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InSphero
Приєднався 2 сер 2010
InSphero provides superior biological relevance to in vitro testing with its easy-to-use solutions for production, culture and assessment of more organotypic 3D cell culture models. Founded in 2009, the company's patented 3D cell culture platforms and methods enable large-scale, reproducible production of a broad range of assay-ready 3D InSightTM Microtissues including models derived from liver, pancreas, tumor, heart,brain, and skin. Microtissues are delivered directly to customers, or are accessible through 3D InSightTM Standard Services, where InSphero scientists conduct tailored screening projects with rapid turnaround and strict confidentiality. Supported by an unrivalled portfolio of 3D-optimized culture media, assay protocols, and imaging solutions, InSphero microtissues and services help to identify promising drugs and toxic liabilities with greater predictivity at early development stages... read more www.insphero.com/company
Akura™ Immune Flow Organ-on-Chip Platform Explainer Video
Building on the features and concept of the Akura™ Flow Chip, the Akura™ Immune Flow enables the addition of suspension cells to the multi-organ system. A patented design of the microfluidic channel prevents sedimentation of the cells and enables a continuous interaction of the cells with multiple spheroids and organoids in the system under flow conditions. The Akura™ Immune Flow adds immune competence to multi-organ systems while ensuring a seamless integration and optimal utilization of standardized 3D models.
Discover Akura™ Immune Flow here: insphero.com/3d-cell-culture-tools/akura-immune-flow-organ-on-chip-platform/
Discover Akura™ Immune Flow here: insphero.com/3d-cell-culture-tools/akura-immune-flow-organ-on-chip-platform/
Переглядів: 70
Відео
InSphero and FDA's NCTR Publish the Largest Benchmark Research on Liver Toxicity
Переглядів 39День тому
In this interview, the first author, Lola Fäs, and the corresponding author, Dr. Bruno Filippi from our Liver Safety team share exclusive insights from the recent publication in Toxicological Sciences. 📄 What’s it about? In this video, our experts discuss the landmark research conducted by InSphero and scientists from the @US_FDA National Center for Toxicological Research. They dive into the gr...
InSphero’s Mission to Reduce Animal Testing in Drug Discovery - an Interview with LSCV
Переглядів 113Місяць тому
In this interview with the Swiss League Against Animal Testing @LSCV_CH we discussed the critical need for advancements in biotechnology to address the limitations of traditional animal testing in drug development. At InSphero, we develop highly-predictive and scalable 3D in vitro models to reduce, and eventually replace, the need for animal testing in early-stage pharmaceutical research. These...
Manual medium exchange under 2 minutes with InSphero Akura™ 96 Spheroid Microplate
Переглядів 165Рік тому
How fast can you do manual medium exchange? With Akura™ 96 Spheroid Microplate you can fast forward medium exchange in less than 2 minutes, so you have more time for your research. Advance your 3D cell experiment with: 1) Our patented well design which reliably prevents spheroid aspiration during medium exchange 2) The flat, optical grade bottom window that makes images crisp and distortion-fre...
Introducing InSphero
Переглядів 3742 роки тому
InSphero is Swiss-based phenomics biotech that has been perfecting 3D-cell-based drug discovery platforms and scaffold-free 3D organ-on-a-chip technologies for more than 10 years. InSphero deploys its patent-pending technologies for highly scalable drug discovery programs against liver diseases, e.g NASH and NAFLD, T1D, T2D, and solid cancers.
Akura™ 96 Spheroid Microplate | All-in-one plates for spheroids and organoids
Переглядів 1,5 тис.2 роки тому
If you are working with in vitro 3D cell culture and looking to form spheroids & organoids in a reliable scaffold-free manner, then Akura™ 96 Spheroid Microplate is here to help. Its unique design allows you to reliably aggregate spheroids, exchange more than 90% of medium without any loss of precious cell-material. All this in scaffold-free conditions. InSphero Akura™ 96 Spheroid Microplate is...
Human 3D in vitro NASH model for efficacy testing of clinical drug candidates | InSphero
Переглядів 1272 роки тому
Hear what our NASH experts Simon Stroebel, PhD Radina Kostadinova, PhD and Francisco Verdeguer have to say about our unique human NASH 3D in vitro model and the latest publication in Scientific Reports: "A 3D primary human cell‑based in vitro model of non‑alcoholic steatohepatitis for efficacy testing of clinical drug candidates." Read the paper here: www.nature.com/articles/s41598-021-01951-7 ...
How to Evaluate Preclinical and Clinical DILI
Переглядів 922 роки тому
In this webinar, InSphero CSO Prof. Armin Wolf will discuss how the research community gets “lost in translation” and share his strategy for bridging the divide between preclinical and clinical research to bring safe, effective drugs to market - and to patients in need of new therapeutics. Armin will introduce a “causality assay” framework for evaluating drug-induced liver injury (DILI) with no...
Artificial Intelligence in Digital Pathology: Quantification of Fibrosis in Human 3D NASH Model
Переглядів 1703 роки тому
In this webinar, InSphero Scientific Ambassador Dr. Sue Grepper focused on a novel human 3D NASH model, consisting of 4 different liver cell types relevant to this disease development. New findings were shared relating to compound modalities other than classic small molecules, as well as new quantitative fibrotic measurements achievable with this model. PharmaNest CEO Dr. Mathieu Petitjean pres...
