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I think people can get useful information out of this kind of tests, as long you don't look at it like a sort of oracle, but more like a compass (eg. Am I going in the right direction or do I need to correct my course?). But some criticism is valid, this kind of tests have high correlation with lifespan, but have yet to stand the test of time.

Kind of disappointed that Peter Attia is so misinformed and so behind on the latest technologies in the field he is considered an authority in. Loved his book Outlive and hope he can avoid confusing people in future interviews. I found my TruAge report to be insightful and useful, look forward to monitoring changes with regular testing.

Smoke and mirrors. A true lab director would never refer to the instruments as machines. I'm sure he's qualified scenically, just highly inexperienced.

The narrator is a genius and gives a lot of confidence in the company. I just bought the test

I question the accuracy of these measurements, having recently done an OMIC test ( my fourth). My A1C showed 6.4, fasting Blood Sugar 112. I did a real blood test the same week. My A1C, 5.3. ( my highest in years, it’s normally 5.0 ). My fasting BS was 79. It’s never been above 85.

Where can I get the cheat sheet?

ECGC? I think he must mean EGCG. It would be great to know about more supplements, vitamins and minerals. Chocolate polyphenols, olive polyphenols, ergothioneine, hibiscus, artichoke, aronia, lion's mane mushroom, cranberry, pterostilbene, saffron, spermidine, ursolic acid, and pregnenolone. And I really would like results from toxins found in the blood: lead, fluoride, cadmium, iron (at higher than recommended), mercury, arsenic, acrylamide, advanced glycation end-products, polybrominated diphenyl ethers, and organophosphate.

I just received my first SymphonyAge report today. I noted that my "heart age" was 58, higher than my chronological age of 56.66 (while lung age was 50, though they are supposed to be highly correlated). Your video above made it sound like factors such as heart rate, blood pressure, BMI, and weight circumference would be figured in. However, these were not requested/required of the participant, so how can they be part of the calculation? As an endurance runner, my non-blood biomarkers are excellent. So, why is my heart score above my calendar age? And what does seeing a score of 58 do for me when I already run daily and eat a whole-food diet? It doesn't say what can be done to improve it (other than things I already do).

Exciting release team! Will have to check my old tests and do a new one with this!

Congratulations to Ryan and all the Tru Diagnostic team!!! We need tools to better understand our patients, specially in the prevention amd early diagnosis area. And I guess SymphonyAge will help us a lot including to show and convince the patient for a specific treatment or conduct!!!!

is mild hbot good for sleep? what brands do you recommend for home purchase

Would be good to study the effects of plasma donation which removes a significant but lower quantity of plasma on each round. ~25% for donation vs ~60% for TPE. Donation, which can be done monthly, is free at local blood banks in US. vs TPE which physicians in the "longevity" world are charging thousands for. Need dose response (minimum effective volume and frequency) as well as more data on gene expression and tissue changes. May be that it would take many months to see significant tissues changes. As an older person I will try to use some of the blood parameters in the 2022 Conboy paper to assess my plasma donation regime.

"...disrupt red cells for DNA extraction..."? Credibility undermined in first 30 secs.

They will result this as a FASTING blood glucose result - be aware and be fasted for accurate results! It was not clear to me they would be testing fasting glucose when I prepared and sent the sample

❤🙏🏻🎯🚀

Let him talk. That would have been your job.

Reduced pressure results in an increase in red blood cells, however no mention of what happens to red blood cells due to longer / sustained HBOT. I would be cautious.

Please don't call a linear regression model "AI"

Here's a link to the slide deck from the talk: docs.google.com/presentation/d/1vJn3E5WVnjNhOANNxuj9mNHMF-YxmYTYPd0lyc3dr1U/edit?usp=sharing

Where’s part 1?

Great video

My Omic HBA1C came in at 6.5. I get it blood tested twice a year and have never been over 5.3, the average is about 5.0. So the Omic correlation isn’t accurate

This is wonderful. Really useful and well explained

Isoputreanine is in chickens, so is it also in eggs?

Is Hsp70 in Kejun Ying's adaptage?

you call a Hazard Ratio of 1.02..1.08 incredible? (~@3.00) In which direction? incredible good or incredible insignificant? @7:35 you call principal component algorithms "incredibly precise"... Well, that's b.s.. First, PCA in itself is a stupid algorithm, 2nd class at best and second, you can not call an algorithm "incredibly precise". stopped watching.

Fantastic. Really exciting and ground breaking.

Great content. ....🌻🌈💝

This is absolutely INCREDIBLE~~~ Thank you both for partnering up. I am a believer in Dr Shade and in TruDiagnostic!!

This was an amazing presentation Ryan! Holy cow, you guys have been doing great work over the last 5 years. Will be very excited to offer this newer generation testing to our patients. This webinar answered a lot of longstanding questions I had about DNA methylation proxies.

Would like to see a comparison with GrimAge

46:19 is there any reason you don't offer a GrimAge report? You can calculate that with just methylation data, correct?

Love it🔥

Great information🔥

So when is this available commerecially?

My hemoglobin A1C DNAmage is totally not correlated with my actual hemoglobin A1c but I still worry b/c despite having better baseline glucose,I have thicker spikes than most epople, and some kinds of fruit may not be safe for me to eat

Can she biobank my samples? I'm in Boston

PS. There was mention of replacing old plasma with young plasma but this has many drawbacks, Instead it t would be interesting to test simple plasma donation (in older people) as is done at blood banks in the US. Each donation takes out about 25% of plasma and can be done monthly. This isn't as much as the Conboy work on NBE which took out 50% in animals, but it is a significant volume. It's also an easy thing to do unlike the multi-thousand dollar clones of the Conboy process which are being done now and in the pipeline by new startups.

Thanks. On NMN and AKG, I recall a presentation, 2022 I believe, by Adam Antebi in which he showed that low insulin resulted in increased NMN and AKG. How low in humans I have no idea as I think work was done in mice or rats. But low insulin has multiple benefits and it would be interesting to correlate it with rate of epi aging. Also work by Janet Lord which showed that long time exercisers maintained their thymus and immunity well into 70s and 80s. Along with that work from Riekelt Houtkooper's lab which showed that NAD+ was preserved in older people who met certain exercise thresholds. Seems like diet and exercise (assuming no smoking and drinking) may negate the need to involve some of the interventions, like Fahey's work on the thymus, or taking NR and NMN. Would just need some work to sort out, but maybe something as simple as determining if rate of aging is slowed to maximum amount by diet and exercise regimes alone. It appeared that modest CR by itself when a long way to doing this.

Any idea when trial results will publish?

1:00 DNA extraction from red blood cells is not scientifically accurate - since there is no DNA (no nucleus) inside RBC (en.wikipedia.org/wiki/Red_blood_cell)

My epitoc2 is 592

This is fantastic, thank you.

Is it possible or can be possible in near future to increase height at any age or after growthplates fusion. Can person of 5’ become 6’ or , 6’ person become 7’ . Is it possible? I want research should be done in this area . No cut or operation just some machine n biological team who will supervise everything and plans diet n schedule . Something like that.

Is it safe to undergo HBOT for a person who has had a Stapedectomy (middle ear surgery)? Will the 2X Oxygen pressure damage the inserted prosthesis?

Many of my patients are on testosterone replacement after menopause or oophorectomy, and that is not mentioned instead of DHEA. DHEA is only useful in men and is a precursor to Testosterone. After menopause women are healthier if they are treated with E2 and T. Has Testosterone been considered?

Are you looking for a test subject ? Sign me up!

Do the plasma bags touch a lot of plastic?

Excited for the results of his study.