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EP 153: How genomics is re-writing the taxonomy of disease with Lon Cardon | The Genetics Podcast
Summary:
This week, Patrick welcomes President and CEO of The Jackson Laboratory, Lon Cardon. They discuss the rise of genome-wide association studies (GWAS) and how they changed the face of genetics research and why Lon took the plunge and moved from academia to industry in an era when it was an unpopular choice. Plus, they cover the future of disease taxonomy and why data sharing remains vital to the field of genetics.
Show Notes:
0:00 Intro to The Genetics Podcast
01:00 Welcome to Lon
01:51 Lon’s involvement in the very first GWAS and what drew him to large-scale genomics research
03:32 Was moving away from candidate genes towards GWAS and data sharing initially a controversial idea?
05:25 What Lon believes has driven collaboration and data sharing within research communities
07:38 How and why Lon transitioned from academia to working for GlaxoSmithKline (GSK)
10:43 Why GSK was one of the largest initial investors in genetics and how the company came to have the largest genetics department in the world in the early 2000s
11:46 How the emergence of tens of thousands of biomarkers for genetic diseases has changed the way Lon thinks about the role of genetics in drug discovery
13:29 The future of genetics research and how much that path has diverged from expectations 20 years ago
18:14 The current challenge: From exquisitely precise genetics tools to clumsy phenotype predictions
19:45 Paradigm shifts in the taxonomy of disease
22:29 What it takes to reorganize the taxonomic definition and approach to diseases such as metabolic dysfunction-associated steatohepatitis (MASH)
24:22 The changes needed within biotech and pharma to fully harness the possibilities of genetics in drug development
26:18 What drew Lon to the Jackson Lab, how it has evolved, and what he’s been focused on for the past three years
31:02 The Jackson Lab’s new precision medicine and cancer program, plus future plans for the institute’s legacy
35:56 What Lon has learned about running an international organization and global scientific collaboration
37:30 Lon’s advice to early career scientists on up-and-coming fields and technologies
41:40 Closing remarks
Переглядів: 56

