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Journal of Cell Biology
Приєднався 29 лис 2021
Journal of Cell Biology (JCB) is an international peer-reviewed journal owned by The Rockefeller University and published by Rockefeller University Press.
JCB publishes advances in any area of basic cell biology as well as applied cellular advances in fields such as immunology, neurobiology, metabolism, microbiology, developmental biology, and plant biology. Est. 1955
JCB publishes advances in any area of basic cell biology as well as applied cellular advances in fields such as immunology, neurobiology, metabolism, microbiology, developmental biology, and plant biology. Est. 1955
A Truncated Isoform of Connexin43 Caps Actin to Organize Forward Delivery of Full Length Connexin43
Original paper: rupress.org/jcb/article/224/3/e202402112/277188/A-truncated-isoform-of-Connexin43-caps-actin-to
Video summary by Rachel Baum and Vu Nguyen (University of Utah)
Description:
In this work, Baum and Nguyen et al discover that the same mRNA, which encodes the gap junction protein Connexin43, also encodes a smaller isoform (GJA1-20k) that binds directly to actin and arranges the cytoskeleton delivery apparatus for efficient delivery and localization of the larger Connexin43 membrane channel to its appropriate membrane subdomain.
Keywords:
Connexin43, GJA1-20k, mRNA, actin, microtubule, heart, arrhythmia, gap junctions, targeted delivery, forward delivery, membrane protein trafficking.
Video summary by Rachel Baum and Vu Nguyen (University of Utah)
Description:
In this work, Baum and Nguyen et al discover that the same mRNA, which encodes the gap junction protein Connexin43, also encodes a smaller isoform (GJA1-20k) that binds directly to actin and arranges the cytoskeleton delivery apparatus for efficient delivery and localization of the larger Connexin43 membrane channel to its appropriate membrane subdomain.
Keywords:
Connexin43, GJA1-20k, mRNA, actin, microtubule, heart, arrhythmia, gap junctions, targeted delivery, forward delivery, membrane protein trafficking.
Переглядів: 34
Відео
Nap1 and Kap114 co-chaperone H2A-H2B and facilitate targeted histone release in the nucleus
Переглядів 602 місяці тому
Original paper: rupress.org/jcb/article/224/1/e202408193/277126/Nap1-and-Kap114-co-chaperone-H2A-H2B-and Video Summary by H.Y. Joyce Fung (Chook Lab, University of Texas Southwestern Medical Center) In this video, I present the biochemical and structural analyses of interactions between histone H2A-H2B, its importin Kap114, its histone chaperone Nap1 and the GTPase RanGTP, to understand their r...
Automatic detection of spatio-temporal signaling patterns in cell collectives
Переглядів 18810 місяців тому
Video summary by Paolo Armando Gagliardi and Benjamin Grädel (University of Bern) Original paper: rupress.org/jcb/article/222/10/e202207048/276138/Automatic-detection-of-spatio-temporal-signaling An increasing body of scientific literature highlights the widespread occurrence of collective signaling events, such as Calcium or ERK waves, in diverse biological systems. In this study, we present A...
CEP104/FAP256 and associated cap complex maintain stability of the ciliary tip
Переглядів 89Рік тому
Original paper: rupress.org/jcb/article/222/11/e202301129/276296/CEP104-FAP256-and-associated-cap-complex-maintain In this video, Dr Thibault Legal introduces his paper published in the Journal of Cell Biology. This work describes in detail the tips of motile cilia from Tetrahymena thermophila. We know that the ciliary tips have different structures and a different molecular composition compare...
Endocytic myosin-1 is a force-insensitive, power-generating motor
Переглядів 158Рік тому
Original paper: rupress.org/jcb/article/222/10/e202303095/276159/Endocytic-myosin-1-is-a-force-insensitive-power Authors: Ross TA Pedersen, Aaron Snoberger, Serapion Pyrpassopoulos, Daniel Safer, David G Drubin, E Michael Ostap In this video, Ross Pedersen summarizes the results of a recent collaboration between the laboratories of David Drubin and Mike Ostap, now published in the Journal of Ce...
