Sino Biological, Inc.
Sino Biological, Inc.
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Cellular Senescence and Senolytics in Aging and Diseases
Join us for a BioTalk webinar on cellular senescence, a hallmark of aging where cells permanently exit the cell cycle due to damage and stress.
Cellular senescence, a hallmark of aging, involves the stable exit from the cell cycle in response to cellular damage and stress. Senescent cells (SnCs) often develop a pathogenic senescence-associated secretory phenotype (SASP) that promotes secondary senescence and disrupts tissue homeostasis, impairing tissue repair and regeneration. Transgenic mouse models with the capability for genetic ablation of SnCs have demonstrated their crucial role in driving aging and related diseases.
Consequently, senotherapeutics have been developed to either pharmacologically eliminate SnCs (senolytics) or suppress the SASP and other senescence markers (senomorphics). Extensive preclinical studies and initial clinical trials have shown the potential benefits of senotherapeutics, leading to multiple ongoing clinical trials. In conclusion, targeting cellular senescence presents a promising therapeutic strategy for slowing aging and treating age-related diseases.
This webinar is made in collaboration with GenoBioTx
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Speaker
Yi Zhu - Assistant Professor, Mayo Clinic
Dr. Yi Zhu earned her BS from Beijing Normal University, followed by a PhD from the University of Michigan. She completed her postdoctoral training under the mentorship of Dr. James Kirkland at the Mayo Clinic, where she later joined the faculty in the Department of Physiology and Biomedical Engineering. Now an assistant professor at Mayo Clinic, Dr. Zhu is renowned for her groundbreaking work on cellular senescence. Her research primarily focuses on how senescent cells drive age-related diseases and neurological disorders. Among her significant achievements is the discovery of the first generation of senolytics in 2015, which has shown great promise in preclinical trials for mitigating age-associated dysfunction. Currently, Dr. Zhu’s research targets senescent glial cells and explores the role of peripheral senescent cells in brain aging and Alzheimer's disease. She also utilizes cutting-edge spatial-OMICs techniques to map senescent cells in human diseased tissues, advancing the understanding of cellular senescence in age-related pathologies.
Переглядів: 151

