Hannah Went
Hannah Went
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Unlocking the Secrets of Healthy Aging
What does it take to live not just longer but healthier lives? In this week’s episode of the Everything Epigenetics podcast, Dr. Jamie Justice and I explore the groundbreaking research and initiatives shaping the future of healthy aging. From bridging the gap between lifespan and healthspan to revolutionary breakthroughs like the XPRIZE Healthspan prize, we dive deep into the science and innovations driving progress in geroscience.
You'll learn about:
- What “healthy aging” truly means and why it’s vital for everyone.
- How the gap between lifespan and healthspan impacts society and what can be done to close it.
- The critical factors influencing long-term healthspan and actionable steps individuals can take.
- The goals and potential of the XPRIZE Healthspan initiative and the exciting innovations emerging from it.
- How targeted initiatives like the SOLVE FSHD Bonus Prize could shape the future of disease-specific health research.
- A look ahead: breakthroughs and milestones expected in the next 5-10 years in aging research.
Chapters:
00:00 Welcome and Introduction
02:30 What “healthy aging” means to Dr. Jamie Justice
07:15 Lifespan vs. Healthspan: Bridging the gap
15:40 Key factors influencing long-term healthspan
22:10 Overview of the XPRIZE Healthspan Prize
28:45 Promising innovations from XPRIZE participants
35:20 The SOLVE FSHD Bonus Prize and its impact
42:10 Future breakthroughs in geroscience and aging research
49:30 Where to connect with Dr. Jamie Justice
Where to Find Us:
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Twitter - EverythingEpi
Facebook - EverythingEpigenetics
Follow us on
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Visit our website for more information and resources: everythingepigenetics.com
Переглядів: 58

