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KETODOXAPRAM AS A TREATMENT FOR ATRIAL FIBRILLATION - Annelies Decloedt, Ghent University
KETODOXAPRAM AS A TREATMENT FOR ATRIAL FIBRILLATION - Annelies Decloedt, Ghent University
One Sentence Summary: This study is to determine if Ketodoxapram is a promising novel treatment method for horses with atrial fibrillation.
Importance to the Equine Industry: A novel treatment option for atrial fibrillation is important for the equine industry, especially the sports horse industry of all disciplines (racing, jumping, eventing, dressage,...). Atrial fibrillation often results in decreased sports performance and potentially collapse or even sudden cardiac death. Cardiac disease is the third most common cause for poor performance, and atrial fibrillation is seen as the most common pathological arrhythmia causing performance loss in sport horses. Horses with atrial fibrillation that need to perform at high levels, have abnormally elevated heart rates during exercise or show additional arrhythmias should undergo cardioversion. In addition, prompt treatment after the initiation of atrial fibrillation is important to prevent atrial remodeling. Atrial remodeling stabilizes the arrhythmia and makes it even more difficult to treat. At the Faculty of Veterinary Medicine in Ghent, horses are routinely treated with transvenous electrical cardioversion, with a success rate of about 95%. However, this treatment can only be performed in highly specialized centers and is not available in every country. The other option is medical treatment. Traditionally, quinidine sulphate is used in horses with atrial fibrillation. However, the success rate is lower (60-80% depending on the type of horse treated) and this medication is increasingly difficult to obtain in many countries: indeed, the product is disappearing from the market because of frequent side effects in humans and animals. Other available products give conversion in 50% of cases at most. Moreover, serious side effects are described for each of these products. Therefore, a novel safe and effective treatment for atrial fibrillation is urgently needed. The aim of this study is to evaluate a new drug, ketodoxapram, for the treatment of atrial fibrillation. In the future, ketodoxapram may become the treatment of choice for horses with acute or chronic atrial fibrillation.
Переглядів: 383