Відео

Lock & Key Webinar: Novel Small Proteins & Single Domain Antibodies As Therapeutics
Переглядів 9114 днів тому
SkunkWorx Bio, has developed a new generation of precision therapeutics that it terms SKWX proteins and SKWX antibodies. They are derived from the Company’s unique drug discovery platforms based on a suite of integrated technology modules using naturally occurring templates or rationally designed constructs. SkunkWorx has 3 cornerstones that drive versatility and allow flexibility in the select...
Optimizing Protein Manufacturing with Octet BLI at Sino Biological's Center for Bioprocessing
Переглядів 2621 день тому
Discover how Sino Biological utilizes the Octet BLI instrument to enhance protein manufacturing with high-quality kinetic assays. This cutting-edge technology offers label-free molecular interaction analysis, measuring association, dissociation, and binding affinity with minimal sample preparation. Learn how this industry-standard tool supports diverse projects, from antibody studies to protein...
Sino Biological's Center for Bioprocessing in Houston, Texas, USA.
Переглядів 1002 місяці тому
Curious about cutting-edge recombinant protein and antibody production? Our new Center for Bioprocessing in Houston, TX is revolutionizing the field with state-of-the-art technology and a world-class team. See how we're delivering high-purity products with lightning-fast turnaround times. 🎥 Watch now to explore our advanced facilities and services! 🔗 Learn more on our website: www.sinobiologica...
The Biology of Human Appetite and Weight Regulation
Переглядів 1204 місяці тому
Obesity is a serious global health problem due to its increasing prevalence and comorbidities. Through decades of research using experimental animals as model systems, a great deal of knowledge has been obtained regarding mechanisms for body weight regulation in animals. However, a major question in the field still remains unsolved: what causes human obesity? Human genetic studies revealed vari...
Lock and Key: Spatomics' CFP Technology
Переглядів 764 місяці тому
The ability to profile the comprehensive molecular states in single cells in situ is crucial for our understanding of cancer, neurobiology, and stem cell biology. However, existing single cell genomics and proteomics technologies are carried out on isolated and amplified biomolecules. Thus, they conceal the spatial relationships among biomolecules. Meanwhile, other in situ imaging based methods...
Lock and Key with SignalChem Biotech: Drug Discovery in Action
Переглядів 3378 місяців тому
Kinase inhibitors are an established and growing class of therapeutics in precision medicine. Kinases are the principal regulators of many key cellular signaling cascades essential in maintaining normal cell function. Due to this central role, mutations in kinases and/or misregulation of kinase activities are often linked to the development of various pathologies making kinases an attractive ta...
Podcast: Next-generation antibody therapeutics
Переглядів 1698 місяців тому
In this episode, we speak to two experts from Sino Biological US Inc. (PA, USA) about the latest developments in antibody technologies and how these developments have led to the next generation of antibodies that are revolutionizing therapeutic approaches to a number of diseases.
Introducing next-generation antibodies
Переглядів 2388 місяців тому
This video details the three key categories of next-generation antibody therapeutics: bi-specific antibodies, antibody-drug conjugates (ADC), and nanobodies. Discover their structures and mechanisms of action in this short, introductory video.
Introducing Sino Biological's Center for Bioprocessing (C4B) in Houston, Texas
Переглядів 4599 місяців тому
Sino Biological is a leading global provider of comprehensive CRO services, offering a wide range of solutions from gene synthesis to protein and antibody expression and purification. Boasting more than a decade of expertise in protein expression and purification, Sino Biological has effectively produced over 6000 proteins for our customers. Our new US-based Center for Bioprocessing (C4B) will ...
Biotalk Tuesday: Next-gen Nanovial Platforms
Переглядів 3549 місяців тому
Nanovials are emerging as an accessible platform for performing single-cell functional screening leveraging standard instrumentation, such as flow cytometers and microfluidic single-cell sequencing platforms. Each cell and its secreted products are captured in nanovials where they can be analyzed and sorted using widely available fluorescence activated cell sorters operating at up to a 1000 cel...
Empowering Oncology Research: Transmembrane Proteins and Cutting-edge Production Platforms
Переглядів 6910 місяців тому
Transmembrane proteins play a critical role in signal transduction, cell adhesion, nutrient uptake, and immune response modulation. However, dysregulation of transmembrane proteins can contribute to tumor initiation, metastasis, and evasion of immune surveillance. Unraveling their intricate roles provides valuable insights for the development of targeted therapies and personalized treatment str...
Advances in Influenza Research: Developing Effective Vaccines
Переглядів 13110 місяців тому
This webinar outlines recent advancements in the development and use of different types of influenza vaccines, as well as future directions, such as creating universal influenza vaccines. Furthermore, the immune response is a critical factor in evaluating the vaccine's efficacy and side effects, and it is measured by detecting cytokines such as IFN-α, IL-6, and G-CSF. The association between cy...
Current Landscape and Future Directions of Multi-specific Antibodies
Переглядів 13410 місяців тому
Antibody therapeutics is a fast-growing market boosted by developments in bispecific antibodies and in newly emerging tetra-specific antibodies. With the ability to recruit a combination of antibody conjugates and immune cells to target cells, as well as the capacity to bind multiple epitopes simultaneously, multi-specific antibodies are equipped with an improved level of specificity. Moreover,...
CAR-T and CAR-NK Cell Therapy Development
Переглядів 8310 місяців тому
In this video, we introduce CAR-T and CAR-NK cell therapies and compare their advantages and disadvantages.
Advancing RSV Research: Expanding Therapeutic Options with Recombinant Antibodies and Antigens
Переглядів 4510 місяців тому
Advancing RSV Research: Expanding Therapeutic Options with Recombinant Antibodies and Antigens
Tools for Accelerating Research Using Next-generation Cell Models
Переглядів 9810 місяців тому
Tools for Accelerating Research Using Next-generation Cell Models
BioTalk: Broadening B cell response using a nanoparticle adjuvant
Переглядів 303Рік тому
BioTalk: Broadening B cell response using a nanoparticle adjuvant
CAR-T and CAR-NK Cell Therapies
Переглядів 316Рік тому
CAR-T and CAR-NK Cell Therapies
Recombinant Antibody Production: Novel Antibody Generation Platforms
Переглядів 1,1 тис.Рік тому
Recombinant Antibody Production: Novel Antibody Generation Platforms
Recombinant Protein Expression Optimization Strategies and Process Development
Переглядів 1,9 тис.Рік тому
Recombinant Protein Expression Optimization Strategies and Process Development
Disease Progression in Tendinosis - BioTalk Tuesday
Переглядів 72Рік тому
Disease Progression in Tendinosis - BioTalk Tuesday
Carterra's High-throughput Epitope Analysis and the Latest in Antibody Discovery
Переглядів 447Рік тому
Carterra's High-throughput Epitope Analysis and the Latest in Antibody Discovery
Natural Killer Cell Online Symposium
Переглядів 116Рік тому
Natural Killer Cell Online Symposium
AI-based Antibody Discovery Service Supporting De novo Antibody Design &Antibody Affinity Maturation
Переглядів 1,1 тис.Рік тому
AI-based Antibody Discovery Service Supporting De novo Antibody Design &Antibody Affinity Maturation
In Situ Cell-Surface Proteomics - BioTalk Tuesday
Переглядів 189Рік тому
In Situ Cell-Surface Proteomics - BioTalk Tuesday
TV Segment | Watch Sino Biological’s segment that appeared on World’s Greatest TV for more insight!
Переглядів 95Рік тому
TV Segment | Watch Sino Biological’s segment that appeared on World’s Greatest TV for more insight!
The Ragon Insititute on Waning and Boosting of Antibody Functions upon SARS-CoV-2 Vaccination
Переглядів 167Рік тому
The Ragon Insititute on Waning and Boosting of Antibody Functions upon SARS-CoV-2 Vaccination
RedShiftBio's Microfluidic Modulation Spectroscopy Technology
Переглядів 215Рік тому
RedShiftBio's Microfluidic Modulation Spectroscopy Technology
Aureka's High Throughput Bispecific Antibody Discovery Pipeline - Lock and Key Webinar
Переглядів 576Рік тому
Aureka's High Throughput Bispecific Antibody Discovery Pipeline - Lock and Key Webinar

