UCSF Center for AIDS Prevention Studies (CAPS) & Prevention Research Center (PRC)
UCSF Center for AIDS Prevention Studies (CAPS) & Prevention Research Center (PRC)
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Controversies and Unresolved Issues in the Design of Randomized Controlled Trials
Steve Gregorich, PhD
Department of Medicine & Department of Preventive and Restorative Dental Sciences, UCSF
Within the context of an efficacy, effectiveness, or implementation science trial (RCT), many clinical/behavioral trialists insist that optimal study designs require (i) intervention and control groups that are matched with respect to the amount of time and attention required of study participants and (ii) adjustments to alpha levels for 'multiple comparisons.' Other clinical/behavioral trialists argue that (i) a 'usual care' control group design often is best and (ii) adjustments for 'multiple comparisons' are unnecessary and undesirable. In this talk, I detail scientific, policy-related, and ethical arguments for the superiority of the latter perspective. Additionally, some scientists contend that pilot trials, in part, are intended to yield an effect size estimate that will inform a power analysis supporting the design of a future full-scale RCT, whereas others argue that pilot trials should limit their focus to evaluating acceptability and feasibility of the intervention and study procedures. The latter viewpoint is the correct one, but raises a question about how to determine the appropriate effect size estimate to use in a power analysis. We will discuss related issues including implications for obtaining research funding and publishing results from RCTs.
Steve's research focuses on disease prevention and preventive health behaviors within diverse populations. His 24-year career includes over 75, largely federally funded, research projects, centers, and career development awards. Relevant to this talk, he has served as principal statistician and/or data coordinating center director of 20 large-scale randomized controlled trials testing behavioral/clinical interventions.
Переглядів: 49