Відео

Epigenetics and Canine Longevity: Unlocking Healthier, Longer Lives for Dogs
Переглядів 7714 днів тому
In this week’s episode of the Everything Epigenetics podcast, Dr. Christopher Minteer, Nicholas Minteer, and I dive into the fascinating intersection of canine health, longevity, and epigenetics. We explore how their company, Woofgenix, is revolutionizing the field through cutting-edge research and innovative products that aim to extend the lifespan and healthspan of our beloved pets. From unde...
Epigenetic Hacks for Longevity: Strategies to Thrive at 62
Переглядів 1,1 тис.Місяць тому
In this episode of Everything Epigenetics, host Hannah Went sits down with Dave Pascoe, a retired network security architect who’s redefining the way we think about aging. Despite being 62, Dave has been able to have a lower "biological age" and slow pace of aging, a testament to his dedication to health optimization, epigenetics, and biological tuning. Known for ranking among the top contender...
From Aging to Cancer Risk in Epigenetics with Dr. Chiara Herzog
Переглядів 120Місяць тому
In this week's episode of the Everything Epigenetics podcast, Dr. Chiara Herzog and I talk about how epigenetics is making waves in the medical world and how it could change treatment. Translational scientist and research fellow Dr. Herzog provides insights from her role in the Biomarkers of Aging Consortium and her work on the TirolGESUND project, one of the largest multi-omic human lifestyle ...
Epigenetic Aging in Mood Disorders: Exploring the Role of Lithium and Future Therapies
Переглядів 190Місяць тому
In this week’s episode of the Everything Epigenetics podcast, Dr. Gabriel Fries and I discuss the fascinating intersections of epigenetics, aging, and psychiatric disorders. Dr. Fries, an Assistant Professor in Psychiatry and Behavioral Sciences at UTHealth, shares his groundbreaking research on the molecular underpinnings of mood disorders such as bipolar disorder and suicide risk. We dive int...
Detecting the Undetectable: Epigenetics in Early Cancer Detection with Dr. Joshua Routh
Переглядів 2082 місяці тому
Recent research from the University of Chicago shows that only 14% of cancers in the U.S. are diagnosed after the patient had a recommended screening test. 57% of diagnosed cancers do not have screening tests and account for 70% of all cancer-related deaths. 86% of cancer cases still go undiagnosed after recommended screenings. ‍16M life years saved in the U.S. from early-detection screenings. ...
The Future of Kidney Health: How Dr. Charles Breeze Is Changing the Game with Epigenetics
Переглядів 2892 місяці тому
In this week’s episode of the Everything Epigenetics podcast, I’m joined by Dr. Charles Breeze, an expert in computational epigenetics. We talk about his inspiring journey into the field of epigenetics, his trailblazing research on kidney function across diverse ethnic groups, and the innovative tools he's developed to push the boundaries of epigenetic research. Dr. Breeze shares how his fascin...
Alzheimer’s Disease as an Epigenetic Disease with Dr. David Katz
Переглядів 3993 місяці тому
Alzheimer’s disease is a devastating neurodegenerative condition that slowly erodes memory, cognitive function, and the ability to perform even the simplest tasks. It’s heartbreaking not only for those diagnosed but also for their loved ones as they watch a gradual loss of the person they knew. This is exactly how I felt in 2015 when I watched my grandmother be taken by this awful disease. The ...
The Power of Single-Cell Epigenetic Profiling
Переглядів 1573 місяці тому
In this week’s episode of the Everything Epigenetics podcast, Dr. Hannah Went sits down with Alex Trapp, a computational biologist deeply involved in aging research. The two explore the cutting-edge development of single-cell epigenetic clocks and their potential applications in the field of longevity science. Alex shares his journey from experimental biology to computational approaches and dis...
Development and Application of Epigenetic Predictors with Dr. Varun Dwaraka
Переглядів 1514 місяці тому
The development and application of epigenetic predictors of health is revolutionizing the way we understand and approach personalized medicine. These predictors, derived from analyzing DNA methylation patterns, provide a powerful tool for assessing biological age, disease risk, and overall health. By leveraging advanced machine learning and AI, researchers can identify specific epigenetic marke...
Unraveling the Complexity of Epigenetics in the Brain with Dr. Esther Walton
Переглядів 2664 місяці тому
In Europe, people aged 65 typically spend about half of their remaining years managing disabilities. Much of the existing research on aging has predominantly focused on identifying "cures" rather than exploring strategies for healthy aging. Dr. Esther Walton’s is breaking new frontiers with the unconventional approach that aging begins at birth and should be approached through a comprehensive l...
Epigenetic Regulation of Immunity with Dr. Andrew DiNardo
Переглядів 1845 місяців тому
The immune system adapts to various threats through innate and adaptive responses, utilizing epigenetic mechanisms to regulate gene activity without changing DNA sequences. These mechanisms help maintain long-term immune phenotypes, allowing the immune system to respond to changing environments. In innate immunity, epigenetic changes enable immediate pathogen responses, while in adaptive immuni...
Trauma's Epigenetic Impact on Mental Disorders with Dr. Janitza Montalvo-Ortiz
Переглядів 895 місяців тому
In this week’s episode of Everything Epigenetics, I am joined by Dr. Janitza Montalvo-Ortiz, Assistant Professor of Psychiatry at Yale University, who shares her journey into the world of epigenetics and psychiatry. Dr. Montalvo-Ortiz explains the pivotal role of epigenetics in understanding the genetic and environmental factors contributing to psychiatric disorders and emphasizes the importanc...
A therapeutic trip: From experience to epigenome with Dr. Candace Lewis
Переглядів 996 місяців тому
We are entering a new phase of understanding how our social environments affect our biology, particularly how they influence the genes involved in brain development and function. This knowledge helps us see how experiences like stress, trauma, and isolation can cause changes at the molecular level that may increase the risk of mental disorders. On the other hand, we're also exploring how positi...
Personalized Nutrition and Epigenetics with Dr. Lucia Aronica
Переглядів 2606 місяців тому
Personalized nutrition tailors dietary recommendations to an individual's unique biological needs, factoring in genetics, lifestyle, and health conditions to optimize health, prevent disease, and maintain overall well-being. Central to this approach is the role of epigenetics, which studies changes in gene expression that do not involve alterations to the DNA sequence but can be influenced by e...
Epigenetic Gestational Age Prediction with Kristine Løkås Haftorn
Переглядів 1189 місяців тому
Epigenetic Gestational Age Prediction with Kristine Løkås Haftorn
Causal Epigenetic Age Uncouples Damage and Adaptation with Kejun (Albert) Ying
Переглядів 38010 місяців тому
Causal Epigenetic Age Uncouples Damage and Adaptation with Kejun (Albert) Ying
The Importance of the Imprintome with Dr. Randy Jirtle
Переглядів 33810 місяців тому
The Importance of the Imprintome with Dr. Randy Jirtle
Integrating Epigenetics into the Social Models of Heath Disparities with Dr. Lauren Schmitz
Переглядів 17911 місяців тому
Integrating Epigenetics into the Social Models of Heath Disparities with Dr. Lauren Schmitz
Prioritizing Your Health Investment with Dr. Jeoff Drobot
Переглядів 19411 місяців тому
Prioritizing Your Health Investment with Dr. Jeoff Drobot
Unlocking the Epigenome from a Single Drop of Blood with Dr. Toinét Cronjé
Переглядів 108Рік тому
Unlocking the Epigenome from a Single Drop of Blood with Dr. Toinét Cronjé
Tracking and Measuring Biomarkers to Maximize Longevity with Dr. Michael Lustgarten
Переглядів 1,6 тис.Рік тому
Tracking and Measuring Biomarkers to Maximize Longevity with Dr. Michael Lustgarten
Methylation Risk Scores with Dr. Michael Thompson
Переглядів 259Рік тому
Methylation Risk Scores with Dr. Michael Thompson
The Role of Epigenetics in Functional Medicine with Dr. Jeffrey Bland
Переглядів 1,2 тис.Рік тому
The Role of Epigenetics in Functional Medicine with Dr. Jeffrey Bland
Assessing the Reproducibility and Integrity of DNA Methylation with Dr. Karen Sugden
Переглядів 149Рік тому
Assessing the Reproducibility and Integrity of DNA Methylation with Dr. Karen Sugden
MOSAIC: Multi-Organ Scores of Aging across Integrated Components with Raghav Sehgal
Переглядів 205Рік тому
MOSAIC: Multi-Organ Scores of Aging across Integrated Components with Raghav Sehgal
Personalized Biomarkers to Predict Surgery Outcomes with Dr. Christopher Ames
Переглядів 259Рік тому
Personalized Biomarkers to Predict Surgery Outcomes with Dr. Christopher Ames
Reduce Your Biological Age in Just 8-Weeks with Dr. Kara Fitzgerald
Переглядів 4,3 тис.Рік тому
Reduce Your Biological Age in Just 8-Weeks with Dr. Kara Fitzgerald
A Deeper Dive into DunedinPACE with Dr. Daniel Belsky
Переглядів 848Рік тому
A Deeper Dive into DunedinPACE with Dr. Daniel Belsky
How Fit Are You According to Your DNA? With Kristen McGreevy
Переглядів 108Рік тому
How Fit Are You According to Your DNA? With Kristen McGreevy