КОМЕНТАРІ

  • @vivekbkandimalla8431
    @vivekbkandimalla8431 Місяць тому

    Very informative presentation, Thanks to Dr Xuejiao Zhang

  • @POLLIVILLE0
    @POLLIVILLE0 2 місяці тому

    I have publisert universal vaccine

  • @technovols
    @technovols 3 місяці тому

    great

  • @Ron-b7g
    @Ron-b7g 5 місяців тому

    IF YOU HAVE CANCER CK OUT JOE TIPPENS CANCER PROTOCOL FENBENDAZOLE RIGHT AWAY, FENBENDAZOLE REDUCES AND KILLS CANCER CELLS WITH OUT ANY SIDE EFFECTS AND CAN BE USED AS A PROPHYLACTIC AGAINST CANCER. JESUS LOVES YOU ❤❤❤

  • @scottbenson2327
    @scottbenson2327 7 місяців тому

    Are there any current products available in embryonic stem cells that are reproducing swan cells

  • @kailashsingh9737
    @kailashsingh9737 8 місяців тому

    Very beautiful sweet tq so much ❤❤❤❤❤❤

  • @bhaskardesai4106
    @bhaskardesai4106 10 місяців тому

    Is there any research going on for elimating or stop production of Aquaporin 4 Antibody in spinal Cerebral water channel, a main route cause of Neurological disorder disease, NMOSD. IF possible, kindly give details of present condition in research for NMOSD.

  • @Denise-ux4xd
    @Denise-ux4xd 10 місяців тому

    Read the DESCRIPTION of the vaccine insert, AIDS, Cancer, Infertility...

