Lugazi FC, originally founded as Kampala University FC in 2010, has steadily climbed the ranks of Ugandan football. After winning the Luweero District Football Association in their debut season, they progressed through divisions, reaching the Buganda Regional League in 2012/2013. Despite a setback in the FUFA Big League play-offs in their inaugural BRL season, they rebounded under new management in 2020.

Rebranded as Lugazi FC, the club clinched the BRL championship in 2021/2022, securing promotion to the FUFA Big League. Their ascent continued with a strong emphasis on core values: Diversity, Integrity, Accountability, Fun, Innovation, and Team Work.

Their vision extends beyond domestic success, aiming to establish Lugazi FC as a force in African football, aspiring to compete in CAF competitions. With a focus on developing talent and fostering a sustainable professional team, they strive for a future among the continent's football elite.