Human Islet Microtissues as an In Vitro and an In Vivo Model System for Diabetes | Joan Mir Coll
Переглядів 1223 роки тому
Hey Joan Mir Coll! Tell everyone about your recent paper "Human Islet Microtissues as an In Vitro and an In Vivo Model System for Diabetes" which you published together with AstraZeneca and Karolinska Institutet. Read the full publication here: www.mdpi.com/1422-0067/22/4/1813
InSphero and Hamilton Collaborate to Improve the Production and Handling of Spheroids
Переглядів 4903 роки тому
InSphero AG, the pioneer of 3D cell-based assay technology and Hamilton, an innovation-driven leading supplier of automated liquid handling equipment, have entered into a collaboration to improve the production and handling of 3D in vitro spheroid microtissues. 3D InSightTM Microtissues and MagPip™ technology on the Microlab VANTAGE ™
Implementing High Resolution High Content Image Analysis in 3D Spheroid Models | InSphero Webinars
Переглядів 1513 роки тому
In this webinar, InSphero Senior Application Scientist and SBI2 President Elect Judi Wardwell-Swanson and Yokogawa Life Sciences Senior Executive Dr. Gerd Heimlich provide a detailed introduction to HCA with multicellular 3D models for drug discovery, review platform requirements and recommendations, and present two case studies to illustrate the power of HCA in complex drug discovery applicati...
Microfluidic Perifusion Platform for Studying Insulin Release Dynamics | InSphero Webinars
Переглядів 1663 роки тому
In this webinar, InSphero Head of Islet Solutions, Dr. Burcak Yesilag teams up with Dr. Patrick Misun of the ETH Zürich Department of Biosystems Science and Engineering, to discuss how dynamic insulin release can be studied in vitro using a novel microfluidic perifusion system. They present results of their collaborative study, recently published in Advanced BioSystems, and offer their vision f...
Predicting Metabolism Related Drug-Drug Interactions with Organ on a Chip | InSphero Webinars
Переглядів 993 роки тому
Drug-drug interactions (DDIs) occur when the pharmacological activity of one drug is altered by a second drug. As multimorbidity and polypharmacotherapy are becoming more common due to aging populations, the risk of DDIs is rapidly increasing. In this webinar, InSphero Head of Technologies and Platforms Dr. Olivier Frey and Dr. Christian Lohasz from the Bio Engineering Laboratory at ETH Zurich,...
Optimizing 3D Spheroid Models for Efficient DILI Screening | InSphero Webinars
Переглядів 2143 роки тому
In this webinar, InSphero Senior Application Scientist Sue Grepper, PhD will provide an overview of the many different types of in vitro and in vivo models used for studying NAFLD and NASH. Then she’ll take you on a virtual tour of how the InSphero scientific team evaluates new drugs and therapies under development, using Gilead's Firsocostat, an ACC inhibitor currently in Phase II trials, as a...
A Novel Causality Framework for Teasing Out DILI Mechanisms | InSphero Webinars
Переглядів 503 роки тому
A Novel Causality Framework for Teasing Out DILI Mechanisms | InSphero Webinars
InSide InSphero with Armin on alternatives to animal testing
Переглядів 1143 роки тому
InSide InSphero with Armin on alternatives to animal testing
High Content Imaging of 3D In Vitro Cell Culture with InSphero & Yokogawa
Переглядів 1493 роки тому
High Content Imaging of 3D In Vitro Cell Culture with InSphero & Yokogawa
Redefining NASH drug discovery: a new approach to complex disease modeling | InSphero Webinars
Переглядів 1823 роки тому
Redefining NASH drug discovery: a new approach to complex disease modeling | InSphero Webinars
Multi-tissue organ networks in vitro | Akura™ Flow
Переглядів 1143 роки тому
Multi-tissue organ networks in vitro | Akura™ Flow
Unpacking InSphero 3D InSight™ Assay-Ready Microtissues
Переглядів 2183 роки тому
Unpacking InSphero 3D InSight™ Assay-Ready Microtissues
In vitro human liver models of NAFLD and NASH | 3D InSight™ InSphero
Переглядів 3573 роки тому
In vitro human liver models of NAFLD and NASH | 3D InSight™ InSphero
Organ-on-a-chip technology and microphysiological system | Akura™ Flow
Переглядів 1433 роки тому
Organ-on-a-chip technology and microphysiological system | Akura™ Flow
InSphero CEO Jan Lichtenberg Receives EY Entrepreneur of the Year Emerging Entrepreneur Award
Переглядів 283 роки тому
InSphero CEO Jan Lichtenberg Receives EY Entrepreneur of the Year Emerging Entrepreneur Award
Transforming Drug Discovery with InSphero
Переглядів 613 роки тому
Transforming Drug Discovery with InSphero
InSide InSphero with Frank on collaborations and partnerships with pharma
Переглядів 1803 роки тому
InSide InSphero with Frank on collaborations and partnerships with pharma
InSphero Akura™ Flow Organ-on-a- chip Technology
Переглядів 4545 років тому
InSphero Akura™ Flow Organ-on-a- chip Technology
Transforming Islet Research - 3D InSight™ Islet Microtissues - ADA2017
Переглядів 3807 років тому
Transforming Islet Research - 3D InSight™ Islet Microtissues - ADA2017
Discover Akura™ Immune Flow Organ-on-Chip here: insphero.com/3d-cell-culture-tools/akura-immune-flow-organ-on-chip-platform/
Access the full publication here: insphero.com/resource/hepatotoxicity-assessment-insphero-fda-nctr/
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