  • @George-rq1yp
    @George-rq1yp 11 місяців тому

    Brilliant product!

  • @itsnotme8554
    @itsnotme8554 Рік тому

    Are recombinant antigen are safe ? Like HIV test kit have recombinant antigen so while testing it can give infection?

  • @Adi64717
    @Adi64717 Рік тому

    Thank you! Very informative!

  • @bbarry083
    @bbarry083 Рік тому

    This webinar was informative

  • @bhaskardesai4106
    @bhaskardesai4106 Рік тому

    Is there any new research going on Remylination of spine, Brain and overall Immune system.

  • @bhaskardesai4106
    @bhaskardesai4106 Рік тому

    Is there any new research going on cure for Autoimmune diseases like, NMOSD, MS, Transverse Mylitis etc.

  • @cyberrosa4720
    @cyberrosa4720 Рік тому

    Great talk! I can use clarification as to which steps to take towards the embedded block for under or over fixation of the tissue? Is there a protocol for these two scenarios?

  • @arunavadasgupta2147
    @arunavadasgupta2147 Рік тому

    Tendonis Paradoxical To Anti body Cell Helps producing The proteins To grow imunity Of Human body

  • @guilhermemuzy4025
    @guilhermemuzy4025 Рік тому

    This lecture in incredible. Thanks for sharing

  • @charlespeter9914
    @charlespeter9914 Рік тому

    Where is the English version?

  • @timabbott4420
    @timabbott4420 Рік тому

    Promo'SM

  • @paulkatende8736
    @paulkatende8736 Рік тому

    Bravo aux chinois pour leur nouvellte chnologie très efficace !!

  • @isabellerose2196
    @isabellerose2196 Рік тому

    Lets cl to ne paid witney interrestsssssssss@@@@

  • @paulhampel8084
    @paulhampel8084 Рік тому

    The lecturer briefly mentioned DNA advantages of temperature stability and potential efficacy and then moved to LION/repRNA and the Gene Gun where stability is based on Lyophilization. But we do have Lyophilized mRNA for several developing drugs. This is a major technology change. Is LION/repRNA or the Gene Gun worth the change?

  • @yifeicui5666
    @yifeicui5666 Рік тому

    Thank you for the information. It actually helped me with the concept in a course.

  • @deborahfuller3983
    @deborahfuller3983 Рік тому

    Starting at 17:55, fast forward to19:38. There was a disruption in the wifi and the streaming was disrupted.

  • @jameskohl7959
    @jameskohl7959 Рік тому

    The miRNA-mRNA balance links sunlight and humidity to our oxygen-dependent amino acid repertoire via the creation of nucleic acids and oxygen-dependent fixation of amino acid substitutions was linked to all biodiversity on Earth in McEwen et al., (1964) and Dobzhansky (1964).

  • @thymusictoo364
    @thymusictoo364 Рік тому

    Thank you very much to everyone involved with this and making it publicly available! it's helped me very much in learning how to do IHC 🌻

  • @lassorb4752
    @lassorb4752 Рік тому

    Thank you so much 🙏🏼

  • @philippevanblerk792
    @philippevanblerk792 Рік тому

    tres

  • @mastringminds
    @mastringminds Рік тому

    What a about antibody for EBV and CMV?

  • @francescolandini7947
    @francescolandini7947 Рік тому

    Nice presentation! Very Educational! Thanks 🙏

  • @francescolandini7947
    @francescolandini7947 Рік тому

    Hier Pier EPITOPE retrieval! Not Enzyme.. error in the slides

  • @alonzobarnes2839
    @alonzobarnes2839 Рік тому

    Hi! months ago I found out I was diagnosed with Herpes. I was heartbroken, However that same month I was recommended to #DrAjayi on UA-cam who helped me to cure the virus with natural herbal treatment. Now I fully believe in natural treatment thanks to Dr Ajayi. You can visit his UA-cam channel and don't forget to subscribe..

