Відео

2:04 / 22:17 Alexander Comninos im surprised you'd make such a critical mistake with the Testosterone Range. Dr Tom Trvision who made it has never said that the range is healthy. Its only 1k people from Boston all exposed to industrial chemicals. Not to mention there are no population studies for dosing. Not to mention no body is doing body weight calculations like all other drugs are done. So sounds like you need to do combination dose studies from 100mg to 1G to 2G along side kisspeptin and see what works.

Interesting, feeling how the bloating and pain receded within approximately two months made all the difference, I simply go’ogled the latest by Tilly Strankten and her Ovarian Cyst Guide and although it really took about 10 weeks for it to totally shrink and vanish I’ve never felt so light and relaxed.

Thank you so much doctor ❤ really good video

Video summary [00:00:00][^1^][1] - [00:29:10][^2^][2]: Jason S. Carroll presents a comprehensive overview of estrogen receptor transcription in breast cancer, focusing on the role of the estrogen receptor (ER) and its interaction with cofactors and pioneer factors like FoxA1 and GATA3. He discusses the prevalence of hormone-dependent cancers, the effectiveness of drugs targeting ER-positive disease, and the challenge of endocrine resistance. Carroll highlights the importance of understanding where ER interacts with the genome and how it recruits cofactors to modulate gene expression, leading to cell cycle progression. He also explores the dynamic relationship between ER and progesterone receptor (PR), and how PR can influence ER's genomic binding sites, potentially offering new therapeutic opportunities. **Highlights**: + [00:00:00][^3^][3] **Introduction to hormone-dependent cancers** * Prevalence of breast cancer * Role of estrogen receptor in disease progression * Current drugs targeting ER-positive disease + [00:01:14][^4^][4] **Endocrine resistance and predictive assays** * Challenges in predicting treatment response * Progesterone receptor as a biomarker * New insights into ER and PR relationship + [00:04:01][^5^][5] **Estrogen receptor's interaction with the genome** * Importance of pioneer factors like FoxA1 * ER's dependency on pioneer factors for DNA binding * Potential therapeutic targets within the ER complex + [00:07:02][^6^][6] **Mechanisms contributing to endocrine resistance** * Various escape mechanisms in resistant models * The role of FoxA1 across different resistance contexts * The significance of ER mutations in metastatic cases + [00:10:02][^7^][7] **Dynamic relationship between ER and FoxA1** * ER and FoxA1's physical interaction and genomic binding changes * ER binding profile differences in tumors with good vs. poor outcomes * Progesterone's influence on ER binding sites + [00:23:57][^8^][8] **GATA3 mutations and their impact on ER function** * GATA3's challenging role and mutation prevalence in breast cancer * The protective nature of certain GATA3 mutations * Mutant GATA3's reprogramming of ER binding sites

1. 400IU is too low to raise vitamin D level sufficiently. Why is the Society of Endocrinology pretending they don't know this? 2. Research on vitamin D as a treatment for Covid either used dosages that were too low or simply given too late. We don't research the protective effect of helmets by putting them on after a crash. 3. Virtually all medical research is directly is indirectly funded by pharmaceutical companies and their stakeholders. The incentive to properly investigate the effect of proper vitamin d supplementation on covid simply isn't there. This makes it all too easy to use "so far there isn't enough evidence to suggest..." as a cop out. Use common sense: we know hypovitaminosis D increases mortality and risk of serious illness and we know most people are deficient.

Nice video

The one thing that struck me the most from this debate, is that not a single person changed their mind one way or the other. It shows how stuck everyone is on their believes and how little healthy discussion is possible.

Thanx

Reduction of background music would play a lot more understanding of the content.

Wonderful experience with Dr oiwoh herbal home on UA-cam he’s an amazing Doc and the medication was totally helpful to my illness I boldly recommend him to y’all…

Wonderful experience with Dr oiwoh herbal home on UA-cam he’s an amazing Doc and the medication was totally helpful to my illness I boldly recommend him to y’all…

Chronic subcutaneous long-term administration of 50 nmol kisspeptin-54/day for 13 days decreased testicular weight. Histological examination showed degeneration of the seminiferous tubules associated with a significant decrease in the circulating levels of the testes-derived hormone, inhibin B. Plasma free and total testosterone were also lower, although these changes did not reach statistical significance. Further studies examined the effects of shorter periods of continuous kisspeptin administration. Subcutaneous administration of 50 nmol kisspeptin-54 for 1 day increased plasma LH and testosterone. This effect was lost after 2 days of administration, suggesting a downregulation of the HPG axis response to kisspeptin following continuous administration. "Chronic subcutaneous administration of kisspeptin-54 causes testicular degeneration in adult male rats Emily L. Thompson *, Kevin G. Murphy *, Michael Patterson , Gavin A. Bewick ,"

Mice dont go thru menopause

As an Addison’s patient that’s been on both, I would not recommend prednisolone over hydrocortisone. Although I initially felt better 2 years on I felt dreadful and I’m now back on hydrocortisone.

So, my dr. Did not test to see if my primary amenorrhea (no puberty onset) was pituitary or hypothalamus driven. I have low thyroid and low cortisol levels very low FSH, LH, estradiol and progesterone, no GH. I do not menstruate or ovulate, hormone replacement therapy has caused the shedding of the lining of the uterus but no ovulation. I am not currently taking hormone placement therapy. I desire to conceive, I am open to trials of kisspeptin. I am wondering if you have any information that could help me.