Відео

EP 153: How genomics is re-writing the taxonomy of disease with Lon Cardon, President and CEO of ...
Переглядів 2913 годин тому
0:00 Intro to The Genetics Podcast 01:00 Welcome to Lon 01:51 Lon’s involvement in the very first GWAS and what drew him to large-scale genomics research 03:32 Was moving away from candidate genes towards GWAS and data sharing initially a controversial idea? 05:25 What Lon believes has driven collaboration and data sharing within research communities 07:38 How and why Lon transitioned from acad...
EP 152: The secrets of gene regulation with Nadav Ahituv, Director for Institute of Human Genetics
Переглядів 235День тому
This week we’re joined by Nadav Ahituv, the Director of the Institute of Human Genetics at the University of California, Berkeley. Patrick and Nadav discuss his research on gene regulation, including his intriguing work on bats and their unique metabolic adaptations - and what that means for human health. They also discuss the evolution of our understanding of genetics, from ancient DNA insight...
EP 152: Unlocking the secrets of gene regulation with Nadav Ahituv, Director of the Institute of ...
Переглядів 33День тому
01:15 - Introductions 02:02 - How our understanding of the non-coding genome has evolved throughout Nadav’s career 04:56 - Our current understanding of non-coding genome grammar 07:40 - Is there a missing piece to the common variant, common disease paradigm? 10:25 - Introducing ultraconserved elements (UCEs) and human accelerated regions (HARs) 12:50 - Can a simple code explain changes in certa...
EP 151: Understanding cell ageing with Marco Quarta Co-founder & CEO of Rubedo Life Sciences
Переглядів 3514 днів тому
In this episode, Patrick is joined by Marco Quarta, Co-founder and CEO of Rubedo Life Sciences, and previously Director of Bioengineering in Stem Cells and Regenerative Medicine at Stanford University. Since childhood, Marco had the dream of “curing” aging and his work at Rubedo focuses on understanding cell senescence, with the goal of developing novel therapies for age-linked diseases. Join M...
EP 151: Understanding cell aging and its role in disease with Marco Quarta, Co-founder and CEO of...
Переглядів 1114 днів тому
0:00 Intro to The Genetics Podcast 01:00 Welcome to Marco 02:00 The areas Marco focused on during his academic career and what motivated him to found his first company 03:18 How our understanding of aging has changed over the past two decades and some of the current big questions in aging biology 06:01 How to get a clearer picture of the aging process within a tissue or cell and if new technolo...
EP 150: Cracking the biological code of aging with Martin Borch Jensen, Co-Founder and Chief Scie...
Переглядів 3321 день тому
0:00 Intro to The Genetics Podcast 01:00 Welcome to Martin 01:35 How a particularly large Indian meal resulted in a book about intermittent fasting and the biology of ageing 05:10 The biological mechanisms behind intermittent fasting, and whether it’s been established to extend life expectancy in humans. 10:13 What we know (and what we don’t) about the fundamentals of biological ageing and how ...
EP 150: Cracking the biological code of aging with Martin Borch Jensen, Gordian Biotechnology
Переглядів 11821 день тому
In this episode we’re joined by Martin Borch Jensen, Co-Founder and Chief Scientific Officer at Gordian Biotechnology and President of Norn Group, a non-profit dedicated to accelerating research and development of therapies targeting the biology of aging. Patrick and Martin discuss the phenomenon known as the “aging problem,” how understanding biological age could crack the code on age-related ...
EP 149: Sequencing 33 million samples to support the UK’s COVID-19 response with CEO of UK Biocentre
Переглядів 92Місяць тому
In this episode, we’re joined by Tony Cox, CEO of UK Biocentre. After spending more than 20 years at The Wellcome Sanger Institute, where he worked on the Human Genome Project, Tony moved to UK Biocentre in January 2020 - just before the world was turned upside down by the COVID-19 pandemic. The organization pivoted to play a key role in the UK’s response effort, and under Tony’s leadership the...
EP 149: Sequencing 33 million samples to support the UK’s COVID-19 response with Tony Cox, CEO of...
Переглядів 47Місяць тому
0:00 Intro to The Genetics Podcast 01:00 Welcome to Tony 02:00 What Tony was expecting going into the role of CEO at UK Biocentre, and how the COVID-19 pandemic changed his plans 03:38 Receiving a phone call from the UK government in March 2020 asking the UK Biocentre to stop all of its projects and focus on sequencing COVID-19 samples 05:12 The UK Biocentre’s scale-up process, including how ma...
EP 148: Advancing veteran health through the Million Veteran Program with Dr. Mike Gaziano
Переглядів 52Місяць тому
This week, we welcome Dr. Mike Gaziano, professor of medicine at Harvard Medical School and the Director of the Massachusetts Veterans Epidemiology Research and Information Center (MAVERIC). Mike is also one of two Principal Investigators of the Million Veteran Program - a national research project in the US looking at how genes, lifestyle, military experiences, and exposures affect health and ...