  • @talashpeygir2621
    @talashpeygir2621 2 роки тому

    thank you for excellent new information

  • @SarkarSAziz
    @SarkarSAziz 2 роки тому

    Hi Sir. Thanks for the informative presentation. I got a question, please. How do antibodies enter the cells? I need an exact answer. Is it because of: 1- mechanical destruction of the cells during microtomy? 2- Using ethanol and xylene? during the tissue preparartion?

    • @SarkarSAziz
      @SarkarSAziz Рік тому

      @@jlmjkooj thanks a lot for your answer.

  • @farahbeheshti2642
    @farahbeheshti2642 2 роки тому

    سلام نازیین شادی و. سلامتی مهمان همیشگی وجودشما عالی بود عاقبت به عافیت

  • @anamikasingh6992
    @anamikasingh6992 2 роки тому

    where can i get pdf of this ppt

  • @atozbodyfitness1145
    @atozbodyfitness1145 2 роки тому

    Cure is possible or not,, till date 2025

  • @yassinedaadoui7576
    @yassinedaadoui7576 2 роки тому

    Tkirtigterniurte

  • @rennedoeurk8935
    @rennedoeurk8935 2 роки тому

    b

  • @stingsting1132
    @stingsting1132 2 роки тому

    How can I keep calm after Dr Abiola on UA-cam helped me cure HIV

  • @larrysmith9480
    @larrysmith9480 2 роки тому

    A very big appreciation to Dr Osaba on UA-cam for helping me to cure my HIV with his natural herbs medication.may God continue to bless your good work

  • @brooketeddy7129
    @brooketeddy7129 2 роки тому

    Cured from HIV through Dr Abiola medication ❤️

  • @user-zd3km9dr5h
    @user-zd3km9dr5h 2 роки тому

    Can you provide the ppt?

  • @awequayzngs1780
    @awequayzngs1780 2 роки тому

    A lot of ecclesiastical rotten garbage !.

  • @raylim8386
    @raylim8386 2 роки тому

    all cells needs Negative Ion to be strong...tell us something on Negative Ion with cells please...

  • @Orthodoxuk
    @Orthodoxuk 2 роки тому

    How is this new, this is how we were designed!

  • @JesusLovesHisCreations
    @JesusLovesHisCreations 2 роки тому

    As we age, our T cells depletes, so that explains why we succumb to Covid-19, cos both T cells helpers n T cells killers are depleting, so are unable to eliminate the Covid-19….

  • @chesusborrajonicolau4291
    @chesusborrajonicolau4291 3 роки тому

    ¿Conocen los resultados del análisis de viales Pfeizer? Si los conocieran, no estarían hablando de virus, estarían hablando de cosas muy diferentes. Su origen no es biológico. Es químico y tiene total relación con un material llamado Öxido de Grafeno (GO). Nosotros sin medios hemos sido capaces de descubrirlo. Ustedes tienen todos los medios. Investiguen. Si lo desean y me ofrecen un correo, les mando ese análisis, con mucho gusto. Un saludo.

    • @kaela32nintama
      @kaela32nintama 2 роки тому

      Ustedes quienes? Yo trabajo en salud y me interesa lo que plantea, podria compartir esas investigaciones?

  • @cl5193
    @cl5193 3 роки тому

    There's been too much sewage under the bridge. I will never trust the alphabet elite again. I used to believe they had our best interests as their priority. It will be at least 10 years before I even consider another vaccine.

  • @jonathanjollimore7156
    @jonathanjollimore7156 3 роки тому

    HA just check there web sight "Sino Biological Inc. was founded in January 2007 in Beijing, P.R. China by biotech pioneer and worldwide expert, MIT institute professor, Dr. Daniel I.C. Wang and his former student, Dr. Liangzhi Xie. Sino Biological Inc. is quickly becoming the leading global biological solution specialist, offering a comprehensive set of value-added and cost-effective premium quality solutions (services and reagents) to accelerate life science research and biological product development worldwide. Its customers include top-10 global pharmaceutical and biotech companies, small biotech companies, and academic institutions worldwide. " Yea not trusting any of this