КОМЕНТАРІ

  • @dailyui636
    @dailyui636 20 днів тому

    Thank you for this interview. Was really inspiring and informative

  • @boyscout-p3u
    @boyscout-p3u 26 днів тому

    strategies to thrive at 62 and it starts off with the resource person not thriving with a cold , not sure if i wanna watch it at this point

  • @SaschaHeim
    @SaschaHeim 28 днів тому

    👍 good conversation !

  • @spectremanLIVE1
    @spectremanLIVE1 28 днів тому

    🥳🎉🎂

  • @KathMisura
    @KathMisura Місяць тому

    Que orgulho, você é genial Gabriel!

  • @monnoo8221
    @monnoo8221 2 місяці тому

    its getting ridiculous calling everything an -ome.... why not calling the body an ome-ome???? Much like the talking about "anti-oxidants" i is a maker that someone does not understand anything about biology

    • @everythingepigenetics
      @everythingepigenetics 2 місяці тому

      I get what you're saying! The "ome" terminology does seem to be everywhere these days-from genome to proteome and beyond. It can definitely feel overwhelming, but the idea behind using "-ome" is to capture a comprehensive view of a specific biological system (e.g., all genes = genome, all proteins = proteome). It’s just a way scientists classify and analyze complex biological networks. While it might seem like overkill, these terms help researchers break down and study specific areas in detail. And you're right-sometimes the overuse can make it feel a bit like the "antioxidant" buzz, but in many cases, these "-omes" provide useful frameworks for understanding complex systems! And yes, "ome-ome" would certainly be taking it to the extreme! 😄

  • @leandrobecker123
    @leandrobecker123 2 місяці тому

    Very interesting discussion Hannah! I would ask if this new way of early detection of cancer through epigenetic modification could have ro do with mitocondrial dysfunction as we know it is the common pathway to initial cancer development.

    • @everythingepigenetics
      @everythingepigenetics 2 місяці тому

      You’re absolutely right that mitochondrial dysfunction is a known factor in the early stages of cancer development. While this new method of early cancer detection via epigenetic modifications primarily focuses on changes in DNA methylation patterns, it’s certainly plausible that mitochondrial dysfunction could be intertwined with these epigenetic changes. Mitochondrial stress can lead to reactive oxygen species (ROS) production, which can cause damage to DNA, including methylation patterns. This epigenetic dysregulation could, in turn, contribute to the cancer development pathway. So while the primary focus may be on nuclear DNA methylation, mitochondrial health and dysfunction could be part of the larger picture in both cancer initiation and the epigenetic markers being tracked for early detection.

    • @leandrobecker123
      @leandrobecker123 2 місяці тому

      @@everythingepigenetics Great! It would be an intersting study if we could track (test) this DNA methylation patterns in someone that after it developed some kind of cancer. With these big cohorts and biobanks maybe we could better understand it.

    • @everythingepigenetics
      @everythingepigenetics 2 місяці тому

      @@leandrobecker123 Yes!! Check out this review here - onlinelibrary.wiley.com/doi/full/10.1002/ctd2.279

  • @graphicmaterial5947
    @graphicmaterial5947 2 місяці тому

    How to piss off both vegans and carnivores in less than 30 minutes, haha!

  • @Sunny-fx1
    @Sunny-fx1 2 місяці тому

    It has been shown that another demethylase, namely the H3K27me3/2 demethylase JMJD3 cooperates with Tau to specifically control VGLUT1 and VGLUT2 expression for proper synaptic transmission and normal neuron functions under physiological conditions. JMJD3, in immun cell activation, plays a prominent role as providing chromatin accessability for transcription factors and, thus, for gene expression.