Відео

Grayson-Jockey Club Research Foundation
Переглядів 925 місяців тому
Grayson-Jockey Club Research Foundation is traditionally the nation's leading source of private funding for equine medical research that benefits all breeds of horses. Since 1940, Grayson has provided nearly $42.3 million to underwrite more than 437 projects at 48 universities. Additional information about the foundation is available at grayson-jockeyclub.org.
Light Up Racing
Переглядів 196 місяців тому
Light Up Racing, Price Headley Bell, Jr., Manager Mill Ridge Farm, Board of Directors, Light Up Racing
Checklist for Aftercare and Horses Retiring From Racing
Переглядів 636 місяців тому
Checklist for Aftercare and Horses Retiring From Racing. Jeffrey T. Berk, VMD, Associate Equine Medical Associates
Equine Wearable Biometric Sensors: The Next Phase in Early Injury Detection
Переглядів 476 місяців тому
Equine Wearable Biometric Sensors: The Next Phase in Early Injury Detection. Dr. Sara Langsam, Partner Teigland, Franklin and Brokken. Due to technical difficulties at the beigning, we do not have recorded audio for a portion of the presentation.
A Strategy to Expand and Accelerate Surface Safety Programs For Improved Racing Surface Consistency
Переглядів 366 місяців тому
A Strategy to Expand and Accelerate Surface Safety Programs For Improved Racing Surface Consistency. Dr. Mick Peterson, Executive Director, Racing Surfaces Testing Laboratory Professor- Biosystems & Agricultural Engineering, University of Kentucky.
The Regulatory Veterinarian and Attending Veterinarian in the HISA Environment
Переглядів 1216 місяців тому
The Regulatory Veterinarian and Attending Veterinarian in the HISA Environment. Dr. Will Farmer, Equine Medical Director Churchill Downs Dr. Sarah Hinchliffe, Regulatory Veterinarian, New York Racing Association Dr Lyndsay Hagemeyer, Veterinarian, Ohio Regulatory Veterinarian Chip L. Johnson DVM, Veterinarian, Private Practice, Central Kentucky
A Panel Discussion on Sudden Deaths in Racing: “Where are we today?”
Переглядів 616 місяців тому
A Panel Discussion on Sudden Deaths in Racing: “Where are we today?” Dr. Stuart Brown, Vice President of Equine Safety Keeneland Dr. Sian Durward-Akhurst, Professor & Researcher University of Minnesota Dr. Sue Stover, Distinguished Professor Emerita University of California - Davis Dr. Laura Kennedy, Veterinarian Pathologist University of Kentucky Dr. Lynn Hovda, Chief Commission Veterinarian M...
5 Years Later - an Update on Santa Anita Safety Reforms
Переглядів 1496 місяців тому
5 Years Later - an Update on Santa Anita Safety Reforms Dr. Dionne Benson, Chief Veterinary Officer 1/ST RACING Tim Yakteen, Trainer
The Jockey Club Report on Future of Further Reducing Fatalities
Переглядів 376 місяців тому
The Jockey Club Report on Future of Further Reducing Fatalities Jamie Haydon with: Dan Singer, Partner, McKinsey & Company Ben Vonwiller, Partner, McKinsey & Company
Equine Injury Database Update on Risk, Risk Factors, and Prediction • Dr. Tim Parkin
Переглядів 2486 місяців тому
Equine Injury Database Update on Risk, Risk Factors, and Prediction Dr. Tim Parkin, Head of Bristol Veterinary School University of Bristol
Dr. Amanda de Mestre from Cornell University details previews her 2024 Grayson funded research.
Переглядів 1579 місяців тому
SHINING A LIGHT ON THE BLACK BOX OF EARLY PREGNANCY LOSS Amanda de Mestre, Cornell University -Two Year Grant This project will investigate two types of genetic disorders termed triploidy and aneuploidy. Instead of a single whole chromosome being duplicated or lost, as is the case of aneuploidy, in triploidy an individual has an extra copy of all the chromosomes resulting in three full sets as ...
Grayson ambassador Jessica Paquette with a video discussing the equine first aid kit.
Переглядів 16010 місяців тому
Grayson ambassador Jessica Paquette with a video discussing the equine first aid kit.
Grayson ambassador Jessica Paquette with a short video discussing the importance of equine vitals.
Переглядів 55210 місяців тому
Grayson ambassador Jessica Paquette with a short video discussing the importance of equine vitals.
Grayson funded research from Dr. Lynn Pezzanite, Colorado State University.
Переглядів 105Рік тому
Grayson funded research from Dr. Lynn Pezzanite, Colorado State University.
Dr. Couetil-Purdue University discuss the value of the Grayson-Jockey Club Research Foundation
Переглядів 66Рік тому
Dr. Couetil-Purdue University discuss the value of the Grayson-Jockey Club Research Foundation
Dr. Thomas J. Divers, Cornell University College of Veterinary Medicine on the importance of Grayson
Переглядів 146Рік тому
Dr. Thomas J. Divers, Cornell University College of Veterinary Medicine on the importance of Grayson
Dr. Mandi J. Lopez, Louisiana State University details the importance of Grayson funded research
Переглядів 81Рік тому
Dr. Mandi J. Lopez, Louisiana State University details the importance of Grayson funded research
Dr. Kyla Ortved, B.Sc., DVM, PhD. University of Pennsylvania School of Veterinary Medicine.
Переглядів 146Рік тому
Dr. Kyla Ortved, B.Sc., DVM, PhD. University of Pennsylvania School of Veterinary Medicine.
Olympic Event rider, Lauren Nicholson discusses how important it is to support Grayson.
Переглядів 95Рік тому
Olympic Event rider, Lauren Nicholson discusses how important it is to support Grayson.
Grayson-Jockey Club Research Foundation and US Eventing Association Research Partnership
Переглядів 452 роки тому
Grayson-Jockey Club Research Foundation and US Eventing Association Research Partnership
Dr. Andrew Van Eps, University of Pennsylvania. Sirolimus for the control of insulin dysregulation
Переглядів 2202 роки тому
Dr. Andrew Van Eps, University of Pennsylvania. Sirolimus for the control of insulin dysregulation
The Importance Of Welfare And Safety To Youth Entering The Thoroughbred Industry
Переглядів 562 роки тому
The Importance Of Welfare And Safety To Youth Entering The Thoroughbred Industry
Keeneland & the InCompass Programs Including the Thoroughbred Training Center
Переглядів 642 роки тому
Keeneland & the InCompass Programs Including the Thoroughbred Training Center
Racing Surfaces Testing Laboratory
Переглядів 1152 роки тому
Racing Surfaces Testing Laboratory
Positron Emission Tomography: Knowledge Gained From Over 1,000 Racehorse Fetlocks. Dr. Spriet
Переглядів 3622 роки тому
Positron Emission Tomography: Knowledge Gained From Over 1,000 Racehorse Fetlocks. Dr. Spriet
Equine Wearable Technology
Переглядів 2282 роки тому
Equine Wearable Technology
Regulatory Veterinarian Panel
Переглядів 1322 роки тому
Regulatory Veterinarian Panel
Jockey Weights, Wellbeing and Fitness - Supporting the Athlete. Dr. Jerry Hill
Переглядів 772 роки тому
Jockey Weights, Wellbeing and Fitness - Supporting the Athlete. Dr. Jerry Hill
Equine Safety and Welfare- A California Perspective. Dr. Dionne Benson, and Dr. Ryan Carpenter
Переглядів 1782 роки тому
Equine Safety and Welfare- A California Perspective. Dr. Dionne Benson, and Dr. Ryan Carpenter