EP 148: Advancing veteran health through the Million Veteran Program with Dr. Mike Gaziano, profe...
Переглядів 8Місяць тому
0:00 Intro 2:00 Mike’s career prior to the Million Veteran Program (MVP), how Mike got to work on MVP, and important milestones in the project's evolution 8:30 Future goals for the Million Veteran Program in expanding and diversifying the research cohort 11:00 The roles of various omics in advancing the project's development 14:30 The most meaningful outcomes of the Million Veteran Program for ...
EP 147: Delivering medicine in the clinic with Scott Weiss | The Genetics Podcast
Переглядів 85Місяць тому
This week, we’re joined by Scott Weiss, the Professor of Medicine at Harvard University, Associate Director of the Channing Division of Network Medicine at the Brigham and Women’s Hospital, and former Scientific Director at Partners HealthCare Personalized Medicine at Mass General Brigham. Patrick and Scott discuss the challenges of integrating large-scale, longitudinal multi-omic profiling int...
EP 147: From research to delivering precision medicine in the clinic with Scott Weiss, Professor ...
Переглядів 17Місяць тому
0:00 Intro to The Genetics Podcast 01:00 Welcome to Scott 01:55 Scott’s career highlights to date, ranging from epidemiology to the genetics of asthma and chronic obstructive pulmonary disease (COPD) 04:56 How and why Scott decided to transition into genetics 06:30 The advances in our understanding of the genetics of asthma and COPD over the past 20 years 10:00 What Scott has learned about tran...
Enabling research, empowering patients: Sano Genetics’ innovative solutions
Переглядів 41Місяць тому
Discover how Sano enables quality research and empowers patients. Explore how our approach streamlines research; from patient recruitment and at-home genetic testing to patient engagement in our Virtual Waiting Room (VWR). In this webinar, we'll demonstrate Sano's offering and showcase our case studies. If you are interested in connecting with our team and learning how Sano can support with pat...
Sano Product Spotlight
Переглядів 76Місяць тому
Sano Product Spotlight
EP 146: The biology of aging with Austin Argentieri | The Genetics Podcast
Переглядів 422Місяць тому
EP 146: The biology of aging with Austin Argentieri | The Genetics Podcast
EP 146: The biology of aging with Austin Argentieri, Research Fellow at Harvard Medical School, A...
Переглядів 268Місяць тому
EP 146: The biology of aging with Austin Argentieri, Research Fellow at Harvard Medical School, A...
EP 145: Rare disease drug development regulations with Daniel O’Connor | The Genetics Podcast
Переглядів 28Місяць тому
EP 145: Rare disease drug development regulations with Daniel O’Connor | The Genetics Podcast
EP 145: Navigating rare disease drug development regulations with Daniel O’Connor
Переглядів 7Місяць тому
EP 145: Navigating rare disease drug development regulations with Daniel O’Connor
EP 144: Breakthroughs in developmental disorders, PD, SLE, and AD | The Genetics Podcast
Переглядів 772 місяці тому
EP 144: Breakthroughs in developmental disorders, PD, SLE, and AD | The Genetics Podcast
EP 144: Research Roundup with Dr. Veera: breakthroughs in developmental disorders, Parkinson's, S...
Переглядів 92 місяці тому
EP 144: Research Roundup with Dr. Veera: breakthroughs in developmental disorders, Parkinson's, S...
International perspectives on genetic testing in ALS
Переглядів 442 місяці тому
International perspectives on genetic testing in ALS
Power to the patients: how participants with ALS/MND are shaping research, care, and policy
Переглядів 232 місяці тому
Power to the patients: how participants with ALS/MND are shaping research, care, and policy
Light the Way: Lessons Learned from a Genetic Screening & Counselling Platform
Переглядів 262 місяці тому
Light the Way: Lessons Learned from a Genetic Screening & Counselling Platform
From theory to practise: Patient-centric product design in clinical trial technology
Переглядів 222 місяці тому
From theory to practise: Patient-centric product design in clinical trial technology
EP 143: Harnessing human data in drug development with Jakob Steinfeldt | The Genetics Podcast
Переглядів 942 місяці тому
EP 143: Harnessing human data in drug development with Jakob Steinfeldt | The Genetics Podcast
EP 143: Harnessing human data in drug development with Jakob Steinfeldt, Co-Founder and Chief Sci...
Переглядів 232 місяці тому
EP 143: Harnessing human data in drug development with Jakob Steinfeldt, Co-Founder and Chief Sci...
Sano patient finding protocol: Helping you find the right patients faster
Переглядів 322 місяці тому
Sano patient finding protocol: Helping you find the right patients faster
EP 142: From genome to bedside with Dr. Andrea Gropman | The Genetics Podcast
Переглядів 552 місяці тому
EP 142: From genome to bedside with Dr. Andrea Gropman | The Genetics Podcast