    • @everythingepigenetics
      @everythingepigenetics 2 місяці тому

      That's a fascinating connection! The demethylase JMJD3 indeed plays critical roles both in neuronal function and immune cell activation, highlighting its versatile regulatory abilities.

  • @Sunny-fx1
    @Sunny-fx1 2 місяці тому

    Thank you, for yet another interesting conversation. Given that the demethylase JMD3 has been shown to have both demethylation-dependent and -independent functions in T-cell activation, differentiation and lineage stability and that JMJD3 works in synergy with the master transcription factor T-bet in forming the SWI/SNF complex, could it be interesting to consider the immunological processes of Alzheimers as an abberrant immune activation resulting in both upregulation of a specific gene signature as well as a downregulation of another?

    • @everythingepigenetics
      @everythingepigenetics 2 місяці тому

      Yes, it could be very interesting to consider the immunological processes in Alzheimer's disease as a result of aberrant immune activation, with involvement of factors like JMJD3. JMJD3 (a histone demethylase) plays a key role in T-cell activation, differentiation, and lineage stability, often through epigenetic modifications. Its interaction with the master transcription factor T-bet, which is crucial for driving immune responses, particularly in the SWI/SNF complex, suggests a regulatory pathway that controls the expression of specific immune genes. In Alzheimer's disease, there is growing evidence of immune dysregulation, particularly in microglial activation, which parallels some of the processes seen in T-cell activation. The hypothesis of JMJD3-driven aberrant immune activation could provide a mechanistic basis for the upregulation of genes associated with neuroinflammation and immune responses, while concurrently leading to downregulation of protective or regulatory genes. If JMJD3's activity in Alzheimer’s involves both demethylation-dependent and independent functions, this might result in a specific epigenetic signature. Such dysregulation could shift the balance towards chronic inflammation and neurodegeneration, while suppressing pathways that normally protect the brain or resolve inflammation.

  • @Sunny-fx1
    @Sunny-fx1 2 місяці тому

    Thank you, interesting conversation! Does your guest look at the methylation status of CpG DNA or just CpG islands? Does the fact that the mice CpG DNA is unmethylated, and the human CpG is methylated to a high degree constitute a problem for comparison?

    • @everythingepigenetics
      @everythingepigenetics 2 місяці тому

      You're welcome! Great questions. They look at the status of CpG DNA. However, research looks at the methylation status of CpG sites across the genome, which includes both individual CpG sites and CpG islands. The difference in CpG methylation between mice and humans is indeed a challenge for direct comparison. Mice tend to have lower overall CpG methylation compared to humans, where methylation is more widespread. This disparity can complicate translating findings from mouse models to humans, particularly in aging studies or disease models. The evolutionary differences in methylation patterns mean that while mouse models are useful for studying mechanisms of methylation, their direct applicability to human methylation patterns requires careful interpretation and validation.

  • @Sunny-fx1
    @Sunny-fx1 2 місяці тому

    How does immune-cells change the epigenetic landscape during activation and transition from innate to adaptive immunity,- and can aging be studied from observing and understanding stemness and lineage commitment during T-cell activation.

    • @everythingepigenetics
      @everythingepigenetics 2 місяці тому

      When immune cells, particularly T-cells, are activated and transition from innate to adaptive immunity, they undergo significant changes in their epigenetic landscape. These changes involve alterations in DNA methylation, histone modifications, and chromatin structure, which regulate gene expression by turning specific genes on or off in response to the immune challenge. During activation, T-cells receive signals from pathogens or stimuli that lead to epigenetic modifications, enabling the rapid upregulation of genes necessary for their immune response, such as those involved in proliferation, cytokine production, and effector functions. This transition from the more generalized innate immune response to the specialized adaptive immune response is tightly controlled by epigenetic mechanisms, which ensure that the cells are primed to fight infections effectively. Studying these epigenetic changes during T-cell activation can offer valuable insights into the aging process, particularly by examining stemness (the ability of cells to remain undifferentiated) and lineage commitment (the process by which cells become specialized). As T-cells age, their capacity for effective activation and differentiation diminishes, largely due to changes in their epigenetic regulation.

  • @donnosborne9723
    @donnosborne9723 3 місяці тому

    Thanks for the video

  • @donnosborne9723
    @donnosborne9723 3 місяці тому

    Aging is not fun believe md

  • @donnosborne9723
    @donnosborne9723 3 місяці тому

    You are left handed?

  • @foxfiregal
    @foxfiregal 3 місяці тому

    53:49 I'd be a swallow = joy, play, rejuvenation, coming back home, being FREE ❤🎉

  • @bipindeshpande2043
    @bipindeshpande2043 3 місяці тому

    Excellent podcast. Dr. Randy Jirtle was very eloquent and simple in his explanation of such a difficult topic. I appreciate it. Dr. Bipin Deshpande, Dermatologist, India.