КОМЕНТАРІ

  • @daniel_moretti
    @daniel_moretti 8 місяців тому

    Great questions and answers! Thank you!

  • @raygordonteacheschess5501

    Watched Ms. Cantey since I was a kid in NYC and she was on Channel 9.

  • @Caroni100
    @Caroni100 2 роки тому

    Christopher John McCarron (27 de Marzo 1955 - ) * 34.241 Montas * 7.141 Primeros * 5.670 Segundos * 4.672 Terceros * $ 263.986.005 producidos * Jinete Campeón en Estados Unidos por carreras ganadas 1974, 1975, 1980 * Jinete Campeón en Estados Unidos por dinero ganado 1980, 1981, 1984, 1991 * Jinete Aprendiz del Año 1974 en Estados Unidos * Premio Eclipse al Jinete del Año 1980 * Premio George Woolf Memorial 1980 * Premio Mike Venezia Memorial 1991 * Premio Deporte del Hipismo 1993 * Exaltado al Museo Nacional de las Carreras y Salón de la Fama en 1989 * Saludos desde Venezuela Christopher John McCarron (March, 25 1955 - ) * 34,241 Mounts * 7,141 Wins * 5,670 Seconds * 4,672 Thirds * $ 263,986,005 earned * 1974, 1975, 1980 United States Champion Jockey by wins * 1980, 1981, 1984, 1991 United States Champion Jockey by earnings * 1974 United States Champion Apprentice Jockey * 1980 Eclipse Award for Outstanding Jockey * 1980 George Woolf Memorial Award * 1991 Mike Venezia Memorial Award * 1993 Big Sport of Turfdom Award * Inducted to The National Museum of Racing and Hall of Fame in 1989 * Greetings from Venezuela

  • @rossturcotte419
    @rossturcotte419 3 роки тому

    'seabiscuit' got me thru a rly hard time in my life, ty

  • @tomcooley3778
    @tomcooley3778 3 роки тому

    Informative.