Відео

PrEP My Way: Peer-Supported Delivery of PrEP for Young Women in Kenya
Переглядів 570Місяць тому
PrEP My Way: Peer-Supported, Community-Based Delivery of PrEP and Other Sexual Health Services for Young Women in Kenya. Jessica Haberer, MD, MS, Professor of Medicine Harvard Medical School Jessica Haberer, MD, MS, is an internist at Massachusetts General Hospital and Professor at Harvard Medical School. She has been working in global health and studying adherence to antiretroviral medications...
Spotlight on GloCal Health Fellows from India
Переглядів 63Місяць тому
Spotlight on GloCal Health Fellows from India: Mental health, Migrant workers, HPV & HIV, Culturally sensitive risk reduction for cardiovascular disease, and more. Merlyn Joseph, MBBS, MD, DNB: St. John’s Medical College Hospital Mental health status of migrant workers in the tea plantation industry of South India - a mixed methods study. Dr. Joseph is a senior resident in the Department of Com...
Conceptualizing Large Multi-Topic Qualitative Studies with Michael Duke, PhD
Переглядів 133Місяць тому
Conceptualizing Large Multi-Topic Qualitative Studies with Michael Duke, PhD Qualitative interview studies tend to be relatively modest in scope, both in terms of sample size and the number of data items subject to interpretation and analysis. In contrast, large complex studies require a rethinking of scale, study design, saturation, analytic approaches, and other considerations. For this prese...
PrEP Choice: Are we ready for all the options?
Переглядів 1262 місяці тому
PrEP Choice: Are we ready for all the options? Hyman Scott, MD, MPH Clinical Research Medical Director, Bridge HIV San Francisco Department of Public Health (SFDPH) Assistant Clinical Professor of Medicine, UCSF. Hyman Scott, MD, MPH is the Clinical Research Medical Director at Bridge HIV in the San Francisco Department of Public Health (SFDPH), and an Assistant Clinical Professor of Medicine a...
Insights from the Suubi+ Adherence4Youth Trial: Uganda
Переглядів 212 місяці тому
Insights from the Suubi Adherence4Youth Trial: An Ongoing Psychosocial and Economic Empowerment Intervention for Viral Suppression among Youth Living with HIV in Uganda. Our special group presentation will provide an overview of the Suubi Adherence4Youth trial, discuss the progress to date, and share lessons learned for conducting a large-scale factorial experiment using the Multiphase Optimiza...
Using Multidimensional IRT Latent Transition Analysis to Examine Stigma and HIV Health Outcomes
Переглядів 432 місяці тому
Using Multidimensional IRT Latent Transition Analysis and Markov Models to Examine the Longitudinal Associations between Intersectional Stigma and HIV Health Outcomes. Featuring Andrea Norcini Pala PhD, SUNY Downstate NY, and Bulent Turan, Koc University, Turkey PhD Goals of the Workshop • Learn about Multidimensional IRT Latent Transition Analysis (MIRT/LTA). • Application of MIRT/LTA to exami...
Leveraging Private-Sector Pharmacies to Expand the Reach of HIV Prevention Services in Kenya
Переглядів 513 місяці тому
Leveraging Private-Sector Pharmacies to Expand the Reach of HIV Prevention Services in Kenya. Katrina Ortblad, ScD, MPH Assistant Professor of Public Health Sciences and Global Health, Fred Hutchinson Cancer Center, University of Washington. The delivery of HIV PrEP and PEP services at private, retail pharmacies may overcome barriers to clinic-delivered PrEP/PEP services (i.e., HIV-associated s...
Community-Based Strategies for Scale-Up of HIV Prevention Methods for Youth in South Africa
Переглядів 1023 місяці тому
Community-Based Strategies for Scale-Up of Current and New HIV Prevention Methods for Adolescent and Young People in Cape Town, South Africa. Elzette Rousseau, PhD(c), Socio-Behavioural Scientist. Desmond Tutu Health Foundation (DTHF) University of Cape Town, South Africa. About INSIGHTS (Innovative Non-traditional Healthcare Settings in HIV Research Lecture Series): The purpose of this lecture...
Pharmacies as Innovative Settings for Promoting HIV PrEP Adherence
Переглядів 1583 місяці тому
Pharmacies as Innovative Settings for Promoting HIV PrEP Adherence. Lorraine Dean, ScD, Social Epidemiologist and Associate Professor in Epidemiology, Johns Hopkins Bloomberg School of Public Health. About INSIGHTS (Innovative Non-traditional Healthcare Settings in HIV Research Lecture Series): The purpose of this lecture series is to provide the community of HIV researchers with space and time...
Navigating Overdose and Structural Vulnerability amidst a Toxic Drug Supply
Переглядів 684 місяці тому
