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Mutation, Randomness and Evolution
Приєднався 20 сер 2020
Video content for "Mutation, Randomness and Evolution," covering the randomness doctrine, biases in the introduction of variation, Synthesis mythology, and related topics
The role of the mutation spectrum in evolution (theory)
This short series of screencasts develops a foundation of concepts and theory for understanding a dispositional role of mutation in evolution. Classical neo-Darwinian thinking says that mutation is a random source of raw materials, and that selection determines the course of evolutionary change. But work from the past few decades has shown that mutation sometimes plays a dispositional role in evolution, i.e., as a difference-maker causing some things to be more likely than others. How can we re-think mutation to understand this kind of dispositional role?
Переглядів: 58
Відео
The role of the mutation spectrum in evolution (introduction)
Переглядів 147Місяць тому
This short series of screencasts develops a foundation of concepts and theory for understanding a dispositional role of mutation in evolution. Classical neo-Darwinian thinking says that mutation is a random source of raw materials, and that selection determines the course of evolutionary change. But work from the past few decades has shown that mutation sometimes plays a dispositional role in e...
04.01. A critique of the "isotropic variation" critique
Переглядів 142Рік тому
An emerging critique of orthodoxy in evolutionary biology says that classical thinking assumes variation is "isotropic", i.e., without tendencies or non-uniformities. Is this true? What are the implications? In this screencast, I explain that, whereas the classical neo-Darwinian view holds that variation has no dispositional role in determining the course of evolution, this was never based on a...
05.03 The Shifting Gene Frequencies Paradigm
Переглядів 116Рік тому
The idea that evolution is shifting gene frequencies is familiar, but what does it really mean? In this screencast I explain how the shifting-gene-frequencies paradigm provides clear guidance on how to think about evolution, how this guidance has shaped evolutionary theories and evolutionary thinking, and what are the limitations of the paradigm
How the introduction of variation biases evolution, and why it matters (Manchester, 17-02-2023)
Переглядів 157Рік тому
A lecture that begins with the empirical case for mutation-biased adaptation (first half) and proceeds to explain how a theory for the evolutionary impact of mutational and developmental biases in the introduction of variation provides a grounding for internalist-structuralist thinking in regard to evo-devo, molecular evolution, and structuralism.
A bad theory about theories
Переглядів 1582 роки тому
The internet is littered with a renegade definition of "theory" so obviously wrong that anyone with an internet connection can verify its wrongness in minutes. The source? A white paper on science from the US National Academy of Sciences. The blog version of this content (with a list of sources) is available at www.molevol.org/bad-theory-of-theory
Introduction biases: theory, evidence, and implications
Переглядів 882 роки тому
The course of adaptation reflects what is mutationally likely, to such a degree that a several-fold bias in mutation may have a several-fold effect on the changes involved in adaptation. Though this effect seems obvious in some ways, it is a radical concept for evolutionary biology: it contrasts with the passive material role assigned to variation in neo-Darwinism, it undermines the conception ...
02.04. Theory: causes and consequences of biases in introduction
Переглядів 822 роки тому
The course of adaptation reflects what is mutationally likely. The previous lectures established this point empirically. But how does this happen? How do we understand this theoretically? Other theories about the role of variation in evolution say that variation is merely a source of raw materials that selection shapes into adaptations, or that mutation is a weak pressure easily overcome by sel...
02.03 A second look at the case for mutation-biased adaptation
Переглядів 972 роки тому
This screencast revisits the empirical argument that mutation biases are an important influence on adaptation, with a view to assessing the likelihood of some alternative interpretations
02.02 The empirical case for mutation-biased adaptation
Переглядів 1653 роки тому
Mutational and developmental biases in the introduction of variation are possible causes or orientation or direction in evolution. This screencast summarizes the empirical case for the reality and the importance of this type of evolutionary causation.
02.01 Introduction - Bias in the introduction of variation as an evolutionary cause
Переглядів 1833 роки тому
Mutational and developmental biases in the introduction of variation are possible causes or orientation or direction in evolution. This is the introduction to a series of screencasts on this topic.
The anomaly of a basic population-genetic cause missing from the historic evolutionary Synthesis
Переглядів 2563 роки тому
A process of evolutionary change dependent on events of mutation that introduce new alleles is subject to biases in the introduction process, via a simple "first come, first served" logic. The implications of this kind of causation, formally demonstrated in 2001 and elaborated in subsequent theoretical work, include a novel prediction of mutation-biased adaptation that is now verified empirical...
Hey Arlin love your videos thanks for the new part
Some sources C. Darwin. On the Origin of Species. John Murray, London, 1st edition, 1859. W. Gilbert. The exon theory of genes. Cold Spring Harbor Symp. Quant. Biol., 52:901-5, 1987 T. Kasbeer. Bibliography of Continental Drift and Plate Tectonics. Geological Society of America, Boulder, CO, 1975. M. Kimura. Evolutionary Rate at the Molecular Level. Nature, 217(February 17): 624-626, 1968. J. King and T. Jukes. Non-Darwinian Evolution. Science, 164:788-797, 1969. M. Kreitman. The neutral theory is dead. Long live the neutral theory. Bioessays, 18(8):678-83, 1996. National Academy of Sciences and Institute of Medicine. Science, Evolution, and Creationism. Report, National Academy of Sciences, USA, 2008. H. Roscoe and A. Harden. A New View of the Origin of Dalton’s Atomic Theory. MacMillan and Co., London, 1896. C. R. Woese and G. E. Fox. The concept of cellular evolution. J Mol Evol, 10(1): 1-6., 1977. Working Group on Teaching Evolution. Teaching About Evolution and the Nature of Science (fermat.nap.edu/books/0309063647/html/index.html; published ; accessed June 26, 2020). Report 0-309-06364-7, National Academy Press, 1998.
In summary: Mutation bias plays a larger role in evolution than previously thought. Knowing this helps us make better evolutionary forecasts. Is that a fair summary?
Yeah
Thanks, Arlin! You can let references as a fixed comment! We need more videos!
Thanks for your suggestion. I added a link to the description, pointing to a text version with sources. I have planned a series of videos but my rate of production is just ~1 per month so it's a slow process.
Hi, i really like your series. This subject is very interesting. I don't know if you would consider doing an even more basic introduction to mutation biases? Coming from an undergrad, I understand the importance of using the right words for new ideas and not falling in the neo-darwinian paradigm vocabulary. But, I must admit it took me quite a lot of reading of blog and listening before having a «correct» understanding of the subject. I think it could benefit newcomer and help spreading the ideas!