  • @deanosborne6854
    @deanosborne6854 3 роки тому

    Bigger races for older horses so we don’t have to run them so much younger

  • @deanosborne6854
    @deanosborne6854 3 роки тому

    And on running a race 2 times a month should be the average races for a horse

  • @deanosborne6854
    @deanosborne6854 3 роки тому

    I agree with dr Tom bute if you take that away people are going to use something stronger with more side effects witch is harder on the horses

  • @danielmoreno207
    @danielmoreno207 3 роки тому

    Chris Your a great rider. Priceless insight. Thank you God bless you Chris macarron. Angel , Jorge, Laffit, Chris macarron,and Chris antley Truly An honour to have witnessed live these great riders that so much is missed today as well as the rivalries between the jockeys is definitely Not what it was in the 70's and the 80's . Thank you for your videos

  • @asportableskatesharpening4207
    @asportableskatesharpening4207 6 років тому

    Really great and informative video....

  • @bmc06239
    @bmc06239 6 років тому

    No clue...why my comments are being scrubbed...do you?

  • @bmc06239
    @bmc06239 6 років тому

    Horse Behavior...we're blaming the horse now. Your should be ashamed of your research findings...I think you're afraid to dig deeper into the real root causes. I think you need to look at the greedy-stupid trainers. I blame them for horse injuries by locking the horse into an unnatural hoof-fall with shoeing. Ya see the stride of a foal is faster than the stride of an adult horse...but...sooner or later something in the adult horse will give..and the jockey, sadly he's just along for the ride.

  • @bmc06239
    @bmc06239 6 років тому

    We can gather all the statistics, but we cannot improve things until we deal with the truth ... IT'S HOOF-FALL. !!! I kept waiting to see the statistic relating injury to hoof-fall...suspiciously missing...perhaps lost in the unexplained. My comment from Mick's talk is relevant: 'The problem is trainers no longer train at home but are using the track more and more as the only surface some horses move on. Most horses train from a very young age with repetitive movement on these surfaces, most in left turn. This is producing an end product that never develops a balanced confirmation with severely underdeveloped caudal hooves. Some of this imbalance is being hidden in the shoeing protocols. Some are even shoeing to prevent the natural changes that take place in an aging horse. You see a foal’s hoof-fall is much faster than that of an adult, this why farriers are taught to keep them up on their toes...unfortunately for the horse this hoof-fall is devastating for an adult horse...sadly the experts (rood&riddle) exploit this...lameness...it's big business. It's time to recognize the successes of the natural horse world. Sponsor a barefoot only race at all the major tracks...and you will see these problems go away. Email me for more...bmc06239@yahoo...bruce "

  • @bmc06239
    @bmc06239 6 років тому

    Sadly this 2018 report by Mick is a list of problems with little evidence of any new successful solutions. The problem is the model of hoof-fall Mick is using to develop his surfaces is based on research from poorly developed and shod horse. This hoof-fall model is not the way the horse has evolved to move and sadly Mick knows this. The racing surface Mick has developed does not offer sufficient concussion to develop the caudal hoof. Just ask Robert Bowker, maybe he'll find the nerve to stand-up to the pressure coming from those who profit from the status quo. The problem is trainers no longer train at home but are using the track more and more as the only surface some horses move on. Most horses train from a very young age with repetitive movement on these surfaces, most in left turn. This is producing an end product that never develops a balanced confirmation with severely underdeveloped caudal hooves. Some of this imbalance is being hidden in the shoeing protocols. Some are even shoeing to prevent the natural changes that take place in an aging horse. You see a foal’s hoof-fall is much faster than that of an adult, this why farriers are taught to keep them up on their toes...unfortunately for the horse this hoof-fall is devastating for an adult horse...sadly the experts (rood&riddle) exploit this...lameness...it's big business. It's time to recognize the successes of the natural horse world. Sponsor a barefoot only race at all the major tracks...and you will see these problems go away. Email me for more...bmc06239@yahoo...bruce

  • @bmc06239
    @bmc06239 6 років тому

    God forbid you spend on dime on natural remedies...call it a disease then patent a drug...please don't think you are putting the horses needs first.

  • @sueellenmcgoey8708
    @sueellenmcgoey8708 7 років тому

    Be great if we could hear it.