  • @aodhfinn
    @aodhfinn 3 місяці тому

    Yes ..audio was very poor , but the information worth the work .I'm subscribed

  • @rudreshp4833
    @rudreshp4833 4 місяці тому

    Link of the paper please

    • @everythingepigenetics
      @everythingepigenetics 4 місяці тому

      It's only a preprint right now! Will be published very soon :) www.ncbi.nlm.nih.gov/pmc/articles/PMC10614756/

  • @hrc6408
    @hrc6408 4 місяці тому

    Excellent podcast and thank you for sharing the info about the Netflix twins study! Dr. Aronica is an amazing teacher, I’ve been fortunate to do her online courses with Stanford!! Thank you both!

  • @glittereagle88
    @glittereagle88 4 місяці тому

    This seems great but the audio and volume is off. Seems like such legitimate and detailed info but I couldn’t hear everything! It got annoying

    • @everythingepigenetics
      @everythingepigenetics 4 місяці тому

      Thanks for the feedback! One man band over here and currently getting help with this :) You can check out the transcript if you're interested.

  • @ChessMasterNate
    @ChessMasterNate 4 місяці тому

    Click that CC button to see what he is saying. Definite fuel for disaster movie. "Existential risk" may not be an exaggeration. There is evidence that people had much better memories in the past. Possibly diminished by some change to the epigenome? Though, I suspect, they did a lot more rhymes with toddlers, and young kids. Rote memory is practically a dirty word, today. But just because you do rote memory exercises does not mean you can't teach reasoning and creativity as well. I have drifted off-topic. I suspect lead and many other exposures have harmed us. Is it truly permanent? Can we do something to reset it? Is there even a default state? If reset, would we lose a lot of important adjustments that have been with us for eons? What about those Yamanaka factors? Or maybe there is another one or set that does do a reset. So many questions. I read about this nearly 20 years ago. Though I had no idea, it was effectively permanent. I figured it would fade fairly quickly. It makes one wonder about what the impacts on children are from a father who did all sorts of drugs, and then quit, settled down and had a family. That describes vast numbers of people who grew up in the 1980s and 1990s. I was the oddball, never smoked, drank, or used at all, but obviously I wasn't very popular either. I always wanted to live a long time. Most men smoked back in the late 1940s until the early 1980s. Mostly it shot up during WW2, when they put cigarettes in every soldier's gear. So many toxins. Our farmland is covered with lead from the top-selling pesticide in the early 1950s, lead arsenate and auto exhaust. And, even today, from crop dusting aircraft virtually all of which still used leaded aviation fuel, and from bone meal fertilizer. For countless generations, humanity was besieged by smallpox. For at least 3,500 years in the old world, 1/3 of all children died of smallpox, and everyone else was scared all over, and some left blind. Many did not even name their children until they had smallpox and survived. In the early 1800s, large numbers started to get inoculated, but there was still a significant risk of death. It was not until vaccination, that you had a very low chance of death. And now no one dies of smallpox because we eradicated it. Probably the single greatest accomplishment of humanity after agriculture. I have got to think that epigenic effects from smallpox must be present. Probably from plague, polio and leprosy as well. Almost certainly we can develop tools to edit epigenetics...if not a blanket reset...targeted repairs. Though, Congress is paranoid and outlaws so much stuff that can make large positive changes in our lives. I wonder if being routinely electrocuted affects the epigenome. I grew up in a house where it was always wet in the laundry, and to load or empty the washer or dryer meant being continuously electrocuted when you touch either appliance or anything wet in them. You get used to it. But, it is still unpleasant, and requires effort to move your arms where you intend. I am sure it would kill anyone with a weak heart. Must have been that way at least a decade.

  • @freddykruger3320
    @freddykruger3320 4 місяці тому

    Brilliant

  • @frikanetwork
    @frikanetwork 5 місяців тому

    Hi can you highlight the parallels between epigenetic coaching, biohacking coaching and intuitive transformation coaching?

    • @everythingepigenetics
      @everythingepigenetics 4 місяці тому

      Of course!! Epigenetic coaching, biohacking coaching, and intuitive transformation coaching share several parallels, all centered around personalized health and wellness. Epigenetic coaching utilizes an individual's genetic and epigenetic information to create tailored interventions aimed at optimizing health and preventing disease. This involves analyzing gene pathways, DNA methylation, and other epigenetic markers to recommend specific lifestyle, nutrition, and exercise modifications. Similarly, biohacking coaching emphasizes personalized health strategies but focuses on using technology, supplements, and lifestyle changes to enhance physical and mental performance. Biohackers often experiment with various interventions to find what works best for their unique biology, trying to improve aspects such as energy levels, cognitive function, and overall well-being. Intuitive transformation coaching also prioritizes personalized wellness but takes a more holistic and introspective approach. This type of coaching usually encourages individuals to tap into their intuition to identify and address barriers to personal growth and health. Coaches guide clients through practices like mindfulness, meditation, and emotional awareness to foster a deeper connection with themselves and make informed decisions about their health and life goals. All three coaching styles really emphasize the importance of individualized strategies, whether through scientific data, technological experimentation, or intuitive self-awareness, to achieve optimal health and transformation.