Navigating Overdose and Structural Vulnerability amidst a Toxic Drug Supply: Insights from a Program of Community-Engaged Research in Vancouver, Canada's Downtown Eastside with Ryan McNeil, PhD Associate Professor of Internal Medicine Director of Harm Reduction Research, Program in Addiction Medicine, Yale University School of Medicine. Follow the UCSF Division of Prevention Science on Social a...
A Real Discussion about Artificial Intelligence (AI) in Research
Переглядів 1704 місяці тому
A Real Discussion about Artificial Intelligence (AI) in Research. Follow the UCSF Division of Prevention Science on Social: ☀️UCSF Prevention Science Linkedin www.linkedin.com/school/ucsf-dps/ ☀️UCSF Prevention Science on UA-cam www.youtube.com/@ucsfcenterforaidspreventio3461/ ☀️Sign up for our quarterly CAPS/PRC e-newsletter - lnkd.in/gCzkZQE Dr. William Brown, III is an Associate Professor of...
Pharmacy-Based Approaches to Improving Equity in HIV and Substance Use-Related Harm.
Переглядів 1125 місяців тому
Pharmacy-Based Approaches to Improving Equity in HIV and Substance Use-Related Harms. Natalie Crawford, PhD, Associate Professor, Co-Director, Prevention and Implementation Sciences Core, Emory CFAR. About INSIGHTS (Innovative Non-traditional Healthcare Settings in HIV Research Lecture Series): The purpose of this lecture series is to provide the community of HIV researchers with space and time...
Using Photographs to Understand the Context of Health
Переглядів 1476 місяців тому
Using Photographs to Understand the Context of Health: A Novel Two-Step Systematic Process for Coding Visual Data. This interactive session will focus on the development and potential uses of a novel two-step systematic coding process for visual data including photos that was recently published in Qualitative Health Research. Presenters: Antony Nguyen MPH and Jane Jih MD MPH MAS Follow the UCSF...
Implementation Science in the HIV Prevention Space for Young Adults in Southern Africa
Переглядів 1177 місяців тому
Next Steps for Implementation Science in the HIV Prevention Space for Adolescents and Young Adults in Southern Africa. Audrey Pettifor, PhD, Professor and Associate Chair of Epidemiology University of North Carolina at Chapel Hill. This presentation will focus on gaps in the current Implementation Science (IS) research agenda about HIV and care for adolescent girls and young women and provide e...
Mainstreaming Behavioral and Social Sciences in HIV Prevention and Treatment. Andrew Forsyth, Ph.D.
Переглядів 1147 місяців тому
Mainstreaming Behavioral and Social Sciences in HIV Prevention and Treatment. Andrew Forsyth, Ph.D.
The R-EIGHT Method. Inductive Analysis with Jason Johnson-Peretz MA
Переглядів 847 місяців тому
The R-EIGHT Method. Inductive Analysis with Jason Johnson-Peretz MA
Y2TEC. A Program to Improve HIV Health Outcomes.
Переглядів 278 місяців тому
Y2TEC. A Program to Improve HIV Health Outcomes.
Greg Rebchook: Chancellor Award for LGBTQI Leadership
Переглядів 849 місяців тому
Greg Rebchook: Chancellor Award for LGBTQI Leadership
The NIH All of Us Research Program: Researcher Engagement at UCSF
Переглядів 859 місяців тому
The NIH All of Us Research Program: Researcher Engagement at UCSF
Report Back from the International AIDS Conference (IAS) 2023
Переглядів 14210 місяців тому
Report Back from the International AIDS Conference (IAS) 2023
Preparing for Pharmacy-based Delivery of Long-Acting Injectable HIV Antiretrovirals
Переглядів 17910 місяців тому
Preparing for Pharmacy-based Delivery of Long-Acting Injectable HIV Antiretrovirals
Southwest Asian / North African (SWANA) Racial/Ethnic Categorization in the United States
Переглядів 17811 місяців тому
Southwest Asian / North African (SWANA) Racial/Ethnic Categorization in the United States
Multi-Disciplinarity in HIV Cure Research. Karine Dube, DrPH, MPhil (Oxon)
Переглядів 2,4 тис.11 місяців тому
Multi-Disciplinarity in HIV Cure Research. Karine Dube, DrPH, MPhil (Oxon)
Black Americans' Health and Healthcare Experiences. Kimberly J. Martin PhD
Переглядів 9411 місяців тому
Black Americans' Health and Healthcare Experiences. Kimberly J. Martin PhD
HIV Testing Among Key Populations in Iran with Leila Taj, MD
Переглядів 115Рік тому
HIV Testing Among Key Populations in Iran with Leila Taj, MD
Effecting Change in Health Care Systems: Transforming Practice and Policy to Improve HIV Outcomes
Переглядів 42Рік тому
Effecting Change in Health Care Systems: Transforming Practice and Policy to Improve HIV Outcomes
Antiracism. Moving Beyond the Equity Statement. PRC Week 2023
Переглядів 47Рік тому
Antiracism. Moving Beyond the Equity Statement. PRC Week 2023
Extrapolation and New Methods for Population Size Estimation
Переглядів 319Рік тому
Extrapolation and New Methods for Population Size Estimation
CAPS 2023 ART Biomarker Update
Переглядів 118Рік тому
CAPS 2023 ART Biomarker Update