  • @bmc06239
    @bmc06239 7 років тому

    60% weight on front limbs while standing ((1:37) is not relevant...ever seen a horse injured standing...Dr. Mary Scollary "the weight is carried by the front legs and the hind legs server as the thrusters"...this inaccurate ideology is the root cause for the snow plow effect. (3:02) "The lower leg and hoof endure tremendous pressures...extremely important to learn and understand proper mechanics..." this is almost comical...the research paid for by the Jockey club is built on studies of lame horses to protect an ideology of poor hoof care.

  • @bmc06239
    @bmc06239 8 років тому

    WOW...you nailed it (18:34) !!!!!!!!!! starts at (17:53)

    • @seantom1672
      @seantom1672 7 років тому

      no shit right?

    • @bmc06239
      @bmc06239 6 років тому

      @@seantom1672 want to get involved ? www.equinenow.com/horse-ad-1241665

  • @bmc06239
    @bmc06239 8 років тому

    All this information and study is helpful but until you fix the understanding of hoof-fall you will never resolve this.

  • @bmc06239
    @bmc06239 8 років тому

    All this information and study is helpful but until you fix the understanding of hoof-fall you will never resolve this.

  • @bmc06239
    @bmc06239 8 років тому

    (30:29)...this is foundered hoof with under-run heels...why do they not see it?

  • @bmc06239
    @bmc06239 8 років тому

    (47:05) what limb do most farrier's start and end with should give you a clue

    • @lclarke7280
      @lclarke7280 5 років тому

      I can start and end with any foot on my horse and I also mount from both sides and I can work him from both sides the same.

  • @bmc06239
    @bmc06239 8 років тому

    (46:20) that horse is foundered with under-run heels...(45:46)...the right limb plows more and the weight is behind the limb because the horse was short striding for years due to caudal hoof pain...creating muscle memory even after the hoof is corrected.

  • @blackdeuce10gmail
    @blackdeuce10gmail 8 років тому

    Good speech...

  • @bmc06239
    @bmc06239 8 років тому

    (2:50) then (3:02) My guess this is same hoof...nice job shearing the heels Mitch !

  • @traviswilson2195
    @traviswilson2195 8 років тому

    great series of videos very informative thanks!

  • @bmc06239
    @bmc06239 8 років тому

    The video study shows the barefoot horse...the Right Front (11:00) the horse is reluctant to land heel first because of an under-run heel...the shod horse comparison with the same horse at (11:57) is the other hoof the Left front hoof which has better caudal hoof development. Mitch's slide effect theory is interesting but his study was flawed. At (18:07) it's clear to me that this horse is stabbing...the toe wants to land heel first and is pointed up close to the end of flight but just prior to the final phase right before impact the toe points down protecting the week underdeveloped caudal (back) of the hoof causing Mitch's slide effect. Fix the caudal hoof.

  • @blackdeuce10gmail
    @blackdeuce10gmail 8 років тому

    Informative. Thanks.

  • @bmc06239
    @bmc06239 8 років тому

    no foot...no horse...no clue

  • @bmc06239
    @bmc06239 8 років тому

    A team of professionals...yet at (0:36) they show a hoof with severely contracted heels...If you want to win learn what's needed to race barefoot.

  • @bmc06239
    @bmc06239 8 років тому

    Until they stop the CYA and stop shoeing for all times...they will NEVER fix this. If you want to save money and win...learn what's needed to go racing barefoot.

  • @ericmalko7170
    @ericmalko7170 9 років тому

    really

  • @JohnPGrier-sm8cl
    @JohnPGrier-sm8cl 9 років тому

    Is the number of starts really a good measure of soundness? Because geldings usually start in 3 times as many races as non-geldings and surely they are not more sound. It may just make more sense to quit running the horse once they have made enough money to be marketable as stallions which can be accomplished in relatively few starts if they have a fashionable pedigree and some talent - why risk losing races and getting injured when they can start making money as stallions?

  • @ModernCowdogTraining
    @ModernCowdogTraining 10 років тому

    good job

  • @nayrod6466
    @nayrod6466 11 років тому

    Kudos Chris