Def Dames Dope was a girl group from Belgium during the 1990s, most successful from 1993 to 1996. They released one more single in 2002.
The group was initially made up of the two sisters Larissa and Axana Ceulemans together with Yousra Lemaire. Larissa married Berre Bergen, and left the group. Ingrid Gerits and Edith Verlinden joined Def Dames Dope. Axana composed many of the lyrics and music, and the group was a project of techno producers Phil Wilde and Jean-Paul De Coster.
In the summer of 1993, the group held the number one position of the Belgium charts for 2 weeks and won the summer hit award from radio station Radio 2 with their song "Ain't Nothing To It". One of their notable lyrics included "Hey you, don't be silly, put a condom on your willy" from a 1994 single which made number 9 in the charts. Their first album sold gold.
In South Africa, the band was the opening act for a tour of La Toya Jackson. They made the charts in the Czech Republic, the United Kingdom, France, Canada and Israel.