in the next step without any purification. m.p = 212-214 C [217-218 C (Barthel et al., 2009)]; IR (KBr, cm-1 ): 701, 1640, 1685, 2939, 2978, 3272; 1 H NMR (CDCl3, 400 MHz): d 4.22 (s, 2H), 7.56 (d, 4H, J = 11.6 Hz), 7.66 (d, 1H, J = 6.8 Hz), 7.75 (d, 2H, J = 6.4 Hz), 8.62 (d, 1H, J = 8.8), 11.5 (s, 1H); 13C NMR (CDCl3, 100 MHz): d 43.1, 123.1, 125.6, 128.4, 128.6, 130.0, 132.7, 133.2, 133.8, 137.6, 137.6, 165.4, 197.9. Synthesis of 1-acetyl-7-chloro-5-phenyl-1H-benzo[e][1,4]- diazepin-2(3H)-one (2) To a vigorously stirred mixture of nordiazepam (1) (0.27 g, 1 mmol), a powder mixture of K2CO3 (0.55 g, 4 mmol)/KOH (0.22 g, 4 mmol) and acetic anhydride (0.18 mL, 2 mmol) was added. The progress of the reaction was monitored by TLC. After completion of the reaction (3 h), water (3 9 10 mL) was added and the 1-acetyl-7-chloro-5-phenyl-1H-benzo[e][1,4]diazepin-2(3H)- one (2) was easily isolated by a simple filtration in more than 80 % yield with high purity. The product was used in the next step without any purification. m.p = 163-165 C [162-163 C (Usui et al., 1970)]; IR (KBr, cm-1 ): 706, 1672, 1690, 1766, 2923, 2854; 1 H NMR(CDCl3, 400 MHz): d 2.2 (s, 3H), 7.25 (d, 1H, J = 2.4), 7.35 (m, 3H), 7.44 (d, 2H, J = 8.8), 7.49 (m, 3H), 7.57 (m, 2H); 13C NMR (CDCl3, 100 MHz): d 20.3, 117.7, 121.2, 126.1, 128.7, 128.8, 129.1, 130.4, 131.5, 134.9, 138.2, 141.1, 158.7, 168.7

What is the need for using too many softwares when you can do everything in autodock itself?

thanks sir ji❤️❤️

Thank you sir❤️ Discuss synthesis of cyclopentolate, pyridostigmine, pethidine, furosemide,triamterene ,indapamide,Mebendazole, metronidazole,ampicillin... If you can sir

Exposure of video should be locked sir while you shoot.. It's ok🥰

Prochlorperazine also

If you can please discuss thiamyl sodium and dibucaine synthesis. This is a year wise syllabus topic please consider us also. I have those materials but I can't mugup sir.🙏

I literally liked that way you approached every topics...these are not adjective words I know you won't like it... But I should say you are a gem🥳

My favourite teacher ever I want to keep in touch with you. Trust I won't misuse it. Please

Good going sir 👏 👍 👌 🙏

Very good class. Thankyou sir

Thankyou very much sir, For this elaborative docking tutorial, it helps a lot about understanding the environment for basic drug design. But my key concern is the quality of video it is a bit difficult to keep track without your voice over although you explained explicitly. Sir, I have 2 more questions..... 1. Can we do the energy-minization steps using genetic algorithm(GA) in autodock itself? 2. Can we do one more step at the end that is post docking energy minimization to study change in protein confirmation ? Hope you would resolve my questions!!!!!

Please give me your contact details sir Please 🙏