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Novilytic LLC
United States
Приєднався 30 бер 2022
A weakness of drug development and manufacturing is that testing the quality of their medicinal batches requires manual sampling and time-consuming tests on a complex and fragile instrument called a mass spectrometer.
This testing process takes anywhere from four hours to days. However, bad broth from contaminants can develop in as little as an hour. At this point, significant filtering and purification of the drug are required before making pills or syringe solutions.
Novilytic’s new Proteometer, aka “proteoform meter,” performs at-line, real-time batch analysis roughly every 10 minutes. It was designed, patented (10+ and counting!), and developed by some of the smartest chemistry minds in the world.
We will give pharmaceutical companies better control of their batches by drastically reducing the cost and time of manufacturing, hopefully resulting in life-saving drugs that are more accessible.
This testing process takes anywhere from four hours to days. However, bad broth from contaminants can develop in as little as an hour. At this point, significant filtering and purification of the drug are required before making pills or syringe solutions.
Novilytic’s new Proteometer, aka “proteoform meter,” performs at-line, real-time batch analysis roughly every 10 minutes. It was designed, patented (10+ and counting!), and developed by some of the smartest chemistry minds in the world.
We will give pharmaceutical companies better control of their batches by drastically reducing the cost and time of manufacturing, hopefully resulting in life-saving drugs that are more accessible.
Instructions for the Proteometer-UFT: Single-Pump Method
Evaluating the quality of medicinal batches can take hours or days. However, significant contamination can occur after just 60-minutes, making the endeavor timely and expensive. With the Proteometer-UFT Kit, titer analysis can now be performed at-line every 90 seconds, resulting in the increased accessibility of lifesaving drugs.
Переглядів: 19
Відео
Protein Metrics: Automating Antibody Characterization with Mobile Affinity Sorbent Chromatography
Переглядів 5719 годин тому
Join Protein Metrics, a software provider for comprehensive protein analysis across the development process, along with Johnson&Johnson, in a webinar titled “Automating Antibody Characterization with Mobile Affinity Sorbent Chromatography (MASC).” The presentation explores how the two organizations have collaborated to utilize our Proteometer-L Kit, powered by our patented MASC technology, for ...
Novilytic Whiteboard Series: High Throughput Molecular Recognition Assay for mAb Quality Assessment
Переглядів 38Місяць тому
In this discussion, world-renowned scientist Dr. Fred Regnier discusses high-throughput molecular recognition assays. He discusses the current FDA approach to critical performance attribute assays and Novilytic’s new approach, which is developing early warning systems for assessing mAb quality via molecular recognition of the intact molecules. He describes the molecular coding process and discu...
Proteometer-UFT Kit Technical Presentation
Переглядів 762 місяці тому
Director of Product Management, Eric Bowen, explains the benefits and use cases for the Proteometer-UFT. The Proteometer-UFT (Ultra Fast Titer) Kit runs an at-line titer measurement of mAbs in less than 90 seconds. It requires no sample preparation or Protein A and is utilized with a dual pump liquid chromatograph with a fluorescence detector (single pump systems are usable with minimal sample ...
HPLC 2024: Analysis of IgG Biosimilars Using the Novilytic Proteometer-L Kit
Переглядів 1053 місяці тому
HPLC 2024's Presentation “Analysis of IgG Biosimilars using the Proteometer-L Kit” by Eric Bowen, Director of Product Management. The Proteometer (Proteoform Meter) works with existing HPLCs to provide at-line monitoring of monoclonal antibodies directly in clarified fermentation broth. Learn the ins and outs of this technology and explore how it can be used in various phases of the drug develo...
Instructions for Proteometer-L Kit
Переглядів 287Рік тому
Whether in drug development or manufacturing, evaluating the quality of medicinal batches takes anywhere from multiple hours to days. However, significant contamination can occur after just 60-minutes, thus making the endeavor timely and expensive. With the Proteometer-L Kit, batch analysis can now be performed at-line roughly every 10-minutes, resulting in the increased accessibility of lifesa...
Analytical Innovations to Speed-up Antibody Characterization
Переглядів 329Рік тому
This video is a presentation that was given by Janssen Research (Johnson & Johnson) demonstrating their usage of Novilytic’s Proteometer-L Kit. Kit contents were used to separate therapeutic bispecific antibody (bsAb) monomers and high molecular weight (HMW) species in crude culture filtrate, without the need for Protein A purification and mass spectrometry. Rapid results included titer and rel...
Continuous Process Validation (CPV): A New Analytical Strategy
Переглядів 385Рік тому
CEO, Paul Dreier's 2023 Scientific Talk at BPI West. Using a form of Mobile Affinity Sorbent Chromatography (MASC), we will demonstrate a method that can be used to rapidly separate, label, and analyze mAb samples in crude culture filtrate with no mass spec and no additional sample preparation. We will share results for current methods and for methods currently under development.
Critical Quality Attribute Analysis in Continuous Process Validation - BPI West 2022 Presentation
Переглядів 1372 роки тому
A presentation by Novilytic CTO, Dr. Fred Regnier at BioProccessing International's BPI West Conference. Dr. Regnier held the J.H. Law Distinguished Professor of Chemistry position at Purdue University. He has co-authored 306 peer-reviewed publications in the fields of chromatography, proteomics, and metabolomics and holds 47 patents in analytical and diagnostic science. He is considered by man...