КОМЕНТАРІ

  • @SarahMia3p
    @SarahMia3p 29 днів тому

    I will always be thankful to Dr Obulor on UA-cam In helping me cure HIV Totally with your herbal supplements I will always recommend him,

  • @SarahMia3p
    @SarahMia3p 29 днів тому

    I will always be thankful to Dr Obulor on UA-cam In helping me cure HIV Totally with your herbal supplements I will always recommend him,

  • @imabideoChannelSEOexpert
    @imabideoChannelSEOexpert Місяць тому

    I saw your UA-cam channel . Your content and videos are very good. i am UA-cam video SEO & keyword recharge service provider. here are some problems:- 1. SEO score is very low. 2. Title, Description, Tags are not SEO friendly. 3. Content is not sharing in your any social media platforms. 4. Subscribe.and .Video, Views. Very. low can I help you

  • @cesarpina4115
    @cesarpina4115 Місяць тому

    Thanks for share your results and methodology!! Amazing work! Congrats!!

  • @AnitaSharkey-nq6oi
    @AnitaSharkey-nq6oi 2 місяці тому

    I want to sir a big thanks to Dr Obulor for helping me curing HIV totally, much love ND appreciation glad I meet you on UA-cam🇱🇷🇱🇷

  • @AnitaSharkey-nq6oi
    @AnitaSharkey-nq6oi 2 місяці тому

    I want to sir a big thanks to Dr Obulor for helping me curing HIV totally, much love ND appreciation glad I meet you on UA-cam🇱🇷🇱🇷

  • @imabideoChannelSEOexpert
    @imabideoChannelSEOexpert 2 місяці тому

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  • @GodstimeMiracle5yz
    @GodstimeMiracle5yz 2 місяці тому

    Thank you Dr Obulor on UA-cam for helping me get Rid of HIV totally, I so much thank & respectful to you sir,,,,

  • @GodstimeMiracle5yz
    @GodstimeMiracle5yz 2 місяці тому

    Thank you Dr Obulor on UA-cam for helping me get Rid of HIV totally, I so much thank & respectful to you sir,,,,

  • @KorolineTobias
    @KorolineTobias 3 місяці тому

    I want to thank Dr Obulor for curing my hiv completely with your medication products,,,

  • @KorolineTobias
    @KorolineTobias 3 місяці тому

    I want to thank Dr Obulor for curing my hiv completely with your medication products,,,

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    @imabideoChannelSEOexpert 3 місяці тому

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  • @DanielDave-xc3ky
    @DanielDave-xc3ky 3 місяці тому

    Giving so much thank you a wonderful doctor Obulor @UA-cam, for curing Hiv infection totally. You are truly wonderful....

  • @DanielDave-xc3ky
    @DanielDave-xc3ky 3 місяці тому

    Giving so much thank you a wonderful doctor Obulor @UA-cam, for curing Hiv infection totally. You are truly wonderful....

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    @imabideoChannelSEOexpert 4 місяці тому

    video SEO & keyword recharge service provider. can I help you UA-cam video work response you will.

  • @LHVMleodragonlamb
    @LHVMleodragonlamb 5 місяців тому

    what if theyre unwanted

  • @imabideoChannelSEOexpert
    @imabideoChannelSEOexpert 5 місяців тому

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  • @rohmatullah40
    @rohmatullah40 6 місяців тому

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  • @sunny56255
    @sunny56255 7 місяців тому

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  • @veraperi9382
    @veraperi9382 10 місяців тому

    Thanks a million times Dr Abiola for playing a vital role on my Hiv virus, you are indeed a dedicated and compassionate doctor, you’ll forever have a place in my heart ❤ Am grateful sir

  • @veraperi9382
    @veraperi9382 10 місяців тому

    Thanks a million times Dr Abiola for playing a vital role on my Hiv virus, you are indeed a dedicated and compassionate doctor, you’ll forever have a place in my heart ❤ Am grateful sir

  • @rokogunh9117
    @rokogunh9117 10 місяців тому

    Thank you doctor for the Professionalism with which you do your work. You listen to your client and you always put their needs first, to ensure they live another day healthily and vibrant. Cheers to you my doctor, I celebrate the way you do your job. If it was up to me I would give you the award of being the best doctor. Thank you Dr Igho for curing my HIV naturally..