    • @frikanetwork
      @frikanetwork 4 місяці тому

      @@everythingepigenetics 💯 Thank You

  • @EkilRevolution
    @EkilRevolution 6 місяців тому

    About the discussion of women liveing longer than men, I think the "how" is multi-factorial and too complex to explain well. But I have an idea about the "why", and it extends to most mammals not just humans: Males are able to produce more offspring in their lifetime, whilst females are limited by the burden of sheer time, as well as resources, required for pregnancy. A mechanism to prevent a particular organism (carrier of genetic information), fecundity evolves to be more limited as longevity increases. This evolutionary (not necessarily physical) trade-off improves adaptability of a groups of organisms. I may not be explaining this clearly, but group selection is real and the Selfish Gene theory is only a partial truth. The same concepts of adaptability and group selection gave rise to ageing. Ageing is not an evolutionary dysfunction, and neglect does not fully explain the existence of ageing. Ageing is beneficial (obviously not at an organismal level). Josh Mitteldorf deserves credit for helping me realize this. This is why caloric restriction can delay ageing across most species. Delaying the program of ageing can prevent extinction during famine when successful reproduction is limited. Ageing faster when overeating is beneficial to prevent rampant population growth. So basically I suspect males age faster because they have greater potential to spread their genetic information, and a shorter lifespan can off-set this imbalance. Makes me wonder if abstaining could slow male ageing (after controlling for the beneficial aspect of emotional reward). About the how females age faster, anything that happened to give rise to slower ageing compared to males would serve the same function. It's possible that male hormones are more pro-ageing, or that increased growth is pro ageing. It's possible that the identical sex chromosomes (XX) of the female confer a DNA repair advantage.

    • @EkilRevolution
      @EkilRevolution 6 місяців тому

      this imbalance of potential reproductive success of males vs females explains the paradox where females begin puberty earlier yet don't live shorter. The later puberty in males limits the time period of potential reproduction. Evolution creates balanced organisms not superorganisms.

    • @monnoo8221
      @monnoo8221 2 місяці тому

      You should read Aristotle about his descripion of the anatomy of the "Why" question.... Each and every "Why" is composed of 4 divergent/othognoal/independent aspects (wikipedia has ias it too).

  • @kotone4516
    @kotone4516 6 місяців тому

    Just watched a bunch of these, they are so interesting as an undergraduate genetics student !! Please keep uploading :D

    • @everythingepigenetics
      @everythingepigenetics 6 місяців тому

      Thank you!! Season 2, episode 1 will be launched in about a week. You can always check out my page on Instagram if you want to learn more, @everythingepigenetics

    • @lifeexplorer3247
      @lifeexplorer3247 3 місяці тому

      Biotech undergrad here. Same. Cool podcast

  • @geladaizlabon3605
    @geladaizlabon3605 7 місяців тому

    Interview Bryan Johnson next 😅

  • @scotttremblay5782
    @scotttremblay5782 7 місяців тому

    Come on, zero real usable content on ur title. All talk on self sponsorship and course.

    • @everythingepigenetics
      @everythingepigenetics 7 місяців тому

      Thanks for the feedback, Scott!

    • @scotttremblay5782
      @scotttremblay5782 7 місяців тому

      @everythingepigenetics np. Super interested in the topic, and u had a great guest yet not real info

  • @katharina1439
    @katharina1439 7 місяців тому

    ❤thank you so much. This Intel is fascinating!😃 I'm using earphones so my audio quality is good😊

  • @WaltonXeller
    @WaltonXeller 8 місяців тому

    Pretty good stuff, I just realized that Mario updated his favorite way to tackle ED and it's crazy! Although what he previously talked about was pretty decent, it was difficult to follow, I just go'ogled the latest in Mario's Thunderous Erections, it's so much simpler and potent now!

  • @DrOlegKulikov
    @DrOlegKulikov 8 місяців тому

    The only reliable and easy-to-measure mark of aging is the stiffness of your arteries. Surrogate measures of it are Pulse Pressure which is a difference between Systolic and Diastolic blood pressures, and resting heart beat rate. The epigenetic clocks based on methylation or telomere shortening are absolutely overhyped, expensive, and not reliable tools. Micro-biome is very important, it is true.

    • @everythingepigenetics
      @everythingepigenetics 8 місяців тому

      I'd love to see the hazard and odds ratio to disease for the stiffness of your arteries and learn more! Do you have this information or any reference you can provide?

    • @DrOlegKulikov
      @DrOlegKulikov 8 місяців тому

      @@everythingepigenetics sure. drive.google.com/file/d/1kfgA23C3cxlWwvoFiMwjM-TPcGqRqkI6/view?usp=drivesdk There are links inside too.

