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SignalChem Biotech Inc.
Приєднався 18 чер 2019
Here to signal you to the right path
Bioluminescent assay technologies for studying cell signaling, drug discovery and beyond.
Explore the fundamental principles of bioluminescence in assays, learn how bioluminescent assays are pivotal in drug discovery, and discover the role of innovative Lumit technology in cell signaling.
About the Speaker
Dr. Hicham Zegzouti is a Senior Research Scientist in Promega Assay Design-R&D. His group develops biochemical and cell-based assay technologies to interrogate diverse enzyme activities and cellular pathways (kinases, glycosyltransferases, and other drug targets). Dr. Zegzouti received his PhD in 1997 from the National Polytechnic Institute of Toulouse, France. Prior to joining Promega, he was a postdoctoral researcher in Molecular, Cell and Developmental Biology at UC-Los Angeles studying auxin hormone signaling in an Arabidopsis plant model. His work focused on the identification and characterization of AGC kinase family and its regulation during plant development. Dr. Zegzouti has authored over 30 journal articles and book chapters, co-edited a Kinase screening methods book and is an inventor on several patents.
About the Webinar
1. Bioluminescent Assay Fundamentals
Gain a deep understanding of the core principles underlying bioluminescence and its significance in crafting cutting-edge assays.
2. Bioluminescent Assays in Drug Discovery
Delve into the practical applications of bioluminescent biochemical assays, with a focus on detecting activity of PTM enzymes like methyltransferases and kinases. Real-world examples will illustrate their pivotal role in accelerating drug discovery efforts.
3. LumitTM A Novel Homogeneous Immunoassay
Dive into the cutting-edge Lumit technology, a bioluminescent homogeneous cell-based immunoassay, and explore its potential in detecting phosphorylation events within cell signaling pathways.
About the Speaker
Dr. Hicham Zegzouti is a Senior Research Scientist in Promega Assay Design-R&D. His group develops biochemical and cell-based assay technologies to interrogate diverse enzyme activities and cellular pathways (kinases, glycosyltransferases, and other drug targets). Dr. Zegzouti received his PhD in 1997 from the National Polytechnic Institute of Toulouse, France. Prior to joining Promega, he was a postdoctoral researcher in Molecular, Cell and Developmental Biology at UC-Los Angeles studying auxin hormone signaling in an Arabidopsis plant model. His work focused on the identification and characterization of AGC kinase family and its regulation during plant development. Dr. Zegzouti has authored over 30 journal articles and book chapters, co-edited a Kinase screening methods book and is an inventor on several patents.
About the Webinar
1. Bioluminescent Assay Fundamentals
Gain a deep understanding of the core principles underlying bioluminescence and its significance in crafting cutting-edge assays.
2. Bioluminescent Assays in Drug Discovery
Delve into the practical applications of bioluminescent biochemical assays, with a focus on detecting activity of PTM enzymes like methyltransferases and kinases. Real-world examples will illustrate their pivotal role in accelerating drug discovery efforts.
3. LumitTM A Novel Homogeneous Immunoassay
Dive into the cutting-edge Lumit technology, a bioluminescent homogeneous cell-based immunoassay, and explore its potential in detecting phosphorylation events within cell signaling pathways.
Переглядів: 249
Відео
SignalChem Webinar - Unraveling the Intricacies of Protein Phosphorylation in Signaling Pathways
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SignalChem Webinar - Unraveling the Intricacies of Protein Phosphorylation in Signaling Pathways
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Thanks so much for sharing
Work for free? Miss me with that
Can you train me please ?
Can we change genetic pathways growth rates with this and can we grow a maple tree in a week with this technique
No. Or at least not yet. Messing about with the genes involved in cell division almost always causes cancer.
What is a co-op
See I’m writing a paper on this and nothing is more infuriating than everyone saying “it cuts a target sequence” HOW?! In what capacity does it know where to cut? If it’s programmed, how is it programmed? Y’all leave out the most important details smh. “With crispr now you can recognise genes” SICK BUT GODDAMN HOW?!
Aren’t they protecting their trade secrets?
My dude, you are already past the level of 90% of youtube videos. Get on to Google Scholar and read papers.
Sometimes PhDs give a horrible explanation like this and then justify said horrible description by saying they are putting it into terms the public can understand, haha. This is one of the worst descriptions of CRISPR I have seen. Not only does he fail to explain how it works, but the way he worded it just doesn’t even make sense.
So how it works is...there is an RNA which is paired with Crispr/Cas9(it's an enzyme/protein ).they go together towards the target sequence. The RNA that go with the Crispr will guide the Crispr to target sequence by complimentary base pairing. Crispr will then cut the target area.(the target area is present upstream of a "6 base pair sequence"). More clarification: Crispr recognizes the "6 base pair sequence" and cuts the sequence upstream of the six base pair sequence. So the "6 base pair sequence "which is called "PAM" is called the " recognition site " of Crispr and the "target site" that is present upstream of the recognition site is called the "cleavage site" for Crispr.
is there any possibility to change face bones with genetic engineering?pls someone tell me this
So right now CRISPR is only used in blood clinically. When we do develop crisper to change facial bones it will only work for people who are young.
It can't change bone structure at an older level. It would be like switching out the blueprints for a house that's already built; the structure is built nothing can be done.
@@rickmay4458 search about Adam Rainer he changed bones
@@rickmay4458 That's true, but theoretically, it could be possible with advances in ex vivo CRISPR editing. By targeting genes like BMP2 and RUNX2 in mesenchymal stem cells, we might upregulate osteogenesis and potentially reshape facial bones. It's speculative, but the science could get there one day!
So it can target specific genes and cut them?
🙂👌👌👌👌👍👍👍👍
How can I join the lab
I felt that 😢
this was super cool!! I'd love to hear why you were doing this and what you were looking for?
Я поставил лайк только чтобы потом песню скачать афтор живи с этим
That literally told me nothing about getting a phd
💗
WELL I'm a lab tech student... I think UA-cam knows me because it just recommended me that video and I litterally took pictures of my gels many times 😂
The algorithm does not miss -- just like your gel doc.
The best to control covid 19...two eggs everyday. True....
Ummmm nope #NoJab4Me I'll take #Ivermectin instead thankyou. #GeneTherapy #EmergencyUseAuthorization
FIRST!
Thanks for this.