  • @codyx8233
    @codyx8233 Рік тому

    *promosm* 😍

  • @R1GAMBLER
    @R1GAMBLER Рік тому

    we have arrived at Weimar. where is our House Painter???

  • @Piggy123407
    @Piggy123407 Рік тому

    The audio of one speaker was so bad otherwise it was good

  • @timeisrunningoutforthebeast

    Thanks

  • @exuberantyouth8765
    @exuberantyouth8765 Рік тому

    Great work team. Can I have the link to the dataset if it's legitimate for you to share? I want to work and make my contribution

  • @Vic2point0
    @Vic2point0 Рік тому

    It's actually not even possible to misgender anyone, on your worldview. Since you can never provide objective definitions for terms like "man" or "woman", on transgenderism, no one can ever be correct/incorrect while using these terms. Ironically, it's only those of us who *reject* modern gender theory who can accuse another of misgendering them in a coherent way.

  • @abdulkarimshabanmhandeni847
    @abdulkarimshabanmhandeni847 2 роки тому

    Thank you so much. You have saved my academic life.

  • @alemitutsige6533
    @alemitutsige6533 2 роки тому

    Very good introduction. Many thanks.

  • @keywee849
    @keywee849 2 роки тому

    HIV is in the Covid19 vaccine.

  • @pegado67
    @pegado67 2 роки тому

    LATINX: ANOTHER RACIAL SLUR FOR HISPANICS, A NEW FORM OF NEOCOLONIALISM AND LINGUISTIC IMPERIALISM....

  • @mdnpmalappuram4898
    @mdnpmalappuram4898 2 роки тому

    👍 i am from kerala

  • @khorthastatus3841
    @khorthastatus3841 2 роки тому

    Plz sir iska ilaj nikalye 😭

  • @kathrynowen196
    @kathrynowen196 2 роки тому

    The audio is poor; other than that, it looks like it'd be really helpful.

  • @donisecyre6746
    @donisecyre6746 2 роки тому

    The attempt to make a deadly disease as common as diabetes is like if everyone has HIV then nobody has HIV/AIDS? Remember to manage HIV one must take daily pharma to attempt to stop AIDS blow out.

  • @donisecyre6746
    @donisecyre6746 2 роки тому

    I really am trying to find a disconnect between this invisible enemy, aka C19 and the visible one known as AIDS for this vaccine experiment. Forty plus years of research and development towards an Hiv/AIDS jab to warp speed a flu shot.......... ?? Someone help me understand how this isn't the same *science? How forcing the jab is not using the population en masse as lab rats. You would need non infected subjects for actual trials.

  • @DvineSpectacle
    @DvineSpectacle 2 роки тому

    Educative

  • @m.venkatm.venkat.kaveripat1960
    @m.venkatm.venkat.kaveripat1960 2 роки тому

    Please. Help. Me.iam.H.i.v..in.tamil.nado.my.age.36

  • @beckyt2480
    @beckyt2480 2 роки тому

    🤥🤥

  • @beckyt2480
    @beckyt2480 2 роки тому

    🤥

  • @beckyt2480
    @beckyt2480 2 роки тому

    “Stupid is as Stupid does.” 😂🙄💀💀

  • @aminatawilliams2018
    @aminatawilliams2018 2 роки тому

    WHO is a scam just imagine 40 years old sickness doesn’t have any cure till now 🤭😏😏😂

  • @lasu596
    @lasu596 2 роки тому

    Drug mafia wants to make money from those who r negative Nothing concrete done for positive people

  • @biaalbino4218
    @biaalbino4218 2 роки тому

    Sensacional!

  • @sunday6371
    @sunday6371 2 роки тому

    All thanks to Dr Abiola on UA-cam for curing me permanently from HIV #drabiolahome ..

  • @sunday6371
    @sunday6371 2 роки тому

    All thanks to Dr Abiola on UA-cam for curing me permanently from HIV #drabiolahome ..

  • @bintayusif6782
    @bintayusif6782 2 роки тому

    Thanks to Dr Odoma for the good work of your products ua-cam.com/channels/d0aC1ey2rRQ39JW8MEcq4Q.html