    • @monnoo8221
      @monnoo8221 2 місяці тому

      Besides the fact that your statement is in parts self-contradictory, I agree on the statement regarding the overhyped TL or DNA methylation methods. The actual problem around assessing aging is one of scientific culture, which is still heavily infected with, and sick from, a crude form of positivism. Everybody is seeking for a single factor, instead of trying to describe the most predictive profiles. What is considered the gold standard of empirical work is more or less rotten FeS2. Singularizing empiric data into single factors by "statistical adjustments" is just complete BS. You are kind of infected too ;) ...quote "The only reliable and easy-to-measure mark of aging is ..."

    • @DrOlegKulikov
      @DrOlegKulikov 2 місяці тому

      @@monnoo8221Epigenetic clocks that are so popular nowadays are very confusing and have very little in common with functional aging. Therefore, stem cell infusion and some supplements give unrealistic extimation of rejuvenation. So, it is a part of business to promote useless and expensive procedures. People make good money - this is the purpose.

  • @robinwallace7097
    @robinwallace7097 9 місяців тому

    When I was studying biology 40 years ago, I just knew there was more to the story! I couldn't believe convergent evolution evolution would happen randomly! There had to be a mechanism for environmental influence

  • @erwinrogers9470
    @erwinrogers9470 9 місяців тому

    NAD, is the key, to reverse aging🔥

  • @erwinrogers9470
    @erwinrogers9470 9 місяців тому

    Excellent episode👍

  • @erwinrogers9470
    @erwinrogers9470 9 місяців тому

    I'm with you, guys👍

  • @erwinrogers9470
    @erwinrogers9470 9 місяців тому

    Great interview🔥👏

  • @erwinrogers9470
    @erwinrogers9470 9 місяців тому

    Love it🔥👏

  • @helencanky9408
    @helencanky9408 9 місяців тому

    Can you let the doctor talk?

  • @staceygantt1119
    @staceygantt1119 9 місяців тому

    Loved this podcast. New subscriber 💙💙

  • @ericscaillet2232
    @ericscaillet2232 9 місяців тому

    Defenitely did not get his Phd in sound engeneering.... why upload such bad sound

    • @everythingepigenetics
      @everythingepigenetics 9 місяців тому

      Thanks for the feedback, Eric! I'm working on getting better at this.

    • @angelinaderpina6210
      @angelinaderpina6210 6 місяців тому

      Correct..that is because his life’s work and energy is directed in other disciplines, which includes finding out how many generations back the stick was methylated up your arse. If you have skills to improve someone else’s process, find a solution not derail the entire purpose of this talk, which was both coherent and a point far more memorable than the audio.

    • @everythingepigenetics
      @everythingepigenetics 6 місяців тому

      @@angelinaderpina6210 Thank you!! ^^^

  • @missmurrydesign7115
    @missmurrydesign7115 9 місяців тому

    Delicious...

  • @yannaubin7617
    @yannaubin7617 9 місяців тому

    Bad audio.

  • @alas_poor_Yorick
    @alas_poor_Yorick 9 місяців тому

    Audio is totally fucked...

    • @everythingepigenetics
      @everythingepigenetics 9 місяців тому

      Thank you for the feedback! If you'd like to view the transcript, you can see it on my website here - everythingepigenetics.com/episode/dr-michael-skinner-epigenetic-transgenerational-inheritence/

  • @AyubKhan-el9kk
    @AyubKhan-el9kk 9 місяців тому

    Women live longer than men because their red blood cell population is renewed each month due to mensuration. Holding other variables constant this biological difference would result in optimisation of blood biomarkers (Hct, Hmg, RDW etc) and down stream benefits of younger RBC population on other organs and tissue.

    • @everythingepigenetics
      @everythingepigenetics 9 місяців тому

      Thanks for the insight! I'd love to see the research around this. Do you have that you can share with me? I think it may be a great hypothesis, however, we know that according to TruDiagnostic's new OMICmAge (the most predictive biological age clock created to-date), we want to increase Hct and Hmg and decrease RDW to optimize aging. This has also been validated in previous literature as well!

    • @freddykruger3320
      @freddykruger3320 5 місяців тому

      @@everythingepigenetics Blood letting for health has been around for hundreds if not thousands of years.

    • @monnoo8221
      @monnoo8221 2 місяці тому

      if you would correct for the greater tendency of risk taking in men, the higher incidence of smoking in men historically, the anti-inflammatory effects of estrogen, the difference is just vanishing

  • @thinktwice888-p4d
    @thinktwice888-p4d 9 місяців тому

    Really enjoyed this deep dive - really informative.