Recruitment of the SNX17-Retriever recycling pathway regulates synaptic function and plasticity
Переглядів 146Рік тому
Original paper: rupress.org/jcb/article/222/7/e202207025/214090/Recruitment-of-the-SNX17-Retriever-recycling Video summary by Pilar Rivero-Ríos (University of Michigan) In this video, Dr. Pilar Rivero-Ríos presents her paper published in the Journal of Cell Biology. This work describes novel roles for the SNX17-Retriever endomembrane recycling pathway in synaptic function and plasticity. Disrup...
ATG8-dependent LMX1B-autophagy crosstalk shapes human midbrain dopaminergic neuronal resilience
Переглядів 276Рік тому
Original paper: rupress.org/jcb/article/222/5/e201910133/213994/ATG8-dependent-LMX1B-autophagy-crosstalk-shapes Video summary by Natalia Jimenez-Moreno (University of Bristol) In this video, Dr Natalia Jimenez-Moreno introduces her paper published in the Journal of Cell Biology. This work describes how autophagy-a process of cellular self-eating-is regulated in the types of neurons that are los...
GxcM-Fbp17/RacC-WASP signaling regulates polarized cortex assembly in migrating cells via Arp2/3
Переглядів 144Рік тому
Original paper: rupress.org/jcb/article/222/6/e202208151/213991/GxcM-Fbp17-RacC-WASP-signaling-regulates-polarized Video summary by Dong Li (the Institute of Biophysics, CAS, Beijing, China; Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, China) Description: To elucidate the mechanism underlying rear cortical F-actin network in highly-polarized migr...
TLN1 contains a cancer-associated cassette exon that alters talin-1 mechanosensitivity
Переглядів 166Рік тому
Original paper: rupress.org/jcb/article/222/5/e202209010/213923/TLN1-contains-a-cancer-associated-cassette-exon Video summary by Lina M. Gallego-Paez (Biomed X Institute, Germany) This short video summary provides an introduction to our recent paper in Journal of Cell Biology where we report the discovery of an additional exon in the TLN1 gene. Keywords: Talin, mechanobiology, mechanotransducti...
Engineered kinases as a tool for phosphorylation of selected targets in vivo
Переглядів 1752 роки тому
Original Paper: rupress.org/jcb/article/221/10/e202106179/213463/Engineered-kinases-as-a-tool-for-phosphorylation Video Summary by Katarzyna Łepeta (Affolter lab, Biozentrum, University of Basel) In this video, I present the synopsis of the approach for targeted protein phosphorylation that we developed in the lab and described in detail in the paper. I first briefly introduce protein kinases a...
APC/CCdc20-mediated degradation of Clb4 prompts astral microtubule stabilization at anaphase onset
Переглядів 1162 роки тому
APC/C-Cdc20-mediated degradation of Clb4 prompts astral microtubule stabilization at anaphase onset Original study: rupress.org/jcb/article/222/1/e202203089/213563/APC-CCdc20-mediated-degradation-of-Clb4-prompts Video summary by Federico Zucca (European Institute of Oncology IRCCS, Milan, Italy) Description: Zucca et al. Identify in budding yeast two evolutionary conserved mitotic machineries, ...
RUFY1 binds Arl8b and mediates endosome-to-TGN CI-M6PR retrieval for cargo sorting to lysosomes
Переглядів 4412 роки тому
RUFY1 binds Arl8b and mediates endosome-to-TGN CI-M6PR retrieval for cargo sorting to lysosomes Original paper: rupress.org/jcb/article/222/1/e202108001/213572/RUFY1-binds-Arl8b-and-mediates-endosome-to-TGN-CI Video summary by Shalini Rawat (Indian Institute of Science Education and Research Mohali) This video provides a brief overview of our work entitled "RUFY1 binds Arl8b and mediates endoso...
Induced nanoscale membrane curvature bypasses the essential endocytic function of clathrin
Переглядів 2372 роки тому
Video Summary by Robert Cail Original Paper: rupress.org/jcb/article/221/7/e202109013/213203/Induced-nanoscale-membrane-curvature-bypasses-the In this video, I introduce the membrane curvature evolution that occurs during clathrin-mediated endocytosis (CME), and I discuss the clathrin lattice’s ubiquity on plasma membranes of different shapes. I explain the nanofabrication method we employ to d...