КОМЕНТАРІ

  • @trevorashton4598
    @trevorashton4598 16 днів тому

    Tic tok distraction has brainwashed kids sooo deep sport for the adults and talk about educational having no time

  • @trevorashton4598
    @trevorashton4598 16 днів тому

    This is all wacko and with ai seeing this and with bill gates on this earth and nano bots me heart and brain hurts as children completely walking into this new word organization of order 😳

  • @DEVanderbiltCecil
    @DEVanderbiltCecil 18 днів тому

    FBI. Holland. Chesney. Aggravated stalking.

  • @SejalPatelDrSej
    @SejalPatelDrSej Місяць тому

    Great discussion - is the proteomics test available to the public ?

  • @nicolewolfeceo8
    @nicolewolfeceo8 Місяць тому

    Partner collab nwc 😎

  • @kendoSiwakorn
    @kendoSiwakorn 2 місяці тому

    Thank you for the clip. I am a bit new to this industry though I found it fascinating when you explain it. I like that when you tried to explain the history and the context first before diving into each paper. It helped me a lot. One thing I would prefer is to have a shorter videos. One hour is too long for me. I would prefer a bite size video like 20-30 mins. Hope this help. 🎉 keep up the good work.

  • @PeloresanterOctagenarima
    @PeloresanterOctagenarima 3 місяці тому

    Bravo!

  • @taylormichaela6451
    @taylormichaela6451 5 місяців тому

    Promo`SM 💖

  • @minakadri2906
    @minakadri2906 5 місяців тому

    AMAZING!!💯🌠👏👏👏👏 thank you for sharing! I don't know how i came across the video but I'M already a fan! This is just EPIC 🙌

  • @BUY_YOUTUB_VIEWS_481
    @BUY_YOUTUB_VIEWS_481 6 місяців тому

    How did you start youtube

  • @exploreyourdreamlife
    @exploreyourdreamlife 7 місяців тому

    Much appreciation for making this video on genetic medicine. Can genetic meds be given to infants? I’m impressed, I liked this video and you've got yourself a new subscriber!

  • @gonzalodelamaza760
    @gonzalodelamaza760 Рік тому

    Super interesting, I truly hope we could get more into possible intervention, I know we are currently trying to prove causality, but ones this is accomplished, what is next? not just prevention, or slowing down, but rather actually full on removing this high mutation burden cells.

  • @ancestortracer
    @ancestortracer 3 роки тому

    Interesting

  • @bluedream9317
    @bluedream9317 3 роки тому

    Take the out of Africa theory out of the equation because it is documented that all skin color was in America. And there are American "genetic " relations to oceanic people and Australians. So when it comes to markers, is there a way to tell who passed down that marker, which way it came from? For example, lets say an American has the same marker as an African, how can one tell which way it came from? Was it an American who passed it down to an African via past migration or was it an African who passed it down to an American? Are those markers exact matches or is it just similar to each other and somebody just went on ahead and said this is an African marker or this an American marker and they are genetically ancestral related? Or they saying they are genetically related because of similarities or exact matches? If so, how can they tell who receive what from who?

  • @katiecorin1
    @katiecorin1 3 роки тому

    Doctors don't just over look the mental health side of Chronic illness they even over look the physical and leave people suffering with no help and miss diagnosis.

  • @clairesablejamieson541
    @clairesablejamieson541 4 роки тому

    My son got diagnosed with Ring chromosome 20 syndrome in April this year after having seizures for a year and he's had every anti epilepsy drug and made no difference .He's now on topiramate it helps a bit . The worst is the night seizures I can't get used to them .I'm having proberley 3 hours sleep a night .

    • @sanogenetics
      @sanogenetics 4 роки тому

      Hi Claire Sable Jamieson, we're really sorry to hear about the health issues your son is facing. We do have another podcast episode where we speak to Allison Watson, co-founder of ring 20 Research and Support UK, that might be of interest to you. Here is the link to the charity: ring20researchsupport.co.uk/about-us/ it was set up to support families, individuals and professionals who are affected by, or who come into contact with Ring Chromosome 20 Syndrome (r20). You can find the podcast here: ua-cam.com/video/nAtB3vGQQt4/v-deo.html We wish you and your son all the best and hope that this helps.