  • @jonathonmills3563
    @jonathonmills3563 10 місяців тому

    There was a recent Horvath presentation on Life Extension symposium I believe where he talked about a complete Mammalian genome for methylation, and that 30% of species over express maximum life genes in women. Humans are one of those mammals

  • @JoeUser9997
    @JoeUser9997 10 місяців тому

    @everythingepigentics, Great podcast Hannah! When and where will the blood test MOSAIC for 11 organ systems be available commercially to the public? I looked online and the only commercially available test product of Raghav's that I could find was an older saliva based test "Systems Age" through Elysium Health which only evaluates 9 organ systems for $299, I would assume the newer one, Mosaic, is more comprehensive since it is a blood draw. Really hoping this is currently available somewhere, since I just got back my results for my OmicAge/DunedInPace test this past December and it was not good--aging at a rate of 1.22 and 3.4 years older Omic than calendar age (50 yr), so I'd like to take a targeted approach, with additional data from this test to focus on the "oldest" organs first. I am currently using lifestyle mods, HRT, and injectable peptides--but I'd like to optimize my protocols and in specific organ stacks of oral Khavinson bioregulators, similar to Dr. Bill Lawrence's tissue/organ specific research approach, to try to recover that age pacing back to at least baseline 1.0 as quickly as practically possible or hopefully even slower over time.

    • @everythingepigenetics
      @everythingepigenetics 10 місяців тому

      Thanks for the kind words! I'm glad you enjoyed the episode. This algorithm will be available hopefully in Q2 of this year. You will be able to get it from my company, TruDiagnostic. The algorithm/report will now be called "SYMPHONYAge" and included in the TruAge Complete Kit. The outcome that Elysium offers is not the true algorithm from Raghav. The algorithm they use is not published, actually, so we do not know how it performs in comparison. I appreciate the additional insight you've given me as well. Since you've already taken the TruAge Complete kit, you can add SYMPHONYAge on for a one-time fee when it's available. Let me know if you have any other questions!

    • @JoeUser9997
      @JoeUser9997 10 місяців тому

      @@everythingepigenetics That's great news! Is there any plans to also add in the Symphony/AGE organ aging algorithm info into the TruAge Pacing reports as well? I bought the OMICAge Report Suite upgrade and feel that was well worth it. I'm trying to find a new Primary Care physician in my area (eastern NC) that is tuned into "aging as disease" mindset, but so far have come up dry. I reached out to your staff recently to see if any doctors in my area have gotten setup with you guys yet--figured maybe that would be my best place to start looking if any physicians are already setup with your reports. I'd even be willing to drive to Durham/Chapel Hill (waiting to hear back from Claire-keeping my fingers crossed!). Thank you and Ryan Smith for doing all this--such an exciting field of endeavor! I also have followed Bill Faloon with keen interest for years since his group at the Age Reversal Network have been running some private controlled studies with folks self experimenting with metformin, Rapamycin and senoletics protocols since 2018--maybe they could share data or utilize your services as well there or even partner to interested individuals through his popular Life Extension supplement product line/website and or RAADfest which he is also very active in.

    • @everythingepigenetics
      @everythingepigenetics 10 місяців тому

      @@JoeUser9997At this time, there is not! The TruAge PACE is run on a custom aging array that only includes 10,000 CpGs, while the TruAge Complete kit is run a custom EPICv2 that includes about 1.2 million CpGs. We are currently working on being able to recommend healthcare providers to customers like yourself. We will keep this top of mind! We were also at RAADfest last year and will be there this year as well. If you plan on attending, I hope to see you there.

  • @musuyanguba4226
    @musuyanguba4226 10 місяців тому

    Chemo is not preventative care. It might kill the cell but it will create an environment for more cancer and other diseases cells. Epigenetic is reversible. The problem is the environment. If the gene are not in a healing environment, it’s hard to reverse. Epigenetic are not the only thing being passed but also the toxins can be passed on from mother to children. And also families live in the same environment and get exposed to the same toxins. Offspring detoxification system also get affected by parents exposure. But I think if we change the environment (body) with the right lifestyle changes, diet, nutrients, avoid toxins in foods, environment and personal products then the genes can change for the better. Also lack of the right nutrients is promoting epigenetic. Polyphenols can reverse epigenetic and acetyl l-Carnitine can improve the quality of a sperm preventing some epigenetic. There are many other nutrients people are deficient in that can prevent epigenetic. Conventional medicine in the long run can cause epigenetic because many have synthetic ingredients and they also deplete nutrients.

  • @brucenicholas1413
    @brucenicholas1413 10 місяців тому

    Hannah another great interview thank you so much. The cancer drug mentioned I believe to be Zebularine.

    • @everythingepigenetics
      @everythingepigenetics 10 місяців тому

      Thank you :) You are correct! See this paper here - www.ncbi.nlm.nih.gov/pmc/articles/PMC2713825/

  • @KoiRun50
    @KoiRun50 10 місяців тому

    In general men have thicker bloods than women. They tend to run higher in hgb, hct and rbcs. I think is one key reason why women live longer than men.