Music is too loud

Being a fan of Dr Campbell, I an taking 4,000 IU Vit D + vit K2 daily. Anything that helps my immune system is welcome, even if it’s a little help. By the way: 400 IU is a sad joke

What people don't understand is that vitamin D studies, are purposely designed with extremely low test levels of vitamin D. This is because the US government won't allow high dose studies, like 20,000 IU daily. The FDA has to approve studies, and I have watched doctors say that the government is really strict on making tester follow the rules. Since an average of zero people per year die from vitamin D toxicity, and humans can get 20,000 IU daily of vitamin D3 from the sun, why is the government not allow high dose testing? This tells me they are afraid of something. Maybe the government is trying to keep the beneficial effects of vitamin D from being known. This would make sense. If vitamin D was protective of viruses, then the drug companies would lose billions of dollars. Is it possible the government is protecting their funding sources? Are the drug and medical communities paying off the government to keep a cheap and effective treatment a secret so they can profit off of people's illnesses? Does the government have a track record of hiding the truth to keep certain industries profitable? The evidence strongly suggests this is the case. Why is it that every C19 video of any kind has a notice telling the viewer to get the latest information about it from the CDC? UA-cam wants everybody to blindly just trust the government like a bunch of unquestioning morons without any thought. This is how misinformed people think...

At this point i'm still very shocked with the negative result I got after suffering from PCOS for so long. Thanks once again DR RORPOPOR HERBAL on UA-cam for your natural supplements 🤓🤓🤓

You know you can put references in the description too.

Appreciation to Dr IGUDIA on UA-cam who cured my type two diabetes with his natural herbs medication which I ordered from him.

"modest but significant..." Classic

It's not true that there are no studies showing vit d prevents worsening of C-+9. Early treatment protocols they've known about forever include high doses of vit D. Deaths and hospitalizations could've been prevented had they WANTED to.

The fact that causation hasn't been proven with more than 95% certainty isn't the same as there "being no link". I love how linear regression is used to show that the vitamin d correlation is really explained by "real" risk factors such as obesity or ethnicity(which are not independent variables since they correlate with vitamin d levels, and not linear either, and thus cannot be corrected for). To be honest, you could just as well do this the other way around, and then vitamin d would be the real risk factor and the correlation with weight and ethnicity would vanish. There are lies, damn lies, and then there are statistics.

Fauci who has never mentioned vit D to us little people, takes 8,000 IU vit D a day. Do the research

Let's clarify the father of vitD I call him..Dr Micheal Holick book The Vitamin D Solution will save your life...he takes 6000 iu..his ngml is 65 ngml....also 75 % of elderly have level below 20 ngml..and research shows the deficiency results in bad outcomes with respiratory virus and bacterial infection .and this study was pre covid19..so Drs treat the VitD deficiency with active forms hidroferol calcifediol prescription grade VitD..so simple..your not treating covid your treating VitD deficiency..come on...look at the Spain's clinical trials..

Thank you Dr IGUDIA on UA-cam the great traditional healer who cured my Diabetes disease with his herbs medication.

I will forever thank Dr IGUDIA on his UA-cam who cured me from my type 2 Diabetes with his herbs medication

Is it is or is it ain't ?

This video is garbage. Spending a few minutes outside and eating an occasional egg salad or bit of salmon will NOT get you anywhere near healthy levels, presumed to be 50ng and above. To reach these levels, you need deliberate sun bathing, or supplements on the order of thousands of IU per day.

400 iu per day is a pathetic joke. Ancestral VD levels are generally above 50ng/ml. To achieve this level, you will need to take many thousands of IU per day or sunbathe regularly. (One sun session can generate tens of thousands of IU in under an hour.)

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Anyone know what is Zonopelarge Secrets about? I hear lots of people achieve total control over their premature ejaculation with this popular premature ejaculation natural treatment.

Anybody know what is Zonopelarge Secrets about? I hear most people get more intense erections with this popular male enhancement.

I think I have this , it seems a fight to get a referral to and endocrinologyst from my gp , hope I get a diagnosis soon, not sure how can I contact an endocrinologist without a go referral

Wow this was not educational. Still a mans world.

It works great I use it on trt, makes me feel happy

Hot flashes is a B🥵

This whole video just needs to be deleted. Diabetes will never cure itself.

As a patient with Kallmann syndrome this video is of great interest. I have been involved as a patient in two clinical trials using Kisspeptin. Early diagnosis of Kallmann syndrome / CHH can be so important to patients so the use of the Kisspeptin challenge test to distinguish a case of Kallmann syndrome / CHH from standard delay of puberty could be very beneficial to patients. I did not respond to Kisspeptin injections, as would be expected in a Kallmann syndrome patient, even though I responded to GnRH injections.

Hot flashes are evil!

But when will this occur.

This is insane bruv

I’ve been living with Central DI for 10 years. Although this disease is manageable, is there any research to support a cure for this disease?

Is there a way to make my brain produce ADH again?

Thanks for this!

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I have diabetes insipidus since 2007 after tumor removable in pituitary

This peptide sounds incredible. Would be a much better alternative to HCG in testosterone replacement therapy .

Great video!